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Declining metabolic scaling parallels an ontogenetic change from elongate to deep-bodied shapes in juvenile Brown trout

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Current Zoology 2023年第3期69卷 294-303页

作者： Jorge-Ruben sanchez-Gonzalez Alfredo G.Nicieza Department of Organisms andSystems Biology University of Oviedo33006O OviedoSpain Biodiversity Research Institute(IMIB) University of Oviedo-Principality of Asturias-CSIC33600 MieresSpain Department of Animal Science-Wildlife Section University of Lleida25006 LleidaSpain

Body shape and metabolic rate can be important determinants of animal performance,yet often their effects on influential traits are evaluated in a non-integrated *** creates an important gap because the integration between shape and metabolism may be crucial to evaluate metabolic scaling ***,we measured standard metabolic rate in 1-and 2-years old juvenile brown trout Salmo trutta,and used a geometric morphometrics approach to extricate the effects of ontogeny and size on the link between shape and metabolic *** evidenced near-isometric ontogenetic scaling of metabolic rate with size,but also a biphasic pattern driven by a significant change in metabolic scaling,from positive to negative ***,the change in metabolic allometry parallels an ontogenetic change from elongate to deep-bodied *** is consistent with the dynamic energy budget(DEB)and surface area(SA)theories,but not with the resource transport network theory which predicts increasing allometric exponents for trends towards more robust,three-dimensional *** addition,we found a relationship between body shape and size independent metabolic rate,with a positive correlation between robustness and metabolic rate,which fits well within the view of Pace-of-Life Syndromes(POLS).Finally,our results align with previous studies that question the universality of metabolic scaling exponents and propose other mechanistic models explaining the diversity of metabolic scaling relationships or emphasizing the potential contribution of ecological factors.

关键词： biphasic allometric scaling metabolic rate ontogenetic allometry shape surface-area trout

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Device performance and light characteristics stability of quantum-dot-based white-light-emitting diodes

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Nano Research 2018年第3期11卷 1575-1588页

作者： Bruno clasen Hames Ivan Mora-Sero Rafael S. sanchez Institute of Advanced Materials (INAM) Universitat Jaume 1 12071 Castello Spain

Advances in image quality in recent decades have made it necessary to develop new technologies for producing displays to meet remarkably stricter standards. The display market is governed mainly by liquid crystal display and light-emitting diode （LED） technology; however, it suffers from limitations that can be overcome by developing the next generation of electroluminescent displays. The introduction of colloidal quantum dots （QDs） as down-converters has enabled the production of displays with extremely high color purity and gamut. Therefore, colloidal nanocrystals are excellent candidates for the preparation of electroluminescent devices, which represent a straightforward approach to the development of unprecedented high-quality displays. We synthesized light-emitting QDs covering the entire visible spectrum with high fluorescence quantum yields and color purity, and produced high-brightness single-color LEDs with external quantum efficiencies of 0.39%, 1.04%, 2.10%, and 1.30% for red-, orange-, green-, and blue-emitting dots, respectively. Additional136 white LEDs were prepared by mixing QDs; they showed color temperatures of 5,300 K and color rendering indices exceeding 80%. Very importantly, we exhaustively characterized the LED performance, including the response time, stability, and evolution of the light characteristics, thus providing crucial information toward the development of high-quality electroluminescent displays.

关键词： colloidal quantum dots quantum dotlight-emitting diodes white light-emitting diode(LED) displays electroluminescence LED stability

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Deep panoramic depth prediction and completion for indoor scenes

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Computational Visual Media 2024年第5期10卷 903-922页

作者： Giovanni Pintore Eva Almansa Armando sanchez Giorgio Vassena Enrico Gobbetti Visual and Data-intensive Computing CRS4Cagliari 09134Italy Gexcel srl Elmas(CA)09097Italy Department of Civil EnvironmentArchitectural Engineeringand Mathematics(DICATAM)Universita degli Studi di Brescia(UNIBS)Brescia(BS)25123Italy.

We introduce a novel end-to-end deeplearning solution for rapidly estimating a dense spherical depth map of an indoor *** input is a single equirectangular image registered with a sparse depth map,as provided by a variety of common capture *** is inferred by an efficient and lightweight single-branch network,which employs a dynamic gating system to process together dense visual data and sparse geometric *** exploit the characteristics of typical man-made environments to efficiently compress multiresolution features and find short-and long-range relations among scene ***,we introduce a new augmentation strategy to make the model robust to different types of sparsity,including those generated by various structured light sensors and LiDAR *** experimental results demonstrate that our method provides interactive performance and outperforms stateof-the-art solutions in computational efficiency,adaptivity to variable depth sparsity patterns,and prediction accuracy for challenging indoor data,even when trained solely on synthetic data without any fine tuning.

关键词： machine learning image processing and computervision visionand scene understanding 3D stereo scene analysis

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Winkler Support Model and Nonlinear Boundary Conditions Applied to 3D Elastic Contact Problem Using the Boundary Element Method

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Acta Mechanica Solida Sinica 2019年第2期32卷 230-248页

作者： J.Vallepuga-Espinosa Lidia sanchez-Gonzalez Ivan Ubero-Martinez Departamento de Tecnologia Minera Topografiay de EstructurasUniversidad de LeonCampus de Vegazana s/n24071 LeonSpain Departamento de Ingenierias Mecanica Informatica y AeroespacialUniversidad de LeonCampus de Vegazana s/n24071 LeonSpain

This work presents a numerical methodology for modeling the Winkler supports and nonlinear conditions by proposing new boundary conditions. For the boundary conditions of Winkler support model, the surface tractions and the displacements normal to the surface of the solid are unknown, but their relationship is known by means of the ballast coefficient, whereas for nonlinear boundary conditions, the displacements normal to the boundary of the solid are zero in the positive direction but are allowed in the negative direction. In those zones, detachments of nodes might appear, leading to a nonlinearity, because the number of nodes that remain fixed or of the detached ones (under tensile tractions) is unknown. The proposed methodology is applied to the 3D elastic receding contact problem using the boundary element method. The surface t r actions and the displacements of the common int erface bet ween the two solids in contac t under the influence of different supports are calculated as well as the boundary zone of the solid where the new boundary conditions are applied. The problem is solved by a double-iterative met hod, so in the final solut ion, t here are no t r act ions or pene trations between the two solids or at the boundary of the solid where the nonlinear boundary conditions are Simula ted. The effectiveness of the proposed method is verified by examples.

关键词： Boundary element method Elastic contact problem Winkler support model Nonlinear boundary conditions

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TWO COUNTERMEASURE STRATEGIES TO MITIGATE RANDOM DISRUPTIONS IN CAPACITATED SYSTEMS

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Journal of Systems Science and Systems Engineering 2010年第2期19卷 210-226页

作者： Niyazi O.BAKIR Alex SAVACHKIN Andrés Uribe-sanchez Department of Industrial Engineering Bilkent University Department of Industrial and Management Systems Engineering University of South Florida

We examine a capacitated system exposed to random stepwise capacity disruptions with exponentially distributed interarrival times and tmiformly distributed magnitudes. We explore two countermeasure policies for a risk-neutral decision maker who seeks to maximize the long-nm average reward. A one-phase policy considers implementation of countermeasures throughout the entirety of a disruption cycle. The results of this analysis form a basis for a two-phase model which implements countermeasures during only a fraction of a disruption cycle. We present an extensive numerical analysis as well as a sensitivity study on the fluctuations of some system parameter values.

关键词： Capacity analysis capacitated system lean random disruptions countermeasure policy

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Novel human immunomodulatory T cell receptors and their double-edged potential in autoimmunity,cardiovascular disease and cancer

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Cellular & Molecular Immunology 2021年第4期18卷 919-935页

作者： Pilar Martin Rafael Blanco-Dom fnguez Raquel sanchez-Diaz Vascular Pathophysiology Area Centro Nacional de Investigaciones Cardiovasculares(CNIC)MadridSpain CIBERCV MadridSpain

In the last decade,approaches based on T cells and their immunomodulatory receptors have emerged as a solid improvement in treatments for various types of ***,the roles of these molecules in the therapeutic context of autoimmune and cardiovascular diseases are still relatively ***,we review the best known and most com m only used immunomodulatory T cell receptors in clinical practice(PD-1 and CTLA-4),along with the rest of the receptors with known functions in animal models,which have great potential as modulators in human pathologies in the medium *** ong these other receptors is the receptor CD69,which has recently been described to be expressed in mouse and human T cells in autoimmune and cardiovascular diseases and ***,inhibition of these receptors individually or in combination by drugs or monoclonal antibodies generates a loss of immunological tolerance and can trigger multiple autoimmune disorders in different organs and immune-related adverse *** the coming decades,knowledge on the functions of different immunomodulatory receptors will be pivotal for the development of new and better therapies with less harmful side *** this review,we discuss the roles of these receptors in the control of immunity from a perspective focused on therapeutic potential in not only cancer but also autoimmune diseases,such as systemic lupus erythematosus,autoimmune diabetes and rheumatoid arthritis,and cardiovascular diseases,such as atherosclerosis,acute myocardial infarction,and myocarditis.

