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Hepatocellular carcinoma risk after viral response in hepatitis C virus-advanced fibrosis: Who to screen and for how long?

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World Journal of Gastroenterology 2021年第40期27卷 6737-6749页

作者： Adriana Ahumada Laura Rayón clara usón Rafael Bañares Sonia Alonso Lopez Liver Unit Hospital General Universitario Gregorio MarañónMadrid 28007Spain Liver Unit Instituto de Investigación Sanitaria Gregorio Marañón(IiSGM)Madrid 28007Spain Medicine Universidad Complutense de MadridMadrid 28006Spain Centro de Investigación Biomédica En Red de Enfermedades Hepáticas y Digestivas(CIBERehd) Instituto de Salud Carlos IIIMadrid 28029Spain

Hepatitis C virus(HCV)chronic infection is associated with fibrosis progression,end-stage liver complications and *** surprisingly,HCV infection is a leading cause of liver-related morbidity and mortality *** sustained virological response(SVR),the risk of developing hepatocellular carcinoma is not completely eliminated in patients with established cirrhosis or with advanced ***,lifelong surveillance is currently *** strategy is likely not universally cost-effective and harmless,considering that not all patients with advanced fibrosis have the same risk of developing *** related to the severity of liver disease and its potential to improve after SVR,the molecular and epigenetic changes that occur during infection and other associated comorbidities might account for different risk levels and are likely essential for identifying patients who would benefit from screening programs after *** to develop predictive models and risk calculators,biomarkers and genetic panels and even deep learning models to estimate the individual risk of HCC have been made in the direct-acting antiviral agents era,when thousands of patients with advanced fibrosis and cirrhosis have reached *** tools could help to identify patients with very low HCC risk in whom surveillance might not be *** this review,factors affecting the probability of HCC development after SVR,the benefits and risks of surveillance,suggested strategies to estimate individualized HCC risk and the current evidence to recommend lifelong surveillance are discussed.

关键词： Hepatitis C virus Hepatocellular carcinoma Liver fibrosis Surveillance Sustained virologic response Epigenetic changes Predictive models Cost-effectiveness

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Impact of tropospheric modelling on GnSS vertical precision:an empirical analysis based on a local active network

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International Journal of Digital Earth 2018年第9期11卷 880-896页

作者： MªSelmira Garrido Mªclara de Lacy Ana MªRojas Department of Cartographic Geodetic and Photogrammetric EngineeringUniversity of JaénJaenSpain Center for Advanced Studies in Earth Sciences University of JaénJaenSpain Research group RnM282–Microgeodesia Jaén University of JaénJaenSpain

The troposphere affects Global navigation Satellite System(GnSS)signals due to the variability of the refractive *** delay is a function of the satellite elevation angle and the altitude of the GnSS receiver and depends on the atmospheric *** the residual tropospheric delay is not modelled carefully a bias error will occur in the vertical *** order to analyse the precise altimetric positioning based on a local active network,four scenarios in Southern Spain with different topographical,environmental,and meteorological conditions are presented,considering both favourable and non-favourable *** use of surface meteorological observations allows us to take into account the tropospheric conditions instead of a standard atmosphere,but introduces a residual tropospheric bias which reduces the accuracy of precise GnSS ***,with short observation times it is recommended not to estimate troposphere parameters,but to use an a priori model together with the standard *** results confirm that it is possible to achieve centimetre-scale vertical accuracy and precision with real time kinematic positioning even with large elevation differences with respect to the nearest reference *** numerical results may be taken into consideration for improving the altimetric configuration of the local active network.

关键词： Altimetry GnSS meteorological data active network tropospheric refraction

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The current trend of autologous costal cartilage harvest by facial plastic surgeons for rhinoplasty in the United States

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Plastic and Aesthetic Research 2019年第2期6卷 1-7页

作者： clara M.Olcott Steven J.Pearlman Inland Ear nose&Throat-Facial Plastics UplandCA 91784USA Pearlman Aesthetic Surgery New YorkNY 10022USA

