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The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural regeneration research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María JoséMorillo-Bargues Carla Perpiñá-clérigues Francisco García-García Victoria Moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSC-eVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSC-derived eVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

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Hierarchy: enhancing performances beyond limits

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National Science review 2020年第11期7卷 1624-1625页

作者： clément Sanchez Chimie de la Matière Condensée de Paris UMR 7574 Collège de France CNRS UMPC Université Paris 06 Sorbonne University PSL Research University Chemistry of Ultra-Divided Matter at USIAS University of Strasbourg Institute for Advanced Study

Living organisms, for their survival and reproduction, have evolved to produce complex hierarchical three-dimensional structures ranging from nanometers to meters with extraordinary and unusual sets of properties. Over the last 20 years,hierarchically porous materials that replicate complex living structures have attracted intense attention from both the academic and industrial worlds.

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5-Bromo-2'-deoxyuridine labeling:historical perspectives,factors infiuencing the detection,toxicity,and its implications in the neurogenesis

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Neural regeneration research 2024年第2期19卷 302-308页

作者： Joaquín Martí-clúa Unidad de Citología e Histología.Departament de Biologia Cel·lular de Fisiologia i d’Immunologia.Facultad de Biociencias.Institut de Neurociències.Universidad Autónoma de Barcelona08193 BellaterraBarcelonaSpain

The halopyrimidine 5-bromo-2′-deoxyuridine(BrdU)is an exogenous marker of DNA *** the introduction of monoclonal antibodies against BrdU,an increasing number of methodologies have been used for the immunodetection of this synthesized bromine-tagged base analogue into replicating *** labeling is widely used for identifying neuron precursors and following their fate during the embryonic,perinatal,and adult neurogenesis in a variety of vertebrate species including birds,reptiles,and *** to BrdU toxicity,its incorporation into replicating DNA presents adverse consequences on the generation,survival,and settled patterns of *** may lead to false results and misinterpretation in the identification of proliferative *** this review,I will indicate the detrimental effects of this nucleoside during the development of the central nervous system,as well as the reliability of BrdU labeling to detect proliferating ***,it will show factors influencing BrdU immunodetection and the contribution of this nucleoside to the study of prenatal,perinatal,and adult *** adult neurogenesis will also be *** is my hope that this review serves as a reference for those researchers who focused on detecting cells that are in the synthetic phase of the cell cycle.

关键词： 5-bromo-2′-deoxyuridine adult neurogenesis human adult neurogenesis labeling pitfalls prenatal neurogenesis proliferation S-phase suturing S-phase toxicity

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The role of plasmacytoid dendritic cells(pDCs)in immunity during viral infections and beyond

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Cellular & Molecular Immunology 2024年第9期21卷 1008-1035页

作者： clémence Ngo clémence Garrec elena Tomasello Marc Dalod Aix-Marseille University CNRSINSERMCIMLCentre d’Immunologie de Marseille-LuminyTuring Center for Living SystemsMarseilleFrance

Type I and III interferons(IFNs)are essential for antiviral immunity and act through two different but complimentary ***,IFNs activate intracellular antimicrobial programs by triggering the upregulation of a broad repertoire of viral restriction ***,IFNs activate innate and adaptive *** of IFN production can lead to severe immune system *** is thus crucial to identify and characterize the cellular sources of IFNs,their effects,and their regulation to promote their beneficial effects and limit their detrimental effects,which can depend on the nature of the infected or diseased tissues,as we will *** dendritic cells(pDCs)can produce large amounts of all IFN subtypes during viral *** are resistant to infection by many different viruses,thus inhibiting the immune evasion mechanisms of viruses that target IFN production or their downstream ***,pDCs are considered essential for the control of viral infections and the establishment of protective immunity.A thorough bibliographical survey showed that,in most viral infections,despite being major IFN producers,pDCs are actually dispensable for host resistance,which is achieved by multiple IFN sources depending on the ***,primary innate and adaptive antiviral immune responses are only transiently affected in the absence of *** surprisingly,pDCs and their IFNs can be detrimental in some viral infections or autoimmune *** makes the conservation of pDCs during vertebrate evolution an enigma and thus raises outstanding questions about their role not only in viral infections but also in other diseases and under physiological conditions.

关键词： Interferon Plasmacytoid dendritic cells Viral infection Tissue Homeostasis

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Onset for the electron Velocity Overshoot in Indium Nitride

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Chinese Physics Letters 2012年第12期29卷 177-180页

作者： clóves G.Rodrigues Departamento de Matemática e Física Pontifícia Universidade Católica de Goiás CP 8674605-010 GoianiaGoiásBrazil

A theoretical study on the electron drift velocity and electron nonequilibrium temperature of indium nitride(InN)is *** is based on a nonlinear quantum kinetic theory which provides a description of the dissipative phenomena developing in the *** ultrafast time evolution of the electron drift velocity and electron nonequilibrium temperature is obtained,and overshoot effects are evidenced on both of *** overshoot onsets are shown to occur at 4 kV/cm,electric field intensity which is considerably smaller than those recently derived by resorting to Monte Carlo simulations.

