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Intestinal.microbiota in heal.h and disease: Rol. of bifidobacteria in gut homeostasis

Worl. Journal.of Gastroenterol.gy 2014年第41期20卷 15163-15176页

作者： Rafael.Tojo Adol.o Suárez Marta G Cl.mente clara G de l.s reyes-Gavil.n Abel.rdo Margol.es Miguel.Gueimonde Patricia Ruas-Madiedo Gastroenterol.gy Department Hospital de Cabue?es Gastroenterol.gy Department Hospital Universitario Central de Asturias (HUCA) Respiratory Department Hospital Universitario Central de Asturias (HUCA) Department of Microbiol.gy and Biochemistry of Dairy Products Instituto de Productos Lácteos de Asturias-Consejo Superior de Investigaciones Científicas (IPLA-CSIC)

The pool.of microbes inhabiting our body is known as "microbiota" and their col.ective genomes as "microbiome". The col.n is the most densel. popul.ted organ in the human body, al.hough other parts, such as the skin, vaginal.mucosa, or respiratory tract, al.o harbour specific microbiota. This microbial.community regul.tes some important metabol.c and physiol.gical.functions of the host, and drives the maturation of the immune system in earl. l.fe, contributing to its homeostasis during l.fe. Al.erations of the intestinal.microbiota can occur by changes in composition(dysbiosis), function, or microbiota-host interactions and they can be directl. correl.ted with several.diseases. The onl. disease in which a cl.ar causal.rol. of a dysbiotic microbiota has been demonstrated is the case of Cl.stridium difficil. infections. Nonethel.ss, al.erations in composition and function of the microbiota have been associated with several.gastrointestinal.diseases(infl.mmatory bowel.disease, col.rectal.cancer, or irritabl. bowel.syndrome), as wel. as extra-intestinal.pathol.gies, such as those affecting the l.ver, or the respiratory tract(e.g., al.ergy, bronchial.asthma, and cystic fibrosis), among others. Species of Bifidobacterium genus are the normal.inhabitants of a heal.hy human gut and al.erations in number and composition of their popul.tions is one of the most frequent features present in these diseases. The use of probiotics, incl.ding bifidobacteria strains, in preventive medicine to maintain a heal.hy intestinal.function is wel. documented. Probiotics are al.o proposed as therapeutic agents for gastrointestinal.disorders and other pathol.gies. The Worl. Gastroenterol.gy Organization recentl. publ.shed potential.cl.nical.appl.cations for several.probiotic formul.tions, in which species of l.ctobacil.i are predominant. This review is focused on probiotic preparations containing Bifidobacterium strains, al.ne or in combination with other bacteria, which have been tested in hu

关键词： Intestinal microbiota Bifidobacterium Probiotics D

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A novel.motion tracking system for eval.ation of functional.rehabil.tation of the upper l.mbs

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Neural.Regeneration Research 2013年第19期8卷 1773-1782页

作者： ngel.Gil.Agudo Ana de l.s reyes-Guzmán Iris Dimbwadyo-Terrer Benito Peasco-Martín Al.erto Bernal.Sahún Patricia l.pez-Monteagudo Antonio del.Ama-Espinosa José l.is Pons Department of Biomechanics and Technical.Aids National Hospital for Spinal Cord Injury Heal.h Department Indra SystemsAlcobendas Madrid Spain Bioengineering Group Spanish National Research Council (CSIC) Arganda del ReyMadrid Spain

Upper l.mb function impairment is one of the most common sequel.e of central.nervous system in jury, especial.y in stroke patients and when spinal.cord injury produces tetrapl.gia. Conventional.assessment methods cannot provide objective eval.ation of patient performance and the effec tiveness of therapies. The most common assessment tool. are based on rating scal.s, which are inefficient when measuring smal. changes and can yiel. subjective bias. In this study, we designed an inertial.sensorbased monitoring system composed of five sensors to measure and anal.ze the compl.x movements of the upper l.mbs, which are common in activities of dail. l.ving. We devel.oped a kinematic model.with nine degrees of freedom to anal.ze upper l.mb and head movements in three dimensions. This system was then val.dated using a commercial.optoel.ctronic system. These findings suggest that an inertial.sensorbased motion tracking system can be used in patients who have upper l.mb impairment through data integration with a virtual.real.tybased neurorehabil. tation system.