关键词： Immunomodulatory receptors Autoimmune diseases T cells Immunotherapy

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Low concentrations of atrazine,glyphosate,2,4-dichlorophenoxyacetic acid,and triadimefon exposures have diverse effects on Xenopus laevis organ morphogenesis

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Journal of Environmental Sciences 2010年第9期22卷 1305-1308页

作者： Jenny R.Lenkowski Gabriela sanchez-Bravo Kelly A.Mclaughlin Department of Biology Tufts University

Many chemicals are released into the environment, and chemical contamination has been suggested as a contributing factor to amphibian declines. To add to a growing body of knowledge about the impact of individual chemicals on non-target organisms, we examined the specificity of deformities induced by exposure to four pesticides （atrazine, 2,4-dichloropheoxyacetic acid （2,4-D）, triadimefon, and glyphosate） in the model amphibian species, Xenopus laevis. We focused on the period of organ morphogenesis, as it is frequently found to be particularly sensitive to chemical exposure yet also commonly overlooked. We found similar levels of intestine malformations and edemas, as well as disruption of skeletal muscle, in atrazine and triadimefon exposed tadpoles. The effects of 2,4-D were only apparent at the highest concentrations we examined; glyphosate did not induce dramatic malformations at the concentrations tested. While researchers have shown that it is important to understand how chemical mixtures affect non-target organisms, our results suggest that it is first crucial to determine how these chemicals act independently in order to be able to identify consequences of individual pesticide exposure.

关键词： amphibian pesticide organ morphogenesis teratogenesis toxicology Xenopus laevis

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Mesenchymal stem cells and cell-free preparations for treating atopic dermatitis

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BIOCELL 2022年第11期46卷 2363-2367页

作者： TRINIDAD MONTERO-VILCHEZ MANUEL sanchez-DIAZ CAROLINA MONTERO-VILCHEZ ALVARO SIERRA-sanchez SALVADOR ARIAS-SANTIAGO Dermatology Department Virgen de las Nieves University HospitalGranadaSpain Instituto de Investigación Biosanitaria Granada GranadaSpain Pharmacy Department Virgen de las Nieves University HospitalGranadaSpain Dermatology Department Faculty of MedicineUniversity of GranadaGranadaSpain

Atopic dermatitis(AD)is a chronic cutaneous inflammatory disease caused by an interaction between genetic,immune and epidermal barrier *** treatments can be used to treat this disease but there are patients that do not respond to actual ***,there is a need to develop effective therapies for *** stem cells(MSCs)are non-hematopoietic multipotent adult progenitor cells with immunomodulatory power and self-regenerating capacity to repair tissue damage,so they could be a potential effective treatment for ***-Conditioned Medium(CM)and MSCs-exosomes are cell-free preparation with molecules secreted by stem cells that could be also beneficial for *** viewpoint reviews the actual development of MSCs,MSCs-CM and MSCs-exosomes for treating patients with AD.

关键词： Atopic dermatitis Conditioned medium Dermatology Mesenchymal stem cells Stem cells

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The political economy of city diplomacy

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Economic and Political Studies 2022年第2期10卷 228-249页

作者： Juan Luis Manfredi-sanchez Department of International Studies&Journalism University of Castilla-La ManchaToledoSpain

City diplomacy is a major trend in the soft power *** cities face daily political issues deriving from globalisation(such as mass tourism,migration,climate change,and commodifi-cation of culture),they demand for,rather than contesting with a nationstate,an operational reinterpretation of sovereignty ori-ented to solve *** economy approach is a useful method to understand the role of global cities where the nation state has many *** global city establishes rules to influence international legal development and practice,even with-out a traditional legal basis(such as sovereignty,monopoly on violence,and legal exclusivity).As these‘superstar cities’grow,other cities are losing opportunities to develop and take advan-tage of *** risk of inter-urban inequality feeds *** will become the middle power in global political organisations in the future,and political economy will shed light on how power and values operate at the urban level.

关键词： City diplomacy leadership political economy sanctuary city urban agenda

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A kinetic model for horizontal transfer and bacterial antibiotic resistance

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International Journal of Biomathematics 2017年第4期10卷 131-151页

作者： Damian A. Knopoff Juan M. sanchez Sanso Centro de Investigacion y Estudios de Matemdtica CONICET -- FaMAF Universidad Nacional de Cordoba Medina AUende s/n Cordoba 5000 Argentina Department of General Surgery Hospital Misericordia Nuevo Siglo Cordoba 5000 Argentina

This paper presents a mathematical model for bacterial growth, mutations, horizontal transfer and development of antibiotic resistance. The model is based on the so-called kinetic theory for active particles that is able to capture the main complexity features of the system. Bacterial and immune cells are viewed as active particles whose microscopic state is described by a scalar variable. Particles interact among them and the temporal evolution of the system is described by a generalized distribution function over the microscopic state. The model is derived and tested in a couple of case studies in order to confirm its ability to describe one of the most fundamental problems of modern medicine, namely bacterial resistance to antibiotics.

关键词： Kinetic theory active particles antibiotic resistance horizontal gene transfer

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