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Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress

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World Journal of Gastroenterology 2017年第28期23卷 5146-5157页

作者： Veruska cintia Alexandrino de souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio Carvalho Maria Carolina Accioly Brelaz de Castro Carolline Guimaraes D’assuncao Andreia Ferreira de Barros Camila Lima Carvalho Virgínia Maria Barros de Lorena Vláudia Maria Assis Costa Alvaro Aguiar Coelho Teixeira Regina Celia Bressan Queiroz Figueiredo Sheilla Andrade de Oliveira Centro de Pesquisas Aggeu Magalhaes Fundacao Oswaldo Cruz Immunopathogenesis Section Laboratory of Parasitic DiseasesNational Institute of Allergy and Infectious DiseaseNational Institutes of HealthBethesdaMDUSA and Laboratório de Doencas Parasitárias e infecciosasFaculdade de MedicinaUniversidade Federal de Minas Gerais Departamento de Morfologia e Fisiologia Animal Universidade Federal Rural de Pernambuco Departamento de Biofísica e Radiobiologia Universidade Federal de Pernambuco Centro Acadêmico de Vitória Universidade Federal de Pernambuco Departamento de Medicina Tropical Universidade Federal de Pernambuco

AIM To evaluate the therapeutic effects of bone marrowderived CD11b+CD14+ monocytes in a murine model of chronic liver damage. MeTHODS Chronic liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry,biochemical assessment,immunohistochemistry and enzyme-linked immunosorbent assay. ReSULTS CD11b+CD14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines,including tumor necrosis factor-α,interleukin(IL)-6 and IL-1β,in addition to pro-fibrotic factors,such as IL-13,transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased,while IL-10 and matrix metalloproteinase-9 increased in the monocytetreated group. CD11b+CD14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and osteopontin. CONCLUSION Monocyte therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation,as well as increasing antifibrogenic factors.

关键词：单核白血球骨头髓 mononuclear 房间房间治疗巨噬细胞谷胱甘肽肝纤维变性

effect of ions on the activity of brain acetylcholinesterase from tropical ifsh

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Journal of Coastal Life Medicine 2015年第7期 505-514页

作者： Caio Rodrigo Dias Assis Amanda Guedes linhares Vagne Melo Oliveira Renata Cristina Penha Franca Juliana Ferreira Santos elba Verônica Matoso Maciel Carvalho Ranilson souza Bezerra Luiz Bezerra Carvalho Jr Laboratory of enzymology-LABeNZ Biochemistry Department and Laboratory of Immunopathology Keizo AsamiFederal University of PernambucoRecife-PEBrazil Academic Unit of Serra Talhada Federal Rural University of PernambucoSerra Talhada-PEBrazil Laboratory of Glycoproteins Biochemistry DepartmentFederal University of PernambucoRecife-PEBrazil

Objective:To investigate the effect of ions on brain acetylcholinesterase(AChe;eC 3.***.1.7)activities from economic important fish[pirarucu,Arapaima gigas;tambaqui,Colossoma macropomum;cobia,Rachycentron canadum(***)and Nile tilapia,Oreochromis niloticus(***)]comparing with a commercial enzyme from electric eel[electrophorus electricus(***)].Methods:Thein vitro exposure was performed at concentrations ranging from 0.001 to 10 mmol/L(except for ethylene diamine tetraacetic acid;up to 150 mmol/L).Inhibition kinetics *** *** were also observed through four methods(Michaelis-Menten,Lineweaver-Burk,Dixon and Cornish-Bowden plots)in order to investigate the type of inhibition produced by some ***:Hg^(2+),As^(3+),Cu^(2+),Zn^(2+),Cd^(2+)caused inhibition in all the species under ***^(2+),Mg^(2+)and Mn^(2+)induced slight activation *** enzyme while Pb^(2+),Ba^(2+),Fe^(2+),Li+inhibited the AChe from some of the analyzed *** lowest IC50 and Ki values were estimated *** AChe in presence of Hg^(2+),Pb^(2+),Zn^(2+).Under our experimental conditions,the results *** ***,As^(3+),Cu^(2+),Cd^(2+),Pb^(2+)and Zn^(2+)showed a non-competitive/mixed-type inhibition,while Hg^(2+)inhibited the enzyme in a mixed/competitive-like ***:*** AChe activity was affected by ten of fifteen ions under study showing that this enzyme could undergo interference by these ions when used as pesticide biosensor in environmental *** hindrance would be less relevant for the crude extracts.

