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减少条片缺陷的结晶器保护渣设计,改进与应用

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湘钢译丛 1994年第4期 5-12页

作者： clark,b 刘戈

The Use of Hypothermically Stored Amniotic Membrane for Cartilage Repair: A Sheep Study

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Stem Cell Discovery 2015年第4期5卷 62-71页

作者： Samuel K. Tabet Alisa L. clark Eric b. Chapman Doug Thal New Mexico Orthopaedic Associates Albuquerque NM USA School of Medicine University of New Mexico Albuquerque NM USA Thal Equine LLC Albuquerque NM USA

Objective: To evaluate the use of hypothermically stored human amniotic membrane for cartilage repair in adult sheep. Studies show that human amniotic membrane contains pluripotent mesenchymal stem cells that can be influenced to produce chondrocytes. It is unknown if human amniotic cells can produce hyaline-like cartilage. This study evaluates the use of hypothermically stored amniotic membrane (HSAM) to fill chondral defects in a sheep model. We hypothesized HSAM would fill defects with hyaline-like cartilage with chondrocytes populating the matrix. One sheep was used as a control, and four sheep received amniotic membrane. Two of these sheep were used as a normal control comparison. A 1 cm2 defect was created on the trochlear grove in all specimens. Each membrane was sized and laid over with the stromal layer facing the subchondral bone and covered with Fibrin sealant. The knees were harvested at five months and underwent morphological, histological, and immunohistological evaluation based on the original validated scoring system by O’Driscoll. The control defect didn’t fill in with hyaline cartilage or fibrocartilage. The defects that successfully retained the graft had evidence of diffuse chondrocyte cell proliferation and showed a stromal matrix similar to hyaline cartilage. The graft samples showed a near 100% morphological fill in the HSAM defect contrasting to <10% fill in the control defect. The retained HSAM grafts scored 2.5 on a 0 - 3 cartilage appearance scale compared with 0.5 for the control defects. HSAM is a potential source of pluripotent cells that can influence chondrogenesis in a sheep model. The implications for application in a human model are promising and warrant further study.

关键词： Mesenchymal Stem Cells Chondrocytes Cartilage Repair Amniotic Membrane

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介绍一种平稳启动电潜泵的新方法

石油石化节能与计量 1985年第1期 40-44+47页

作者： A.b.neely M.M.Patterson 樊掌信张扬

电潜泵由于其开关的特性,所以都不宜采用反复操作(时开时停)。按正常方法,启动电流有时会比工作电流大5～8倍。这种波动容易损坏电动机和电缆,还会引起线路电压波动。同样,在停泵时也会使电流和电压明显波动。由于这种原因,大多数操作... 详细信息

电潜泵由于其开关的特性,所以都不宜采用反复操作(时开时停)。按正常方法,启动电流有时会比工作电流大5～8倍。这种波动容易损坏电动机和电缆,还会引起线路电压波动。同样,在停泵时也会使电流和电压明显波动。由于这种原因,大多数操作人员都不愿意频繁地启-停电潜泵。这就产生了不同规格泵的设计问题。

关键词：电潜泵降压启动器

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随钻电磁波测井：理论和实验

国外测井技术 1991年第5期6卷 76-87页

作者： clark,b 贵兴海

Disubstituted piperazine analogues of trifluoromethylphenylpiperazine and methylenedioxybenzylpiperazine: analytical differentiation and serotonin receptor binding studies

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Forensic Sciences Research 2018年第2期3卷 161-169页

作者： Jack DeRuiter Ashleigh Van Cleave Audinei de Sousa Moura Younis Abiedalla C.Randall clark Department of Drug Discovery and Development Harrison School of PharmacyAuburn UniversityAuburnALUSA Department of Pharmacy Federal University of PiauiTeresinaBrazil Faculty of Pharmacy Department of Medicinal ChemistryOmar Al-Mukhtar UniversityEl-BeidaLibya