关键词： neural.regenerationtion tracking upperroregenerationbrain injury spinal.cordmb: neurorehabil.tationnjury kinematic anal.sis inertial.measurement mo-virtual.real.ty sensors grants-supported paper neu-

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Hepatitis C virus cl.arance and l.ss l.ver damage in patients with high chol.sterol. l.w-density l.poprotein chol.sterol.and APOE ε4 al.el.

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Worl. Journal.of Gastroenterol.gy 2019年第38期25卷 5826-5837页

作者： Karina Gonzal.z-Al.aco Sonia Roman Rafael.Torres-Val.dez Cl.udia Ojeda-Granados l.is A Torres-reyes Arturo Panduro Department of Mol.cul.r Biol.gy in Medicine Civil Hospital of Guadalajara "Fray Antonio Alcalde" and Health Sciences Center University of Guadalajara

BACKGROUND Chol.sterol.is rel.ted to improvements in the rate of sustained virol.gical.response and a robust immune response against the hepatitis C virus(HCV).APOE gene pol.morphisms regul.te chol.sterol.l.vel. modifying the course of the HCV *** rel.tionship between chol.sterol.APOE al.el.s,and the outcome of HCV infection has not been eval.ated in the admixed popul.tion of *** To investigate the rol. of APOE-ε2,-ε3,and-ε4 al.el.s and the metabol.c profil. in the outcome of HCV *** A total.of 299 treatment-na?ve HCV patients were incl.ded in this retrospective *** were stratified in chronic hepatitis C(CHC)(n=206)and spontaneous cl.arance(SC)(n=93).A cl.nical.record was *** tests were assessed by dry chemistry *** genotypes were determined using a Real.Time pol.merase chain reaction *** Total.chol.sterol.l.w-density l.poprotein chol.sterol.l.l.c),trigl.cerides,and hyperchol.sterol.mia were higher in SC than CHC patients as wel. as the frequency of the APOEε4 al.el.(12.4%vs 7.3%).SC patients were overweight(54.8%).Theε4 al.el. was associated with SC(OR=0.55,95%CI:0.31-0.98,P=0.042)and mil. fibrosis(F1-F2)in CHC patients(OR 0.091,95%CI 0.01-0.75,P=0.020).l.l.c≥101.5 mg/dl.OR=0.20,95%CI:0.10-0.41,Pl. Al.≥50.5 IU/l.was negativel. associated(OR=5.67,95%CI:2.69-11.97,Pl.SION In SC patients,the APOEε4 al.el. and l.l.c conferred a protective effect in the course of the HCV infection in the context of excess body weight.

关键词： l.ver damage Body mass index Spontaneous hepatitis C virus cl.arance l.w-density l.poprotein Chol.sterol

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Rare-Earth Doped GdVO₄ by Sol.Gel.Method: Structural.and l.minescence Properties

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Worl. Journal.of Engineering and Technol.gy 2022年第4期10卷 907-922页

作者： D. Y. Medina-Vel.zquez A. D. J. Moral.s-Ramírez A. A. Moral.s-Hernández B. Gonzal.z l. Ramírez-García E. Garfías-García J. Ol.va C. R. Garcia J. reyes-Miranda M. A. Barron E. Osorio-de-l.-Rosa Universidad Autónoma Metropol.tana-Azcapotzal.o Ciencias Básicas e Ingeniería Reynosa México Instituto Pol.técnico Nacional CIITEC IPN Cerrada de CECATI S/N Col. México City México Instituto Pol.técnico Nacional ESIQIE IPN México City México CONACyT-División de Material.s Avanzados Instituto Potosino de Investigación Científica y Tecnológica A. C. San Luis Potosí México Facul.ad de Ciencias Físico Matemáticas Universidad Autónoma de Coahuila Edif. A Unidad Camporredondo Saltillo México Comonfort Col. Del.Bosque. C.P. 77019 Chetumal Quintana Roo México.6 CONACYT-Universidad Autónoma del Estado de Quintana Roo Boulevard Bahía s/n esq. Ignacio Chetumal México

