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Diazinon Toxicokinetics, Tissue Distribution and Anticholinesterase Activity in the Rat

Biomedical and Environmental Sciences 1996年第4期9卷 359-369页

作者： H. X. WU cl. evreux-gros AND J. DESCOTESa (Department of Pharmacology and Medical Toxicology, INSERM U80,LYON-RTH Laennec Faculty of Medicine, 69008 Lyon France) Department of Pharmacology and Medical Toxicology INSERM U80 LYON-RTH Laennec Faculty of Medicine France.

The toxicokinetics, tissue distribution, and anticholinesteruse (antiChE ) activity of diazinon were investigated in the rat. Plasma concentrations most adequately fitted a two-compartment open model after iv administration of 10 mg/kg and a one-compartment model after oral administration of 80 mg/kg. Diazinon elimination half-life following iv and oral dosing was 4.70 and 2.86 h, respectively. The oral bioavailabllity was found to be low (35.5%). Hepatic extraction ratios after iv administration of 5 or 10 mg

关键词： Activity Diazinon Toxicokinetics Tissue Distribution and Anticholinesterase Activity in the Rat

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Rapid Gas Chromatographic Assay of Diazinon:Application to the Study of Diazinon Kinetics in Rats

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Biomedical and Environmental Sciences 1994年第4期7卷 357-361页

作者： WU HONG-XING cl. evreux-gros AND J. DESCOTES(Poisons Centre and Laboratory of Fundamental and cl.nical Immunotoxicology, INSERM U80, Alexis Carrel Faculty of Medicine, 69008 Lyon, France Department of Public Health, Medical College, Jinan University, Gu Poisons Centre INSERM U80 Alexis Carrel Faculty of Medicine Lyon France.

A rapid method was developed for the determination of diazinon in plasma using gas chromatography with electron-capture detection (GC-ECD). Following a single extraction with hexane from 100μl of plasma, diazinon was quantitated on a 3% OV-17 column. The detection limit was 10 ng/ml and linearity was obtained in the range of 25 ng/ml-2500 ng/*** applicability of the assay to single-dose kinetics in rats is illustrated

关键词： Rapid Gas Chromatographic Assay of Diazinon

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Effect of age on visual and refractive results after LASIK: mechanical microkeratome versus femtosecond laser

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 488-495页

作者： Montserrat Garcia-Gonzalez Juan gros-Otero Isabel Rodriguez-Perez Alberto Rodero Miguel A.Teus cl.nica Novovisión Madrid cl.nica Rementería Universidad Europea de Madrid Villaviciosa de Odón 28670 Hospital Universitario "Príncipe de Asturias" University of Alcalá

AIM: To evaluate the effect of age on visual and refractive results after laser in situ keratomileusis(LASIK) obtained with a mechanical microkeratome or a femtosecond ***: Retrospective, nonrandomized, cohort study. A total of 3826 eyes were incl.ded in the study(1725 eyes treated with mechanical LASIK and 2101 eyes treated with femtosecond LASIK). The relationship between patient age and the 3-month postoperative visual and refractive results of both procedures were analyzed by linear regression ***: Three months postoperatively, we found a significant correlation between age and the postoperative spherical equivalent(SE; r2=0.004, P=0.006), efficacy(r2=0.006, P=0.001), and safety indexes(r2=0.05, P=0.0001) in the mechanical LASIK group. On the other hand, we found a significant correlation between age and the postoperative SE(r2=0.02, P=0.0001) and the efficacy index(r2=0.01, P=0.0001) but not the safety index in the femtosecond laser group. Mechanical LASIK provided slightly but significantly better efficacy and predictability in patients 18 to 40 years of age and femtosecond LASIK did so in patients older than 40 years of age. The femtosecond laser provided better safety results than the mechanical microkeratome in both age groups. CONcl.SION: A tendency toward undercorrection and less predictability is found with aging after myopic LASIK regardless of whether the flap was created with a mechanical microkeratome or a femtosecond laser. However, femtosecond laser provides significantly betteroutcomes in terms of efficacy, safety and predictability compared to mechanical microkeratome for the correction of myopia in patients over 40 y.

关键词： laser in situ keratomileusis femtosecond femtosecond laser in situ keratomileusis age

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Nanoscale Stiffness Distribution in Bone Metastasis

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World Journal of Nano Science and Engineering 2015年第4期5卷 219-228页

作者： Ludovic Richert Laetitia Keller Quentin Wagner Fabien Bornert Catherine gros Sophie Bahi Francois cl.uss William Bacon Philippe cl.zardin Nadia Benkirane-Jessel Florence Fioretti Centre National de la Recherche Scientifique(CNRS) UMRFacultéde Pharmacie de l’Universitéde Strasbourg(UdS)IllkirchFrance Institut National de la Santéet de la Recherche Médicale(INSERM) Osteoarticular and Dental Regenerative NanomedicineUMRFacultéde Médecine de l’Universitéde Strasbourg and FMTSStrasbourgFrance Facultéde Chirurgie Dentaire de l’Universitéde Strasbourg(UdS) StrasbourgFrance Hopitaux Universitaires de Strasbourg StrasbourgFrance Institut National de la Santéet de la Recherche Médicale(INSERM) UMRFacultéde Médecine Laennec de l’UniversitéClaude Bernard Lyon 1LyonFrance

Nanomechanical heterogeneity is expected to have an effect on elasticity, injury and bone remodelling. In normal bone, we have two types of cells (osteocl.sts and osteoblasts) working together to maintain existing bone. Bone cancers can produce factors that make the osteocl.sts work harder. This means that more bone is destroyed than rebuilt, and leads to weakening of the affected bone. We report here the first demonstration of the nanoscale stiffness distribution in bone metastases before and after treatment of animals with the bisphosphonate Risedronate, a drug which is currently used for the treatment of bone metastases in patients with advanced cancers. The strategy used here is applicable to a wide cl.ss of biological tissues and may serve as a new reflection for biologically inspired scaffolds technologies.

关键词： Bone Metastasis Stiffness Risedronate

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