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Preliminary study on overproduction of reactive oxygen species by neutrophils in diabetes mellitus

World Journal of Diabetes 2016年第13期7卷 271-278页

作者： Noridzzaida Ridzuan cini mathew john Pratheep Sandrasaigaran Maryam Maqbool Lee Chuen Liew Jonathan Lim Rajesh Ramasamy Immunology Laboratory Department of PathologyFaculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang 43400 Selangor Malaysia Stem Cell Research Laboratory Genetic and Regenerative Medicine Research Center Faculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang 43400 SelangorMalaysia Department of Physiology and Pharmacology Faculty of Medicine University of Calgary CalgaryAB T2N 4N1 Canada Department of Medicine Faculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang 43400Selangor Malaysia

AIM:To assess the amount and pattern of reactive oxygen species(ROS)production in diabetic patientderived ***:Blood samples from type 2 diabetes mellitus(DM)patients and volunteers(controls)were subjected to neutrophil isolation and the assessment of neutrophil oxidative burst using chemiluminescence *** were activated by using phorbol myristate acetate(PMA)and neutrophils without activation were kept as a negative *** chemilu-minescence readings were obtained by transferring cell suspension into a 1.5 m L Eppendorf tube,with PMA and *** mixtures were gently vortexed and placed inside luminometer for a duration of 5 ***:Our results showed that in the resting condition,the secretion of ROS in normal non-diabetic individuals was relatively low compared to diabetic ***,the time scale observation revealed that the secreted ROS declined accordingly with time in non-diabetic individuals,yet such a reduction was not detected in diabetic patients where at all the time points,the secretion of ROS was maintained at similar *** preliminary study demonstrated that ROS production was significantly higher in patients with DM compared to non-diabetic subjects in both resting and activated ***:The respiratory burst activity of neutrophils could be affected by DM and the elevation of ROS production might be an aggravating factor in diabetic-related complications.

关键词： Neutrophils Diabetes mellitus Reactive oxygen species Chemiluminescence

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