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Age exerts a continuous effect in the outcomes of Asian breast cancer patients treated with breast-conserving therapy

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Cancer Communications 2018年第1期38卷 410-420页

作者： Fuh Yong Wong Wei Ying Tham Wen Long Nei cindy lim Hui Miao Division of Radiation Oncology National Cancer Centre Singapore11 Hospital DriveSingapore 169610Singapore Saw Swee Hock School of Public Health National University of SingaporeSingaporeSingapore

Background:Asians are diagnosed with breast cancer at a younger age than Caucasians *** studied the effect of age on locoregional recurrence and the survival of Asian breast cancer patients treated with breast-conserving ***:Medical records of 2492 patients treated with breast-conserving therapy between 1989 and 2012 were *** Kaplan-Meier method was used to estimate locoregional recurrence,breast cancer-free survival,and breast cancer-specific survival *** rates were then compared using log-rank *** and age were modeled by Cox proportional *** polynomials were then used to test for non-linear relationships between age and ***:Patients≤40 years old were more likely to have locoregional recurrence than were older patients(Hazard ratio[HR]=2.32,P<0.001).Locoregional recurrence rates decreased year-on-year by 4%for patients with luminal-type breast cancers,compared with 8%for those with triple-negative ***,breast cancer-free survival rates increased year-on-year by 4%versus 8%for luminal-type and triple-negative cancers,*** cancer-spe-cific survival rates increased with age by 5%*** breast cancer-free survival and breast cancer-specific survival rates in patients with luminal cancers exhibited a non-linear(“L-shaped”)relationship-where decreasing age at presentation was associated with escalating risks of relapse and *** influence of age on overall survival was confounded by competing non-cancer deaths in older women,resulting in a“U-shaped”***:Young Asian breast cancer patients have a continuous year-on-year increase in rates of disease relapse and cancer deaths compared with older patients with no apparent threshold.

关键词： Breast cancer Breast-conserving therapy Locoregional recurrence Breast cancer-specific survival Breast cancer-free survival Younger age

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年龄对接受保乳治疗的亚洲乳腺癌患者结局的影响呈现连续性

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癌症 2018年第6期37卷 229-239页

作者： Fuh Yong Wong Wei Ying Tham Wen Long Nei cindy lim Hui Miao Division of Radiation Oncology National Cancer Centre Singapore Saw Swee Hock School of Public Health National University of Singapore

背景与目的亚洲人被诊断为乳腺癌的年龄比高加索人年轻。我们研究了年龄对接受保乳治疗的亚洲乳腺癌患者的局部区域复发及生存期的影响。方法分析了1989年至2012年接受保乳治疗的2492例乳腺癌患者的病历。采用Kaplan-Meier法分析了局部... 详细信息

背景与目的亚洲人被诊断为乳腺癌的年龄比高加索人年轻。我们研究了年龄对接受保乳治疗的亚洲乳腺癌患者的局部区域复发及生存期的影响。方法分析了1989年至2012年接受保乳治疗的2492例乳腺癌患者的病历。采用Kaplan-Meier法分析了局部区域复发率、无乳腺癌生存期和乳腺癌特异生存期,log-rank检验进行差异比较。采用Cox比例风险回归模型分析了结局与年龄的关系。分段多项式函数法用于评估年龄与结局之间的非线性关系。结果年龄≤40岁的患者出现局部区域复发的可能性更大(风险比[hazard ratio,HR]=2.32,P<0.001)。管腔型乳腺癌局部区域复发率降低4%,同比三阴性乳腺癌降低8%。与之相似,管腔型和三阴性乳腺癌患者的无乳腺癌生存率分别增加4%和8%。乳腺癌特异生存率随年龄同比增加5%。管腔型乳腺癌患者的无乳腺癌生存率和乳腺癌特异生存率都呈非线性("L型")关系:递减的发病年龄与逐步增加的复发和死亡风险相关。在年老女性中年龄对总生存的影响受到非癌症死亡的混杂,导致"U-型"关系。结论与年老患者相比,年轻亚洲乳腺癌患者的疾病复发率和癌症死亡率呈持续逐年递增趋势,但无明显年龄阈值。

关键词：乳腺癌保乳治疗局部区域复发乳腺癌特异生存期无乳腺癌生存期较年轻

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Prevalence and risk factors of intestinal parasitism among two indigenous subethnic groups in Peninsular Malaysia

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Infectious Diseases of Poverty 2016年第1期5卷 700-714页