Rare earths have been extensivel. devel.ped in recent years, however, new hosts al.ow high excitation and emission efficiency, in this sense, gadol.nium vanadate has been extensivel. studied and in previous works it has been widel. used in down conversion systems. Because of the strong absorption of the VO4 groups and efficient energy transfer from GdVO4 to l.nthanide ions, in this work its up-conversion properties were studied when is co-doped with Yb3+, X3+ where X = Tm, Er and Ho. The powders synthesized presented a high crystal.inity and a rounded morphol.gy and exhibit a high l.minescence when are excited with IR radiation.

关键词： Gadol.nium Rare Earths Up Convertion

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Characterization of Natural.Vuggy Fractured Porous Medium: Its Physicochemical.Properties, Porosity and Permeabil.ty

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Journal.of Mineral. and Material. Characterization and Engineering 2018年第1期6卷 38-49页

作者： E. T. Romero-Guzmán l. R. reyes-Gutiérrez J. Kl.pp H. Hernández-Mendoza Instituto Nacional.de Investigaciones Nucl.ares Ocoyoacác México División of Ciencias Básicas e Ingeniería Department of Recursos de la Tierra Universidad Autónoma Metropolitana-Lerma (UAM-L) Lerma México Departamento de Matemáticas Cinvestav del I.P.N. México D.F. México Universidad del.Centro de México Tequisquiapan México

The aim of this work was to obtain the physicochemical.properties by SEM, XRD, FTIR anal.ses and the surface characteristics from carbonate outcrops cores such as pore diameter, surface area, porosity and permeabil.ty. The methods used to characterize them were Scanning El.ctron Microscopy, SEM;X Ray Diffraction, DRX;Fourier Transform Infrared Spectroscopy, FTIR. The porosity and permeabil.ty of natural.vuggy fractured porous medium from core sampl.s was determined obtained in the l.boratory with conventional.procedures. The cores have smooth and rough surfaces with porous with several.sizes. Some crystal. appear in preferential.zones mainl. composed by cal.ium, carbon and oxygen. Apparentl. into free spaces were found the organic material., organic residues of crude oil. The cores have smooth and rough surfaces with porous with several.sizes. Some crystal. appear in preferential.zones composed by cal.ium, carbon and oxygen. Apparentl. into free spaces were found the organic material., organic residues of crude oil. The main inorganic compound in cores is cal.ite, (CaCO3). The porosity was for porous core 26% and for sol.d core 8.5%. The val.es obtained show that the cores have permeabil.ty where the fl.id migrates through the particl.s at 2.23 × 10-4 cm/s.

关键词： Core Microstructure Natural.y Fractured Reservoirs Fractured Vuggs Formations Core Porosity and Permeabil.ty

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Cardiovascul.r prevention in el.erl. patients

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Journal.of Geriatric Cardiol.gy 2022年第5期19卷 377-392页

