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Asian Pacific Journal of Tropical Medicine 2016年第5期9卷 420-424页

作者： Silmara Baroni Bruno Ambrosio da Rocha Juliana Oliveira de Melo Jurandir Fernando Comar Silvana Martins Caparroz-Assef ciomar aparecida bersani-amado Department of Pharmacology and Therapeutic State University of MaringaParanaBrazil Department of Biochemistry State University of MaringaParanaBrazil

Objective: To evaluate the effect of hydroethanolic extract of yacon on the hyperglycemia induced by streptozotocin(STZ) in neonatal rats. Methods: Wistar rats aged two days old received an intraperitoneal injection of STZ(160 mg/kg); after seven weeks, glycosuria was determined and animals with glucose levels above 250 mg/d L were included in the study. Groups of diabetic and non-diabetic rats were treated orally with yacon extract at a dose of 400 mg/kg/d for 14 d. Tests were made for phytochemical characterization, glucose tolerance and toxicity. Results: The results showed that treatment with the extract reduced the glucose levels of fed diabetic rats and did not change the glucose levels of fasting diabetic and normal rats. Additionally, also it was observed that treatment with the extract reduced blood glucose levels of diabetic rats during the oral and intravenous glucose tolerance tests. There was no change in body weight, liver enzymes or mortality with yacon extract treatment. The phytochemical screening revealed the presence of caffeic acid, chlorogenic acid, ferulic acid and gallic acid. Conclusions: The data suggest that yacon extract reduces hyperglycemia, possibly by improving insulin sensibility through its phytochemicals constituents(phenolic compounds).

关键词： Yacon extract Hyperglycemia Insulin sensibility Streptozotocin

Oral pharmacological treatment for patent ductus arteriosus in premature neonates with hemodynamic repercussions

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Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1080-1083页

作者： Clarissa de Albuquerque Botura Bruno Ambrósio da Rocha Thiely Balensiefer Franciele Queiroz Ames ciomar aparecida bersani-amado Roberto Kenji Nakamura Cuman Department of Medicine Faculdade Uningá Department of Pharmacology and Therapeutics State University of Maringá Hospital Pharmacy at Santa Rita Hospital

Objective: To evaluate the efficacy of oral indomethacin, ibuprofen, and paracetamol in oral dosage form on patent ductus arteriosus(PDA) in premature neonates with significant clinical and hemodynamic repercussions(CHRs) and to determine the effect of these respective treatments on renal ***: A retrospective study of cases of PDA in premature neonates in the Neonatal Intensive Care Unit was conducted. The treatments consisted of indomethacin[0.2 mg/(kg$d), 3-day cycle], ibuprofen [10 mg/(kg$d) followed by 5 mg/(kg$d), 3-day cycle], and paracetamol(15 mg/kg every 6 h, 5-day cycle). The drugs were administered as an oral solution. The following variables were considered: gestational age,newborn weight at birth, Apgar score, diuresis, serum creatinine and urea levels, and serum electrolyte levels(sodium and potassium).Results: Treatment with indomethacin presented efficacy of 87.5% in closure of the ductus with a mean outcome period of 3.5 d. In premature neonates with CHRs and contraindications for indomethacin, the initial treatment with either ibuprofen or paracetamol failed to close the ductus. However, when this treatment was followed by indomethacin, closure occurred in 66.7% of the neonates, with an outcome period of9.66 d. The initial treatment with one cycle of ibuprofen followed by one or two cycles of paracetamol failed to close the ***: Oral indomethacin was effective for closure of the PDA in premature neonates with severe CHRs. Oral paracetamol or ibuprofen for PDA closure in premature neonates with severe CHRs and contraindications for indomethacin was ***, results in clinical improvements of neonates allowed the subsequent use of indomethacin and successful closure of the ductus. A significant reduction of diuresis occurred in neonates who were treated with indomethacin, either as a first-line treatment or after the failure of ibuprofen or paracetamol.

关键词： Patent ductus arteriosus Premature neonatal Indomethacin Ibuprofen Paracetamol

Intradermal irritation of dental bleaching agents in rats

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Acta Pharmacologica Sinica 1998年第5期 27-29页

作者： Carla Elisa Borin GONALVES1 (CNPqfellowship), Ligiane Vieira TOKANORAMOS1 (CNPqfellow-ship), Renata Correa PASCCOTO (Departamento de Odontologia, Universidade Estadual de Maring) ciomar aparecida bersaniamado2 (Departamento de Far

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关键词：牙齿漂白脲过氧化氢刺激剂皮内注射伊文思蓝

Canova medication changes TNF-α and IL-10 serum levels in mice infected with Trypanosoma cruzi Y strain

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Asian Pacific Journal of Tropical Medicine 2016年第9期9卷 838-843页

作者： áurea Regina Telles Pupulin Lívia Bracht Márcia Machado de Oliveira Dalalio Francielli Maria de Souza Silva-Comar Bruno Ambrósio da Rocha Franciele Queiroz Ames Roberto Kenji Nakamura Cuman ciomar aparecida bersani-amado Laboratory of Parasitology Department of Basic Sciences of HealthState University of Maringá-PR Laboratory of Hepatic Metabolism Department of BiochemistryState University of Maringá-PR Laboratory of Immunology Department of Basic Sciences of HealthState University of Maringá-PR Laboratory of Inflammation Department of Pharmacology and TherapeuticState University of Maringá-PR