Aim: To assess the safety profile and practice trend of autologous costal cartilage harvest by facial plastic surgeons in the United States (us).Methods: A 10-question online survey was distributed by the American Academy of Facial Plastic and Reconstructive Surgery to its ***: Of the 2,639 members, 2,379 received the survey with 137 (5.76%) members responded. The majority (33.6%)of the respondents were expert facial plastic surgeons. One hundred and nine (79.6%) of the respondents performed rib harvest with 49.6% of them performing the procedure at a hospital facility. Among them, 21.5% exclusively performed their surgery at an ambulatory surgical center not physically attached to a hospital while 6.67% of them at the in-office accredited operating room. When comparing techniques, 64.7% performed only full-thickness rib grafts vs. 12.0%harvesting partial-thickness rib grafts. Most used an incision length between 2.1 and 4 cm (64.4%) while 2 surgeons used ncision. The occurrence of pneumothorax after autologous rib harvest remained low (n most (73.1%).Regarding safety practices of the surgeons, only 24.6% would order a chest X-ray post-operatively while 54.5% would not. In addition, 58.7% of respondents never kept their patients overnight for observation after autologous rib grafting while 15.0% always would. For pain management, most respondents (50.4%) did not utilize any additional analgesia protocol besides oral pain ***: Two thirds of the us facial plastic surgeons performed autologous costal cartilage harvest in a hospital setting. Routine chest imaging or overnight observation post-operatively was not warranted as the percentage of pneumothorax remained low and pain control was adequate.

关键词： Rib graft autologous costal cartilage rhinoplasty current practice pneumothorax

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A new algorithm for the diagnosis of celiac disease

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Cellular & Molecular Immunology 2011年第2期8卷 146-149页

作者： Orit Rozenberg Aaron Lerner Avi Pacht Maya Grinberg Dina Reginashvili clara Henig Mira Barak Central Laboratory of Haifa and Western Galilee Clalit Health Services and Pediatric GastroenterologyHaifaIsrael nutrition Unit Carmel Medical CenterHaifaIsrael Technion-Israel Institute of Technology HaifaIsrael

Celiac disease(CD)affects at least 1%of the Western population but remains largely *** our laboratory,we utilize a novel algorithm to diagnose pediatric CD that offers both high sensitivity and high specificity for diagnosis in an outpatient *** aim of the present study was to challenge this algorithm and to test its performance in children and adults suspected of having *** a three-assay algorithm,screening with the most sensitive tissue transglutaminase(tTG)complexed with deamidated gliadin peptide neoepitope immunoglobulin A(IgA)1IgG assay and confirming with the two specific tTG IgA and tTG IgA1IgG assays,we examined the serological results from 112 children aged 0–17 years old and 60 adults in comparison to their respective biopsy *** algorithm performance was calculated by statistical *** use of the new algorithm enabled us to diagnose CD with 98%sensitivity,93%specificity and 95%accuracy in the pediatric group and 94%sensitivity,92%specificity and 93%accuracy in the total population *** false-negative cases in the adult group were attributed to previous adherence to a gluten-free diet,and the single false-negative result in a young child became a true positive after 6 *** have also monitored three celiac patients before and after diagnosis and found that the algorithm may be suitable for disease *** newly proposed three-assay algorithm for celiac detection is very reliable in both children and *** to the high performance of this assay,the further need for confirmatory intestinal biopsies will be reassessed.

关键词： celiac disease diagnosis intestinal histopathology sensitivity specificity tissue transglutaminase

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Career and Gender： Between Rivers and Paths

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Psychology Research 2012年第10期2卷 600-605页

作者： clara Selva Olid Autonomous University of Barcelona Barcelona Spain

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Immune response-related genes associated to blocking midgut dengue virus infection in Aedes aegypti strains that differ in susceptibility

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Insect Science 2019年第4期26卷 635-648页

作者： Paola A. Caicedo Idalba Mildred Serrato Shuzhen Sim George Dimopoulos Heather Coatsworth Carl Lowenberger clara B. Ocampo Centro Internacional de Entrenamiento e Investigaciones Medicas (CIDEIM) Cali Colombia 2W. Harry Feinstone Department of Molecular Microbiology and Immunology Bloomberg School of Public Health Johns Hopkins University Baltimore Maryland USA Department of Biological Sciences Simon Fraser University Burnaby Canada

