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American Journal of Analytical Chemistry 2019年第9期10卷 404-414页

作者： Alain N’Guessan Armand Koffi Ismaë l L. Dally Christophe N’Cho Amin claire gueutin Nicolas Tsapis Elias Fattal Institute Galien Paris-Sud Paris-Sud University Orsay France School of Pharmacy University Félix Houphouet-Boigny Abidjan C&ocirc te d’Ivoire

A high-performance liquid chromatography (HPLC) method has been developed and validated for the determination of dexamethasone palmitate (DXP) in bronchoalveolar fluid lavage samples (BALF). DXP in rat BALFs containing the internal standard (IS), testosterone decanoate (TD), was extracted using a mixture of chloroform and methanol (9:1, v/v). Extracts were then centrifuged, dried and dissolved in acetonitrile. A chromatographic separation based on an isocratic elution was done using acetonitrile and water (85:15, v/v) as a mobile phase at a flow rate of 1.2 mL/min. The graph of the developed method was linear within the tested calibration range of 0.5 - 40 μg/mL. The overall extraction recovery of DXP from BALF samples was 84.3% ± 1.6%. The accuracy (relative error) and precision (coefficient of variation) values were within the pre-defined limits of ≤15% at all concentrations. This methodology has been applied to determine levels of DXP in BALF samples collected from rats treated with DXP large porous particles. The measured concentrations were successfully evaluated using a non-compartment pharmacokinetic model. Since the developed method requires only a microvolume (100 μL) of BALF sample for analysis, it is therefore particularly suitable for the evaluation of drug biodistribution in lung.

关键词： Dexamethasone Palmitate Bronchoalveolar Lavage Fluid HPLC

The Artificial Disc Nucleus and Other Strategies for Replacement of the Nucleus Pulposus:Past,Present and Future Designs for an Emerging Surgical Solution

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Engineered Regeneration

Engineered Regeneration 2024年第2期5卷 269-281页

作者： Greg Sacks Vincent DeStefano claire Parker Ryan Lebens Harry Mushlin Renaissance School of Medicine at Stony Brook University Stony BrookNYUSA

Nucleus Pulposus(NP)Replacement is a developing surgical methodology for the treatment of pathology related to degeneration of intervertebral discs(IVDs).This article provides necessary context regarding the patholo-gies treated with this technology,the biomechanical structure and function of the IVD,and the procedures this technology aims to ***,it provides an overview and discussion of commercial and experimental preformed and in situ curing prosthesis designs reported in the scientific literature and summarizes the results of biomechanical and clinical studies evaluating their *** and updated information on the most recent research into NP replacement with novel hydrogel and tissue engineering(TE)strategies is *** of the NP allows for potential improvement in the treatment of degenerative spinal pathologies through minimally invasive surgical techniques.

关键词： Nucleus Pulposus Intradiscal Prosthesis Hydrogel Artificial Disc Implant Spine Surgery

A decomposition of light’s spin angular momentum density

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Light(Science & Applications) 2024年第8期13卷 1578-1589页

作者： Alex J.Vernon Sebastian Golat claire Rigouzzo Eugene A.Lim Francisco J.Rodríguez-Fortuño Department of Physics King’s College LondonStrandLondon WC2R 2LSUK London Centre for Nanotechnology LondonUK

Light carries intrinsic spin angular momentum(SAM)when the electric or magnetic field vector rotates over time.A familiar vector equation calculates the direction of light’s SAM density using the right-hand rule with reference to the electric and magnetic polarisation *** Maxwell’s equations,this vector equation can be decomposed into a sum of two distinct terms,akin to the well-known Poynting vector decomposition into orbital and spin *** present the first general study of this spin decomposition,showing that the two terms,which we call canonical and Poynting spin,are chiral analogies to the canonical and spin momenta of light in its interaction with *** canonical momentum,canonical spin is directly *** canonical and Poynting spin incorporate spatial variation of the electric and magnetic fields and are influenced by optical *** decomposition allows us to show that a linearly polarised vortex beam,which has no total SAM,can nevertheless exert longitudinal chiral pressure due to equal and opposite canonical and Poynting spins.

