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创意与设计 2012年第3期 75-82页

作者： cinzia Ferrara 陈欣(译) 郑慧(译) 意大利菲拉拉巴勒莫大学建筑系不详

在上世纪的七八十年代,意大利的设计工业被打上了"意大利制造"的标签,它不仅代表着在地理概念上的产品原产地,也是高质量、创新和无与伦比的标志。在这样的背景下,在整个意大利,许多与设计有关的研究机构,与高科技新材料相关的设计、生... 详细信息

在上世纪的七八十年代,意大利的设计工业被打上了"意大利制造"的标签,它不仅代表着在地理概念上的产品原产地,也是高质量、创新和无与伦比的标志。在这样的背景下,在整个意大利,许多与设计有关的研究机构,与高科技新材料相关的设计、生产和研究部门正在接连不断地进行实验研发工作。阿基米亚和孟菲斯就是其中的佼佼者。它们颠覆了原本的设计,给予像色彩、装饰品在内的设计元素新的价值并创造出新的设计词汇。

关键词：色彩都市文化交际面设计

Optimizing the Dose Distribution in Stereotactic Body Radiotherapy with Standard Multileaf Collimator(MLC) ： A Planning Study

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肿瘤预防与治疗 2017年第2期30卷 79-84页

作者： Francesco DEODATO Savino CILLA Gabriella MACCHIA cinzia DIGES Anna IANIRO Mariangela BOCCARDI Vincenzo VALENTINI Alessio G.MORGANTI Radiotherapy Unit Fondazione di Ricerca e Cura"Giovanni Paolo Ⅱ"Università Cattolica del S.Cuore Medical Physics Unit Fondazione di Ricerca e Cura "Giovanni Paolo Ⅱ"Università Cattolica del S.Cuore Radiotherapy Department "A.Gemelli"HospitalCatholic University Radiation Oncology Unit Department of ExperimentalDiagnostic and Specialty MedicineDIMES University of BolognaS.Orsola-Malpighi Hospital

导读：体部立体定向放射治疗（SBRT）可实现靶区剂量的集中、精准和生物有效性，同时避开重要的正常器官。它在当今放疗世界扮演着越来越重要的地位。为了得到更好的剂量优化，目前有很多关于定位、处方剂量技术的研究，运用IMRT可实现S... 详细信息

导读：体部立体定向放射治疗（SBRT）可实现靶区剂量的集中、精准和生物有效性，同时避开重要的正常器官。它在当今放疗世界扮演着越来越重要的地位。为了得到更好的剂量优化，目前有很多关于定位、处方剂量技术的研究，运用IMRT可实现SBRT的剂量优化，但各个放疗中心的结果却不尽相同，尚未完全统一。

关键词：体部立体定向放射治疗放射学肿瘤临床治疗

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维苏威火山地下水的地球化学监测

水文地质工程地质技术方法动态 2007年第4期 19-36页

作者： cinzia Federicoa 葛秀珍（翻译）苑惠明（校对） Istituto Nazionale di Geofisica e Vulcanologia （INGV） Sezione di Palermo Via La Malfa 153 90146 Palermo Italy 不详

本文介绍了1998年5月-2001年12月期间对维苏威火山水文地球化学研究的结果，多数问题的焦点集中在这个时间观测的累积时间变化。根据化学性质，把地下水样分成2组（1组和2组），分别说明了火山区南部和北部的水循环特征。与2组相比，1... 详细信息