Aedes (Stegomyia) aegypti, the principal global vector of dengue viruses, has difTerences in its susceptibility to dengue virus infection. We compared the global expres? sion of genes in the midguts of Colombian Ae. aegypti dengue-susceptible (Cali-S) and dengue-refractory (Cali-MIB) field derived strains after ingesting either a sugarmeal, a bloodmeal, or a bloodmeal containing dengue virus serotype 2 (DEnV-2). Microarraybased transcriptome analysis among treatments indicated a total of 4725 transcripts with differential expression between the two strains. Eleven genes were selected from different functional groups based on their significant up or down expression levels as well as reports in the literature suggesting they are associated with dengue virus elimination. We measured mRnA abundance of these 11 genes at 0, 8, 24, and 36 h postinfection using quantitative real time PCR (qPCR) to confirm the microarray results and assess any temporal patterns. Four genes were selected (Gram-negative binding protein—GnBP [AAEL009176], niemann Pick Type-C2一nPC2 [AAEL015136], Keratinocyte lectin [AAEL009842], and Cathepsin-b [AAEL007585]) for knockdown experiments using RnA interference (RnAi) methodology to determine the phenotype (DEnV-2 susceptible or refractory). Silencing GnBP、Cathepsin-b and Keratinocyte lectin reduced the percentage of mosquitoes with disseminated virus in the Cali-S strain to 8%, 20%, and 12% respectively compared with 96% in the controls. Sile ncing of nPC2 increased the percentage of mosquitos with disseminated virus infections in Cali-MIB to 66% compared with 35% in the controls. This study provides in sight into genes that may contribute to the Cali-S susceptible and Cali-MIB refractory phenotypes in 昇匕 aegypti.

关键词： Aedes aegypti dengue virus innate immune response knockdown microarray vector competence

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Vehicle Dynamics with Additional Entry Lane of a Roundabout

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Journal of Transportation Technologies 2022年第3期12卷 498-532页

作者： nikolay nazaryan clara Fang College of Engineering Technology and Architecture University of Hartford West Hartford USA Department of Civil Environmental and Biomedical Engineering College of Engineering Technology and Architecture University of Hartford West Hartford USA

This research is dedicated to the study of dynamics of vehicles moving through the additional entry lanes of a roundabout. using the data created on the base of that model the constant coefficients of the sixth-degree polynomial function, previously proposed by us, have been found. In result of this there were obtained two analytic equations of vehicles’ movement, where one of them presented with the positive sign of the leading coefficient and the other one negative. These two equations allowed to make comprehensive investigation of the delays and the kinematics of the vehicles moving by such kinds of lanes. Based on the appropriate calculations it is determined vehicles’ consequent delays, velocities, accelerations and decelerations. Analyzing the delays, the dynamics of accelerations and decelerations, it is done an assumption that if the leading coefficient of algorithm of movement of vehicles is negative than it will lead to larger deceleration and consequently higher environmental pollutions and higher noises.

关键词： Hypothetical Statistical Simulation Movement Acceleration Deceleration Delay Pollution noise Harsh

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Efficiency and sustainability of the tourism industry in Latin America

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Regional Sustainability 2024年第4期5卷 57-70页

作者： clara Inés PARDO MARTÍnEZ Alexander COTTE POVEDA School of Administration Universidad del RosarioBogotá110111Colombia Department of Economics Universidad Santo TomasBogotá110111Colombia Escuela Superior de Administración Pública(ESAP) Bogotá110111Colombia

The tourism industry is economically very *** to the World Travel Tourism Council,in 2019,the tourism industry accounted for a quarter of all new jobs created worldwide,10.3%of all jobs,and 9.6×1012 usD of the global gross domestic *** study aimed to calculate the tourism efficiency index for different Latin American countries from 2010 to 2021 using data envelopment analysis,which analyzes the relationships between input variables(including the number of employees in the tourism industry and the number of hotel-type establishments)and output variables(including tourism expenditures in other countries and public social expenditures in recreation and culture per capita).Additionally,this study aimed to identify the countries with greater tourism development and the factors that may affect the development of the tourism industry through the stochastic frontier production *** results of the tourism efficiency index for Central America(including Costa Rica,Dominica,El Salvador,Honduras,Mexico,and Panama)and South America(including Argentina,Brazil,Chile,Colombia,Ecuador,Paraguay,Peru,and Uruguay)exhibited different ***,after the global health crisis,the tourism industry recovered,showing new opportunities to promote *** results of the stochastic frontier production function demonstrated that countries with higher levels of inbound and outbound tourism,contribution of tourism to the economy,natural resources,and literacy rate exhibited more efficient tourism industry,whereas countries with higher pollution levels exhibited less efficient tourism *** findings of this study could allow us to formulate suitable public policies to promote tourism,maintain natural resources,and diversify these sectors with more inclusive programmes that can facilitate growth and benefit vulnerable communities.