作者： Yuee Teng Chin Yvonne Ai Lian lim Chun Wie Chong cindy Shuan Ju Teh Ivan Kok Seng Yap Soo Ching Lee Mian Zi Tee Vinnie Wei Yin Siow Kek Heng Chua Department of Biomedical Science Faculty of MedicineUniversity of Malaya50603 Kuala LumpurMalaysia Department of Parasitology Faculty of MedicineUniversity of Malaya50603 Kuala LumpurMalaysia Department of Life Sciences School of PharmacyInternational Medical University57000 Kuala LumpurMalaysia Department of Medical Microbiology Faculty of MedicineUniversity of Malaya50603 Kuala LumpurMalaysia

Background:Intestinal parasitic infections(IPIs)among indigenous people have been widely documented in Malaysia,however,the prevalence of these infections remains *** the past,most studies have focused on specific species of parasites but polyparasitism has received limited *** addition,epidemiology studies on indigenous people tend to consider them as a homogenous group,whereas in reality different sub-ethnic groups have different cultural and living *** in living habits such as personal hygiene practices may predispose different groups to different parasitic *** better understand prevalence and risk factors of intestinal parasitism among different sub-ethnic groups,the present study was conducted among two sub-ethnic groups of indigenous people(Temuan and Mah Meri)residing in Selangor state,***:A cross-sectional study that focused on two distinct sub-ethnic groups was carried out from February to September *** samples were collected from 186 participants and examined using the formalin-ether sedimentation technique.A molecular approach was adopted to conduct a genetic characterisation of the ***,questionnaires were administered to obtain information on the demographics,socioeconomic backgrounds and behavioural risks relating to the participants,as well as information about their *** analyses(*** and multivariate logistic regression analyses)were performed to measure risk ***:For Temuan communities,trichuriasis(64.2%)was the most common infection found,preceding hookworm infection(34%),ascariasis(7.5%),giardiasis(14.2%)and amoebiasis(7.5%).As for the Mah Meri communities,trichuriasis(77.5%)prevailed over ascariasis(21.3%),hookworm(15%),giardiasis(7.5%)and amoebiasis(3.8%).Significant differences in proportions of trichuriasis,ascariasis and hookworm infections were observed between the Temuan and Mah Meri sub-ethnic *** was more

关键词： Intestinal parasites Intestinal parasitism Indigenous people Risk factors Prevalence Sub-ethnic group Temuan sub-ethnic group Mah Meri sub-ethnic group Peninsular Malaysia

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Alanine aminotransferase is an inadequate surrogate marker for detecting lamivudine resistance

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World Journal of Gastroenterology 2010年第37期16卷 4691-4696页

作者： Lee Guan lim Myat Oo Aung Bee Leng Seet cindy Tan Yock Young Dan Yin Mei Lee Dede Selamat Sutedja Mark Fernandes Guan Huei Lee Evelyn Koay Seng Gee lim Department of Gastroenterology and Hepatology National University Health System Yong Yoo Lin School of Medicine National University of Singapore Department of Medicine National University Health System Yong Yoo Lin School of Medicine National University of Singapore Molecular Diagnostic Centre National University Health System Yong Yoo Lin School of Medicine National University of Singapore Investigative Medicine Unit National University Health System Yong Yoo Lin School of Medicine National University of Singapore

AIM: To investigate the accuracy of serum alanine aminotransferase (ALT) in diagnosing lamivudine resistance and factors that contributed to abnormal serum ***: This was a retrospective study of chronic hepatitis B patients on lamivudine therapy who were followed for 3-mo with liver function tests and hepatitis B virus (HBV) DNA measurement. Lamivudine resistance was defined as HBV DNA ≥ 1 log from nadir on at least 2 occasions, confirmed by genotyping. Serum ALT levels in patients with lamivudine resistance were compared to serum ALT levels in those without lamivudine resistance. RESULTS: There were 111 patients with and 117 without lamivudine resistance. The area under the receiver operating characteristic of serum ALT to diagnose lamivudine resistance was 0.645 ± 0.037. Serum ALT > 42.5 U/L gave the best diagnostic accuracy with sensitivity = 61%, specificity = 60%, positive predictive value = 60%, negative predictive value = 61%, positive likelihood ratio = 1.53 and negative likelihood ratio = 0.65 for predicting lamivudine resistance, missing 39% of resistant patients. Using other serum ALT cutoffs, diagnostic accuracy was lower. By multivariate analysis, baseline abnormal serum ALT was associated with abnormal ALT during resistance (OR = 5.98, P = 0.003), and males were associated with serum ALT flares during resistance (OR = 8.9, P = 0.016). CONCLUSION: Serum ALT is inadequate for diagnosing lamivudine resistance and has implications where viral resistance testing is suboptimal and for reimbursement of rescue therapy.

关键词： Antiviral therapy Chronic hepatitis B Sensitivity Specificity YMDD mutants

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