检索结果-南通市图书馆

国外医学.精神病学分册 1981年第4期 218-220页

作者： Smith WO clark ml 周天骍周志良

自1962年作者报导两例精神分裂症患者在没有其他疾病的情况下,自体产生饮水中毒的病例以来,陆续有17篇文献报导,共包括25例病人。这27例中16例患者至少是有暂

关键词：水中毒病人水-电解质代谢紊乱精神分裂症患者分泌异常自体

Robust Machine Learning Mapping of sEMG Signals to Future Actuator Commands in Biomechatronic Devices

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2024年第1期21卷 270-287页

作者： Ali Nasr Sydney Bell Rachel L.Whittaker clark R.Dickerson John McPhee Systems Design Engineering University of WaterlooWaterloo N2L 3G1Canada Kinesiology and Health Sciences University of WaterlooWaterloo N2L3G3Canada

A machine learning model for regression of interrupted Surface Electromyography(sEMG)signals to future control-oriented signals(e.g.,robot’s joint angle and assistive torque)of an active biomechatronic device for high-level myoelectric-based hierarchical control is proposed.A Recurrent Neural Network(RNN)was trained using output data,initially obtained from offline optimization of the biomechatronic(human–robot)device and shifted by the prediction *** input of the RNN consisted of interrupted sEMG signals(to mimic signal disconnections)and previous kinematic signals of the assistive *** RNN with a 0.1-s prediction horizon could predict the control-oriented joint angle and assistive torque with 92%and 86.5%regression accuracy,respectively,for the test *** proposed approach permits a fast,predictive,and direct estimation of control-oriented signals instead of an iterative process that optimizes assistive torque in the inverse dynamic simulation of a multibody human–robot *** with these interrupted input signals significantly improves the regression accuracy in the case of sEMG signal *** Robust Predictive Control-oriented Machine Learning(Robust-MuscleNET)model can support volitional high-level myoelectric-based control of biomechatronic devices,such as exoskeletons,prostheses,and assistive/resistive *** work should study the application to prosthesis control as well as the repeatability of the high-level controller with electrode *** low-level hierarchical controller that manages the human–robot interaction,the assistance/resistance strategy,and the actuator coordination should also be studied.

关键词： Myoelectric-based control-Surface electromyography Machine learning Multibody system dynamics Exoskeleton Bionic

Convergent plate boundary environments for formation of≥3800 Ma mafic-ultramafic assemblages(Isua area,Greenland):Implications for early global geodynamics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2024年第3期15卷 119-136页

作者： Allen P.Nutman clark R.L.Friend Vickie C.Bennett School of Earth Atmospheric and Life SciencesUniversity of WollongongWollongongNSW 2522Australia Glendale TiddingtonOxon OX92LQUK Research School of Earth Sciences Australian National UniversityCanberraACT 2601Australia

In the gneiss terrane on the south side of the Eoarchean Isua supracrustal belt,ultramafic rocks with relict abyssal peridotite mineralogy(Bennett et al.,2002;Friend et al.,2002;Nutman et al.,2007;Rollinson,2007;van de Löcht et al.,2020),layered gabbros with cumulate ultramafic rocks,basalts and associated siliceous sedimentary rocks were tectonically-imbricated,prior to and during intrusion of ca.3800 Ma *** with3800 Ma basalts in the Outer Arc Group of the nearby Isua supracrustal belt,the composition of all these mafic rocks(e.g.,Th-Hf-Nb systematics,high Th/Yb,Ba/Nb,Ba/Yb ratios and negative Nb and Ti anomalies)shows affinity with modern suprasubduction rocks whose genesis involved fluid fluxing of the upper ***,the majority of these samples have Ba/Nb and Ba/Yb values less than in modern island arc magmas,but similar to many backarc basin magmas(e.g.,Pearce and Stern,2006).It is unknown whether these ca.3800 Ma mafic rocks are,(i)arc rocks where the Ba/Nb and Ba/Yb signatures reflect lower surficial Ba in Eoarchean oceanic settings,or(ii)in direct comparison with Phanerozoic suites,these signatures reflect a back-arc setting with interplay between fluid fluxing and decompressional *** tectonic intercalation of upper mantle with lower and upper crustal rocks,combined with the fluid-fluxing influences seen in chemistry of all the mafic rocks is best accommodated in a compressional Eoarchean convergent plate boundary setting within a mobile-lid *** stagnant lid scenarios of crust formation,if operative,must have co-existed or alternated with mobile-lid regimes by 3800 Ma.