关键词： canonical momentum angular

Understanding antimicrobial pharmacokinetics in critically ill patients to optimize antimicrobial therapy:A narrative review

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Journal of Intensive Medicine 2024年第3期4卷 287-298页

作者： claire Roger Department of Anesthesiology and Intensive Care Pain and Emergency MedicineNîmes-Caremeau University HospitalNîmesFrance UR UM 103 IMAGINE(Initial Management and prévention of orGan failures IN critically ill patiEnts) Faculty of MedicineMontpellier UniversityMontpellierFrance

Effective treatment of sepsis not only demands prompt administration of appropriate antimicrobials but also requires precise dosing to enhance the likelihood of patient survival. Adequate dosing refers to the administration of doses that yield therapeutic drug concentrations at the infection site. This ensures a favorable clinical and microbiological response while avoiding antibiotic-related toxicity. Therapeutic drug monitoring (TDM) is the recommended approach for attaining these goals. However, TDM is not universally available in all intensive care units (ICUs) and for all antimicrobial agents. In the absence of TDM, healthcare practitioners need to rely on several factors to make informed dosing decisions. These include the patient's clinical condition, causative pathogen, impact of organ dysfunction (requiring extracorporeal therapies), and physicochemical properties of the antimicrobials. In this context, the pharmacokinetics of antimicrobials vary considerably between different critically ill patients and within the same patient over the course of ICU stay. This variability underscores the need for individualized dosing. This review aimed to describe the main pathophysiological changes observed in critically ill patients and their impact on antimicrobial drug dosing decisions. It also aimed to provide essential practical recommendations that may aid clinicians in optimizing antimicrobial therapy among critically ill patients.

关键词： Pharmacokinetics/pharmacodynamics ICU Antibiotics Dose optimization TDM

Cardialysis 40年:领先欧洲的心血管研究机构

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中华心血管病杂志 2024年第1期52卷 107-110页

作者： Spitzer Ernest Ren claire Ben Cardialysis 鹿特丹3012KM 欧洲心血管研究所鹿特丹3012KM 荷兰鹿特丹伊拉斯谟大学医学中心胸部中心心内科鹿特丹3015GD

该文总结了Cardialysis的定位、过往成就及其未来发展的方向,其核心是在全球层面巩固和扩大临床试验研究者和临床研究专业人员之间的合作。Cardialysis的独特性在于其学术优势与独立性的结合以及高质量学术成果的产出。该文还总结了Card... 详细信息

该文总结了Cardialysis的定位、过往成就及其未来发展的方向,其核心是在全球层面巩固和扩大临床试验研究者和临床研究专业人员之间的合作。Cardialysis的独特性在于其学术优势与独立性的结合以及高质量学术成果的产出。该文还总结了Cardialysis心血管影像核心实验室和其过往完成的重要介入心脏病学临床试验;同时阐述了该组织提供的科技服务。此外,它还介绍了由Cardialysis(参与)创立的学术研究联盟(ARC)和欧洲心血管研究所(ECRI)两个非营利性学术组织。最后文章提到了Cardialysis成功的最重要贡献者,并分享了未来发展的方向。

关键词：心血管疾病核心实验室研究机构合作介入心脏病学心血管影像

Promoting Healthy Longevity Should Start Young: A Life Course Journey

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Maternal-Fetal Medicine 2024年第1期6卷 1-4页

作者： Cuilin Zhang claire Guivarch Global Centre for Asian Women's Health Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of Obstetrics and Gynaecology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Bia-Echo Asia Centre for Reproductive Longevity and Equality(ACRLE) Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of Nutrition Harvard T.H.Chan School of Public HealthBoston 02115USA

Introduction Throughout a woman’s life,several unique health characteristics are related to an increased risk of later disease morbidity and/or premature mortality(Fig.1).For instance,these include early age at menarche1,2(ie,“short,irregular or long menstrual cycles”)3,4,a history of infertility5,pregnancy loss6,several major pregnancy complications(eg,preeclampsia,gestational hypertension,gestational diabetes mellitus(GDM)and preterm delivery)7–9,and menopause characteristics(eg,long menopause transition period,early age at menopause,and the presence of vasomotor symptoms).