关键词： Ions Acetylcholinesterase Biomarkers Fish

Chemical Composition and Allelopathic Activity of the essential Oil from Callistemon viminalis(Myrtaceae)Blossoms on Lettuce(Lactuca sativa L.)Seedlings

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American Journal of Plant Sciences 2014年第24期5卷 3551-3557页

作者： Christiane Maria de Oliveira Maria das Gracas Cardoso Ana Cristina da Silva Figueiredo Maria Laene Moreira de Carvalho cintia Alvarenga Santos Fraga de Miranda Luiz Roberto Marques Albuquerque David Lee Nelson Marcos de souza Gomes Lucilene Fernandes Silva Juliana de Andrade Santiago Maria Luisa Teixeira Rafaela Magalhaes Brandao Department of Chemistry Federal University of LavrasLavrasBrazil Centro de Biotecnologia Vegetal/IBB Departamento de Biologia VegetalFaculdade de Ciencias de LisboaUniversidade de LisboaLisbonPortugal Department of Agriculture Federal University of LavrasLavrasBrazil Federal University of Valleys Jequitinhonha and Mucuri DiamantinaBrazil

The extraction of essential oils was performed by using the technique of hydrodistillation modified Clevenger apparatus, identification and quantification of the constituents was achieved by Gas Chromatography coupled to Mass Spectrometry, and Gas Chromatography equipped with a flame ionization detector. Assessment of allelopathic activity was evaluated with the use of the method that assesses the direct contact of essential oils on germination and vigor of lettuce seeds. The major constituents that characterize the essential oil from the flowers of Callistemon viminalis were 1, 8-cineole, α-pinene and limonene at concentrations of 66.9%, 16.0% and 10.0%, respectively. The essential oil presented allelopathic activity at intensities that varied proportionately to the concentration of the essential oil, with a reduction in the percentage of germination and the germination speed index (GSI) of lettuce seeds and in the dry mass and length of shoots and roots of lettuce seedlings.

关键词： Biological Activity Myrtaceae Allelopathy

R&D of back-end electronics for improved resistive plate chambers for the phase 2 upgrade of the CMS end-capmuon system

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Radiation Detection Technology and Methods 2022年第3期6卷 306-316页

作者： H.Kou Z.-A.Liu J.Zhao J.Song Q.Hou W.Diao P.Cao W.Gong N.Wang A.Samalan M.Tytgat M.el Sawy G.A.Alves F.Marujo e.A.Coelho F.Torres Da Silva De Araujo e.M.Da Costa H.Nogima A.Santoro S.Fonseca De souza D.De Jesus Damiao M.Thiel M.Barroso Ferreira Filho K.Mota Amarilo A.Aleksandrov R.Hadjiiska P.Iaydjiev M.Rodozov M.Shopova G.Sultanov A.Dimitrov L.Litov B.Pavlov P.Petkov A.Petrov e.Shumka S.J.Qian C.Avila D.Barbosa A.Cabrera A.Florez J.Fraga J.Reyes Y.Assran M.A.Mahmoud Y.Mohammed I.Laktineh G.Grenier M.Gouzevitch L.Mirabito K.Shchablo C.Combaret W.Tromeur G.Galbit A.Luciol X.Chen I.Bagaturia I.Lomidze Z.Tsamalaidze V.Amoozegar B.Boghrati M.ebraimi e.Zareian M.Mohammadi Najafabadi M.Abbrescia G.Iaselli G.Pugliese F.Loddo N.De Filippis R.Aly D.Ramos W.elmetenawee S.Leszki I.Margjeka D.Paesani L.Benussi S.Bianco D.Piccolo S.Meola S.Buontempo F.Carnevali L.Lista P.Paolucci F.Fienga A.Braghieri P.Salvini P.Montagna C.Riccardi P.Vitulo e.Asilar J.Choi T.J.Kim S.Y.Choi B.Hong K.S.Lee H.Y.Oh J.Goh I.Yu C.Uribe estrada I.Pedraza H.Castilla-Valdez R.L.Fernandez A.Sanchez-Hernandez e.Vazquez M.Ramirez-Garcia N.Zaganidis A.Radi H.Hoorani S.Muhammad A.Ahmad I.Asghar M.A.Shah W.A.Khan J.eysermans I.Crotty on behalf of the CMS Muon Group Department of Physics and Astronomy Ghent UniversityProeftuinstraat 869000 GhentBelgium UniversitéLibre de Bruxelles Avenue Franklin Roosevelt50-1050 BruxellesBelgium Centro Brasileiro Pesquisas Fisicas R.Dr.Xavier Sigaud150UrcaRio de JaneiroRio de Janeiro 22290-180Brazil Department de Fisica Nuclear e Altas energias Instituto de FisicaUniversidade do Estado do Rio de JaneiroRua Sao Francisco Xavier524Rio de JaneiroRio de Janeiro 20559-900Brazil Bulgarian Academy of Sciences Institute for Nuclear Researches and Nuclear EnergyTzarigradsko Shaussee Boulevard 721784 SofiaBulgaria Faculty of Physics University of Sofia5 James Bourchier Boulevard1164 SofiaBulgaria School of Physics Peking UniversityBeijing 100871China State Key Laboratory of Particle Detection and electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences B325Main BuildingNo.19(A)Yuquan RoadShijingshan DistrictBeijing 100049China Universidad de Los Andes Carrera 1No.18A-12BogotáColombia egyptian Network for High energy Physics Academy of Scientific Research and Technology101 Kasr El-Einy St.CairoEgypt Suez University SuezCairo RoadElsalam CitySuez 43522Egypt Center for High energy Physics(CHeP-FU) Faculty of ScienceFayoum UniversityEl-Fayoum 63514Egypt Univ Lyon Univ Claude Bernard Lyon 1CNRS/IN2P3IP2I LyonUMR 582269622 VilleurbanneFrance Georgian Technical University 77 Kostava Str.0175 TbilisiGeorgia School of Particles and Accelerators Institute for Research in Fundamental Sciences(IPM)P.O.Box 19395-5531 TehranIran School of engineering Damghan UniversityDamghan ***Iran INFN Sezione di BariVia Orabona 470126 BariItaly INFN Laboratori Nazionali di Frascati(LNF)Via Enrico Fermi 4000044 FrascatiItaly INFN Sezione di NapoliComplesso University Monte S.AngeloVia Cintia80126 NapoliItaly Dipartimento di Ingegneria elettrica e delle Tecnologie dell’Informazione UniversitàDegli Studi di Napoli Federico II80126 NapoliI