Objective:To identify whether Canova medication changes TNF-α and IL-10 serum levels in mice infected with Trypanosoma cruzi Y ***:Animals were divided into five groups:non-treated infected animals(I); benznidazole-treated infected animals(Bz; 100 mg/kg body weight,single daily dose by gavage); Canova medication(CM) treated infected animals(CM;0.2 mL/animal,single daily dose by gavage); benznidazole- and Canova medication–treated infected animals with the above-mentioned dose(Bz+CM);and non-infected animals(C).TNF-α and IL-10 levels were determined in serum aliquots after 4,7,10,13,and 29 days of *** ELISA technique was employed with R&D System *** ***:A high increase in TNF-α and IL-10 levels occurred in the infected and CM-treated groups within the treatment employed on the 10 th day after infection,coupled with a IL-10 decrease on the 13 th day after infection when compared with the other experimental ***:CM may change the balance between plasma cytokine levels(TNF-α and IL-10) in mice infected with Y strain ***,with important consequences leading towards a more severe infection.

关键词： Trypanosoma cruzi Canova medication Cytokines

A single administration of fish oil inhibits the acute inflammatory response in rats

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Asian Pacific Journal of Tropical Medicine 2017年第8期10卷 830-837页

作者： Laura Licia Milani de Arruda Franciele Queiroz Ames Damila Rodrigues de Morais Renata Grespan Ana Paula Maziero Gil Maria Angelica Raffaini Covas Pereira Silva Jesui Vergilio Visentainer Roberto Kenji Nakamura Cuman ciomar aparecida bersani-amado Department of Pharmacology and Therapeutics State University of MaringaMaringa-PRBrazil Department of Chemistry State University of MaringaMaringa-PRBrazil

Objective: To investigate the antiinflammatory effects of a single administration of fish oil(FO) on the acute inflammatory response. Methods: The paw edema and pleurisy models were used to evaluate the effects of FO dissolved in olive oil(FOP) orally administered in a single dose in rats. Nitric oxide(NO) concentrations in the pleural exudate were performed according to the Griess method and the cytokine concentrations were determined by Luminex bead-based multiplex assay. Results: FOP treatment(30 and 300 mg/kg) significantly reduced paw edema. FOP treatment at 18.75, 37.5, 75.0, 150.0, and 300 mg/kg decreased both the volume of pleural exudate and cellular migration into the pleural cavity and each of these doses presented the same effectiveness. Treatment with FOP(300 mg/kg) reduced NO, TNF-α, IL-1β, and IL-6 concentrations in the pleural exudate. Conclusions: The present data provide evidence that FO has inhibitory effects on the acute inflammatory response when administered in a single dose in rats. This effect might be attributable to a direct inhibitory effect of FO on the production or release of inflammatory mediators that are involved in the pathological processes evaluated herein.

关键词： Omega-3 fatty acid Polyunsaturated fatty acid Pleurisy Leukocyte migration EPA DHA

The in Vitro Antioxidant Capacities of Hydroalcoholic Extracts from Roots and Leaves of Smallanthus sonchifolius (Yacon) Do Not Correlate with Their in Vivo Antioxidant Action in Diabetic Rats

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Journal of Biosciences and Medicines 2016年第2期4卷 15-27页

作者： Ana Carla Broetto Biazon Mariana Marques Nogueira Wendt Júlia Rosa Moreira Cristiane Vizioli Castro Ghizoni Andreia Assunção Soares Sandra da Silva Silveira Anacharis Babeto de Sá-Nakanishi ciomar aparecida bersani amado Rosane Marina Peralta Adelar Bracht Jurandir Fernando Comar Pharmacy Department Faculdades Integrado Campo Mourao Brazil Biochemistry Department University of Maringá Maringá Brazil Pharmacology and Therapeutics Department University of Maringá Maringá Brazil

Leaf and root extracts of Smallanthus sonchifolius (yacon), have antihyper-glycemic activity and antioxidant properties. The present study aims to compare the in vivo hepatic antioxidant activity of hydroalcoholic extracts of yacon leaves and roots in rats with streptozotocin-induced diabetes in terms of their in vitro antioxidant capacity. Rats were treated during 14 days with 1060 mg·Kg-1 root extract or 400 mg·Kg-1 leaf extract. The latter was richer in phenolics and possessed a much higher in vitro antioxidant activity. Both extracts prevented hyperglycemia in diabetic rats. The liver of diabetic rats presented increased levels of protein carbonyls and ROS and decreased activities of antioxidant enzymes. Treatment with both root and leaf extracts restored the protein carbonyl levels to normality. The root extract also restored the ROS levels to normality, but the leaf extract was not effective. The root extract was also more effective in restoring the activity of at least two important antioxidant enzymes (glucose 6-phosphate dehydrogenase and glutathione peroxidase). In terms of the antioxidant load (which was 17 times lower in the root extract treatment), the in vivo action of the root extract was more effective than the leaf extract in reducing the hepatic oxidative stress that accompanies diabetes.

关键词： Smallanthus sonchifolius Yacon Streptozotocin-Induced Diabetes Liver Oxidative Status