关键词： Eoarchean Fluid-fluxing Plate tectonics Suprasubduction Crustal evolution

Carbon dioxide enrichment affected flower numbers transiently and increased successful post-pollination development stably but without altering final acorn production in mature pedunculate oak (Quercus robur L.)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2024年第4期35卷 1-12页

作者： Ryan McClory Richard H.Ellis Martin Lukac Jo clark Carolina Mayoral Kris M.Hart Andrew R.G.Plackett A.Rob MacKenzie School of Agriculture Policy and DevelopmentUniversity of ReadingAgricultureEarley GateWhiteknights RoadPO Box 237Reading RG66EUUK Faculty of Forestry and Wood Sciences Czech University of Life Sciences PraguePrague 165000Czechia Future Trees Trust Harwell Innovation CentreBuilding 173Curie AvenueHarwellOxford OX110QGUK Birmingham Institute of Forest Research University of BirminghamEdgbastonBirmingham B152TTUK School of Biosciences University of BirminghamEdgbastonBirmingham B152TTUK School of Geography Earth and Environmental SciencesUniversity of BirminghamEdgbastonBirmingham B152TTUK

Acorn production in oak(Quercus spp.)shows considerable inter-annual variation,known as masting,which provides a natural defence against seed predators but a highly-variable supply of acorns for uses such as in commercial tree planting each *** emissions of greenhouse gases have been very widely reported to influence plant growth and seed or fruit size and quantity via the‘fertilisation effect’that leads to enhanced *** examine if acorn production in mature woodland communities will be affected by further increase in CO_(2),the contents of litter traps from a Free Air Carbon Enrichment(FACE)experiment in deciduous woodland in central England were analysed for numbers of flowers and acorns of pedunculate oak(Quercus robur L.)at different stages of development and their predation levels under ambient and elevated CO_(2) ***-annual variation in acorn numbers was considerable and cyclical between 2015 and 2021,with the greatest numbers of mature acorns in 2015,2017 and 2020 but almost none in *** numbers of flowers,enlarged cups,immature acorns,empty acorn cups,and galls in the litter traps also varied amongst years;comparatively high numbers of enlarged cups were recorded in 2018,suggesting *** at this site is a fruit maturation masting species(i.e.,the extent of abortion of pollinated flowers during acorn development affects mature acorn numbers greatly).Raising the atmospheric CO_(2) concentration by 150μL L^(−1),from early 2017,increased the numbers of immature acorns,and all acorn evidence(empty cups+immature acorns+mature acorns)detected in the litter traps compared to ambient controls by 2021,but did not consistently affect the numbers of flowers,enlarged cups,empty cups,or mature *** number of flowers in the elevated CO_(2) plots’litter traps was greater in 2018 than 2017,one year after CO_(2) enrichment began,whereas numbers declined in ambient *** with CO_(2) also increased the number o

关键词： Quercus robur L. Acorns Masting Pedunculate oak Carbon dioxide

Clinical gait analysis in older children with autism spectrum disorder

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sports Medicine and Health Science 2024年第2期6卷 154-158页

作者： Xinye Wu D.clark Dickin Laura Bassette Caroline Ashton He Wang School of Kinesiology Ball State UniversityMuncieINUSA Department of Special Education Ball State UniversityMuncieINUSA

Individuals with autism spectrum disorder(ASD)often exhibit motor deficits that increase their risk of *** is a lack of understanding regarding gait biomechanics demonstrated by older children with *** purpose of the study was to determine differences in gait patterns between older children with ASD and typically developing *** children with ASD and 11 age-and gender-matched typically developing children were recruited for the *** walked on a force-instrumented treadmill at a constant speed(1.1 m/s-1.2 m/s)for five minutes(min).Participants performed maximal voluntary contractions to assess their knee muscular *** between individuals with ASD and matched control participants were examined through paired t-tests with a significance level of p*** with ASD demonstrated a smaller knee extensor torque compared to controls(p=0.002).Participants with ASD exhibited a shorter stride length(p=0.04),a greater cadence(p=0.03),and a higher variation in stride width(p=0.04)compared to control *** individuals with ASD experienced a greater braking ground reaction force(p=0.03)during loading *** results indicate older children with ASD develop a unique gait pattern signified by a reduced stride length,increased cadence,and an increase of variation in stride *** unique gait pattern may represent a movement strategy used by the individuals with ASD to compensate for the weakness associated with their knee extensor *** with ASD who demonstrate these unique gait deviations may face reduced postural stability and an increased risk of fall-related injuries.