Purpose The Large Hadron Collider(LHC)at european Organization for Nuclear Research is planned to be upgraded to the high luminosity *** the luminosity makes muon triggering reliable and ofﬂine reconstruction very *** enhance the redundancy of the Compact Muon Solenoid(CMS)Muon system and resolve the ambiguity of track reconstruction in the forward region,an improved Resistive Plate Chamber(iRPC)with excellent time resolution will be installed in the Phase-2 CMS *** iRPC will be equipped with Front-end electronics(Fee),which can perform high-precision time measurements of signals from both ends of the *** Back-end electronics(Bee)need to be researched and developed to provide sophisticated functionalities such as interacting with Fee with shared links for fast,slow control(SC)and data,in addition to trigger primitives(TPs)generation and data acquisition(DAQ).Method The Bee prototype uses a homemade hardware board compatible with the MTCA standard,the back-end board(BeB).Bee interacts with Fee via a bidirectional 4.8 Gbps optical paired-link that integrates clock,data,and control *** clock and fast/slow control commands are distributed from BeB to the Fee via the *** uplink is used for BeB to receive the time information of the iRPC’sﬁred strips and the responses to the fast/slow control *** have a pipelined detector data for clusterﬁnding operation,recover(DeMux)the time relationship of which is changed due to the transmission protocol for the continuous incoming MUXed data from *** at each bunch crossing(BX),clusteringﬁred strips that satisfy time and spatial constraints to generate *** incoming raw MUXed detector data and TPs in a time window and latency based on the trigger signal are read out to the DAQ *** ethernet(Gbe)of SiTCP and commercial 10-Gbe are used as link standards for SC and DAQ,respectively,for the BeB to interact with the *** The joint test results of

关键词： CMS iRPC Bee TP DAQ SC

Research and development of the back-end electronics for the two-dimensional improved resistive plate chambers in CMS upgrade

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Radiation Detection Technology and Methods 2021年第2期5卷 181-191页