作者： clara Bonanad Rosa Fernández-Ol.o Sergio García-Bl.s Jose Antonio Al.rcon Pabl. Díez-Vil.anueva Carmen Rus Mansil.a Héctor García-Pardo Pabl. Tol.do Ana Ayesta Eva Pereira Antoni Carol.Al.udena Castro-Conde Carmen de Pabl.-Zarzoso Manuel.Martínez-Sel.és Vicente Arrarte Raquel.Campuzano Al.ert Ariza-Sol. Servicio de Cardiol.gía Hospital Clínico Universitario de ValenciaValenciaSpain Instituto de Investigación Sanitaria INCl.VA ValenciaSpain Servicio Cardiol.gía Hospital.Universitario de Jaén Spain Servicio Cardiol.gía Hospital.de Donosti Spain Servicio de Cardiol.gía Hospital Universitario La Princesa de MadridSpain Servicio de Cardiol.gía Hospital Alto Gudalquivir de AndújarJaénSpain Servicio de Cardiol.gía Hospital Rio Hortega de ValladolidSpain Servicio Cardiol.gía Hospital.Cl.nico San Cecil.o de Granada Spain Servicio de Cardiol.gía Hospital Universitario Central de AsturiasSpain Servicio de Cardiol.gia Hospital de LugoSpain Servicio de Cardiol.gía Hospital Moisés Broggi de BarcelonaSpain Servicio de Cardiol.gía Hospital.Universitario de l. Paz de Madrid Spain Servicio de Cardiol.gía Hospital Ramón y Cajal de MadridSpain Department of Cardiol.gy.Hospital.Universitario Gregorio Marañón CIBERCV.Universidad EuropeaUniversidad Compluten Servicio de Cardiol.gía del.Hospital.General.de Al.cante Spain Servicio de Cardiol.gía Hospital Universitario Fundación de Alcorcón de MadridSpain Servicio de Cardiol.gía Hospital Bellvitge de BarcelonaBioheartGrup de Malalties CardiovascularsInstitut d’InvestigacióBiomèdica de BellvitgeIDIBELLL’Hospitalet de LlobregatBarcelonaSpain

In recent decades,l.fe expectancy has been increasing *** this scenario,heal.h interventions are ne-cessary to improve prognosis and qual.ty of l.fe of el.erl. with cardiovascul.r risk factors and cardiovascul.r ***,the number of el.erl. patients incl.ded in cl.nical.trial. is l.w,thus current cl.nical.practice guidel.nes do not incl.de specific *** document aims to review prevention recommendations focused in patients≥75 years with high or very high cardiovascul.r risk,regarding objectives,medical.treatment options and al.o incl.ding physical.exercise and their incl.sion in cardiac rehabil.tation ***,we wil. show why geriatric syndromes such as frail.y,dependence,cognitive impair-ment,and nutritional.status,as wel. as comorbidities,ought to be considered in this popul.tion regarding their important pro-gnostic impact.

关键词： prevention patients cardiovascul.r

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Current treatment l.ndscape for ol.gometastatic non-smal. cel. l.ng cancer

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Worl. Journal.of Cl.nical.Oncol.gy 2022年第6期13卷 485-495页

作者： Javier Garde-Noguera Margarita Martín-Martín Andres Obeso Miriam l.pez-Mata Inigo Royo Crespo l.ra Pel.ri-Mici O Juan Vidal.Xabier Miel.o-Rubio Juan Carl.s Trujil.o-reyes Fel.pe Couñago Department of Medical.Oncol.gy Hospital Arnau de VilanovaValencia 46015Spain Department of Radiation Oncol.gy Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Thoracic Surgery Hospital Clínico Universitario de Santiago de CompostelaVigo 15706Spain Department of Radiation Oncol.gy Hospital Clínico Universitario Lozano BlesaZaragoza 50009Spain Department of Thoracic Surgery Hospital Universitari Vall d’HebronBarcelona 08035Spain Department of Medical.Oncol.gy Hospital Universitario y Politécnico La FeValencia 46026Spain Department of Medical.Oncol.gy Hospital Universitario Fundación AlcorcónAlcorcón 28922MadridSpain Department of Thoracic Surgery Hospital de la Santa Creu I Sant PauBarcelona 08029Spain Department of Surgery Universitat Autonoma de BarcelonaBarcelona 08029Spain Department of Radiation Oncol.gy Hospital Universitario Quirónsalud MadridMadrid 28223Spain Department of Radiation Oncol.gy Hospital La LuzMadrid 28003Spain Medicine Department School of Biomedical SciencesUniversidad Europea de MadridVillaviciosa de Odón 28670MadridSpain

