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clinical application and management of temporary mechanical circulatory support:A clinical consensus

Chinese Medical Journal 2024年第10期137卷 1135-1139页

作者： Nianguo Dong Liangwan Chen Xin Chen Huishan Wang Yingbin Xiao Xianqiang Wang Jinsong Huang Yang Yan Pramod bonde neel.Sodha Pavan Atluri Juan Pablo Maureira AndréVincentelli Masanobu Yanase Yixuan Wang Haitao Zhang Xiaotong Hou Yoshijuki Takami Pascal Leprince Thierry Folliguet Frank W Sellke Chinese Society for Thoracic and Cardiovascular Surgery Chinese Association of Cardiovascular Surgeons Cardiac Critical Care Professional Committee of Chinese Medical Association Chinese Society of Extracorporeal Life Support European Society of Cardiovascular and Endovascular Surgery French Society of Thoracic and Cardiovascular Surgery Japanese Society for Cardiovascular Surgery Japanese Society of Artificial Organs Department of Cardiovascular Surgery Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Cardiovascular Surgery Fujian Medical University Union HospitalFuzhouFujian 350000China Department of Thoracic and Cardiovascular Surgery Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210000China Department of Cardiovascular Surgery General Hospital of Northern Theater CommandShenyangLiaoning 110000China Department of Cardiovascular Surgery Xinqiao HospitalThird Military Medical UniversityChongqing 400037 China Department of Cardiovascular Surgery Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100000 China Department of Cardiovascular Surgery Guangdong Provincial Cardiovascular InstituteGuangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510000 China Department of Cardiovascular Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Department of Cardiac Surgery Yale School of Medicine330 Cedar St204 BoardmanNew HavenCT 06510USA Department of Cardiothoracic Surgery Alpert Medical SchoolBrown University Rhode Island HospitalProvidenceRI 02912USA Department of Cardiovascular Surgery Department of SurgeryUniversity of PennsylvaniaPhiladelphiaPA 19113USA Department of Cardiovascular Surgery and Transplantation University Hospital of NancyUniversity of LorraineVandoeuvre-lès-Nancy 54500France Department of Cardiovascular Surgery University Hospital of LilleUniversity of LilleLille 59037France Department of Cardiology Fujita Health University School of MedicineToyoakeAichi 470-1192Japan Department of Adult Surgical Intensive Care Unit Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100000China Department of Cardiac Intensive Care Beijing Institute of HeartLung and B

Temporary mechanical circulatory support(tMCS)plays a pivotal role in managing severe or refractory cardiogenic shock(CS),furnishing essential hemodynamic support,and sustaining organ perfusion from hours to weeks,or to even *** the past decade,the utilization of tMCS has witnessed a signicant increase in American and European *** in Asia,the newly developed concepts and devices constituting tMCS have also made rapid ***,the absence of a consensus or standardized guidelines,especially for the Asian population considering inherited polymorphism,is *** address this knowledge gap,eight associations/societies and experts in thiseld came up with the present consensus after repeated discussions,more specically for the Asian *** comprehensively elucidates the commonly employed tMCS devices,criteria for patient selection,indications and contraindications,clinical management,and the optimal timing for implantation and *** goal of this statement is to promote the standardized application of tMCS and make reasonable decisions in clinical ***-length version of the consensus can be seen in Supplementary File,http://***/CM9/b883.

关键词： application statement discussions

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Modulation of signal transduction pathways by natural compounds in cancer

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Chinese Journal of Natural Medicines 2015年第10期13卷 730-742页

作者： Alok Ranjan neel.M.Fofaria Sung-Hoon Kim Sanjay K.Srivastava Department of biomedical Sciences and Cancer biology Center Texas Tech University Health Sciences Center Cancer Preventive Material Development Research Center College of Korean Medicine Department of Pathology Kyunghee University

Cancer is generally regarded as the result of abnormal growth of cells. According to World Health Organization, cancer is the leading cause of mortality worldwide. Mother nature provides a large source of bioactive compounds with excellent therapeutic efficacy. Numerous phytochemicals from nature have been investigated for anticancer properties. In this review article, we discuss several natural compounds, which have shown anti-cancer activity. Natural compounds induce cell cycle arrest, activate intrinsic and extrinsic apoptosis pathways, generate Reactive Oxygen Species(ROS), and down-regulate activated signaling pathways, resulting in inhibition of cell proliferation, progression and metastasis of cancer. Several preclinical studies have suggested that natural compounds can also increase the sensitivity of resistant cancers to available chemotherapy agents. Furthermore, combining FDA approved anti-cancer drugs with natural compounds results in improved efficacy. On the basis of these exciting outcomes of natural compounds against several cancer types, several agents have already advanced to clinical trials. In conclusion, preclinical results and clinical outcomes against cancer suggest promising anticancer efficacy of agents from natural sources.