作者： P.Cao Z-A.Liu J.Zhao H.Kou J.Tao J.Song W.Gong N.Wang A.Samalan M.Tytgat N.Zaganidis G.A.Alves F.Marujo F.Torres.Da.S.ilva.De.Araujo e.M.Da Costa D.De Jesus Damiao H.Nogima A.Santoro S.Fonseca De souza A.Aleksandrov R.Hadjiiska P.Iaydjiev M.Rodozov M.Shopova G.Sultanov M.Bonchev A.Dimitrov L.Litov B.Pavlov P.Petkov A.Petrov S.J.Qian C.Bernal A.Cabrera J.Fraga A.Sarkar S.elsayed Y.Assran M.el Sawy M.A.Mahmoud Y.Mohammed X.Chen C.Combaret M.Gouzevitch G.Grenier I.Laktineh L.Mirabito K.Shchablo I.Bagaturia D.Lomidze I.Lomidze V.Bhatnagar R.Gupta P.Kumari J.Singh V.Amoozegar B.Boghrati M.ebraimi R.Ghasemi M.Mohammadi Najafabadi e.Zareian M.Abbrescia R.Aly W.elmetenawee N.De Filippis A.Gelmi G.Iaselli S.Leszki F.Loddo I.Margjeka G.Pugliese D.Ramos L.Benussi S.Bianco D.Piccolo S.Buontempo A.Di Crescenzo F.Fienga G.De Lellis L.Lista S.Meola P.Paolucci A.Braghieri P.Salvini P.Montagna C.Riccardi P.Vitulo B.Francois T.J.Kim J.Park S.Y.Choi B.Hong K.S.Lee J.Goh H.Lee J.eysermans C.Uribe estrada I.Pedraza H.Castilla-Valdez A.Sanchez-Hernandez C.A.Mondragon Herrera D.A.Perez Navarro G.A.Ayala Sanchez S.Carrillo e.Vazquez A.Radi A.Ahmad I.Asghar H.Hoorani S.Muhammad M.A.Shah I.Crotty Department of Physics and Astronomy Ghent UniversityProeftuinstraat 869000 GhentBelgium Centro Brasileiro Pesquisas Fisicas R.Dr.Xavier Sigaud150-UrcaRio de JaneiroRJ 22290-180Brazil Dep.de Fisica Nuclear e Altas energias Instituto de FisicaUniversidade do Estado do Rio de JaneiroRua Sao Francisco Xavier524BR-Rio de Janeiro 20559-900RJBrazil Bulgarian Academy of Sciences Inst.for Nucl.Res.and Nucl.EnergyTzarigradsko shaussee Boulevard 721784 SofiaBulgaria Faculty of Physics University of Sofia5 James Bourchier Boulevard1164 SofiaBulgaria School of Physics Peking UniversityBeijing 100871China Institute of High energy Physics UCAS/CAS19(B)Yuquan RoadShijingshan DistrictBeijing 100049China Universidad de Los Andes Apartado Aereo 4976Carrera 1Eno.18A 10BogotaCOColombia egyptian Network for High energy Physics Academy of Scientific Research and Technology101 Kasr El-Einy St.CairoEgypt The British University in egypt(BUe) P.O.Box 43Elsherouk CitySuez Desert RoadCairo 11837Egypt Suez University Elsalam CitySuez-Cairo RoadSuez 43522Egypt Department of Physics Faculty of ScienceBeni-Suef UniversityBeni-SuefEgypt Center for High energy Physics Faculty of ScienceFayoum UniversityEl-Fayoum 63514Egypt Univ Lyon Univ Claude Bernard Lyon 1CNRS/IN2P3IP2I LyonUMR 582269622 VilleurbanneFrance Georgian Technical University 77 Kostava Str.Tbilisi 0175Georgia Department of Physics Panjab UniversityChandigarh 160014India School of Particles and Accelerators Institute for Research in Fundamental Sciences(IPM)P.O.Box 19395-5531TehranIran School of engineering Damghan UniversityDamghan ***Iran INFN Sezione di BariVia Orabona 470126 BariItaly INFN Laboratori Nazionali di Frascati(LNF)Via Enrico Fermi 4000044 FrascatiItaly INFN Sezione di NapoliComplesso Univ.Monte S.AngeloVia Cintia80126 NaplesItaly INFN Sezione di PaviaVia Bassi 6PaviaItaly INFN Sezione di Pavia and University of PaviaVia Bassi 6PaviaItaly Hanyang University 222 Wangsimni-roSageun-dongSeongdong

Purpose To complement and ensure redundancy in the endcap muon system of the Compact Muon Solenoid(CMS)detector and to extend the Resistive Plate Chamber(RPC)system coverage,improved RPCs(iRPCs)with either orthogonal layer strips with one-end electronics or single layer strips with two-end electronics providing more precise time measurement will be installed in the very forward pseudorapidity region of|η|eadout system needs to support twodimensional(2D)or two-end *** addition,it must combine detector data with Timing,Trigger and fast Control(TTC)and Slow Control(SC)into one data stream over a bi-directional optical link with a line rate of 4.8 Gb/s between the Front-end electronics(Fee)and the Back-end electronics(Bee).To fulfill these requirements,a prototype Bee for the iRPC 2D chamber has been researched and *** A Micro-Telecommunication and Computing Architecture(μTCA)-based processing card was designed in this study to establish a prototype system together with aμTCA *** Giga-Bit Transceiver(GBT)protocol is integrated to provide bi-directional communication between the Fee and Bee.A server is connected with the Bee by a Gigabit ethernet(Gbe)link for SC and a 10-Gbe link for Data AcQuisition(DAQ).Results The Bit error Rate(BeR)test of the back-end board and a joint test with the iRPC 2D prototype chamber were *** less than 1.331×10−16 was *** timemeasurement with a resolution of 3.05 nswas successfully realized,and detector efficiencies of 97.7%for longitudinal strips and 96.0%for orthogonal strips were *** results demonstrate the correctness and reliability of the prototype *** The Bee prototype satisfies the requirements for the iRPC 2D chamber,and it worked stably and reliably during a long-term joint test run.

关键词： CMS iRPC TTC SC Bee μTCA GBT DAQ