本文介绍了1998年5月-2001年12月期间对维苏威火山水文地球化学研究的结果，多数问题的焦点集中在这个时间观测的累积时间变化。根据化学性质，把地下水样分成2组（1组和2组），分别说明了火山区南部和北部的水循环特征。与2组相比，1组的水样酸性和温度以及碱性都高于2组。水样中还有较高的CO2和CH4含量，这主要是深部向上部挥发的物质含量过高，加之延长了水-岩石的作用时间所致。时间序列说明整个含水层化学成分相当稳定。本项研究期间，地下水温度、pH值、重碳酸盐和溶解的CO2非常稳定．特别是深井（压力计水位高于100米）。较浅的水体表现出了很明显的季节性和人为原因造成的瞬时变化。本文还描述了1999年10月地震事件引起的水化学性质的重要变化，特别是位于火山北侧的Olivella泉。在这个位置，观测出水的pH和氧化还原势降低得很多，而溶解性CO2和3^He/4^He比值却表现出增加的趋势。这些化学性质和同位索成分的变化证明了地震期间，岩浆诱发的氦和二氧化碳进入含水层（该含水层补给Olivella泉）的假设。

关键词：维苏威火山火山岩监测地下水水文地球化学 δ18^O

Drug-Eluting Stent for the Treatment of Early Fistula Failure

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International Journal of Clinical Medicine 2011年第3期2卷 196-200页

作者： Luigi Di Serafino Laura Scudiero Mario De Laurentis Federica Ilardi Fabio Magliulo Giuseppe Carotenuto cinzia Perrino Giovanni Esposito 不详

Introduction: Morbidity and mortality in chronic haemodialysis patients is related to dialysis efficiency. Several complications may occur with vascular access, usually associated with a stenosis. This is known to occur frequently in the venous outflow. Stenosis of the arterial side is not as frequently discussed, but it is also likely to compromise fistula function. Traditionally, surgical and percutaneous interventions have been used to treat failing fistulas, but the employment of drug-eluting stents for the treatment of failing fistulas due to the arterial stenosis has been described rarely. Methods: A 65-year-old male patient referred to our ambulatory because of hand ischemia during haemodialysis treatments only few days after radial-cephalic fistula creation. After physical and echo-color-doppler examination, angiography was performed and percutaneous intervention was proposed. After the positioning of a guiding catheter, the lesion was crossed with a 0.014” guide wire followed by direct drug-eluting stent implantation. Results: Final angiogram showed a good result and a preserved flow through the fistula. Six months later the patient was asymptomatic and the fistula was still working. Conclusion: Although further prospective studies are necessary, percutaneous transluminal angioplasty (PTA) with drug-eluting stents implantation could be considered a safe and effective technique for the treatment of arteriovenous fistulas stenosis.

关键词： Arteriovenous Fistula Percutaneous Transluminal Angioplasty Haemodialysis Drug-Eluting Stents

Grafting vigour is associated with DNA de-methylation in eggplant

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Horticulture Research 2021年第1期8卷 3311-3320页

作者： Elisa Cerruti Carmina Gisbert Hajk-Georg Drost Danila Valentino Ezio Portis Lorenzo Barchi Jaime Prohens Sergio Lanteri cinzia Comino Marco Catoni Department of Agricultural Forest and Food SciencesPlant Genetics and BreedingUniversity of TorinoGrugliascoItaly The Sainsbury Laboratory University of CambridgeCambridgeUK Institute for Conservation&Improvement of Valencian Agrodiversity(COMAV) Universitat Politècnica de ValènciaValenciaSpain Computational Biology Group Department of Molecular BiologyMax Planck Institute for Developmental BiologyTübingenGermany School of Biosciences University of BirminghamBirminghamUnited Kingdom Institute for Sustainable Plant Protection National Research Council of ItalyTorinoItaly

In horticulture,grafting is a popular technique used to combine positive traits from two different *** is achieved by joining the plant top part(scion)onto a rootstock which contains the stem and *** can provide resistance to stress and increase plant production,but despite their wide use,the biological mechanisms driving rootstock-induced alterations of the scion phenotype remain largely *** that epigenetics plays a relevant role during distance signalling in plants,we studied the genome-wide DNA methylation changes induced in eggplant(Solanum melongena)scion using two interspecific rootstocks to increase *** found that vigour was associated with a change in scion gene expression and a genome-wide hypomethylation in the CHH ***,this hypomethylation correlated with the downregulation of younger and potentially more active long terminal repeat retrotransposable elements(LTR-TEs),suggesting that graft-induced epigenetic modifications are associated with both physiological and molecular phenotypes in grafted *** results indicate that the enhanced vigour induced by heterografting in eggplant is associated with epigenetic modifications,as also observed in some heterotic hybrids.