关键词： Population health Longevity Women's health

From bibliometric analysis: 3D printing design strategies and battery applications with a focus on zinc‐ion batteries

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SmartMat 2024年第1期5卷 59-82页

作者： Xuan Gao Kejiang Liu Chang Su Wei Zhang Yuhang Dai Ivan P.Parkin claire J.Carmalt Guanjie He Christopher Ingold Laboratory Department of ChemistryUniversity College LondonLondonUK Electrochemical Innovation Lab(EIL) Department of Chemical EngineeringUniversity College LondonLondonUK Department of Physics Hong Kong Baptist UniversityHong KongChina Nanyang Technopreneurship Center Nanyang Technological UniversitySingaporeSingapore

Three‐dimensional(3D)printing has the potential to revolutionize the way energy storage devices are designed and *** this paper,we explore the use of 3D printing in the design and production of energy storage devices,especially zinc‐ion batteries(ZIBs)and examine its potential advantages over traditional manufacturing methods.3D printing could significantly improve the customization of ZIBs,making it a promising strategy for the future of energy *** particular,3D printing allows for the creation of complex,customized geometries,and designs that can optimize the energy density,power density,and overall performance of ***,we discuss and compare the impact of 3D printing design strategies based on different configurations of film,interdigitation,and framework on energy storage devices with a focus on ***,3D printing enables the rapid prototyping and production of batteries,reducing leading times and costs compared with traditional manufacturing ***,there are also challenges and limitations to consider,such as the need for further development of suitable 3D printing materials and processes for energy storage applications.

关键词： 3D printing battery commercialization bibliometric analysis electrode configurations zinc‐ion battery

Establishment of a system for screening and identification of novel bactericide targets in the plant pathogenic bacterium Xanthomonas oryzae pv. oryzae using Tn-seq and SPR

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Journal of Integrative Agriculture 2024年第5期23卷 1580-1592页

作者： Chaoyue Pang Ling Jin Haoyu Zang Damalk Saint-claire SKoklannou Jiazhi Sun Jiawei Yang Yongxing Wang Liang Xu Chunyan Gu Yang Sun Xing Chen Yu Chen School of Plant Protection Anhui Agricultural UniversityHefei 230036China Institute of Plant Protection and Agro-Products Safety Anhui Academy of Agricultural SciencesHefei 230031China Anhui Province Laboratory for Green Pesticide Development and Application School of Plant ProtectionAnhui Agricultural UniversityHefei230036China Hefei Research Center State Key Laboratory for Biology of Plant Diseases and Insect PestsHefei 230036China Key Laboratory of Integrated Crop Pest Management of Anhui Province School of Plant ProtectionAnhui Agricultural University Hefei230036China Shandong Vicome Greenland Chemical Co. Ltd.Jinan 250204China

Xanthomonas spp. cause severe bacterial diseases. However, effective strategies for prevention and management of these diseases are scarce. Thus, it is necessary to improve the efficiency of control of diseases caused by Xanthomonas. In this study, Xanthomonas oryzae pv. oryzae(Xoo), which causes rice bacterial leaf blight, has been studied as a representative. A transposon insertion library of Xoo, comprising approximately 200,000 individual insertion mutants, was generated. Transposon sequencing data indicated that the mariner C9 transposase mapped at 35.7–36.4% of all potential insertion sites, revealing 491 essential genes required for the growth of Xoo in rich media. The results show that, compared to the functions of essential genes of other bacteria, the functions of some essential genes of Xoo are unknown, 25 genes might be dangerous for the Xanthomonas group, and 3 are specific to Xanthomonas. High-priority candidates for developing broad-spectrum, Xanthomonas-specific, and environment-friendly bactericides were identified in this study. In addition, this study revealed the possible targets of dioctyldiethylenetriamine using surface plasmon resonance(SPR) in combination with high performance liquid chromatography–mass spectrometry(HPLC–MS). The study also provided references for the research of some certain bactericides with unknown anti-bacterial mode of action. In conclusion, this study urged a better understanding of Xanthomonas,provided meaningful data for the management of bacterial leaf blight, and disclosed selected targets of a novel bactericide.