A series of N,N-disubstituted piperazines were synthesized containing the structural elements of both methylenedioxybenzylpiperazine (MDbP) and trifluoromethylphenylpiperazine (TFMPP)in a single *** six potential designer drug molecules having a regioisomeric relationship were compared in gas chromatography-mass spectrometry (GC-MS),gas chromatography-infrared spectroscopy and serotonin receptor affinity *** compounds were separated by capillary gas chromatography on an Rxi(R)-17Sil MS stationary phase film and the elution order appears to be determined by the position of aromatic ring *** majority of electron ionization mass spectral fragment ions occur via processes initiated by one of the two nitrogen atoms of the piperazine *** major electron ionization mass spectrometry (El-MS) fragment ions observed in all six of these regioisomeric substances occur at m/z =364,229,163 and *** relative intensity of the various fragment ions is also equivalent in each of the six El-MS *** vapour phase infrared spectra provide a number of absorption bands to differentiate among the six individual compounds on this regioisomeric ***,the mass spectra place these compounds into a single group and the vapour phase infrared spectra differentiate among the six regioisomeric *** of the TFMPP-MDbP regioisomers displayed significant binding to 5-HT2b receptors and in contrast to 3-TFMPP,most of these TFMPP-MDbP isomers did not show significant binding at 5-HT1 receptor *** the 3-TFMPP-3,4-MDbP (Compound 5) isomer displayed affinity comparable to 3-TFMPP at 5-HT1A receptors (Ki =188 nmol/L).

关键词： Forensic science forensic toxicology gas chromatography-mass spectrometry gas chromatography-infrared spectroscopy regioisomers receptors serotonin disubstituted piperazines

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情感俚语(英文)

疯狂英语（初中天地） 2006年第1期 44-45页

作者： Karen clark

About laughter关于笑 A:Hey!What’s up? b:I am watching ***． A:Cool!You know,everytime I Watch it,I am in stitches[忍俊不禁] b:Yeah．I just can’t keep a straight face[板着面孔, 不露笑容]．I once got into trouble because of ***． A:Really?What happened? b:I burst out laughing[突然大笑起来]in class when I was thinking of ***’s stupid acts．

关键词：俚语 more 社会习惯语

A Light-Independent Allele of Phytochrome b Faithfully Recapitulates Photomorphogenic Transcriptional Networks

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Molecular Plant 2009年第1期2卷 166-182页

作者： Wei Hu Yi-Shin Su J. clark Lagarias Department of Molecular and Cellular biology College of Biological Sciences University of California Davis CA 95616 USA Present address: Carnegie Institution of Washington -Department of Plant Biology Stanford CA 94305 USA

Dominant gain-of-function alleles of Arabidopsis phytochrome b were recently shown to confer lightindependent, constitutive photomorphogenic （cop） phenotypes to transgenic plants （Su and Lagarias, 2007）. In the present study, comparative transcription profiling experiments were performed to assess whether the pattern of gene expression regulated by these alleles accurately reflects the process of photomorphogenesis in wild-type Arabidopsis. Whole- genome transcription profiles of dark-grown phyAphyb seedlings expressing the Y^276H mutant of phyb （YHb） revealed that YHb reprograms about 13% of the Arabidopsis transcriptome in a light-independent manner. The YHb-regulated transcriptome proved qualitatively similar to but quantitatively greater than those of wild-type seedlings grown under 15 or 50 μmol m^-2 m^-1 continuous red light （Rc）. Among the 2977 genes statistically significant two-fold （SSTF） regulated by YHb in the absence of light include those encoding components of the photosynthetic apparatus, tetrapyrrole/pigment biosynthetic pathways, and early light-responsive signaling factors. Approximately 80% of genes SSTF regulated by Rc were also YHb-regulated. Expression of a notable subset of 346 YHb-regulated genes proved to be strongly attenuated by Rc, indicating compensating regulation by phyC-E and/or other Rc-dependent processes. Since the majority of these 346 genes are regulated by the circadian clock, these results suggest that phyA- and phyb-independent light signaling pathway（s） strongly influence clock output. Together with the unique plastid morphology of dark-grown YHb seedlings, these analyses indicate that the YHb mutant induces constitutive photomorphogenesis via faithful reconstruction of phyb signaling pathways in a light-independent fashion.