关键词： Tourism industry Tourism efficiency index Stochastic frontier production function Data envelopment analysis(DEA) Latin America

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Opposing roles of plant laticifer cells in the resistance to insect herbivores and fungal pathogens

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Plant Communications 2021年第3期2卷 93-104页

作者： Lourdes Castelblanque Javier García-Andrade clara Martínez-Arias Juan J.Rodríguez Francisco J.Escaray Ernestina Aguilar-Fenollosa Josep A.Jaques Pablo Vera Instituto de Biología Moleculary Celular de Plantas Universitat Politécnica de Valéncia-C.S.I.CCiudad Politécnica de la InnovaciònEdificio 8EIngeniero Fausto Elios/n46022 ValenciaSpain Universitat Jaume I Departament de Ciéncies Agráries i del Medi NaturalCampus del Riu Sec12003 Castellòde la PlanaSpain

More than 12,000 plant species(ca.10%of flowering plants)exude latex when their tissues are *** is produced and stored in specialized cells named“laticifers”.Laticifers form a tubing system composed of rows of elongated cells that branch and create an internal network encompassing the entire *** constitute a recent evolutionary achievement in ecophysiological adaptation to specific natural environments;however,their fitness benefit to the plant still remains to be *** identification of Euphorbia lathyris mutants(pil mutants)deficient in laticifer cells or latex metabolism,and therefore compromised in latex production,allowed us to test the importance of laticifers in pest *** provided genetic evidence indicating that laticifers represent a cellular adaptation for an essential defense strategy to fend off arthropod herbivores with different feeding habits,such as Spodoptera exigua and Tetranychus *** marked contrast,we also discovered that a lack of laticifer cells causes complete resistance to the fungal pathogen Botrytis ***,a latex-derived factor required for conidia germination on the leaf surface was *** factor promoted disease susceptibility enhancement even in the non-latex-bearing plant *** speculate on the role of laticifers in the coevolutionary arms race between plants and their enemies.

关键词： latex Euphorbia lathyris disease resistance disease susceptibility plant defense

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“I Felt Defeated. I Felt Helpless”: Social Determinants of Health Influencing the Cancer Survivorship of a Young Latina Mother

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Journal of Cancer Therapy 2022年第7期13卷 440-449页

作者： Adriena Hernandez clara L. Reyes Isela Garcia Rebecca L. Palacios Department of Health Promotion Sciences The University of Arizona Tucson AZ USA Department of Public Health Sciences New Mexico State University Las Cruces NM USA

Social determinants of health (SDOH) contribute to cancer disparities among young Latina women (<50 years) residing in the counties along the us-Mexico border. These SDOH are particularly burdensome to young Latina mo... 详细信息

Social determinants of health (SDOH) contribute to cancer disparities among young Latina women (ng in the counties along the us-Mexico border. These SDOH are particularly burdensome to young Latina mothers diagnosed with cancer while they are raising school-age children. Conexiones, a culturally adapted program designed to improve mother and child adjustment to maternal cancer, was piloted with diagnosed Latina mothers residing in border counties in new Mexico and Texas. The purpose of this case analysis was to highlight the SDOH affecting a young Latina mother’s cancer survivorship in the U.S.-Mexico border region. The participant’s Conexiones education sessions were recorded, transcribed, translated to English, back translated to Spanish to establish accuracy, and inductively coded. The participant’s baseline survey indicated she was a young (nish-speaking Latina mother diagnosed with breast cancer while raising a teenage daughter. Seventeen SDOH themes affecting the participant’s cancer experience were identified in the cancer-related emotional triggers she reported across five Conexiones sessions. These themes were organized using Yanez’s conceptual model of determinants of cancer outcomes in Hispanics (i.e., socioeconomic, healthcare, cultural context, and psychosocial). Findings provide direction for cultural adaptations of evidence-based programs.

关键词： Cancer Survivors Latinas Social Determinants of Health U.S.-Mexico Border

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