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Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1-dependent mechanism

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Translational Neurodegeneration 2017年第1期6卷 310-323页

作者： Rafael Lazo-Gomez ricardo tapia División de Neurociencias Instituto de Fisiología CelularUniversidad Nacional Autónoma de MéxicoCircuito exterior s/nCiudad UniversitariaCoyoacán04510 Ciudad de MéxicoMexico

Background:Excitotoxicity is a mechanism of foremost importance in the selective motor neuron degeneration characteristic of motor neuron *** therapeutic strategies are an unmet need for these ***,such as quercetin and resveratrol,are plant-derived compounds that activate sirtuins(SIRTs)and have shown promising results in some models of neuronal death,although their effects have been scarcely tested in models of motor neuron ***:In this work we investigated the effects of quercetin and resveratrol in an in vivo model of excitotoxic motor neuron death induced by the chronic infusion ofα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid(AMPA)into the rat spinal cord *** and resveratrol were co-infused with AMPA and motor behavior and muscle strength were assessed daily for up to ten ***,animals were fixed and lumbar spinal cord tissue was analyzed by histological and immunocytological ***:We found that the chronic infusion of AMPA[1 mM]caused a progressive motor neuron degeneration,accompanied by astrogliosis and microgliosis,and motor deficits and paralysis of the rear *** infusion ameliorated AMPA-induced paralysis,rescued motor neurons,and prevented both astrogliosis and microgliosis,and these protective effects were prevented by EX527,a very selective SIRT1 *** contrast,neither resveratrol nor EX527 alone improved motor behavior deficits or reduced motor neuron degeneration,albeit both reduced ***:These results suggest that quercetin exerts its beneficial effects through a SIRT1-mediated mechanism,and thus SIRT1 plays an important role in excitotoxic neurodegeneration and therefore its pharmacological modulation might provide opportunities for therapy in motor neuron disorders.

关键词： Motor neuron disorder Quercetin Resveratrol Sirtuin Excitotoxicity

Estimation of rainfall thresholds for shallow landslides in the Sierra Madre Oriental, northeastern Mexico

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Journal of Mountain Science 2020年第7期17卷 1565-1580页

作者： Jorge A.Salinas-Jasso Fernando Velasco-tapia Ignacio Navarro de León ricardo A.Salinas-Jasso Efraín Alva-Nino Facultad de Ciencias de la Tierra Universidad Autónoma de Nuevo LeónEx-Hacienda de Guadalupe km 8.Carr.Linares-Cerro PrietoLinaresN.L.67700México Secretaría de Desarrollo Sustentable de Nuevo León Washington #2000Col.ObreraMonterreyN.L.64010México

Landslides induced by prolonged rainfalls are frequent mass movements along the northeastern portion of the Sierra Madre Oriental in Mexico,causing significant damage to *** this work,we have studied the connection between rainfall and landslides in the Santa Rosa Canyon,a catchment located in the northeastern Mexico.A landslide database triggered by major storms and hurricanes that have hit the region over the past 30 years was analyzed.A total of 92 rainfall events in the Santa Rosa Canyon were studied to determine the amount of precipitation needed to trigger shallow *** each event the duration(D,in hours)and the cumulated rainfall event(E,in mm)were determined by using historical rainfall data from weather stations located near the study *** have proposed an ED threshold for rainfall-induced landslides with durations 0.5

关键词： Shallow landslides Cumulated rainfall Rainfall thresholds Northeastern Mexico Early warning systems.

Ecological-Genetic Studies and Conservation of Endemic <i>Quercus sideroxyla</i>(Trel.) in Central Mexico

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Natural Resources 2014年第9期5卷 442-453页

作者： Cecilia Alfonso-Corrado ricardo clark-tapia Alejandro Monsalvo-Reyes Carlos Rosas-Osorio Gabriel González-Adame Francisco Naranjo-Luna Crystian-Sadiel Venegas-Barrera Jorge E. Campos Instituto de Estudios Ambientales Universidad de la Sierra Juárez Ixtlán de Juárez México InstitutoTecnológico de Ciudad Victoria Ciudad Victoria México Laboratorio de Bioquímica Molecular-Unidad de Biotecnología y Prototipos (UBIPRO) Fes-IZTACALA UNAM Tlalnepantla México