关键词： nonequilibrium electron considerably

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earthquake distribution and lithospheric rheology beneath the Northwestern Andes, Colombia

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Geodesy and Geodynamics 2021年第1期12卷 1-10页

作者： Carla Lagardère Carlos A.Vargas Department of Geosciences Universidad Nacional de ColombiaBogotaColombia ecole nationale superieure en environnement georessources et ingenierie du developpement durable(ENSEGID)BordeauxFrance

The rheological behavior of the lithosphere beneath the Northwestern(NW)Andes(Colombian)remains uncertain under a complex geological ***,we analyze the earthquake distribution and the stress drop on the western and the eastern of the transition area between the Upper Magdalena Valley(UMV)and the Middle Magdalena Valley(MMV),a zone related to a plate tectonic transition from steeper to flatter subduction style slabs(Nazca and Caribbean plates).Our results consistently explain the tectonic and geodynamic context of the study area supported in two rheological profiles,which reveal the brittle/ductile transition of the lithospheric crust and mantle and allow to constrain the lithospheric rheological *** subduction phenomenon of the Nazca Plate under the South American Plate is observed in the western *** the eastern region,we find a remarkable aseismic zone under the eastern Cordillera below 20-km-deep,which made more difficultan accurate estimation of the crust/mantle *** seismic particularity leads us to support the hypothesis of a delamination process due to the tectonic overload generated by the eastern Cordillera,and that promotes thermal *** results also suggest that the earthquake dataset correlated with rheological estimations may offer a consistent interpretation of the mechanical behavior of the lithosphere.

关键词： Lithosphere rheology Seismicity Northwestern Andes Delamination process

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Switchable hydrophobic-hydrophilic layer obtained onto porous alumina by plasma-enhanced fluorination

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Science China(Technological Sciences) 2009年第1期52卷 104-110页

作者： A. TreSSAUD C. LABRUGère e. DURAND C. BRIGOULeIX H. ANDRIeSSeN Institute of Condensed Matter Chemistry of Bordeaux (ICMCB-CNRS) University Bordeaux 1 87 Avenue du Dr. A. Schweitzer AGFA GeVAerT NV Septestraat 27

Conventional lithographic printing processes using porous alumina for offset applications generally use "wet" routes. recently "dry" processes have been developed which are based on a heat-induced hydrophilic/oleophilic conversion of one or more layers of the coating so that a stronger affinity to-wards ink or water fountain is created at the exposed areas with respect to the surface of the unex-posed coating. Treatments involving rf plasma-enhanced fluorination (PeF) constitute exceptional tools for modifying the surface properties of materials. Many advantages of these techniques can be indeed outlined, when compared to more conventional methods: room-temperature reactions, chemical modi-fications limited to surface only without changing the bulk properties, possible non-equilibrium reac-tions. The influence of PeF treatments on porous alumina layer used in printing plates has been tested with various fluorinated gases (CF4, C3F8 and C4F8) and characterized by XPS. The hydrophobic prop-erties of the fluorinated layer have been deduced from contact angle measurements. Using C4F8 rf-PeF treatment, the outmost surface of the hydrophilic alumina substrate used for lithographic printing is hydrophobized, or in other words, the hydrophilic substrate is converted into a support with hydro-phobic properties. Once being hydrophobized, the surface layer may be rendered hydrophilic using a heat pulse, thus giving rise to switchable hydrophobic-hydrophilic properties of the material.

关键词： porous alumina rf-plasma fluorination offset applications hydrophobic-hydrophilic switchable layer XPS contact angle

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ICP-AeS法测定蒙药紫癜灵中多种微量元素

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光谱学与光谱分析 2008年第11期28卷 2679-2683页

作者：额尔登桑杭盖巴特尔巴图内蒙古师范大学化学与环境科学学院内蒙古呼和浩特010022 内蒙古中蒙医医院内蒙古呼和浩特010022

蒙药含有多种氨基酸和丰富的微量元素,特别是人体必需的微量元素含量相对较高,而对人体有害的重金属元素含量相对较低。采用微波消解ICP-AeS法同时测定了治疗过敏性紫癜的蒙药紫癜灵中Ca,Mg,Sr,Fe,Mn,Zn,Cu和Pb等15种微量元素。紫癜灵... 详细信息

