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making bridges between preclinical and clinical insights into age-related cognitive decline

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Neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： David VC Brito clévio Nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of medicine and Biomedical Sciences(FmCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

Hierarchy: enhancing performances beyond limits

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National Science Review 2020年第11期7卷 1624-1625页

作者： clément Sanchez Chimie de la matière Condensée de Paris UMR 7574 Collège de France CNRS UMPC Université Paris 06 Sorbonne University PSL Research University Chemistry of Ultra-Divided matter at USIAS University of Strasbourg Institute for Advanced Study

living organisms, for their survival and reproduction, have evolved to produce complex hierarchical three-dimensional structures ranging from nanometers to meters with extraordinary and unusual sets of properties. Over the last 20 years,hierarchically porous materials that replicate complex living structures have attracted intense attention from both the academic and industrial worlds.

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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles méryl-Farelle Oye mintsa mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond martine Saint-Pierre clémence Rouxel line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NlRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana mellado maría Josémorillo-Bargues Carla Perpiñá-clérigues Francisco García-García Victoria moreno-manzano Consuelo Guerri maría Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NlRP3(NOD-,lRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(mSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NlRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NlRP3 inflammasome complex and other NlRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of mSC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NlRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,lRR-and pyrin domain-containing protein 3(NlRP3)

magnesium sulfate and fetal neuroprotection: overview of clinical evidence

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Neural Regeneration Research 2018年第12期13卷 2044-2049页

作者： clément Chollat Stéphane marret Institut National de la Santé et de la Recherche médicale U1245 Genetics and Pathophysiology of Neurodevelopmental Disorders Team 4Neovasc Institute of Research and Innovation in Biomedicine Rouen School of Medicine Normandy University Department of Neonatal Intensive Care Port Royal University Hospital Department of Neonatal Pediatrics and Intensive Care and Neuropediatrics Charles-Nicolle University Hospital

Antenatal administration of magnesium sulfate is an important part of the neuroprotective strategy for preterm infants. Strong evidence from five randomized controlled trials and five meta-analyses has demonstrated that magnesium sulfate, when administered before preterm delivery, significantly reduces the risk of cerebral palsy at two years. Through secondary analyses of randomized controlled trials and other original clinical studies, this state-of-the-art review highlights the absence of serious adverse effects in both pregnant women and neonates, as well as the impact of maternal body mass index and preeclamptic status on the maternal and neonatal magnesium levels, which could influence the magnitude of the neuroprotective effect. Although antenatal magnesium sulfate is a cost-effective strategy, some practice surveys have demonstrated that the use of magnesium sulfate is not sufficient and that its use is heterogeneous, differing among different maternity wards. Since 2010, an increasing number of obstetrical societies have recommended its use to improve the neurological outcomes of preterm infants, especially the International Federation of Gynecology and Obstetrics and World Health Organization in 2015, and France in 2017. Considering the neuroprotective impact of magnesium sulfate when administered before delivery, postnatal administration should be considered, and its effects should be assessed using randomized controlled trials.

关键词： magnesium sulfate preterm birth neuroprotection cerebral palsy neurodevelopment international recommendations clinical studies meta-analysis preeclampsia cost-effectiveness

Effects of finite water depth and lateral confinement on ships wakes and resistance

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Journal of Hydrodynamics 2020年第3期32卷 582-590页

作者： clément Caplier Germain Rousseaux Damien Calluaud laurent David Institut Pprime-CNRS University of PoitiersISAE-ENSMAChasseneuilFrance

Wash waves produced by ships disintegrate river banks and coastal lines. This phenomenon of bank erosion is mainly due to the height of the waves. Various factors govern the formation of these waves and their amplitudes: the geometry of the water channel, the shape and the speed of the boat, etc.. These factors play an important role on the wave generation, in addition on the resistance of the ship and so on its fuel consumption. Whether to study the impact of wash waves on the ship's environment or its resistance, the analysis of the generated wake is essential. Hence a fine characterization of the wave field is necessary. This study proposes a comparison of wakes generated by two generic ships based on a Wigley hull with block coefficients 0.67 and 0.89 respectively representative of maritime and fluvial ships. The wakes generated in deep water and confined water configurations have been measured for different Froude numbers by a non-intrusive optical stereo-correlation method, giving access to a detailed and complete definition of the generated wave fields. The resistance of the ship hulls has been measured in deep and confined water configurations with a hydrodynamic balance. The results permit one to study the influence of both hull and water channel geometries on the ship wake, on the amplitude of the far-field generated waves and on the near-field hydrodynamic response. moreover, resistance curves are obtained for both configurations and highlight the effect of both hull and water channel geometries on the resistance coefficient of the ship. A comparison of the resistance curves with or without the ship trim is conducted and shows the influence of the trim on the resistance coefficient in the different ship speed regimes.