关键词： light signaling signal transduction transcriptome analysis photomorphogenesis Arabidopsis phytochrome.

EMP control and characterization on high-power laser systems

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High Power Laser Science and Engineering 2018年第2期6卷 55-62页

作者： P.bradford N.C.Woolsey G.G.Scott G.Liao H.Liu Y.Zhang b.Zhu C.Armstrong S.Astbury C.brenner P.brummitt F.Consoli I.East R.Gray D.Haddock E Huggard E J.R.Jones E.Montgomery I.Musgrave E Oliveira D.R.Rusby C.Spindloe b.Summers E.Zemaityte Z.Zhang Y.Li P.McKenna D.neely Department of Physics York Plasma InstituteUniversity of YorkHeslingtonYork YO10 5DDUK Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUK Key Laboratory for Laser Plasmas(Ministry of Education)and School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Physics SUPA University of StrathclydeGlasgow G40NGUK ENEA-C.R.Frascati-Dipartimento FSN Via E.Fermi 4500044 FrascatiItaly Space Science Department STFC Rutherford Appleton LaboratoryDidcot OX110QXUK

Giant electromagnetic pulses(EMP) generated during the interaction of high-power lasers with solid targets can seriously degrade electrical measurements and equipment. EMP emission is caused by the acceleration of hot electrons inside the target, which produce radiation across a wide band from DC to terahertz frequencies. Improved understanding and control of EMP is vital as we enter a new era of high repetition rate, high intensity lasers(e.g. the Extreme Light Infrastructure).We present recent data from the VULCAN laser facility that demonstrates how EMP can be readily and effectively reduced. Characterization of the EMP was achieved using b-dot and D-dot probes that took measurements for a range of different target and laser parameters. We demonstrate that target stalk geometry, material composition, geodesic path length and foil surface area can all play a significant role in the reduction of EMP. A combination of electromagnetic wave and 3 D particle-in-cell simulations is used to inform our conclusions about the effects of stalk geometry on EMP,providing an opportunity for comparison with existing charge separation models.

关键词： high energy density physics high-power laser related laser components laser plasmas interaction target design and fabrication

Impact of Iron Availability on <i>bacillus amyloliquefaciens</i>Growth

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Advances in Microbiology 2014年第13期4卷 962-967页

作者： D. clark C. Youngblood M. Taplin E. brown b. S. Williams C. Phillips b. Garner biology Department Tougaloo College Tougaloo USA Department of biology Jackson State University Jackson USA Department of Environmental Science Jackson State University Jackson USA

bacillus amyloliquefaciens is a biocontrol agent whose genome has been sequenced. Within the genome of b. amyloliquefaciens are genes associated with iron chelation, but these genes are not found within all sequenced strains. The impact of iron availability on the b. amyloliquefaciens physiology was examined in this study. b. amyloliquefaciens ATCC 23843 was cultured under ironreplete and iron-deplete conditions for 48 hours, at 37°C. Final growth yields were dependent on iron concentration. Cultures grown in the absence of detectable iron were restricted in growth, but reached their highest yields at 48 hours. Iron restriction was confirmed by the presence of iron chelators in the filtrates. In contrast, b. amyloliquefaciens ATCC 23843 cultures grown with ferric ammonium citrate as the iron source research reached the highest yields at 24 hours. Iron chelator production was not detected in the ferric ammonium samples. A significant decrease in turbidity was observed for these cultures, which coincided with elevated spore production in b. amyloliquefaciens ATCC 23843. A decrease in turbidity was also observed on blood agar, where hemolysis was readily evident. We propose that iron impacts numerous physiological responses and further studies will elucidate the complex regulatory mechanisms governed by iron availability.

关键词： bacillus Catechol Hemolysis Iron