关键词： rice bacterial leaf blight Xanthomonas essential genes Tn-seq dioctyldiethylenetriamine

Recovery rates and long-term olfactory dysfunction following COVID-19 infection

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 121-128页

作者： Melanie Dias Zara Shaida Nora Haloob claire Hopkins ENT Department Guy's HospitalLondonUK

Objectives:Olfactory dysfunction is one of the most recognized symptoms of COVID-19,significantly impacting quality of life,particularly in cases where recovery is *** review aims to explore patterns of olfactory recovery post-COVID-19 infection,with particular focus on delayed *** Sources:Published literature in the English language,including senior author's own work,online and social media platforms,and patients'anecdotal ***:A comprehensive review of the literature was undertaken by the authors with guidance from the senior author with expertise in the field of ***:Based on self-report,an estimated 95%of patients recover their olfactory function within 6 months post-COVID-19 ***,psychophysical testing detects higher rates of persistent olfactory *** has been found to continue for at least 2 years postinfection;negative prognostic indicators include severe olfactory loss in the acute phase,female sex,and older *** in quantitative and qualitative disturbance in prolonged cases likely reflects both peripheral and central pathophysiological *** of many of the reviewed studies reflect lack of psychophysical testing and baseline olfactory ***:Post-COVID-19 olfactory dysfunction remains a significant health and psychosocial *** evidence is improving awareness and knowledge among clinicians to better support patients through their olfactory rehabilitation,with hope of recovery after several months or *** research is needed to better understand the underlying pathogenesis of delayed recovery,identify at risk individuals earlier in the disease course,and develop therapeutic targets.

关键词： anosmia COVID-19 olfaction parosmia recovery

Antenatal Noninvasive Fetal Electrocardiography:A Literature Review

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Maternal-Fetal Medicine 2024年第3期6卷 178-189页

作者： claire Pegorie Becky Liu Basky Thilaganathan Amar Bhide Department of Obstetrics and Gynaecology St George’s University Hospitals NHS Foundation TrustLondon SW170QTUnited Kingdom Vascular Biology Research Centre Molecular and Clinical Sciences Research InstituteSt George’s University of LondonLondon SW170QTUnited Kingdom

Fetal heart rate(FHR)monitoring is one of the central parts of obstetric ***-based technologies such as cardiotocography(CTG)remain the most common method for FHR *** CTG’s limitations,including subjective interpretation,high interobserver variability,and the need for skilled professionals,led to the development of computerized CTG(cCTG).While cCTG demonstrated advantages,its superiority over visual interpretation remains *** has prompted the exploration of alternatives like noninvasive fetal electrocardiography(NIFECG).This review explores the landscape of antenatal FHR monitoring and the need for remote FHR monitoring in a patient-centered care ***,FHR monitoring needs to evolve from the traditional approach to incorporate artificial intelligence and machine *** review underscores the importance of aligning fetal monitoring with modern healthcare,leveraging artificial intelligence algorithms for accurate assessments,and enhancing patient *** physiology of FHR variability(FHRV)is explained emphasizing its significance in assessing fetal *** measures of FHRV and their relevance are *** delves into the promising realm of NIFECG,detailing its history and recent technological *** potential advantages of NIFECG are objective FHR assessment,beat-to-beat variability,patient comfort,remote prolonged use,and less signal loss with increased maternal body mass *** its promise,challenges such as signal loss must be *** clinical application of NIFECG,its correlation with cCTG measures,and ongoing technological advancements are *** conclusion,this review explores the evolution of antenatal FHR monitoring,emphasizing the potential of NIFECG in providing reliable,home-based monitoring *** research directions are outlined,urging longitudinal studies and evidence generation to establish NIFECG’s role in enhancing fetal well-being assess

关键词： Ambulatory monitoring Noninvasive fetal electrocardiography Fetal heart-rate monitoring Fetal heart rate variability