关键词： Ship wakes wash waves confined water ship resistance

mechanisms of electrochemical magnesium(de)alloying of mg-Sn and mg-Pb polymorphs

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Journal of magnesium and Alloys 2022年第6期10卷 1609-1616页

作者： clément Pechberty Antoine Klein Bernard Fraisse lorenzo Stievano Romain Berthelot ICGm CNRSUniv.MontpellierENSCMMontpellierFrance RS2E CNRSHub de l’EnergieAmiensFrance

Different polymorphs of mg-Sn and mg-Pb intermetallic compounds were prepared by high-energy mechanical alloying and then investigated as active material in magnesium batteries. Beside thermodynamically stable mg_(2)Sn and mg_(2)Pb crystallizing in the anti-fluorite structure, other polymorphs mg_(~2)Sn and mg_(~2)Pb were prepared by increasing the ball-milling time. The first dealloying process is almost complete only for the cubic polymorphs, then similar capacities are observed during the subsequent alloying and dealloying *** to operando X-ray diffraction, the electrochemical mechanism is revealed and shows that the cubic polymorphs mg_(2)Sn and mg_(2)Pb tend to preferentially form during the alloying whatever the pristine intermetallic. Weak traces of mg_(~2)Sn and mg_(~2)Pb are observed during the alloying, suggesting that these polymorphs act as a by-product and/or an intermediate phases of the electrochemical process. Finally, the compatibility of cubic mg_(2)Sn and mg_(2)Pb with mg(TFSI)_(2)-based electrolyte is confirmed in full cell vs. a positive electrode based on the Chevrel phase mo6S8, although limited performance is achieved. This fundamental work provides new insights in the behavior of alloy-type negative electrodes for magnesium-ion batteries.

关键词： magnesium batteries Alloy electrode mechanochemistry Operando X-ray diffraction

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark l.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Benzothiadiazole-based materials for organic solar cells

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Chinese Chemical letters 2024年第1期35卷 3-15页

作者： Qiang Bei Bei Zhang Kaifeng Wang Shiming Zhang Guichuan Xing clément Cabanetos Key laboratory of Flexible Electronics(KlOFE)&Institute of Advanced materials(IAm) Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech UniversityNanjing 211816China Jiangsu Seenbom Flexible Electronics Institute Co. Ltd.Nanjing 210043China Institute of Applied Physics and materials Engineering University of MacaoMacao SAR 999078China University of Angers Angers 49045France Building Blocks for Future Electronics laboratory(2BFUEl) IRL2002CNRS-Yonsei UniversitySeoul 03722Republic of Korea

The past few years have witnessed power conversion efficiency(PCE)of organic solar cells(OSCs)skyrocketing to the value of 20%due to the outstanding advantages of organic photoactive *** latter,which consist of donor and acceptor materials,indeed play important roles in OSCs,and particularly one building block has attracted considerable research attention,namely benzothiadiazole(BT).The diversity of OSCs based on the BT structure have indeed sprung up,and the progressive increase in PCE values is more than just eye-catching since it heralds a renewal and bright future of *** review analyzes significant studies that have led to these remarkable progresses and focuses on the most effective BT small-molecules and BT polymers for OSC reported in the last *** pivotal structure-property relationships,donor-acceptor matching criteria,and morphology control approaches are gathered and discussed in this ***,we summarize the remaining challenges and offer a personal perspective on the future advance and improvement of OSCs.

关键词： Organic solar cells Benzothiadiazole Donor Acceptor Polymer Non-fullerene acceptors