关键词： younger driving grafted

Minimally invasive surgery for paediatric inflammatory bowel disease: Personal experience and literature review

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World Journal of Gastroenterology 2015年第40期21卷 11312-11320页

作者： Alessio Pini-Prato Maria Grazia Faticato Arrigo Barabino Serena Arrigo Paolo Gandullia cinzia Mazzola Nicola Disma Giovanni Montobbio Girolamo Mattioli Istituto Giannina Gaslini DINOGMI University of Genoa

The incidence of paediatric inflammatory bowel disease(PIBD) has dramatically increased in the last 20 years. Although first reported in mid 1970s',diagnostic laparoscopy has started to be routinely adopted in paediatric surgical practice since late 1990s'. Minimally invasive surgery was first limited to diagnostic purposes. After 2002 it was also applied to the radical treatment of PIBD,either Crohn's disease(CD) or Ulcerative colitis. During the last decade minimally invasive approaches to PIBD have gained popularity and have recently became the "gold standard" for the treatment of such invalidating and troublesome chronic diseases. The authors describe and track the historical evolution of minimally invasive surgery for PIBD and address all available opportunities,including most recent advancements such as robotic surgery,single port approaches and minimally invasive treatment of perianal fistulising CD. A systematic review of all series of PIBD treated with minimally invasive approaches published so far is provided in order to determine the incidence and type of patients' complications reported up to present days. The authors also describe their experience with minimally invasive surgery for PIBD and will report the results of 104 laparoscopic procedures performed in a series of 61 patients between January 2006 and December 2014.

关键词： Paediatric inflammatory bowel disease Ulcerative c

Non-coding landscapes of colorectal cancer

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World Journal of Gastroenterology 2015年第41期21卷 11709-11739页

作者： Marco Ragusa Cristina Barbagallo Luisa Statello Angelo Giuseppe Condorelli Rosalia Battaglia Lucia Tamburello Davide Barbagallo cinzia Di Pietro Michele Purrello BioMolecular Genome and Complex Systems Bio Medicine Unit (BMGS)-Section of Biology and Genetics G Sichel Department of Bio Medical Sciences and Bio Technology University of Catania

For two decades Vogelstein's model has been theparadigm for describing the sequence of molecular changes within protein-coding genes that would lead to overt colorectal cancer(CRC). This model is now too simplistic in the light of recent studies, which have shown that our genome is pervasively transcribed in RNAs other than m RNAs, denominated non-coding RNAs(nc RNAs). The discovery that mutations in genes encoding these RNAs [i.e., micro RNAs(mi RNAs), long non-coding RNAs, and circular RNAs] are causally involved in cancer phenotypes has profoundly modified our vision of tumour molecular genetics and pathobiology. By exploiting a wide range of different mechanisms, nc RNAs control fundamental cellular processes, such as proliferation, differentiation, migration, angiogenesis and apoptosis: these data have also confirmed their role as oncogenes or tumor suppressors in cancer development and progression. The existence of a sophisticated RNA-based regulatory system, which dictates the correct functioning of protein-coding networks, has relevant biological and biomedical consequences. Different mi RNAs involved in neoplastic and degenerative diseases exhibit potential predictive and prognostic properties. Furthermore, the key roles of nc RNAs make them very attractive targets for innovative therapeutic approaches. Several recent reports have shown that nc RNAs can be secreted by cells into the extracellular environment(i.e., blood and other body fluids): this suggests the existence of extracellular signalling mechanisms, which may be exploited by cells in physiology and pathology. In this review, we will summarize the most relevant issues on the involvement of cellular and extracellular nc RNAs in disease. We will then specifically describe their involvement in CRC pathobiology and their translational applications to CRC diagnosis, prognosis and therapy.