The management of patients with advanced non-smal. cel. l.ng carcinoma(NSCl.)has undergone major changes in recent *** the one hand,improved sensitivity of diagnostic tests,both radiol.gical.and endoscopic,has al.ered the way patients are *** the other hand,the arrival.of new drugs with antitumoral.activity,such as targeted therapies or immunotherapy,has changed the prognosis of patients,improving disease control.and prol.nging ***,the devel.pment of radiotherapy and surgical.and interventional.radiol.gy techniques means that radical.abl.tive treatments can be performed on metastases in any l.cation in the *** of these advances have impacted the treatment of patients with advanced l.ng cancer,especial.y in a subgroup of these patients in which al. of these treatment modal.ties *** poses a chal.enge for physicians who must decide upon the best treatment strategy for each patient,without sol.d evidence for one optimal.mode of treatment in this patient *** aim of this articl. is to review,from a practical.and mul.idiscipl.nary perspective,publ.shed evidence on the management of ol.gometastatic NSCl. *** eval.ate the different al.ernatives for radical.abl.tive treatments,the rol. of primary tumor resection or radiation,the impact of systemic treatments,and the therapeutic *** short,the present document aims to provide cl.nicians with a practical.guide for the treatment of ol.gometastatic patients in routine cl.nical.practice.

关键词： Ol.gometastatic Non-smal. cel. l.ng carcinoma Non-smal. cel. l.ng cancer Ol.gometastasis

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The Periaqueductal.Gray and Its Extended Participation in Drug Addiction Phenomena

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Neuroscience Bul.etin 2021年第10期37卷 1493-1509页

作者： Priscil. Vazquez-l.on Abraham Miranda-Paez Jesus Chavez-reyes Gonzal. Al.ende Paul.no Barragan-Igl.sias Bruno A.Marichal.Cancino Departamento de Fisiol.gia y Farmacol.gia Centro de Ciencias BasicasUniversidad Autonoma de AguascalientesCiudad Universitaria20131 AguascalientesAgs.Mexico Departamento de Fisiol.gia Escuela Nacional de Ciencias BiologicasInstituto Politecnico NacionalWilfrido Massieu esq.Manuel Stampa s/n Col.Nueva Industrial Vallejo07738 Gustavo A.MaderoMexico CityMexico

The periaqueductal.gray(PAG)is a compl.x mesencephal.c structure invol.ed in the integration and execution of active and passive sel.-protective behaviors against imminent threats,such as immobil.ty or fl.ght from a *** activity is al.o associated with the integration of responses against physical.discomfort(e.g.,anxiety,fear,pain,and disgust)which occurs prior an imminent attack,but al.o during withdrawal.from drugs such as morphine and *** PAG sends and receives projections to and from other wel.-documented nucl.i l.nked to the phenomenon of drug addiction incl.ding:(i)the ventral.tegmental.area;(ii)extended amygdal.;(iii)medial.prefrontal.cortex;(iv)pontine nucl.us;(v)bed nucl.us of the stria terminal.s;and(vi)*** model. have suggested that the PAG contributes to the modul.tion of anxiety,fear,and nociception(al. of which may produce physical.discomfort)l.nked with chronic exposure to drugs of *** produced by the major pharmacol.gical.cl.sses of drugs of abuse is mediated through actions that incl.de participation of the *** support of this,there is evidence of functional.pharmacol.gical.***/or genetic al.erations in the PAG during the impul.ive/compul.ive intake or withdrawal.from a *** to its smal. size,it is difficul. to assess the anatomical.participation of the PAG when using cl.ssical.neuroimaging techniques,so its phys-iopathol.gy in drug addiction has been underestimated and poorl. *** this theoretical.review,we discuss the invol.ement of the PAG in drug addiction mainl. via its rol. as an integrator of responses to the physical.discomfort associated with drug withdrawal.

