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Regulatory giants join forces

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Frontiers in Biology 2010年第1期5卷 5-7页

作者： claire agius Andrew LEAMENS Anthony AMILLAR Ming-Bo WANG CSIRO Division of Plant Industry CanberraACT 2601Australia School of Molecular and Microbial Bioscience University of SydneySydney NSW 2006Australia Research School of Biology Australian National UniversityCanberraACT 2601Australia

Numerous disease states are characterized by ectopic expression of *** findings suggest that crosstalk between systems that regulate gene expression during animal development ensures responsiveness to environmental cues.

关键词： finding forces ectopic

Understanding antimicrobial pharmacokinetics in critically ill patients to optimize antimicrobial therapy:A narrative review

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Journal of Intensive Medicine 2024年第3期4卷 287-298页

作者： claire Roger Department of Anesthesiology and Intensive Care Pain and Emergency MedicineNîmes-Caremeau University HospitalNîmesFrance UR UM 103 IMAGINE(Initial Management and prévention of orGan failures IN critically ill patiEnts) Faculty of MedicineMontpellier UniversityMontpellierFrance

Effective treatment of sepsis not only demands prompt administration of appropriate antimicrobials but also requires precise dosing to enhance the likelihood of patient survival. Adequate dosing refers to the administration of doses that yield therapeutic drug concentrations at the infection site. This ensures a favorable clinical and microbiological response while avoiding antibiotic-related toxicity. Therapeutic drug monitoring (TDM) is the recommended approach for attaining these goals. However, TDM is not universally available in all intensive care units (ICUs) and for all antimicrobial agents. In the absence of TDM, healthcare practitioners need to rely on several factors to make informed dosing decisions. These include the patient's clinical condition, causative pathogen, impact of organ dysfunction (requiring extracorporeal therapies), and physicochemical properties of the antimicrobials. In this context, the pharmacokinetics of antimicrobials vary considerably between different critically ill patients and within the same patient over the course of ICU stay. This variability underscores the need for individualized dosing. This review aimed to describe the main pathophysiological changes observed in critically ill patients and their impact on antimicrobial drug dosing decisions. It also aimed to provide essential practical recommendations that may aid clinicians in optimizing antimicrobial therapy among critically ill patients.

关键词： Pharmacokinetics/pharmacodynamics ICU Antibiotics Dose optimization TDM

Promoting Healthy Longevity Should Start Young: A Life Course Journey

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Maternal-Fetal Medicine 2024年第1期6卷 1-4页

作者： Cuilin Zhang claire Guivarch Global Centre for Asian Women's Health Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of Obstetrics and Gynaecology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Bia-Echo Asia Centre for Reproductive Longevity and Equality(ACRLE) Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of Nutrition Harvard T.H.Chan School of Public HealthBoston 02115USA

Introduction Throughout a woman’s life,several unique health characteristics are related to an increased risk of later disease morbidity and/or premature mortality(Fig.1).For instance,these include early age at menarche1,2(ie,“short,irregular or long menstrual cycles”)3,4,a history of infertility5,pregnancy loss6,several major pregnancy complications(eg,preeclampsia,gestational hypertension,gestational diabetes mellitus(GDM)and preterm delivery)7–9,and menopause characteristics(eg,long menopause transition period,early age at menopause,and the presence of vasomotor symptoms).

关键词： Population health Longevity Women's health

Recovery rates and long-term olfactory dysfunction following COVID-19 infection

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 121-128页

作者： Melanie Dias Zara Shaida Nora Haloob claire Hopkins ENT Department Guy's HospitalLondonUK

Objectives:Olfactory dysfunction is one of the most recognized symptoms of COVID-19,significantly impacting quality of life,particularly in cases where recovery is *** review aims to explore patterns of olfactory recovery post-COVID-19 infection,with particular focus on delayed *** Sources:Published literature in the English language,including senior author's own work,online and social media platforms,and patients'anecdotal ***:A comprehensive review of the literature was undertaken by the authors with guidance from the senior author with expertise in the field of ***:Based on self-report,an estimated 95%of patients recover their olfactory function within 6 months post-COVID-19 ***,psychophysical testing detects higher rates of persistent olfactory *** has been found to continue for at least 2 years postinfection;negative prognostic indicators include severe olfactory loss in the acute phase,female sex,and older *** in quantitative and qualitative disturbance in prolonged cases likely reflects both peripheral and central pathophysiological *** of many of the reviewed studies reflect lack of psychophysical testing and baseline olfactory ***:Post-COVID-19 olfactory dysfunction remains a significant health and psychosocial *** evidence is improving awareness and knowledge among clinicians to better support patients through their olfactory rehabilitation,with hope of recovery after several months or *** research is needed to better understand the underlying pathogenesis of delayed recovery,identify at risk individuals earlier in the disease course,and develop therapeutic targets.

关键词： anosmia COVID-19 olfaction parosmia recovery

The Artificial Disc Nucleus and Other Strategies for Replacement of the Nucleus Pulposus:Past,Present and Future Designs for an Emerging Surgical Solution

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Engineered Regeneration

Engineered Regeneration 2024年第2期5卷 269-281页

作者： Greg Sacks Vincent DeStefano claire Parker Ryan Lebens Harry Mushlin Renaissance School of Medicine at Stony Brook University Stony BrookNYUSA

Nucleus Pulposus(NP)Replacement is a developing surgical methodology for the treatment of pathology related to degeneration of intervertebral discs(IVDs).This article provides necessary context regarding the patholo-gies treated with this technology,the biomechanical structure and function of the IVD,and the procedures this technology aims to ***,it provides an overview and discussion of commercial and experimental preformed and in situ curing prosthesis designs reported in the scientific literature and summarizes the results of biomechanical and clinical studies evaluating their *** and updated information on the most recent research into NP replacement with novel hydrogel and tissue engineering(TE)strategies is *** of the NP allows for potential improvement in the treatment of degenerative spinal pathologies through minimally invasive surgical techniques.

关键词： Nucleus Pulposus Intradiscal Prosthesis Hydrogel Artificial Disc Implant Spine Surgery

Cardialysis 40年:领先欧洲的心血管研究机构

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中华心血管病杂志 2024年第1期52卷 107-110页

作者： Spitzer Ernest Ren claire Ben Cardialysis 鹿特丹3012KM 欧洲心血管研究所鹿特丹3012KM 荷兰鹿特丹伊拉斯谟大学医学中心胸部中心心内科鹿特丹3015GD

该文总结了Cardialysis的定位、过往成就及其未来发展的方向,其核心是在全球层面巩固和扩大临床试验研究者和临床研究专业人员之间的合作。Cardialysis的独特性在于其学术优势与独立性的结合以及高质量学术成果的产出。该文还总结了Card... 详细信息

该文总结了Cardialysis的定位、过往成就及其未来发展的方向,其核心是在全球层面巩固和扩大临床试验研究者和临床研究专业人员之间的合作。Cardialysis的独特性在于其学术优势与独立性的结合以及高质量学术成果的产出。该文还总结了Cardialysis心血管影像核心实验室和其过往完成的重要介入心脏病学临床试验;同时阐述了该组织提供的科技服务。此外,它还介绍了由Cardialysis(参与)创立的学术研究联盟(ARC)和欧洲心血管研究所(ECRI)两个非营利性学术组织。最后文章提到了Cardialysis成功的最重要贡献者,并分享了未来发展的方向。

关键词：心血管疾病核心实验室研究机构合作介入心脏病学心血管影像

From bibliometric analysis: 3D printing design strategies and battery applications with a focus on zinc‐ion batteries

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SmartMat 2024年第1期5卷 59-82页

作者： Xuan Gao Kejiang Liu Chang Su Wei Zhang Yuhang Dai Ivan P.Parkin claire J.Carmalt Guanjie He Christopher Ingold Laboratory Department of ChemistryUniversity College LondonLondonUK Electrochemical Innovation Lab(EIL) Department of Chemical EngineeringUniversity College LondonLondonUK Department of Physics Hong Kong Baptist UniversityHong KongChina Nanyang Technopreneurship Center Nanyang Technological UniversitySingaporeSingapore

Three‐dimensional(3D)printing has the potential to revolutionize the way energy storage devices are designed and *** this paper,we explore the use of 3D printing in the design and production of energy storage devices,especially zinc‐ion batteries(ZIBs)and examine its potential advantages over traditional manufacturing methods.3D printing could significantly improve the customization of ZIBs,making it a promising strategy for the future of energy *** particular,3D printing allows for the creation of complex,customized geometries,and designs that can optimize the energy density,power density,and overall performance of ***,we discuss and compare the impact of 3D printing design strategies based on different configurations of film,interdigitation,and framework on energy storage devices with a focus on ***,3D printing enables the rapid prototyping and production of batteries,reducing leading times and costs compared with traditional manufacturing ***,there are also challenges and limitations to consider,such as the need for further development of suitable 3D printing materials and processes for energy storage applications.

