检索结果-南通市图书馆

FOLFIRI regimen in metastatic pancreatic adenocarcinoma resistant to gemcitabine and platinum-salts

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第33期18卷 4533-4541页

作者： cindy Neuzillet Olivia Hentic Benot Rousseau Vinciane Rebours Léla Bengrine-Lefèvre Franck Bonnetain Philippe Lévy Eric Raymond Philippe Ruszniewski Christophe Louvet Pascal Hammel Service de Gastroentérologie-Pancréatologie Hpital Beaujon 100 Boul-evard du Général Leclerc 92110 Clichy La Garenne AP-HP France Service d'Oncologie Médicale Hpital Saint Antoine 184 Rue du Faubourg Saint-Antoine 75012 Paris AP-HP France Unité de Biostatistique et d'Epidémiologie EA 4184 Centre Georges Franois Leclerc 1 Rue du Pr Marion 21079 Dijon France Service d'Oncologie Médicale Hpital Beau-jon 100 Boulevard du Général Leclerc 92110 Clichy La Garenne AP-HP France Département d'Oncologie Médicale Institut Mutualiste Montsouris 42 Boulevard Jourdan 75014 Paris France

AIM: To evaluate the efficacy and safety of the FOLFIRI regimen in patients with metastatic pancreatic adenocarcinoma (PAC) after the failure of gemcitabine and platinum salts. METHODS: All consecutive patients with histologically confirmed, metastatic PAC and World Health Organiza-tion performance status (PS) ≤ 2 received FOLFIRI-1 [irinotecan 180 mg/m2 on day 1 and leucovorin 400 mg/m2 followed by 5-fluorouracil (5-FU) 400 mg/m2 bolus, then 5-FU 2400 mg/m2 as a 46-h infusion, biweekly] or FOLFIRI-3 (irinotecan 100 mg/m2 on day 1 and leucovorin 400 mg/m2, then 5-FU 2400 mg/m2 as a 46-h infusion and irinotecan 100 mg/m2 repeated on day 3, biweekly) after failure of gemcitabine and platinum-based chemotherapies as a systematic policy in two institutions between January 2005 and May 2010. Tumor response, time to progression (TTP), overall survival rate (OS) and grade 3-4 toxicities were retrospectively studied. Subgroup analyses were performed to search for prognostic factors. RESULTS: Sixty-three patients (52.4% male, median age 59 years) were analyzed. Among them, 42.9% were PS 0, 38.1% were PS 1 and 19.0% were PS 2. Fifty one patients (81.0%) had liver metastases. Before the FOLFIRI regimen, patients had received 1 line (n = 19), 2 lines (n = 39) or 3 lines (n = 5) of chemotherapy. Median TTP obtained with the line before FOLFIRI was 3.9 mo (95% CI: 3.4-5.3 mo). A total of 480 cycles was completed (median: 6 cycles, range: 1-51 cycles). The main reason for discontinuing FOLFIRI was tumor progression (90.3%). Tumor control was achieved in 25 patients (39.7%) (partial response: n = 5, stable disease: n = 20) with FOLFIRI. Median TTP was 3.0 mo (95% CI: 2.1-3.9 mo) and median OS was 6.6 mo (95% CI: 5.3-8.1 mo). Dose adaptation was required in 36 patients (57.1%). Fifteen patients (23.8%) had grade 3-4 toxicities, mainly hematological (n = 11) or digestive (n = 4). Febrile neutropenia occurred in 3 patients. There was no toxic death. PS 2 was significantly associated w

关键词：转移性胰腺癌铂盐治疗 5-FU 亚叶酸钙中性粒细胞 TTP

Effects of climate change on potential habitats of the cold temperate coniferous forest in Yunnan province, southwestern China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2016年第8期13卷 1411-1422页

作者： LIWang-jun PENG Ming-chun Motoki HIGA Nobuyuki TANAKA Tetsuya MATSUI cindy Q. TANG OU Xiao-kun ZHOU Rui-wu WANG Chong-yun YAN Hai-zhong Institute of Ecology and Geobotany Yunnan University Kunming 650091 China Kochi University Kochi-shi Kochi 780-8520 Japan Forestry and Forest Products Research Institute 1 Matsunosato Tsukuba Ibaraki 305-8687 Japan Tokyo University of Agriculture 1-1-1 Sakuragaoka Setagaya-ku Tokyo 156-8502 Japan

