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Adventitial Rupture of the Ascending Thoracic Aorta Extended to the Buttock by Thoracic Crushing between Two Tanks at the Thoracic and Cardiovascular Surgery Department at the Besançon CHRU

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Open Journal of Thoracic Surgery 2018年第4期8卷 74-78页

作者： Abdoulaye Kante Andrea Perrotti Brehima Coulibaly Mamadou Almamy Keita Drissa Traore Siaka Diallo Mariam Daou Mamadou Diakite Babou Bah Brehima Bengaly MoustaphIssa Magane Bakary Keita Birama Togola Drissa Ouattara Souleymane Sanogo Timbely Guidere Nouhom Ongoiba Harrison Haight Anne Sophie Lacagne Julie Ritter Anne claire Mogenet Enrica Dorigo Camille Durst Djamel Kaili Francois Clement Sidney Chocron Service of General Surgery CHU Point GBamakoMali Servicet of Thoracic and Cardiovascular Surgery University Hospital of BesanconBesanconFrance Service of Neurology Gabriel Toure Teaching HospitalBamakoMali Service of Cardiology CHU Point GFaculty of Medicine and OdontostomatologyBamakoMali Service of Anesthesia Service and Resuscitation CHU Gabriel ToureBamakoMali

Traumatic rupture of the ascending aorta is rare. We report the case of a 23-year-old man who suffered a service accident by crushing the thorax between two tanks during army maneuvers that resulted in an adventitial rupture of the ascending thoracic aorta extending to the Crosse. Treatment consisted of replacement of the ascending aorta with a 24 mm Hemashield straight tube and re-implantation of supra-aortic vessels at the dome of the prosthesis.

关键词： Traumatic Rupture Ascending Aorta Extended to Lacrosse Service Accident

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节能生活--IECEE认证实现能效

电器工业 2018年第2期 47-47页

作者： claire Marchand 孟子舒（译）张亮（校）中国电器工业协会标准化与技术评价中心不详

我们每天需要依靠多少家用电器和设备？从家里点亮的灯、到吹风机、烤箱和电视机，到办公室的电脑，我们完成的大部分任务需要电气设备的协助。此外，冰箱和加热器等电器每天运作24小时，每周7天。

关键词：能效认证生活节能家用电器电气设备吹风机电视机

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裁员？女性优先！

EGFR Expression Is Unreliable to Decide for Cetuximab Treatment in Patients with Metastatic Colorectal Cancer: Results from “ERBITUX-OUEST”

人力资源开发与管理 2020年第1期

作者： Henry Hoenig Ditas Lopez claire Jiao

相比于男性，发展中国家的女性工人最有可能因自动化而失去工作

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Open Journal of Internal Medicine 2016年第2期6卷 56-67页