蒙药含有多种氨基酸和丰富的微量元素,特别是人体必需的微量元素含量相对较高,而对人体有害的重金属元素含量相对较低。采用微波消解ICP-AeS法同时测定了治疗过敏性紫癜的蒙药紫癜灵中Ca,Mg,Sr,Fe,Mn,Zn,Cu和Pb等15种微量元素。紫癜灵的临床药效实验,选择了过敏性紫癜患者260例,其中男性140例,女性120例;年龄最小6岁,最大62岁,6～16岁年龄段最多,占病人总数的90%左右。治疗结果显示:治愈234例,占90%;显效13例,占5%;有效11例,占4.23%;无效2例,占0.77%;总有效率达99.23%。紫癜灵中含有丰富的微量元素,尤其锶的含量相当高。方法的加标回收率在94.63%～106.40%之间,相对标准偏差RSD≤3.17%,检出限≤0.009μg.L-1。

关键词：蒙药紫癜灵微量元素过敏性紫癜 ICP-AeS

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effects of extracts from Hibiscus macranthus and Basella alba mixture on testosterone production in vitro in adult rat testes slices

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Asian Journal of Andrology 2006年第1期8卷 111-114页

作者： Paul e Moundipa Silvère Ngouela Pierre Kamtchouing etienne Tsamo Félicité M.Tchouanguep Serge Carreau Laboratory of Nutrition and Biochemical Toxicology Laboratory of Organic Chemistry Department of Animal Biology and Physiology University of Yaoundé IP.O.Box 812YaoundéCameroon Faculty of Science University of DschangP.O.Box 67DschangCameroon USC INRA-eA 2608.Laboratoire de Biochimie Esplanade de la paixUniversité de Caen14032 Caen-cedexFrance

Aim： To find an in vitro system for the measurement of the androgenic effects of different extracts of Hibiscus macranthus （Malvaceae） and Basella alba （Basellaceae）. Methods： The production of testosterone from testes slices incubated in two media, either Krebs-Henseleit buffer containing 0.5% Bovine serum albumin （BSA） or Dubecco＇s Modified eagle＇s medium-F12 Ham nutrient mixture （DMe/Ham F12）, under a mixture of 5% CO2 in 95% air was determined either in the presence or absence of cofactors and Hibiscus macranthus plus Basella alba （HMBA） extracts. results： The testosterone production was increased in testes slices incubated in DMe/Ham F12 medium in response to the cofactors （49%） and aqueous extracts （34%-60% according to dilutions）. Under the same atmospheric conditions, there was no positive response of the testes slices to either cofactor or HMBA extract stimulation in Krebs-Henseleit buffer containing 0.5% BSA, In further investigations related to the effect of HMBA, the DMe/ Ham F12 medium was used. The results obtained from the in vitro test showed that the activity was present mainly in methylene chloride and methanol, since these extracts induced an increase in testosterone production by testes slices. Conclusion： The testes slice system is suitable to be used for further in vitro investigations of the isolation of androgenic bioactive components of plants. （Asian J Androl 2006 Jan; 8： 111-114）

关键词： testis testosterone plant extracts Hibiscus macranthus Basella alba

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Artificial neural network approach for multiphase segmentation of battery electrode nano-CT images

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npj Computational Materials 2022年第1期8卷 255-265页

作者： Zeliang Su etienne Decencière Tuan-Tu Nguyen Kaoutar el-Amiry Vincent De Andrade Alejandro A.Franco Arnaud Demortière Laboratoire de Réactivitéet Chimie des Solides(LRCS) CNRS UMR 7314Universitéde Picardie Jules VerneHub de l’EnergieRue Baudelocque80039Amiens CedexFrance Réseau sur le Stockage electrochimique de l’energie(RS2e) CNRS FR 3459Hub de l’EnergieRue Baudelocque80039Amiens CedexFrance MINeS ParisTech–PSL research University CMMCenter for Mathematical Morphology35 rue Saint HonoréFontainebleauFrance renault Technocentre 78084GuyancourtFrance Advanced Photon Source Argonne National LaboratoryLemontUSA Institut Universitaire de France 101 Boulevard Saint Michel75005ParisFrance ALISTOre-european research Institute CNRS FR 3104Hub de l’EnergieRue Baudelocque80039Amiens CedexFrance

The segmentation of tomographic images of the battery electrode is a crucial processing step,which will have an additional impact on the results of material characterization and electrochemical ***,manually labeling X-ray CT images(XCT)is time-consuming,and these XCT images are generally difficult to segment with histographical *** propose a deep learning approach with an asymmetrical depth encode-decoder convolutional neural network(CNN)for real-world battery material *** network achieves high accuracy while requiring small amounts of labeled data and predicts a volume of billions voxel within few *** applying supervised machine learning for segmenting real-world data,the ground truth is often *** results of segmentation are usually qualitatively justified by visual *** try to unravel this fuzzy definition of segmentation quality by identifying the uncertainty due to the human bias diluted in the training *** CNN trainings using synthetic data show quantitative impact of such uncertainty on the determination of material’s ***-XCT datasets of various battery materials have been successfully segmented by training this neural network from *** will also show that applying the transfer learning,which consists of reusing a well-trained network,can improve the accuracy of a similar dataset.

关键词： neural network battery

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