This study examines the distribution, ecology and genetic diversity of Quercus sideroxyla Humb. Bonpl, with an emphasis on its conservation on the Natural Protected Area of Sierra Fría in North Central Mexico. Twenty-nine locations were selected, and in each location, one plot of 1500 m2 was established. At every location, we obtained an abundance of Q. sideroxyla and a basal area for each individual tree, including geographical and climatological data. We used the Outlying Mean Index (OMI) to examine whether environmental conditions had a distributional effect on Q. sideroxyla populations and to obtain the static size population structure of the species. For the genetic analysis, we collected 18 adult individuals from each population, four polymorphic loci were used to estimate genetic diversity. Q. sideroxyla abundance was associated with narrow environmental conditions, especially when considering the topographical and meteorological environmental variables. The allelic richness value was 84 alleles (21 privatealleles), and the expected mean heterozygosity was 0.855 ± 0.009. The high vulnerability of the species to changes in the land use at the local scale and to global climatic changes increases the species’ susceptibility to local disappearance.

关键词： Ecology Genetic Diversity Local Conservation Niche Oaks

Study of the Copper,Chromium,Manganese and Zinc Contents in the Species Azorella spinosa(Apiaceae),Collected in the Maule Region,Chile

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Journal of Environmental Protection 2019年第5期10卷 601-613页

作者： Jaime tapia Jorge Cornejo Margarita Gutierrez Patricio Penailillo ricardo Baettig Luis Vargas-Chacoff Jessica Espinoza Aurelio San Martin Institute of Natural Resources Chemistry University of TalcaTalcaChile Institute of Biological Sciences University of TalcaTalcaChile Faculty of Forestry Sciences University of TalcaTalcaChile Institute of Marine Science and Limnology University Austral of ChileValdiviaChile University of Magallanes Punta ArenasChile

The increase in prevalence of environmental pollution, especially soil contamination with toxic metals has led to their uptake in the human food chains through plant parts. Accumulation and magnification of heavy metals in human tissues through comsuption of herbal medicine can cause hazardous impacts on health. Therefore, chemical profiling of four heavy metals (Cu, Cr, Mn and Zn) was undertaken in samples of Azorella spinosa from coast and mountain of Maule Region in Chile. The Cu, Cr, Mn and Zn concentrations were determined in plants of the species Azorella spinosa and their soils of origin. For each plant, the metal contents in the stalk, leaves and soil were determined by flame atomic absorption spectroscopy. The methodology was validated using certified reference material: BIMEP-432 for the plant samples and MESS-1 for the soil samples. The concentration ranges found in the plant tissue were: Cu: 1.2 - 62.5;Cr: 0.2 - 3.2;Mn: 188.6 - 1345.1 and Zn: 7.5 - 55.9 mg·kg-1 (dry weight). For the soil samples, the ranges were: Cu: 6.4 - 81.5;Cr: 4.6 - 50.4;Mn: 335.6 - 1936.1 and Zn: 15.6 - 65.9 mg·kg-1 (dry weight). The results were evaluated statistically (two-way ANOVA) to correlate the Cu, Cr, Mn and Zn concentrations in Azorella spinosa plant tissues with those in the soil samples from the corresponding sampling areas.

关键词： Azorella spinosa Toxic Metals Atomic Absorption Maule Region

Improving Compost Process Efficiency by Leachates Inoculation and Shredding of the Organic Fraction of Municipal Solid Waste at Bordo Poniente Composting Plant,Mexico City

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Journal of Environmental Science and Engineering(A) 2021年第5期10卷 177-183页

作者： Francisco Javier Barrón-Santos Ma.Eugenia Gutiérrez-Castillo Luis Raúl Tovar-Gálvez Ma.Teresa Núñez-Cardona ricardo Estrada-Núñez Claudia Rodríguez tapia Alfonso Espitia-Cabrera Departamento de Posgrado Salud OcupacionalSeguridad e HigieneEscuela Nacional de Medicina y HomeopatíaInstituto Politécnico NacionalCiudad de México 07320México Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de México 07340México Departamento El Hombre y su Ambiente Universidad Autónoma Metropolitana XochimilcoCiudad de México 04960México Secretaría de Obras y Servicios Gobierno de la Ciudad de MéxicoCiudad de México 06000México Unidad Profesional Interdisciplinaria de Biotecnología Instituto Politécnico NacionalCiudad de México 07340México Departamento de Energía Universidad Autónoma Metropolitana AzcapotzalcoCiudad de México 02200México