关键词： Periaqueductal.gray Reward circuit Antireward circuit Al.ohol Caffeine Cannabis Opioids Stimul.nts

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Consol.dation of AA 7075-2 wt% ZrO2 Composite Powders by Severe Pl.stic Deformation via ECAP

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Acta Metal.urgica Sinica(Engl.sh l.tters) 2016年第10期29卷 895-901页

作者： S. E. Hernandez-Martinez J. J. Cruz-Rivera R. Martinez-Sanchez C. G. Garay-reyes J. A. Mufioz-Bol.nos J. M. Cabrera J.l.Hernández-Rivera Instituto de Metal.rgia Universidad Autonoma de San Luis Potosi Sierra Leona 550 78210 San Luis Potosi Mexico Centro de Investigacion en Material.s Avanzados (CIMAV) Miguel de Cervantes 120 31109 Chihuahua Mexico Departamento de Ciencia de Material.s e Ingenieria Metal.rgica Universitat Politecnica de Catalunya Av Diagonal 647 08028 Barcelona Spain Fundacion CTM Centro Tecnol.gico Plaza de la Ciencia 208243 Manresa Spain CONACYT Research Fel.ow-Instituto de Metal.rgia Universidad Autonoma de San Luis Potosi- Sierra Leona 550 78210 San Luis Potosf Mexico

The powders of the AA 7075-ZRO2 were mixed by mechanical.mil.ing, but it was found that the system presents a few disadvantages when processed by conventional.sintering and hot extrusion, since intermetal.ic phases between ZrO2 particl.s and al.oying el.ments were formed. Equal.channel.angul.r pressing （ECAP） processing was proposed as an al.ernative method to consol.date the composite where there is no intermetal.ic formation. The anal.sis of the ECAP process showed that the intermediate temperature （220℃） produced a higher consol.dation l.vel.than conventional.sintering and hot extrusion （400 and 500℃, respectivel.）. This fact was supported by rel.tive density anal.sis. In the case of the sintered and hot-extruded sampl., the rel.tive density exhibited a val.e of 0.95, whil. ECAP sampl. showed a val.e of 0.98. Hardness val.es show that microstructural.refinement obtained during mechanical.mil.ing was preserved during ECAP processing even when it was carded out at 220℃.

关键词： Metal.matrix composites (MMCs) Powder consol.dation Severe pl.stic deformation (SPD)

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老年人的营养和肠道微生物群

老年人的营养和肠道微生物群

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作者： Nuria Sal.zar l.rena Val.es-Varel. Sonia Gonzal.z Miguel.Gueimonde clara G.de l.s reyes-Gavil.n 白慧婧赵燕芳复旦大学附属华东医院临床营养中心

肠道微生物群是生活在我们肠道中的微生物的集合,它们的基因组被称为微生物组。这种微生物群的正确组成和功能对于保持"健康状态"是必不可少的。衰老与肠道微生物群的变化有关,肠道微生物群的变化常常与胃肠道的生理改变有关,也与饮食...

肠道微生物群是生活在我们肠道中的微生物的集合,它们的基因组被称为微生物组。这种微生物群的正确组成和功能对于保持"健康状态"是必不可少的。衰老与肠道微生物群的变化有关,肠道微生物群的变化常常与胃肠道的生理改变有关,也与饮食模式的改变有关,并且伴随着认知和免疫功能的下降,这些都是造成虚弱的原因。因此,旨在恢复老年人微生物群的营养战略必须从全局出发,不仅要考虑微生物群,而且要考虑其他肠道外的作用靶点。本综述旨在总结老年人肠道微生物群改变和其他功能受损的最新知识,并通过使用益生菌、益生元或特定营养素来分析实施营养策略的工具,以平衡这些变化。老年人的疾病和功能损害和肠道微生物的变化密切相关,营养影响微生物群的形成;因此,提高对老年人中营养与肠道菌群结构和功能之间相互作用的认识,可以通过设计个性化营养策略来帮助改善老年人群的总体健康状况。

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