关键词： Autism spectrum disorder Gait analysis Knee strength Gait development Older children

The Role of Impulsivity and Addiction in Gambling Behaviors: How Applied Neuroscience Research Can Help in the Monitoring and Management of Mental Health Issues

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Medical Psychology 2024年第1期13卷 11-24页

作者： Yingzhen Jia Kimberly Rose clark College of Arts and Sciences Boston University Boston MA USA Department of Psychological and Brain Sciences Dartmouth College Hanover NH USA

One in five Americans experience symptoms associated with at least one mental health disorder every year. These include behavioral addictions, which have long been overlooked despite their similar neural bases with substance addictions. Gambling addiction, a type of behavioral addiction, deserves particular attention given the significant negative effects, this addiction has on financial and interpersonal health. The purpose of this paper is to review the available literature concerning the behavioral and neural processes involved in gambling addiction, including: the anticipation of reward, the role of dopamine, and the neural substrates of the decision-making processes involved in gambling addiction. Market research has also identified solutions that integrate applied neuroscience and self-tracking systems to monitor and manage mental health issues associated with gambling addiction. The authors then propose a gambling treatment-focused mobile app solution that addresses outstanding issues with a special design aimed at reversing plasticity in order to relieve the effects of gambling addiction. .

关键词： Applied Neuroscience Gambling Addiction Mental Health Management

Liver Characterization of a Cohort of Alpha-1 Antitrypsin Deficiency Patients with and without Lung Disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2024年第10期12卷 845-856页

作者： Naweed Mohammad Regina Oshins Tongjun Gu Virginia clark Jorge Lascano Naziheh Assarzadegan George Marek Mark Brantly Nazli Khodayari Division of Pulmonary Critical Care and Sleep MedicineCollege of MedicineUniversity of FloridaGainesvilleFLUSA Interdisciplinary Center for Biotechnology Research Bioinformatics CoreUniversity of FloridaGainesvilleFLUSA Division of Gastroenterology Hepatology and NutritionCollege of MedicineUniversity of FloridaGainesvilleFLUSA Division of Pathology Immunologyand Laboratory MedicineCollege of MedicineUniversity of FloridaGainesvilleFLUSA Division of Gastroenterology and Hepatology Mayo ClinicRochesterMNUSA

Background and Aims:Alpha-1 antitrypsin deficiency(AATD)is a genetic disorder characterized by the misfolding and accumulation of the mutant variant of alpha-1 antitrypsin(AAT)within hepatocytes,which limits its access to the circulation and exposes the lungs to protease-mediated tissue *** results in progressive liver disease secondary to AAT polymerization and accumulation,and chronic obstructive pulmonary disease(COPD)due to deficient levels of AAT within the *** goal was to characterize the unique effects of COPD secondary to AATD on liver disease and gene ***:A subcohort of AATD individuals with COPD(n=33)and AATD individuals without COPD(n=14)were evaluated in this study from our previously reported cross-sectional *** used immunohistochemistry to assess the AATD liver phenotype,and RNA sequencing to explore liver *** observed a distinct transcriptomic profile in liver tissues from AATD individuals with COPD compared to those ***:A total of 339 genes were differentially *** pathways related to fibrosis,extracellular matrix remodeling,collagen deposition,hepatocellular damage,and inflammation were significantly upregulated in the livers of AATD individuals with *** analysis also revealed higher levels of fibrosis and hepatocellular damage in these ***:Our data supports a relationship between the development of COPD and liver disease in AATD and introduces genes and pathways that may play a role in AATD liver disease when COPD is *** believe addressing lung impairment and airway inflammation may be an approach to managing AATD-related liver disease.

关键词： Alpha-1 antitrypsin deficiency Chronic obstructive pulmonary disease Liver fibrosis Liver biopsy Liver histology Transcriptomics

Exercise-induced hypoalgesia in chronic neck pain: A narrative review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sports Medicine and Health Science 2024年第1期6卷 37-47页

作者： Fernando Rojas-Galleguillos Cecilia clark-Hormazabal Eduardo Mendez-Fuentes Francisco Guede-Rojas Cristhian Mendoza Andres Riveros Valdes Claudio Carvajal-Parodi Universidad San Sebastian Programa Magíster en Kinesiología MusculoesqueleticaLientur#1457ConcepcionChile Exercise and Rehabilitation Sciences Laboratory School of Physical TherapyFaculty of Rehabilitation SciencesUniversidad Andres BelloSantiago7591538Chile Universidad San Sebastian Laboratoriode NeurobiologíFacultad de Odontologíay Ciencias dela RehabilitacionLientur#1457ConcepcionChile Universidad San Sebastian Departamento de Ciencias MorfologicasFacultad de MedicinaCienciaLientur#1457ConcepcionChile Universidad San Sebastian Escuelade KinesiologíaFacultad de OdontologíaCiencias dela RehabilitacionLientur#1457ConcepcionChile

Chronic neck pain(CNP)is a worldwide health problem with several risk *** of the most widely used treatments for managing this condition is therapeutic exercise,which could generate a response called exerciseinduced hypoalgesia(EIH).There is no consensus on the best exercise modality to induce ***,this review aims to analyze and synthesize the state-of-the-art about the hypoalgesic effect of exercise in subjects with *** included articles on EIH and CNP in patients older than 18 years,with pain for more than three months,where the EIH response was *** that studied CNP associated with comorbidities or measured the response to treatments other than exercise were *** studies reviewed reported variable *** in healthy subjects has been shown to reduce indicators of pain sensitivity;however,in people with chronic pain,the response is *** investigations reported adverse effects with increased pain intensity and decreased pain sensitivity,others found no clinical response,and some even reported EIH with decreased pain and increased *** is an identifiable,stimulable,and helpful therapeutic response in people with *** research is still needed on subjects with CNP to clarify the protocols and therapeutic variables that facilitate the EIH *** addition,it is necessary to deepen the knowledge of the intrinsic and extrinsic factors that influence EIH in people with CNP.