Management of MSW(Municipal Solid Waste)is a major downside in most of the biggest *** composting of the organic fraction of MSW is one of the oldest and simplest ways of organic waste *** is a self-heating biological conversion that generates appropriate finished merchandise such as soil conditioner or *** City generates about 12,500 ton/day of MSW,44%of it is food scraps and yard trimmings which are the OFMSW(Organic Fraction of Municipal Solid Waste),2,500 ton/day of it is composted at the BPCP(Bordo Poniente Composting Plant)yielding 500 ton/day of *** purpose of this study was to evaluate three treatments to accelerate the composting process,so eventually the city could increase the amount of the OFMSW at *** compared three different treatments;one of them showed a significant reduction in time of the composting process(p≤0.05)i.e.,it took less time to reach the thermophilic stage,maturity and stabilization *** was achieved at 35 days and 60 days to *** conclude that shredding the feedstock plus leachate inoculum addition at the beginning of the process,reduces the composting time in about 61%with respect to the time it takes at the BPCP,where lasted 90 days.

关键词： Composting organic fraction municipal solid waste inoculum leachates size particle

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甘蔗渣芦笋皮加入提高了甘薯淀粉发泡性能

绿色包装 2019年第3期 74-74页

作者： Jam Pier Cruz-Tirado ricardo Vejarano Delia R. tapia-Blácido Luis M. Angelats-Silva Raúl Siche 不详

利用甘蔗蔗渣(SB)和芦笋皮(AP)这两种农业工业废弃物,对以甘薯淀粉为基础的泡沫托盘(分别为淀粉/SB 和淀粉/AP托盘)进行了生物降解,提高了泡沫托盘的性能。制备了含不同浓度SB 和AP(0%-40%w/w)的淀粉/SB和淀粉/AP 托盘,并对其微观结构... 详细信息

利用甘蔗蔗渣(SB)和芦笋皮(AP)这两种农业工业废弃物,对以甘薯淀粉为基础的泡沫托盘(分别为淀粉/SB 和淀粉/AP托盘)进行了生物降解,提高了泡沫托盘的性能。制备了含不同浓度SB 和AP(0%-40%w/w)的淀粉/SB和淀粉/AP 托盘,并对其微观结构、物理、热学和力学性能进行了表征。纤维废料的加入使发泡托盘发黄,与无纤维的甘薯淀粉发泡托盘相比,发泡托盘亮度低,孔隙率高,机械阻力大,变形性好,吸水性好。添加SB的泡沫托板多孔性较低,吸水能力较低,抗拉强度较AP高。AP纤维的浓度越高(大于30%),泡沫托盘就越容易膨胀。纤维废弃物的加入提高了甘薯淀粉泡沫托盘的热稳定性。所制备的复合发泡托盘可作为膨化聚苯乙烯在食品干包装中的替代品。

关键词：甘薯淀粉发泡性能甘蔗渣芦笋皮工业废弃物纤维废弃物无纤维生物降解

Notes,outline and divergence times of Basidiomycota

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Fungal Diversity 2019年第6期99卷 105-367页