作者： Jean-Philippe Metges Erick Gamelin Alain Volant Olivier Capitain Jean-François Ramée Jean-Luc Raoul Jean-Yves Douillard Pierre-Luc Etienne Isabelle Cumin Olivier Dupuis Roger Faroux Marie-Aude Coulon Philippe Deguiral Karine Bideau Nacr Eddine Achour Alain Gourlaouen Corinne Alleaume Annie Wdowik Laurent Miglianico Yann Touchefeu Vincent Klein Alain Penchet Ludovic Rosenfeld Daniel Martin claire Stampfli Jean-Jacques Auger Alain Bargain Murielle Broyer-Petit Jérome Chettrit Louis-Rémi De Ybarlucea Serge Eloit Pierre Marie Girardot Nathalie Heresbach Christian Laboisse Eric Lavoine Gilles Lemasson claire Magois Sophie Michalak Norbert Padilla Joseph Politis Frédéric Staroz Bruno Turlin Arnaud Uguen Viorel Vasiliu Véronique Verriele Fanny Marhuenda Delphine Déniel Lagadec Christian Riché Françoise Grudé Observatoire dédié au Cancer des régions Bretagne et Pays de la Loire France Centre Hospitalier Régional Universitaire (CHRU) Brest France Institut de Cancérologie de l’Ouest (ICO) Paul Papin Angers France Centre Catherine de Sienne Nantes France CRLCC Eugène Marquis Rennes France ICO René Gauducheau Nantes France Centre CARIO-HCPA Plérin France Centre Hospitalier Bretagne Sud (CHBS) Lorient France Clinique Victor Hugo Le Mans France Centre Hospitalier Départemental (CHD) La Roche-sur-Yon France CH Le Mans France Clinique Mutualiste de l’Estuaire Saint-Nazaire France CHIC Quimper France Clinique Pasteur Lanroze Brest France CH MORLAIX France CH Saint-Brieuc France CHBA Vannes France CHP Saint-Grégoire France CHU Nantes France Hopital Privé Océane Vannes France Clinique Saint-Michel et Sainte-Anne Quimper France Pole Santé Sarthe et Loire La Flèche France Polyclinique du Maine Laval France Polyclinique Sud Quimper France CH Laval France Polyclinique Cesson Sévigné France Laboratoire d’anatomie et de cytologie pathologiques Cholet France Cabinet d’anatomie et de cytologie pathologiques Saint-Malo France Laboratoire d’anatomie et de cytologie pathologiques Lorient France Institut d’histopathologie Nantes France Laboratoire de Pathologie Médicale Laval France ARMOR Pathologie Plérin France Laboratoire d’anatomie et de cytologie pathologiques Rennes France Laboratoire d’anatomie et de cytologie pathologiques Angers France Laboratoire Analyses Biologie Glasgow Brest France CHU Angers France Centre d’anatomie et de cytologie pathologiques Le Mans France Cabinet d’anatomie et de cytologie pathologiques Vannes France Laboratoire d’anatomie et de cytologie pathologiques Quimper France CHU Rennes France

Purpose: Although controversial, assessment of epidermal growth factor receptor (EGFR) expression is required for the approved indications of Cetuximab in metastatic colorectal cancer (mCRC). With the objective of improving patient selection, “ERBITUX-OUEST” study aimed at analyzing EGFR status in a large cohort of mCRC patients who received cetuximab without preliminary EGFR screening, and assessing the correlation between EGFR status and response to treatment retrospectively. Patients and methods: 332 patients treated with Irinotecan Cetuximab based regimen after progression on irinotecan or oxaliplatin therapy were included. EGFR status was assessed using three available immunohistochemistry (IHC) tests and in situ hybridization in case of negativity. Clinical outcomes of EGFR-positive and EGFR-non-detected (or considered as negative with at least one test) patients were compared. Results: Of the 332 samples centrally screened, 194 were classified as full-positive (i.e., EGFR-positive for all three tests), 86 as full-negative, and 52 as discordant. One third of the 131 negative samples with FDA approved test should be reclassified as positive with at least one of the two others tests. Regarding results from FDA approved test only, neither objective response rate (ORR), progression-free survival (PFS) nor overall survival (OS) differed significantly between EGFR-negative and EGFR-positive patients (P = 0.788, 0.326 and 0.888, respectively). Similarly, comparison of full-negative to other groups did not show any significant difference in terms of ORR (P = 0.507), PFS (P = 0.222) or OS (P = 0.686). Conclusion: These data strongly argue against mCRC patients selection for Cetuximab treatment based on EGFR expression as measured by currently available IHC technics.

关键词： Metastatic Colorectal Cancer Cetuximab EGFR Expression

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世界顶级时尚大师作品典藏詹尼·范思哲

世界顶级时尚大师作品典藏詹尼·范思哲

Modulation of dopamine release by stimulus pattern in striatum in vivo

2005年

作者：（英）克莱尔·威尔科克斯（claire Wilcox）（英）瓦莱丽·门德斯（Valerie Mendes）（英）希阿娜·巴斯（Chiara Buss）王浙方靖译

本书展示了意大利人詹尼·范思哲——这位20世纪晚期最多姿多彩和天才的设计师在1946～1997年创作的经典作品。

关键词：服装地点:世界年代:现代地点:意大利

来源：汇雅图书（南通市图书馆... 评论

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Modulation of dopamine release by stimulus pattern in striat...

