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Journal of Cancer Therapy 2013年第5期4卷 1005-1017页

作者： Nicoletta Staropoli cirino botta Domenico Ciliberto Lucia Fiorillo Antonina Maria De Angelis Caterina Viscomi Simona Gualtieri Angela Salvino Pierfrancesco Tassone Pierosandro Tagliaferri Medical Oncology Unit Department of Experimental and Clinical MedicineMagna Graecia University and Tommaso Campanella Cancer CenterCampus Salvatore VenutaCatanzaroItaly

Epithelial ovarian cancer (EOC) is the sixth most common malignancy in women. Ovarian tumors consist of several clinical and pathological entities that share an anatomic site. The gold standard treatment, both in front-line and in adjuvant setting, is represented by carboplatin/paclitaxel combination. Conversely, the second-line treatment is not well defined. The response to platinum is the major prognostic factor for survival. In this review we discuss the current views on platinum-refractory/resistant patient treatment only, which includes patients progressing or relapsing within 6 months from the last platinum-based course. Concerning this subgroup, the activity of several conventional drugs was confirmed in different trials without a significant impact in terms of overall survival. In the last years particular emphasis was given to targeted anti-angiogenetic therapy which produced a survival improvement with an acceptable toxicity profile. New “ad hoc” approaches, with a major attention to outcome-predictive factors, are eagerly awaited.

关键词： Ovarian Cancer Systemic Chemotherapy Platinum Sensitivity Status

Water and lysozyme： Some results from the bending and stretching vibrational modes

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Frontiers of physics 2015年第5期10卷 27-34页

作者： FrancescoMallamace Carmelo Corsaro Domenico Mallamace cirino Vasi Nicola Cicero H. Eugene Stanley Dipartimento di Fisica e Scienze della Terra Universita di Messina 1-98166 Messina Italy Department of Nuclear Science and Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA Center for Polymer Studies and Department of Physics Boston University Boston MA 02215 USA Consiglio Nazionale delle Ricerche-IPCF Messina 1-98166 Messina Italy Dipartimento di Scienze dell'Ambiente della Sicurezza del Territorio degli Alimenti e della Salute Universita di Messina Viale F. Stagno d'Alcontres 31 98166 Messina Italy

The dynamic or glass transition in biomolecules is important to their functioning. Also essential is the transition between the protein native state and the unfolding process. To better understand these transitions, we use Fourier transform infrared spectroscopy to study the vibrational bending and stretching modes of hydrated lysozymes across a wide temperature range. We find that these transitions are triggered by the strong hydrogen bond coupling between the protein and hydration water. More precisely, we demonstrate that in both cases the water properties dominate the evolution of the system. We find that two characteristic temperatures are relevant： in the supercooled regime of confined water, the fragile-to-strong dynamic transition occurs at TL, and in the stable liquid phase, T＊ 315 ± 5 K characterizes the behavior of both isothermal compressibility KT（T, P） and the coefficient of thermal expansion ap（T, P）.

关键词： protein unfolding hydration water infrared spectroscopy

A new therapeutic approach to erectile dysfunction： urotensin-II receptor high affinity agonist ligands

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Asian Journal of Andrology 2015年第1期17卷 81-85,I0008,I0009页

作者： Roberta d'Emmanuele di Villa Bianca Emma Mitidieri Erminia Donnarumma Ferdinando Fusco Nicola Longo Giuseppe De Rosa Ettore Novellino Paolo Grieco Vincenzo Mirone Giuseppe cirino Raffaella Sorrentino Department of Pharmacy University of Naples Federico II Via D. Montesano 49 Naples Italy Interdepartmental Centre for Sexual Medicine University of Naples Federico II Via S. Pansini 5 Naples Italy Department of Neurosciences Human Reproduction and Odontostomatology University of Naples Federico II Via S. Pansini 5 Naples Italy.