作者： Mao-Qiang He Rui-Lin Zhao Kevin D.Hyde Dominik Begerow Martin Kemler Andrey Yurkov Eric H.C.McKenzie Olivier Raspe Makoto Kakishima Santiago Sanchez-Ramırez Else C.Vellinga Roy Halling Viktor Papp Ivan V.Zmitrovich Bart Buyck Damien Ertz Nalin N.Wijayawardene Bao-Kai Cui Nathan Schoutteten Xin-Zhan Liu Tai-Hui Li Yi-Jian Yao Xin-Yu Zhu An-Qi Liu Guo-Jie Li Ming-Zhe Zhang Zhi-Lin Ling Bin Cao Vladimir Antonin Teun Boekhout Bianca Denise Barbosa da Silva Eske De Crop Cony Decock Balint Dima Arun Kumar Dutta Jack W.Fell Jozsef Geml Masoomeh Ghobad-Nejhad Admir J.Giachini Tatiana B.Gibertoni Sergio P.Gorjon Danny Haelewaters Shuang-Hui He Brendan P.Hodkinson Egon Horak Tamotsu Hoshino Alfredo Justo Young Woon Lim Nelson Menolli Jr Armin Mesic Jean-Marc Moncalvo Gregory M.Mueller La szlo G.Nagy RHenrik Nilsson Machiel Noordeloos Jorinde Nuytinck Takamichi Orihara Cheewangkoon Ratchadawan Mario Rajchenberg Alexandre G.S.Silva-Filho Marcelo Aloisio Sulzbacher Zdenko Tkalcec ricardo Valenzuela Annemieke Verbeken Alfredo Vizzini Felipe Wartchow Tie-Zheng Wei Michael WeiB Chang-Lin Zhao Paul M.Kirk State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101People’s Republic of China Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand College of Life Sciences University of Chinese Academy of SciencesHuairou DistrictBeijing 100408People’s Republic of China Ruhr-Universitat Bochum AG GeobotanikND03UniversitatsstraBe 15044801 BochumGermany Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures InhoffenstraBe 7B38124 BrunswickGermany Manaaki Whenua-Landcare Research Private Bag 92170AucklandNew Zealand Research Department Meise Botanic GardenNieuwelaan 381860 MeiseBelgium Service General de l'Enseignement superieur et de la Recherche scientifique Federation Wallonie-BruxellesLavallee 11080 BrusselsBelgium University of Tsukuba TsukubaIbaraki 305-8572Japan Department of Ecology and Evolutionary Biology University of Toronto25 Willcocks St.TorontoON M5S 3B2Canada Berkeley USA Institute of Systematic Botany The New York Botanical GardenBronxNY 10458-5126USA Department of Botany Szent Istvan University1518 BudapestHungary Komarov Botanical Institute Russian Academy of SciencesProfessor Popov st.2Saint PetersburgRussia 197376 Institut pour Systematique Ecologie Biodiversite(ISYEB UMR 7205) Sorbonne universiteMuseum National d’Histoire Naturelle CP 39CNRSDepartement Origines et Evolution12 Rue Buffon75005 ParisFrance Institute of Microbiology Beijing Forestry UniversityBeijing 100083People’s Republic of China Department of Biology Research Group MycologyGhent UniversityK.L.Ledeganckstraat 359000 GhentBelgium State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Institute of MicrobiologyGuangzhou 510070People’s Republic of China Department of Botany Moravian Mu

The Basidiomycota constitutes a major phylum of the kingdom Fungi and is second in species numbers to the *** present work provides an overview of all validly published,currently used basidiomycete genera to date in a single *** outline of all genera of Basidiomycota is provided,which includes 1928 currently used genera names,with 1263 synonyms,which are distributed in 241 families,68 orders,18 classes and four *** provide brief notes for each accepted genus including information on classification,number of accepted species,type species,life mode,habitat,distribution,and sequence ***,three phylogenetic analyses with combined LSU,SSU,5.8s,rpb1,rpb2,and ef1 datasets for the subphyla Agaricomycotina,Pucciniomycotina and Ustilaginomycotina are conducted,*** time estimates are provided to the family level with 632 species from 62 orders,168 families and 605 *** study indicates that the divergence times of the subphyla in Basidiomycota are 406-430 Mya,classes are 211-383 Mya,and orders are 99-323 Mya,which are largely consistent with previous *** this study,all phylogenetically supported families were dated,with the families of Agaricomycotina diverging from 27-178 Mya,Pucciniomycotina from 85-222 Mya,and Ustilaginomycotina from 79-177 *** times as additional criterion in ranking provide additional evidence to resolve taxonomic problems in the Basidiomycota taxonomic system,and also provide a better understanding of their phylogeny and evolution.

关键词： Classification Molecular clock Fungi Systematics Taxonomy

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING