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SPIRITS OF A KINDRED

The World of Chinese 2020年第3期 66-69页

作者： cindy liu 不详

With Teochew opera blaring through crackling speakers and throngs of spectators gathered around him,Ly stands motionless with three sticks of incense raised to his forehead at the altar of the Sam Ourng Temple,waiting... 详细信息

关键词： speakers raised opera

面向软件工业培养创造型实用人才——都柏林理工学院计算机学院的实践概述

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计算机教育 2003年第1期 66-68页

作者： BrendanO’Shea Bing Wu cindy liu 爱尔兰都柏林理工学院计算机学院

学院可以自豪的宣称,也许单个老师不能回答学生的某一个最新技术问题,但学生一定能从学院得到问题的答案。

关键词：经济发展软件工业软件出口爱尔兰都柏林发达国家美国学院实用人才创造

Messages from CEISEE 2023 Committee

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计算机教育 2023年第12期 1-1页

作者： Xiaofei Xu Bing Wu Bing Li Luciano Baresi Wei Lu Rong Peng Yves Ducq Jifeng Xuan cindy liu Weiwei Xing Xiaoyuan Xie Peng Liang 不详

The China-Europe International Symposium on Software Engineering Education(CEISEE)is an international educational conference jointly initiated by Harbin Institute of Technology and Technological University Dublin in *** CEISEE is held alternately in China and Europe every *** host cities include Harbin,Dublin in Ireland,Guangzhou,Bordeaux in France,Xi’an,Northampton in the United Kingdom,Shanghai,Milan in Italy,Chengdu,Zwikau in Germany,Shenyang,Athens in Greece,Shenzhen,Lisbon in Portugal,Beijing,and Wuhan in *** conference has been gaining increasing international influence.

关键词： Dublin jointly initiated

Bio-modulation of scaring Glaucoma Filtration Surgery using a novel application of coated magnesium

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Journal of Magnesium and Alloys 2021年第3期9卷 883-894页

作者： Xiangji Li Richard Filek Xiaomin Zhu Huanhuan Gao Liying Qiao Hong liu Lin Xie Yong Wang Fusheng Pan cindy ML Hutnik Department of Ophthalmology Institute of Surgery ResearchDaping HospitalArmy Medical UniversityChongqing 400042China Department of Ophthalmology Western UniversityIvey Eye InstituteSt.Joseph's Health Care LondonLondonONCanada Department of Ophthalmology The Third Affiliated HospitalChongqing Medical UniversityChongqing 400016China Collage of Material Science&Engineering Chongqing UniversityChongqing 400045China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400045China

Filtration surgery still plays a mainstream role of treatment for *** scarring is the main cause of surgical *** study evaluated the biocompatibility and anti-proliferative properties of pure magnesium with three different coatings,which are hydroxyapatite(HA),dicalcium phosphate dihydrate(DCPD)and DCPD+stearic acid(SA),in a primary culture of human tenon's capsule fibroblasts(HTCFs)and in rabbit Glaucoma Filtration *** and glass were used as controls in vitro,and trabeculectomy was used as control in *** results show the number and shape of HTCFs seeded on different coatings showed less quantity and poor cell *** type of coated magnesium demonstrated significantly decreased metabolic activity of ***+SA showed higher cytotoxicity than the other *** inhibition of proliferation was observed with the DCPD+SA *** expression ofα-SMA was decreased in the cells when seeded on all of the coated magnesium *** vivo,no obvious adverse effects were observed after *** significant difference existed for any of the different samples regarding different ion concentrations in the aqueous *** inflammatory response in the titanium,DCPD and DCPD+SA treated eyes was more intense than in the trabeculectomy alone and HA *** Blot analysis showed that collagen-1 andα-SMA expression was significantly lower in the titanium,HA,DCPD and DCPD+SA groups compared with the *** coatings on magnesium were able to affect the corrosive properties,which in turn,influenced the morphology and function of *** coated magnesium may be considered a very promising biodegradable material for the next generation of glaucoma drainage devices.

关键词： Glaucoma Glaucoma drainage device Fibrosis Tenon's capsule fibroblasts Magnesium Coating

A feasibility study of using biodegradable magnesium alloy in glaucoma drainage device

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International Journal of Ophthalmology(English edition) 2018年第1期11卷 135-142页

作者： Xiang-Ji Li Lin Xie Fu-Sheng Pan Yong Wang Hong liu Yu-Rong Tang cindy-ML Hutnik Department of Ophthalmology University of Western Ontario Ivey Eye Institute St.Joseph's Hospital Department of Ophthalmology Institute of Surgery ResearchDaping Hospital Third Military Medical University Collage of Material Science & Engineering ChongqingUniversity National Engineering Research Center for Magnesium Alloys Chongqing University Department of Ophthalmology People's Hospital Zhongshan Branch

Technological advances in glaucoma have challenged the traditional treatment paradigm. Historically incisional surgery has been used in cases of advanced disease and/or uncontrolled intraocular pressures resistant to medical or laser interventions. More recently, perhaps due to advancements in imaging, surgery has been suggested to be beneficial earlier in the treatment paradigm. Despite these trends, surgical manipulation of the tissues and unpredictability of wound healing continue to result in surgical failure. Magnesium is an essential element for human body and plays a critically important role in maintaining the functional and structural integrity of several tissues, including the eye. Due to several of its advantageous properties such as non-toxicity, biodegradability, and high biological compatibility, magnesium alloy has attracted great attention as a novel biomaterial. Biodegradable cardiovascular stents made of magnesium alloy have already been introduced into clinical practice. The purpose of this review is to determine if bioabsorbable magnesium alloys can be utilized as a promising candidate for the development of a new generation of glaucoma surgical assistive devices.

关键词： glaucoma glaucoma drainage implant magnesium alloy anti-scarring

Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development

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Acta Pharmaceutica Sinica B 2022年第6期12卷 2751-2777页

作者： Yurong Lai Xiaoyan Chu Li Di Wei Gao Yingying Guo Xingrong liu Chuang Lu Jialin Mao Hong Shen Huaping Tang cindy Q.Xia Lei Zhang Xinxin Ding Drug Metabolism Gilead Sciences Inc.Foster CityCA 94404USA Department of Pharmacokinetics Pharmacodynamics and Drug MetabolismMerck&Co.Inc.KenilworthNJ 07033USA Pharmacokinetics Dynamics and MetabolismPﬁzer Worldwide Research and DevelopmentGrotonCT 06340USA Eli Lilly and Company IndianapolisIN 46221USA Drug Metabolism and Pharmacokinetics BiogenCambridgeMA 02142USA Drug Metabolism and Pharmacokinetics Accent TherapeuticsInc.LexingtonMA 02421USA Department of Drug Metabolism and Pharmacokinetics GenentechA Member of the Roche GroupSouth San FranciscoCA 94080USA Drug Metabolism and Pharmacokinetics Department Bristol-Myers Squibb CompanyPrincetonNJ 08540USA Bioanalysis and Biomarkers Glaxo Smith KlineKing of the PrussiaPA 19406USA Department of Drug Metabolism and Pharmacokinetics Takeda Pharmaceuticals International Co.CambridgeMA 02139USA Ofﬁce of Research and Standards Ofﬁce of Generic DrugsCDERFDASilver SpringMD 20993USA Department of Pharmacology and Toxicology College of PharmacyUniversity of ArizonaTucsonAZ 85721USA Current afﬁliation:Translational Medicine EMD Serono Research&Development InstituteInc.BillericaMA 01821USA Current afﬁliation:Drug Metabolism Gilead Sciences Inc.Foster CityCA 94404USA

Drug metabolism and pharmacokinetics(DMPK) is an important branch of pharmaceutical *** nature of ADME(absorption,distribution,metabolism,excretion) and PK(pharmacokinetics) inquiries during drug discovery and development has evolved in recent years from being largely descriptive to seeking a more quantitative and mechanistic understanding of the fate of drug candidates in biological *** progress has been made in the past decade,not only in the characterization of physiochemical properties of drugs that influence their ADME,target organ exposure,and toxicity,but also in the identification of design principles that can minimize drug-drug interaction(DDI) potentials and reduce the *** importance of membrane transporters in drug disposition,efficacy,and safety,as well as the interplay with metabolic processes,has been increasingly *** increases in investments on new modalities beyond traditional small and large molecule drugs,such as peptides,oligonucleotides,and antibody-drug conjugates,necessitated further innovations in bioanalytical and experimental tools for the characterization of their ADME *** this review,we highlight some of the most notable advances in the last decade,and provide future perspectives on potential major breakthroughs and innovations in the translation of DMPK science in various stages of drug discovery and development.

关键词： Drug discovery and development New drug application Biologics license application Pharmacokinetics ADME New modalities Model-informed drug development Micro-physiological systems

管理研究中理论构建与理论检验水平的变化趋势：基于《美国管理学会学报》50年历程的分析

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管理世界 2011年第6期27卷 152-164页

作者： JASON A.COLQUITT cindy P.ZAPATA-PHELAN 张杨刘宝宏王慧佛罗里达大学东北财经大学工商管理学院

为考察实证论文的理论贡献,本文提出了一种包含理论构建与理论检验两个维度的分类方法。利用该分类法,本文追踪了过去50年中实证论文对理论贡献的变化趋势。以《美国管理学会学报》(AMJ)75期论文为样本数据的研究结果显示,理论构建与理... 详细信息

为考察实证论文的理论贡献,本文提出了一种包含理论构建与理论检验两个维度的分类方法。利用该分类法,本文追踪了过去50年中实证论文对理论贡献的变化趋势。以《美国管理学会学报》(AMJ)75期论文为样本数据的研究结果显示,理论构建与理论检验水平随时间推移呈上升趋势。此外,论文的理论构建与检验水平是其引用率的显著预测变量。尤其是,当两个维度都呈中高水平时,论文的引用率最高。

关键词：检验水平管理研究学报学会美国年历理论贡献两个维度

A Novel,Monomeric C18 Bonded Phase for High-Resolution Peptide Separations

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A Novel,Monomeric C18 Bonded Phase for High-Resolution Pepti...

8th Chinese International Peptide Symposium

作者： Reno NGUYEN cindy Lou CHEPANOSKE Nathan VerBERKMOES Michael B.STRADER Larry GROSS Grace Vydac Prolexys Pharmaceuticals Chemical Sciences Division Oak Ridge National Laboratory Howard Hughes Medical Institute University of California San Diego

The separation of protein enzymatic digests by RPHPLC is a standard method in protein research and in the development of well-characterized biotechnology pharmaceuticals. Resolution on silicabased RP columns is determined by the nature of the silica, as well as, the silanes and the chemistry that is used to bond them to the stationary phase. Typically, 300A C18 chemistries have carbon coverage ranging from 2.8 to 3.6 μmol/m2. The performance of a novel, monomeric bonded 300A C18 adsorbent with carbon coverage > 4 μmol/m2 is described. The resolution and sensitivity of this stationary phase was assessed using an LC-MS/MS analysis of several tryptic digests including: di

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高嫁还是低娶?人民公园的玻璃标尺

中华女子学院学报 2023年第1期35卷 12-22页

作者：计迎春刘岳范芝芬上海大学社会学院 200444 美国加州大学洛杉矶分校地理学系

我国正在从早婚普婚的社会向晚婚非普婚社会过渡,与此同步,教育也出现了性别差距逆转。在此背景下,我们对上海市人民公园相亲角为子女寻觅配偶的父母展开调查,探索女性向上婚传统规范的延续和变迁。研究发现,传统女性向上婚规范已经发... 详细信息

我国正在从早婚普婚的社会向晚婚非普婚社会过渡,与此同步,教育也出现了性别差距逆转。在此背景下,我们对上海市人民公园相亲角为子女寻觅配偶的父母展开调查,探索女性向上婚传统规范的延续和变迁。研究发现,传统女性向上婚规范已经发生松动,一方面男女双方体现了既传统又现代的杂糅观念;另一方面,这种松动在性别维度上具有不平衡和不对称性。男方家长似乎手持玻璃标尺:希望一定程度上维持传统性别规范,对女方公私领域的成就、责任和角色定位有相对严苛的要求。女方家长对于传统性别角色期待有更多的反思和宽容度,对于男方的教育、经济以及提供婚房惯例的要求均有大幅松动,并更为多元化。维持女性向上婚传统规范的动力更多来自男方对女性传统的顺从、弱势角色的要求,而非女方对男性财富和地位的追求。提倡平等、现代的伴侣关系,增加对于非传统婚配模式的包容,对于缓解全社会婚育压力、促进社会平等和共同富裕,有着重大而长远的意义。

关键词：向上婚规范玻璃标尺马赛克现代性相亲角代际关系