关键词： 3D printing battery commercialization bibliometric analysis electrode configurations zinc‐ion battery

Association between balloon atrial septostomy and prostaglandin E1 therapy until repair of transposition of the great arteries in neonates

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Pediatric Investigation 2024年第2期8卷 135-138页

作者： Samantha Gilg Sebastian Acosta Rohit S.Loomba claire Rizk Gary E.Stapleton David Faraoni Fabio Savorgnan Department of Pediatrics Divisions of Critical Care Medicine and CardiologyTexas Children’s Hospital and Baylor College of MedicineHoustonTexasUSA Department of Pediatrics Division of CardiologyTexas Children’s Hospital and Baylor College of MedicineHoustonTexasUSA Department of Pediatrics The Heart InstituteAdvocate Children’s HospitalChicago Medical School and Rosalind Franklin University of Medicine and ScienceOak LawnIllinoisUSA Department of Anesthesiology Arthur S.Keats Division of Pediatric Cardiovascular AnesthesiaPerioperative and Pain MedicineTexas Children’s HospitalBaylor College of MedicineHoustonTexasUSA

The standard of care in the management of d-transposition of the great arteries(TGA)includes the arterial switch operation(ASO).1,2 Although some institutions have begun to publish the results of performing the ASO within the first few hours of life,most centers continue to"electively"delay ASO for several days to allow for a reduction in pulmonary vascular resistance and the stabilization of renal and liver function.1,2 The early initiation of prostaglandin E1(PGE)infusion to maintain ductal patency is a nearly universal component of therapy in order to maintain adequate arterial oxygen saturation and systemic oxygen delivery during the pre-operative period via intercirculatory mixing at the atrial septal and patent ductus arteriosus levels1,3.

关键词： balloon maintain stabilization

Comparison of methods for deriving phenotypes from incomplete observation data with an application to age at puberty in dairy cattle

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Journal of Animal Science and Biotechnology 2024年第2期15卷 535-545页

作者： Melissa A.Stephen Chris R.Burke Jennie E.Pryce Nicole M.Steele Peter R.Amer Susanne Meier claire V.C.Phyn Dorian J.Garrick DairyNZ Ltd 605 Ruakura RoadHamilton 3240New Zealand AL Rae Centre for Genetics and Breeding-Massey University RuakuraHamilton 3214New Zealand Agriculture Victoria Research AgriBioCentre for AgriBioscienceBundooraVictoria 3083Australia School of Applied Systems Biology La Trobe UniversityBundooraVictoria 3083Australia AbacusBio DunedinNew Zealand

Background Many phenotypes in animal breeding are derived from incomplete measures,especially if they are challenging or expensive to measure *** include time-dependent traits such as reproductive status,or *** measures for these traits result in phenotypes that are subject to left-,interval-and rightcensoring,where phenotypes are only known to fall below an upper bound,between a lower and upper bound,or above a lower bound *** we compare three methods for deriving phenotypes from incomplete data using age at first elevation(>1 ng/mL)in blood plasma progesterone(AGEP4),which generally coincides with onset of puberty,as an example *** We produced AGEP4 phenotypes from three blood samples collected at about 30-day intervals from approximately 5,000 Holstein–Friesian or Holstein–Friesian×Jersey cross-bred dairy heifers managed in 54 seasonal-calving,pasture-based herds in New *** used these actual data to simulate 7 different visit scenarios,increasing the extent of censoring by disregarding data from one or two of the three *** methods for deriving phenotypes from these data were explored:1)ordinal categorical variables which were analysed using categorical threshold analysis;2)continuous variables,with a penalty of 31 d assigned to right-censored phenotypes;and 3)continuous variables,sampled from within a lower and upper bound using a data augmentation *** Credibility intervals for heritability estimations overlapped across all methods and visit scenarios,but estimated heritabilities tended to be higher when left censoring was *** sires with at least 5 daughters,the correlations between estimated breeding values(EBVs)from our three-visit scenario and each reduced data scenario varied by method,ranging from 0.65 to *** estimated breed effects also varied by method,but breed differences were smaller as phenotype censoring *** Our results indicate that using

关键词： Cattle Gibbs sampler Markov-chain Monte Carlo(MCMC) Puberty