巨脑性白质脑病伴皮层下囊肿:一个黎巴嫩家系的研究和文献回顾(法国)

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Shi-Rong WANG~1,Wei YAO~1,Hong-Ping HUANG~1,Jing-Zhi ZHENG~1,Panli ZUO~1,claire Xi ZHANG~1,Bao-Ming LI~2, Zhuan ZHOU~1 1 Institute of Molecular Medicine,Peking University,Beijing 100871 2 Institute of Neurobiology,Fudan University,Shanghai 200433,China

＜正＞A long-standing question in how the nervous system processes information is whether patterns of action potentials（APs）,in addition to their mean frequency,have specific effects on neurotransmitter *** previous studies on different AP patterns showed that the number of AP bursts effectively modulate cell secretion in cultured adrenal chromaffin ***,it is not clear how such patterns modulate transmitter release in the central nervous system in *** answer this question,amperometry was used to measure dopamine release in the rat striatum,in response to electrical stimulation of the medial forebrain *** stimulus pattern was defined by the four parameters, number（"N"） and frequency（"f’） of stimuli pulses,number of bursts（"m"）,and inter-burst interval（"d"）.We found that for a given "N",in addition to "f’,"m" effectively modulated dopamine ***,this "burst effect" was modulated by stimulus numbers,frequency and inter-burst *** dopamine signals were measured also in mice. Cocaine and nomifensine,inhibitors of dopamine transporter,enhanced the burst *** proposed that the secretion efficiency modulated by stimuli code may play an important role in information transfer in neural networks in vivo.

关键词： Dopamine release striatum in vivo action potential pattern

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 6-6页

作者： Koussa S. Roukoz H. rizk T. Mégarbané A. 方伯言 Htel-Dieu de France Université Saint-Jos- eph Beyrouth Lebanon

Introduction. Megalencephalic leukoencephalopathy with subcortical cysts is a rare disease with autosomal recessive inheritance. Materials and methods. Two br others born from a consanguineous marriage, presenting with the phenotype of the disease, their parents, brothers and sisters were examined. Magnetic resonance imaging of the brain was performed for the two patients. Sequence analysis of ML C1 (GenBank mRNA accession no. NM 015166) was performed for the patients using i ntronic primers. PCR restriction fragment length polymorphism analysis was done in patients, their parents and in 100 Lebanese controls in order to exclude gene ***. The clinical features were characteristic of the disease, consisting of an early-onset macrocephaly followed by slowly progressive ataxia , pyramidal tract involvement and epileptic seizures. In one patient, the clinic al manifestations were aggravated by a trivial brain trauma. In his brother and in one female cousin, a status epilepticus was precipitated by a febrile syndrom e. The diffuse cerebral white matter lesions and the subcortical temporo-polar and frontal cysts, best seen on MRI,allowed making the *** genet ics revealed a new mutation involving the MLC1 gene (263G→T, exon 3). As a cons equence, it affects the second transmembrane domain predict (G88V) of the MLC pr otein (protein sequence NP 055981). The mutation was confirmed by PCR restrictio n fragment length polymorphism analysis. Conclusion. Megalencephalic leucoenceph alopathy with subcortical cysts may be individualized on clinical and radiologic al basis and confirmed by molecular genetics. In this Lebanese family, a new mut ation of the MLC1 gene is reported.

关键词：白质脑病巨脑文献回顾脑白质癫痫持续状态近亲婚配共济失调基因多态性锥体束囊性变

一种新型机械瓣静脉输入接口的使用致导管相关的血液感染率上升

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麻醉与监护论坛 2006年第2期13卷 124-126页

作者： Lisa L. Maragakis Karen L.Bradley Xiaoyan Song claire Beers Mariene R.Mitter Sara E.Cosgrove Trish M.Pert 谢灵琼（编译）李永旺（审校）不详 RN BSN RN MSN

静脉导管输入接口技术从带可移动盖帽的开口模式转变成了更加复杂的机械瓣封闭模式。在我们的研究所，我们观察到由一种新型无针正压机械瓣静脉输入接口的使用，而导致的导管相关血液感染率明显上升。

关键词：导管相关血液感染机械瓣静脉输入接口

The Giant Radio Array for Neutrino Detection(GRAND):Science and design

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Science China(Physics,Mechanics & Astronomy) 2020年第1期63卷 1-43页