关键词： Exercise-induced hypoalgesia Neck pain Chronic pain Neck exercise therapy

The NORE1A/RASSF5 Tumor Suppressor Forms a Complex with GSK-3β to Regulate β-Catenin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Biosciences and Medicines 2024年第8期12卷 60-75页

作者： M. Lee Schmidt Howard Donninger Geoffrey J. clark Department Pharmacology and Toxicology University of Louisville Louisville USA US Worldmeds LouisvilleUSA Department of Medicine University of Louisville Louisville USA Experimental Therapeutics Program James Graham Brown Cancer Center University of Louisville Louisville USA

NORE1A (RASSF5) is a tumor suppressor of the RASSF family that is often down-regulated in human tumors. NORE1A has multiple roles in controlling cellular homeostasis, one of them being regulating levels of β-catenin by binding and modulating the ubiquitin ligase substrate recognition factor β-TrCP. β-catenin is a major executor of the Wnt pathway. The ubiquitin SCF-β-TrCP ligase complex acts on a phospho-degron site in β-catenin that can be phosphorylated by GSK-3β. We now show that in addition to binding β-TrCP, NORE1A also promotes the phosphorylation of the β-catenin phospho-degron by complexing with the kinase GSK-3β. Indeed, NORE1A enhances the formation of a GSK-3β/β-TrCP complex. A structural mutant of NORE1A that retains β-TrCP binding but will no longer interact with GSK-3β inhibits the β-catenin degrading action of NORE1A. The GSK-3β interaction with NORE1A plays an important role in the biology of NORE1A as a GSK-3β inhibitor blocks NORE1A induced senescence. Thus, we identify a new role for the tumor suppressor NORE1A: The regulation of GSK-3β. GSK-3β has many other substrates including multiple transcription factors and co-activators such as p53 and the Hippo component TAZ. The work implies that NORE1A may be able to influence all of them via this new kinase scaffolding interaction.

关键词： RAS NORE1A RASSF5 GSK-3β Beta Catenin HIPPO

2023: Weather and Climate Extremes Hitting the Globe with Emerging Features

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2024年第6期41卷 1001-1016页

作者： Wenxia ZHANG Robin clark Tianjun ZHOU Laurent LI Chao LI Juan RIVERA Lixia ZHANG Kexin GUI Tingyu ZHANG Lan LI Rongyun PAN Yongjun CHEN Shijie TANG Xin HUANG Shuai HU State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Met Office Hadley Centre Exeter EX13PBUK University of Chinese Academy of Sciences Beijing 100049China Laboratoire de Météorologie Dynamique CNRSSorbonne UniversitéEcole Normale SupérieureEcole PolytechniqueParis 75230France Max Planck Institute for Meteorology Hamburg 20146Germany Instituto Argentino de Nivología Glaciología Y Ciencias Ambientales(IANIGLA)CCT CONICETMendoza CP 5500Argentina Shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030China Asia-Pacific Typhoon Collaborative Research Center Shanghai 201306China

Globally,2023 was the warmest observed year on record since at least 1850 and,according to proxy evidence,possibly of the past 100000 *** in recent years,the record warmth has again been accompanied with yet more extreme weather and climate events throughout the ***,we provide an overview of those of 2023,with details and key background causes to help build upon our understanding of the roles of internal climate variability and anthropogenic climate *** also highlight emerging features associated with some of these extreme *** extremes are occurring earlier in the year,and increasingly simultaneously in differing parts of the world(e.g.,the concurrent hot extremes in the Northern Hemisphere in July 2023).Intense cyclones are exacerbating precipitation extremes(e.g.,the North China flooding in July and the Libya flooding in September).Droughts in some regions(e.g.,California and the Horn of Africa)have transitioned into flood *** extremes also show increasing interactions with ecosystems via wildfires(e.g.,those in Hawaii in August and in Canada from spring to autumn 2023)and sandstorms(e.g.,those in Mongolia in April 2023).Finally,we also consider the challenges to research that these emerging characteristics present for the strategy and practice of adaptation.

关键词： weather and climate extremes temperature extremes extreme precipitation drought wildfires