Urotensin-II （U-II） is a cyclic peptide that acts through a G protein-coupled receptor （urotensin-II receptor [UTR]） mainly involved in cardiovascular function in humans. The urotensinergic system is also implicated in the urogenital tract. Indeed, U-II relaxes human corpus cavernosum strips and causes an increase in intracavernous pressure （ICP） in rats. In light of this, the U-II/UTR pathway can be considered a new target for the treatment of erectile dysfunction. On this hypothesis, herein we report on two new UTR high affinity-agonists, P5U （H-Asp-c[Pen-Phe-Trp-Lys-Tyr-Cys]-Val-OH） and UPG84（H-Asp-c[Pen-Phe-DTrp-Orn-（pNH2） Phe-Cys]-Val-OH）. The effects of P5U and UPG84 were each compared separately with U-II by monitoring the ICP in anesthetized rats. Intracavernous injection of U-II （0.03-1 nmol）, P5U （0.03-1 nmol） or UPG84 （0.03-1 nmol） caused an increase in ICP. P5U, in particular, elicited a significant increase in ICP as compared to U-II. The observed effect by using P5U at a dose of 0.1 nmol per rat was comparable to the effect elicited by U-II at a dose of 0.3 nmol. Moreover, UPG84 at the lowest dose （0.03 nmol） showed an effect similar to the highest dose of U-II （1 nmol）. Furthermore, UPG84 was found to be more effective than P5U. Indeed, while the lowest dose of P5U （0.03 nmol） did not affect the ICP, UPG84, at the same dose, induced a prominent penile erection in rat. These compounds did not modify the blood pressure, which indicates a good safety profile. In conclusion, UPG84 and P5U may open new perspectives for the management of erectile dysfunction.

关键词： erectile dysfunction intracavernous pressure rat urotensin-II urotensin-II ligands

Strongly enhanced light trapping in a two-dimensional silicon nanowire random fractal array

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Light(Science & Applications) 2016年第1期5卷 855-861页

作者： Barbara Fazio Pietro Artoni Maria Antonia Iatì Cristiano D’Andrea Maria JosèLo Faro Salvatore Del Sorbo Stefano Pirotta Pietro Giuseppe Gucciardi Paolo Musumeci cirino Salvatore Vasi Rosalba Saija Matteo Galli Francesco Priolo Alessia Irrera CNR-IPCF Istituto per i Processi Chimico Fisici98158 MessinaItaly Dipartimento di Fisica e Astronomia Universitàdi Catania95123 CataniaItaly CNR-MATIS IMM Istituto per la Microelettronica e Microsistemi95123 CataniaItaly Dipartimento di Fisica Universitàdegli Studi di Pavia27100 PaviaItaly Dipartimento di Scienze Matematiche e Informatiche Scienze Fisiche e Scienze della TerraUniversitàdi Messina98166 MessinaItaly Scuola Superiore di Catania Universitàdi Cataniavia Valdisavoia995123 CataniaItaly

We report on the unconventional optical properties exhibited by a two-dimensional array of thin Si nanowires arranged in a random fractal geometry and fabricated using an inexpensive,fast and maskless process compatible with Si *** structure allows for a high light-trapping efficiency across the entire visible range,attaining total reflectance values as low as 0.1%when the wavelength in the medium matches the length scale of maximum heterogeneity in the *** show that the random fractal structure of our nanowire array is responsible for a strong in-plane multiple scattering,which is related to the material refractive index fluctuations and leads to a greatly enhanced Raman scattering and a bright *** strong emissions are correlated on all length scales according to the refractive index *** relevance and the perspectives of the reported results are discussed as promising for Si-based photovoltaic and photonic applications.

关键词： light trapping multiple scattering Raman enhancement random fractal silicon nanowires

Noninvasive Ventilation Interfaces in the Treatment of Acute Respiratory Insufficiency: A Critical Review

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Open Journal of Emergency Medicine 2024年第3期12卷 95-103页

作者： Andréa Nóbrega cirino Nogueira Chakira Torres Lima Renata dos Santos Vasconcelos Suzy Maria Montenegro Pontes Arnaldo Aires Peixoto Junior Renan Magalhães Montenegro Junior Clinical Research Unit Walter Cantdio University Hospital Federal University of Cear/EBSERH Fortaleza Brazil

Background: Noninvasive ventilation (NIV) is an important therapeutic modality for the treatment of acute respiratory failure (ARF). In this review, we critically analyze randomized controlled trials on the most used NIV interfaces in the treatments of ARF. Methods: The searches were conducted in the Medline, Lilacs, PubMed, Cochrane, and Pedro databases from June to November 2021. The inclusion criteria were Randomized clinical trials (RCTs) published from 2016 to 2021 in Portuguese, Spanish, or English and involving adults (aged ≥ 18 years). The eligibility criteria for article selection were based on the PICO strategy: Population—Adults with ARF;Intervention—NIV Therapy;Comparison—Conventional oxygen therapy, high-flow nasal cannula (HFNC) oxygen therapy, or NIV;Outcome—improvement in ARF. The search for articles and the implementation of the inclusion criteria were independently conducted by two researchers. Results: Seven scientific articles involving 574 adults with ARF due to various causes, such as chest trauma, decompensated heart failure, coronavirus disease 2019 (COVID-19), and postoperative period, among others, were included. The interfaces cited in the studies included an oronasal mask, nasal mask, full-face mask, and helmet. In addition, some favorable outcomes related to NIV were reported in the studies, such as a reduction in the rate of orotracheal intubation and shorter length of stay in the ICU. Conclusions: The most cited interfaces in the treatment of ARF were the oronasal mask and the helmet.