作者： Jaime Alvarez-Muniz Rafael Alves Batista Aswathi Balagopal V. Julien Bolmont Mauricio Bustamante Washington Carvalho Jr. Didier Charrier Ismael Cognard Valentin Decoene Peter B.Denton Sijbrand De Jong Krijn D.De Vries Ralph Engel Ke Fang Chad Finley Stefano Gabici Quan Bu Gou Jun Hua Gu claire Guépin Hong Bo Hu Yan Huang Kumiko Kotera Sandra Le Coz Jean-Philippe Lenain Guo Liang Léü Olivier Martineau-Huynh Miguel Mostafá Fabrice Mottez Kohta Murase Valentin Niess Foteini Oikonomou Tanguy Pierog Xiang Li Qian Bo Qin Duan Ran Nicolas Renault-Tinacci Markus Roth Frank G.Schroder Fabian Schüssler Cyril Tasse Charles Timmerman Matías Tueros Xiang Ping Wu Philippe Zarka Andreas Zech B.Theodore Zhang Jian Li Zhang Yi Zhang Qian Zheng Anne Zilles Departamento de Fisica de Particulas&lnstituto Galego de Fisica de Altas Enerxias Universidad de Santiago de CompostelaSantiago de Compostela 15782Spain Instituto de Astronomia Geofisica e Ciencias AtmosfericasUniversidade de Sao PauloSao Paulo-SP 05508-090Brazil Department of Physics-Astrophysics University of OxfordDWBOxford 0X13RHUK Institute of Experimental Particle Physics(ETP) Karlsruhe Institute of Technology(KIT)Karlsru he D-76021Germany Laboratoire de Physique Nucleeaire et de Hautes Energies(LPNHE) Sorbonne UniversiteUniversite Paris DiderotSorbonne Paris CiteCNRS place Jussieu F-75252Paris Cedex 5France Niels Bohr International Academy and DARK Niels Bohr InstituteCopenhagen 2100Denmark Discovery Center Niels Bohr InstituteCopenhagen 2100Denmark Center for Cosmology and AstroParticle Physics(CCA.PP)&Department of Physics Ohio State UniversityColumbus OH 43210USA Universidade de Santiago de Compostela Santiago de Compostela 15782Spain 0SUBATECH Institut Mines-Telecom Atlantique-CNRS/IN2P3-Universite de NantesNantes 44300France Laboratoire de Physique et Chimie de KEnvironnement et de VEspace LPC2E CNRS-Universite d'Orleans Orleans F-45071France Station de Radioastronomie de Nancay Observatoire de ParisCNRS/INSU F-18330 NangayFrance Sorbonne Universite UMR 7095Institut d'Astrophysique de Paris98 bis bd AragoParis 75014France Institute for Mathematics Astrophysics and Particle Physics(IMAPP)Radboud UniversiteitNijmegen 6500Netherlands Nationaal Instituut voor Kemfysica en Hoge Energie Fysica(NIKHEF) Amsterdam NL-1009Netherlands IIHE/ELEM Vrije Universiteit BrusselPleinlaan 2Brussels 1050Belgium Institute for Nuclear Physics(IKP) Karlsruhe Institute of Technology(KIT)Karlsruhe D-76021Germany Einstein Fellow Stanford UniversityStanford CA 94305USA Department of Astronomy University of MarylandCollege Park MD 20742-2421USA Joint Space-Science Institute College Park MD 20742-2421USA Oskar Klein Centre Stockholm UniversityStockholm SE-10691Sweden Department of Phy

The Giant Radio Array for Neutrino Detection(GRAND)is a planned large-scale observatory of ultra-high-energy(UHE)cosmic particles,with energies exceeding 10~8 Ge *** goal is to solve the long-standing mystery of the origin of UHE cosmic *** do this,GRAND will detect an unprecedented number of UHE cosmic rays and search for the undiscovered UHE neutrinos and gamma rays associated to them with unmatched *** will use large arrays of antennas to detect the radio emission coming from extensive air showers initiated by UHE particles in the *** design is modular:20 separate,independent sub-arrays,each of 10000 radio antennas deployed over 10000 km^2.A staged construction plan will validate key detection techniques while achieving important science goals *** we present the science goals,detection strategy,preliminary design,performance goals,and construction plans for GRAND.

关键词： radio telescopes neutrinos in astronomical observations cosmic rays in astronomical observations radiowave radiation:sources galactic and extragalactic cosmic rays:galactic and extragalactic