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Effect of non-enzymatic glycation on collagen nanoscale mechanisms in diabetic and age-related bone fragility

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BIOCELL 2023年第7期47卷 1651-1659页

作者： JAMES LROSENBERG WILLIAM WOOLLEY IHSAN ELNUNU JULIA KAMML DAVID SKAMMER claire ACEVEDO Department of Mechanical Engineering University of UtahSalt Lake City84112USA Institute for Building Materials ETH ZurichZurichSwitzerland Department of Biomedical Engineering University of UtahSalt Lake City84112USA

Age and diabetes have long been known to induce an oxidative reaction between glucose and collagen,leading to the accumulation of advanced glycation end-products(AGEs)cross-links in collagenous *** recently,AGEs content has been related to loss of bone quality,independent of bone mass,and increased fracture risk with aging and *** of bone quality is mostly attributed to changes in material properties,structural organization,or cellular *** all these factors play a role in bone fragility disease,some common recurring patterns can be found between diabetic and age-related bone *** main pattern we will discuss in this viewpoint is the increase of fibrillar collagen stiffness and loss of collagen-induced plasticity with AGE *** study focused on recent related experimental studies and discusses the correlation between fluorescent AGEs content at the molecular and fibrillar scales,collagen deformation mechanisms at the nanoscale,and resistance to bone fracture at the macroscale.

关键词： Bone fragility Advanced glycation end-products Collagen Diabetes Aging

Dairy sheep production research at the University of Wisconsin-Madison,USA-a review

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Journal of Animal Science and Biotechnology 2014年第2期5卷 127-138页

作者： David L Thomas Yves M Berger Brett C McKusick claire M Mikolayunas University of Wisconsin-Madison Department of Animal Sciences Spooner Agricultural Research Station Current address:Merial Ltd Midwest Organic Services Association ViroquaWisconsinUSA

Commercial milking of sheep is a new agricultural industry in the United States starting approximately 30 yr ago. The industry is still small, but it is growing. The majority of the sheep milk is used in the production of specialty cheeses. The United States is the major importer of sheep milk cheeses with 50 to 60% of annual world exports coming to the United States during the past 20 yr. Therefore, there is considerable growth potential for the industry in the United States. The only dairy sheep research flock in North America is located at the Spooner Agricultural Research Station of the University of Wisconsin-Madison. The research program started in 1993 and has been multifaceted; dealing with several areas important to commercial dairy sheep farmers. The East Friesian and Lacaune dairy breeds were compared and introduced to the industry through the research program. Both dairy breeds produced significantly more milk than traditional meat-wool breeds found in the U.S., but the two breeds differed in their production traits. East Friesian-cross ewes produced more lambs and slightly more milk than Lacaune-cross ewes whereas Lacaune-cross ewes produced milk with a higher percentage of fat and protein than East Friesian-cross ewes. Lactation physiology studies have shown that ewes with active corpora lutea have increased milk yields, oxytocin release during milking is required to obtain normal fat percentages in the milk, large udder cisterns of dairy ewes can allow for increased milking intervals, and short daylengths during late pregnancy results in increased milk yield. In the nutrition area, legume-grass pastures and forages with a higher percentage of legume will result in increased milk production. Grazing ewes respond to additional supplementation with increased milk yield, but it is important to match the supplement to the quality of the grazing. Ewes on high quality legume-grass pastures that are high in rumen degradable protein respond with increased milk

关键词： Dairy sheep East Friesian Grazing Lacaune Lactation physiology Nitrogen efficiency RDP RUP Supplementation

Some Implications of the Gessel Identity

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Applied Mathematics 2023年第9期14卷 545-579页

作者： claire Levaillant Department of Mathematics University of Southern California Los Angeles CA USA

We generalize the congruences of Friedmann-Tamarkine (1909), Lehmer (1938), and Ernvall-Metsänkyla (1991) on the sums of powers of integers weighted by powers of the Fermat quotients to the next Fermat quotient power, namely to the third power of the Fermat quotient. Using this result and the Gessel identity (2005) combined with our past work (2021), we are able to relate residues of some truncated convolutions of Bernoulli numbers with some Ernvall-Metsänkyla residues to residues of some full convolutions of the same kind. We also establish some congruences concerning other related weighted sums of powers of integers when these sums are weighted by some analogs of the Teichmüller characters.

关键词： Convolutions Involving Bernoulli Numbers Truncated Convolutions Involving Bernoulli Numbers Congruences Binomial and Multinomial Convolutions of Divided Bernoulli Numbers Multiple Harmonic Sums Generalized Harmonic Numbers Miki Identity Gessel Identity Sums of Powers of Integers Weighted by Powers of the Fermat Quotients Generalization of Kummer’s Congruences Generalizations of Friedmann-Tamarkine Lehmer Ernvall-Metsänkyla’s Congruences p-Adic Numbers Weighted Sums of Powers of Integers

Global social archaeologies

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Global social archaeologies

Remodeled structure and reduced contractile responsiveness of ocular ciliary artery in spontaneously hypertensive rats

作者： Koji Mizoguchi and claire Smith.

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 363-368页

作者： Ya-Ru Dong claire E Gustafson Jun Wang Ji-Zhe Cui Takeshi Yoshitomi Department of Ophthalmology the Second Hospital of Jilin University Department of Ophthalmology Akita University School of Medicine Division of Immunology and Rheumatology Department of Medicine Stanford University

AIM: To investigate the alterations in both structure and contractile responsiveness of ocular ciliary artery(OCA) in spontaneously hypertensive rat(SHR).METHODS: In this experiment, 20-week-old male SHR and Wistar Kyoto rat(WKY) were studied. The heart rate(HR), the blood pressure(BP; the systolic BP and the diastolic BP) of rats with an electronic sphygmomanometer were measured. Vascular morphometry and isometric tension measurement were used to investigate the alterations in structure and contractility of ***: A general narrowing of OCAs was observed in SHR compared to the control WYK. In SHR, the media of OCAs were thicker, the luminal diameters were smaller, and the media-to-lumen ratios were higher when compared with WKY(P0.05). Indomethacin(10 μmol/L) decreased the contractions induced by norepinephrine in OCAs from WKY(P0.05).CONCLUSION: Our results demonstrate that the structure and function of OCAs are altered in hypertension. OCAs from SHR are remodeled with decreased lumen diameter and increased media-to-lumen ratio. Moreover, the contractile responsiveness of OCAs from SHR is diminished due to the disruption of vasoconstrictive effect of prostaglandins.

关键词： remodeled structure contractile responsiveness ocular ciliary artery hypertension spontaneously hypertensive rat

The IgH 3′ regulatory region super-enhancer does not control IgA class switch recombination in the B1 lineage

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Cellular & Molecular Immunology 2018年第3期15卷 289-291页

作者： Hussein Issaoui Nour Ghazzaui Alexis Saintamand claire Carrion Christelle Oblet Yves Denizot CNRS UMR 7276 CRIBLUniversitéde LimogesLimogesFrance INSERM U1236 UniversitéRennes 1RennesFrance

The bone marrow-derived B2 population represents the vast majority of bone marrow,blood,lymph node and splenic *** B1 B-cells mostly originate during embryonic life in the liver and represent the main B-cell population in the pleural and peritoneal cavities.1,2,3,4,5 B1 and B2 B-cells differ in their origin,antigen specificity,cell surface markers,tissue distribution and capacity for class switch recombination(CSR).Schematically,B1 B-cells appear earlier than B2 B-cells during fetal development and maintain their self-renewal ability throughout their life.

关键词： maintain specificity mostly

Connections Between Insomnia and Cognitive Aging

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Neuroscience Bulletin 2020年第1期36卷 77-84页

作者： claire E.Sexton Konstantina Sykara Elissaios Karageorgiou Jenny Zitser Talita Rosa Kristine Yaffe Yue Leng Global Brain Health Institute Memory and Aging CenterDepartment of NeurologyUniversity of CaliforniaSan FranciscoCAUSA Department of Psychiatry University of OxfordOxfordUK Neurological Institute of Athens AthensGreece Department of Psychiatry Neurology and EpidemiologyUniversity of CaliforniaSan FranciscoCAUSA

Insomnia is a common sleep disorder among older adults,and a risk factor for poor physical and mental ***,the relationship between insomnia and cognitive health is not well ***,we review observational studies that have investigated whether insomnia is associated with deficits in objective cognitive performance and an increased risk of dementia,magnetic resonance imaging studies that have assessed grey matter volumes and white matter microstructure,and interventional studies that have explored whether the treatment of insomnia can improve cognitive *** are inconsistent findings regarding impaired performance in objective cognitive tests and reduced grey matter volumes,and limited,emerging,evidence that suggests that insomnia is associated with an increased risk of dementia and reduced white matter *** the interventional literature is still in its infancy,there is some indication that treatment may have an impact on ***-powered studies examining sources of heterogeneity are warranted.

关键词： Insomnia Sleep Dementia Cognition

Real-time in situ magnetic measurement of the intracellular biodegradation of iron oxide nanoparticles in a stem cell-spheroid tissue model

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Nano Research 2020年第2期13卷 467-476页

作者： Aurore Van de Walle Alexandre Fromain Anouchka Plan Sangnier Alberto Curcio Luc Lenglet Laurence Motte Yoann Lalatonne claire Wilhelm Laboratoire Matière et Systèmes Complexes MSCUMR 7057CNRS&University of Paris75205Paris Cedex 13France Inserm U1148Laboratory for Vascular Translational ScienceSorbonne Paris NordSorbonne Paris CitéF-93017 BobignyFranc Normafin Sàrl 8 rue Mathilde Girault92300 Levallois-PerretFrance Services de Biochimie et Médecine Nucléaire Hópital Avicenne Assistance Publique-Hôpitaux de ParisF-93009 BobignyFrance

The use of magnetic nanoparticles in nanomedicine keeps expanding and,for most applications,the nanoparticles are internalized in cells then left within,bringing the need for accurate,fast,and easy to handle methodologies to assess their behavior in the cellular ***,a benchtop-size magnetic sensor is introduced to provide real-time precise measurement of nanoparticle magnetism within living *** values obtained with the sensor,of cells loaded with different doses of magnetic nanoparticles,are first compared to conventional vibrating sample magnetometry(VSM),and a strong correlation remarkably validates the use of the magnetic sensor as magnetometer to determine the nanoparticle cellular *** sensor is then used to monitor the progressive intracellular degradation of the nanoparticles,over ***,this real-time in situ measure is performed on a stem cell-spheroid tissue model and can run continuously on a same spheroid,with cells kept alive ***,such continuous magnetic measurement of cell magnetism at the tissue scale does not impact either tissue formation,vibility,or stem cell function,including differentiation and extracellular matrix production.

关键词： magnetic nanoparticles magnetometry real-time in operando measures biodegradation stem cells

Contemporary review of the 532 nm laser for treatment of benign prostatic hyperplasia

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Asian Journal of Urology 2015年第2期2卷 102-106页

作者： Bilal Chughtai Leanna Laor claire Dunphy Alexis Te Department of Urology Weill Cornell Medical CollegeNew York Presbyterian HospitalNew YorkNYUSA

Benign prostatic hyperplasia(BPH)is a condition that occurs increasingly with *** established gold standard treatment for BPH has been the electrocautery-based transurethral resection of the prostate(TURP).TURP,however,is associated with several complications and side ***,there is an increasing interest in a number of emerging minimally invasive therapies as alterative treatment *** therapy using the Greenlight laser is a promising alternative to the traditional *** absorption by hemoglobin allows rapid,hemostatic vaporization of prostate *** advantages include avoidance or minimization of complications such as intraoperative fluid absorption,and bleeding,retrograde ejaculation,impotence,and incontinence,as well as its use in treating high volume *** review the use of the Greenlight laser in the treatment of BPH,when comparing complications and advantages in relation to TURP.

关键词： Benign prostatic hyperplasia Laser prostatectomy 532 nm prostatectomy