关键词： Noninvasive Ventilation Respiratory Insufficiency Respiration Artificial Continuous Positive Airway Pressure

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《SHOCK》2020年第4期新观点

实用休克杂志（中英文） 2020年第2期4卷 114-117,128页

作者： Jennifer A.cirino Matthew J.Delano Lena M.Napolitano 朱浙祥(译) 不详湖南省人民医院(湖南师范大学附属第一医院)急诊科

脓毒症和脓毒性休克、心脏骤停和心源性休克以及失血性休克是ICU重症患者死亡的主要原因。在过去的十年中,重症监护病房的病人人数显著上增,且随着人口的老龄化,预计还会继续增加。鉴于上述休克状态的高死亡率,医务工作者亟需寻求新的... 详细信息

脓毒症和脓毒性休克、心脏骤停和心源性休克以及失血性休克是ICU重症患者死亡的主要原因。在过去的十年中,重症监护病房的病人人数显著上增,且随着人口的老龄化,预计还会继续增加。鉴于上述休克状态的高死亡率,医务工作者亟需寻求新的治疗方法。本期《休克》重点阐述了重症监护医学领域里与上述重要主题相关的一系列优秀研究,其中包括5项临床研究、2项转化性研究和9项基础科学研究,这些研究旨在加深人们对休克的病理生理学和潜在机制的理解,以及推动在未来开发更有效的治疗策略来挽救危重病人和创伤病人的生命。

关键词：心源性休克脓毒性休克失血性休克休克状态基础科学研究病理生理学治疗策略心脏骤停

Adrenal Insufficiency by Adrenoleukodystrophy

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Health 2020年第1期12卷 1-13页

作者： Elda Cristinne Mattos Botelho Eduardo Romero Sampaio Botelho Luciana Correa de Souza Rodrigues Tatiana Prado Wanderley Fernanda Navarini Queiroz Pollyana cirino Gomes Borges Sabrina Arrais Rolim Aragao Ximenes Cruz Janete Pacheco da Silva Larissa Bianca Cunha de Sa Alberto Krayyem Arbex IPEMED Medical School AFYA EducationalBrasíliaBrazil Medical Clinic in Endocrinology and Diabetology Schleswig-FlensburgGermany

The X-linked adrenoleukodystrophy (ALD) is a severe neurodegenerative disorder due to mutations in the ABCD1 gene. Objective: To report a case of a 19-year-old man with adrenal insufficiency due to adrenoleukodystrophy. Method: Case report and literature review. Result: A previously healthy 19-year-old male patient was admitted to the emergency room with nausea and vomiting for 5 days, who progressed to abdominal pain, severe asthenia, and fever (38.5°C). He referred progressive darkening of the skin, oral mucosa, tongue and nail bed of the hands and feet, observed in the last 6 years. Emergency laboratory evaluation showed severe hyponatremia and hyperkalemia, which, together with decreased plasma cortisol, directed the investigation to causes of adrenal insufficiency. High ACTH (Adrenocorticotropic hormone) and very long chain fatty acid levels closed the diagnosis. Discussion: ALD is characterized by progressive demyelination in the central and peripheral nervous system and adrenal insufficiency consequence to the accumulation of very long chain fatty acids (VLCFA) in the adrenal. The overall incidence of ALD is 1:17,000. Adrenal insufficiency may be the first symptom of ALD in boys and adults. The diagnosis is based on the measurement of VLCFA plasma levels. Allogeneic bone marrow transplantation is the only treatment that provides a permanent cure when the procedure is performed at an early stage of brain demyelination, i.e. when patients are asymptomatic, although brain magnetic resonance imaging (MRI) is abnormal. Treatment of Addison’s disease is obligatory, but does not change the course of neurological symptoms.

关键词： Adrenoleukodystrophy Adrenomyeloneuropathy Adrenal Insufficiency Addison’s Disease