关键词： Natural compounds Capsaicin Curcumin Diindolylmethane(DIM) Isothiocyanate Piperine Deguelin Cucurbitacin b Cancer

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Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization

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World Journal of Gastroenterology 2010年第25期16卷 3161-3167页

作者： Johnathan C Chung neel.K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary Department of Radiology North-western University Chicago IL 60611 United States clinical Sciences Research Division Gastrointestinal Oncology Program Robert H. Lurie Comprehensive Cancer Center Chicago IL 60611 United StatesMary F Mulcahy Department of Medicine Division of Hema-tology and Oncology Northwestern Memorial Hospital Chi-cago IL 60611 United States Department of Hepatology Northwestern Uni-versity Chicago IL 60611 United States Reed A Omary Department of Biomedi-cal Engineering Northwestern University Chicago IL 60611 United States

AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P clUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE.

关键词： Hepatocellular carcinoma Transcatheter arterial chemoembolization Diffusion-weighted imaging Apparent diffusion coefficient Functional imaging biomarker

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Outcomes of submucosal(T1b) esophageal adenocarcinomas removed by endoscopic mucosal resection

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World Journal of Gastrointestinal Endoscopy 2016年第20期8卷 763-769页

作者： Darren D ballard neel.Choksi Jingmei Lin Eun-Young Choi b Joseph Elmunzer Henry Appelman Douglas K Rex Hala Fatima William Kessler John M DeWitt Division of Gastroenterology and Hepatology Medical College of Wisconsin Division of Gastroenterology University of Michigan Department of Pathology Indiana University Department of Pathology University of Michigan Division of Gastroenterology and Hepatology University of South Carolina Division of Gastroenterology and Hepatology Indiana University

AIM To investigate the outcomes and recurrences of p T1 b esophageal adenocarcinoma(EAC) following endoscopic mucosal resection(EMR) and associated *** Patients undergoing EMR with pathologically confirmed T1 b EAC at two academic referral centers were retrospectively *** were divided into 4 groups based on treatment following EMR:Endoscopic therapy alone(group A),endoscopic therapy with either chemotherapy,radiation or both(group b),surgicalresection(group C) or no further treatment/lost to follow-up(by a central ***-up data was obtained from the academic centers,primary care physicians and/or referring *** analysis was performed to identify factors predicting recurrence of *** Fifty-three patients with T1 b EAC underwent EMR,of which 32(60%) had adequate follow-up ≥ 12 mo(median 34 mo,range 12-103).There were 16 patients in group A,9 in group b,7 in group C and 21 in group *** follow-up in groups A to C was 34 mo(range 12-103).Recurrent EAC developed overall in 9 patients(28%) including 6(38%) in group A(median:21 mo,range:6-73),1(11%) in group b(median:30 mo,range:30-30) and 2(29%) in group C(median 21 mo,range:*** of 9 recurrences were local;of the 6 recurrences,5 were treated with endoscopy *** predictors of recurrence of EAC were *** Endoscopic therapy of T1 b EAC may be a reasonable strategy for a subset of patients including those either refusing or medically unfit for esophagectomy.

关键词： Esophageal cancer Submucosal T1b Endoscopic mucosal resection Chemotherapy Esophagectomy

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Effect of Plastic Deformation on Magnetic Properties of Fe-40%Ni-2%Mn Austenitic Alloy

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Journal of Iron and Steel Research(International) 2007年第4期14卷 56-60页

作者： Selva büyükakka■ H Aktas S Akturk Physics Department Nigde UniversityNigde 51100NigdeTurkey Physics Department Kirikkale UniversityYahsihan 71450KirikkaleTurkey

The effects of plastic deformation on the magnetic properties of austenite structure in an Fe-40% Ni-2 % Mn alloy is investigated by using Mossbauer spectroscopy and Differential Scanning Calorimetry （DSC） techniques The morphology of the alloy has been obtained by using Scanning Electron Microscopy （SEM）. The magnetic behaviour of austenite state is ferromagnetic. After plastic deformation, a mixed magnetic structure including both paramagnet- ic and ferromagnetic states has been obtained at the room temperature. The volume fraction changes, the effective hyperfine fields of the ferromagnetic austenite phase and isomery shift values have also been determined by Mossbauer spectroscopy. The Curie point （Tc） and the neel.temperature （TN） have been investigated by means of DSC system for non-deformed and deformed Fe-Ni-Mn alloy. The plastic deformation of the alloy reduces the TN and enhances the paramagnetic character of austenitic Fe-Ni-Mn alloy.

关键词： Mossbauer spectroscopy differential scanning calorimetry (DSC) scanning electron microscopy (SEM) plastic deformation magnetically ordered material ferromagnetic austenite

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Digital Circuits Using SOI Four-Gate Transistor

Digital Circuits Using SOI Four-Gate Transistor

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2006 8th International Conference on Solid-State and Integrated Circuit Technology

作者： K.Akarvardar b.blalock S.Chen S.Cristoloveanu P.Gentil M.M.Mojarradi IMEP Minatec 3 Parvis Louis Neel 38016 GrenobleFrance ECE Department The University of TennesseeKnoxvilleTN 37996USA JPL California Institute of TechnologyPasadenaCA 91109USA

Novel G-FET based logic-circuits(adjustable-threshold inverter,real-time reconfigurable logic gates and DRAM cell) are experimentally *** independent action of the four gates helps minimize the required transistor cou... 详细信息

ISBN: (纸本)1424401607

关键词： digital circuits Logic functions Transistor Device Component silicon-on-insulator gates styrene oxide isomerase Reconfigurable logic

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