关键词： Colorectal cancer Micro RNA Long noncoding RNAs Ci

Evaluation of a Therapeutic Alternative for Telogen Effluvium: A Pilot Study

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Journal of Cosmetics, Dermatological Sciences and Applications 2013年第3期3卷 9-16页

作者： Alfredo Rossi Lara Priolo Alessandra Iorio Enrica Vescarelli Martina Gerardi Daniele Campo Donato Di Nunno Simona Ceccarelli Stefano Calvieri Antonio Angeloni cinzia Marchese Department of Experimental Medicine Sapienza University of Rome Rome Italy Department of Internal Medicine and Medical Specialties Sapienza University of Rome Rome Italy Department of Molecular Medicine Sapienza University of Rome Rome Italy. Italian Orthodermic Institute Rome Italy

Background/Aim: Telogen effluvium (TE) is a scalp disorder characterized by the thinning or shedding of hair resulting from the early entry of hair in the telogen phase. Nigella sativa (NS) is a dicotyledonous belonging to the Ranunculacae family. It has been shown that its major constituent, tymoquinon (TQ), exerts anti-oxidant and anti-inflammatory effects by inhibiting pro-inflammatory mediators, such as cyclooxygenase and prostaglandin D2. The aim of this study is to evaluate the efficacy of NS essential oil as a potential treatment for TE, a pathology characterized by a significant inflammatory component. Study Design/Methods: Twenty patients affected by TE for this double-blind, placebo controlled and randomized study were enrolled. Ten of these patients were treated with a scalp lotion containing 0.5% NS, daily for 3 months, while the other ten patients were treated with placebo daily for 3 months. Videodermatoscopic analysis (Trichoscan Dermoscope Fotofinder?) and evaluation of three independent dermatologists were performed before treatment (T0), after 3 months of treatment (T3) and at the 6 months follow-up (T6). Results: The results showed a significant improvement in 70% of patients treated with NS. Videodermatoscopic analysis showed a significant increment of hair density and hair thickness in patients treated with NS. NS was also able to reduce the inflammation observed in the majority of patients affected by TE. Conclusions: The results of this study suggest that NS can be considered potentially useful for the treatment of TE.

关键词： Telogen Effluvium Nigella sativa Hair Density Hair Thickness

心理干预治疗儿童青少年焦虑症的有效性与可接受性：网络荟萃分析计划书

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英国医学杂志中文版 2016年第3期19卷 136-141页

作者：张玉清周新雨 Anthony C James 覃彬 Craig J Whittington Pim Cuijpers cinzia Del Giovane 刘艺昀 David Cohen John R. Weisz 谢鹏重庆医科大学附属第一医院神经内科中国重庆牛津大学精神科英国伦敦牛津大学Warneford医院海菲尔德家庭与青少年研究中心英国伦敦伦敦大学学院教育与健康心理学的临床研究中心英国伦敦阿姆斯特丹自由大学临床心理科荷兰阿姆斯特丹意大利摩德纳大学临床与公共卫生学的诊断科萨伯特慈善医院儿童与青少年精神中心法国巴黎哈佛大学心理学研究中心美国波士顿

前言儿童青少年焦虑症给社会公共健康带来显著的沉重负担。认知行为治疗（CBT）是儿童青少年焦虑症中应用最为广泛的心理治疗方法，但先前的研究受限于纳入的试验数量，且试验为直接比较不同心理治疗及实施方式。因此本研究的目的为调... 详细信息

前言儿童青少年焦虑症给社会公共健康带来显著的沉重负担。认知行为治疗（CBT）是儿童青少年焦虑症中应用最为广泛的心理治疗方法，但先前的研究受限于纳入的试验数量，且试验为直接比较不同心理治疗及实施方式。因此本研究的目的为调查比较儿童青少年焦虑症患者接受不同心理治疗及同一心理治疗不同实施方式的有效性和可接受性。

关键词：心理干预治疗儿童青少年焦虑症网络荟萃分析计划书药物治疗