We built a classification tree(CT) model to estimate climatic factors controlling the cold temperate coniferous forest(CTCF) distributions in Yunnan province and to predict its potential habitats under the current and future climates, using seven climate change scenarios, projected over the years of 2070-2099. The accurate CT model on CTCFs showed that minimum temperature of coldest month(TMW) was the overwhelmingly potent factor among the six climate variables. The areas of TMW<-4.05 were suitable habitats of CTCF, and the areas of -1.35 < TMW were non-habitats, where temperate conifer and broad-leaved mixed forests(TCBLFs) were distribute in lower elevation, bordering on the CTCF. Dominant species of Abies, Picea, and Larix in the CTCFs, are more tolerant to winter coldness than Tsuga and broad-leaved trees including deciduous broad-leaved Acer and Betula, evergreen broadleaved Cyclobalanopsis and Lithocarpus in TCBLFs. Winter coldness may actually limit the cool-side distributions of TCBLFs in the areas between -1.35°C and -4.05°C, and the warm-side distributions of CTCFs may be controlled by competition to the species of TCBLFs. Under future climate scenarios, the vulnerable area, where current potential(suitable + marginal) habitats(80,749 km^2) shift to nonhabitats, was predicted to decrease to 55.91%(45,053 km^2) of the current area. Inferring from the current vegetation distribution pattern, TCBLFs will replace declining CTCFs. Vulnerable areas predicted by models are important in determining priority of ecosystem conservation.

关键词：寒温带针叶林气候变化云南省生境中国阔叶树种植被分布格局生态系统保护

Connexin therapeutics:blocking connexin hemichannel pores is distinct from blocking pannexin channels or gap junctions

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第3期16卷 482-488页

作者： Monica L.Acosta Mohd N.Mat Nor cindy X.Guo Odunayo O.Mugisho Frazer P.Coutinho Ilva D.Rupenthal Colin R.Green School of Optometry and Vision Science University of AucklandAucklandNew Zealand Faculty of Medicine Universiti Sultan Zainal AbidinTerengganuMalaysia Department of Ophthalmology University of AucklandAucklandNew Zealand Buchanan Ocular Therapeutics Unit Department of OphthalmologyAucklandNew Zealand New Zealand National Eye Centre University of AucklandAucklandNew Zealand Centre for Brain Research Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Brain Research New Zealand–Rangahau Roro Aotearoa AucklandNew Zealand

Compounds that block the function of connexin and pannexin protein channels have been suggested to be valuable therapeutics for a range of *** of these compounds are now in clinical trials,but for many of them,the literature is inconclusive about the molecular effect on the tissue,despite evidence of functional *** the different channel types has distinct physiological and pathological implications and this review describes current knowledge of connexin and pannexin protein channels,their function as channels and possible mechanisms of the channel block effect for the latest therapeutic *** summarize the evidence implicating pannexins and connexins in disease,considering their homeostatic versus pathological roles,their contribution to excesive ATP release linked to disease onset and progression.

关键词： connexin gap junction gap19 hemichannel pannexin retina tonabersat

Interprofessional education development: A road map for getting there

在线全文

学校读者我要写书评

暂无评论

Open Journal of Nursing 2013年第3期3卷 323-329页

作者： Yondell Masten cindy Acton Alyce Ashcraft Christina Esperat Faculty of Texas Tech University Health Sciences Center School of Nursing Lubbock USA

Improvement of relationships among health clinicians is important for reducing adverse clinical outcomes. To improve clinician relationships, the relationship development process is best initiated during health professional education, rather than “refitting” the interrelationship model learned during the health education process. While Interprofessional Education (IPE) has been identified as an effective model to fill the gap for both education and practice, IPE requires moving to an integrative curricular approach with a strong practice component. As a developmental process, IPE implementation faces challenges at every stage. The Interprofessional Education Development: The Roadmap for Getting There article describes the five stages of IPE, discusses important components of creating an IPE culture, suggests strategies for overcoming the challenges for each stage, and describes signs related to achievement of the five developmental stages of IPE.

关键词： Interprofessional Education

印尼学生非疑问句中“啊”“吧”“呢”的偏误研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

印尼学生非疑问句中“啊”“吧”“呢”的偏误研究

作者： cindy Claudia Agustiani（朱雅梅）上海外国语大学

学位级别：硕士

语气词为汉语表情达意起到了很好的作用,却为外国学生习得汉语带来一些困难,成为了印尼学生习得汉语的难点之一。我们认为尽早研究并解决其中的偏误问题十分必要。本文对中高级水平印尼学生在汉语非疑问句中使用语气词“啊”“吧”“呢... 详细信息

语气词为汉语表情达意起到了很好的作用,却为外国学生习得汉语带来一些困难,成为了印尼学生习得汉语的难点之一。我们认为尽早研究并解决其中的偏误问题十分必要。本文对中高级水平印尼学生在汉语非疑问句中使用语气词“啊”“吧”“呢”的偏误情况进行研究,同时通过访谈学生了解目前语气词教学情况,为印尼学生学习汉语语气词提供有针对性的学习策略和教学建议。本文以116名中高级水平在华印尼留学生为研究对象,通过问卷共收集了1477条偏误语料。调查结果显示,中高级水平印尼学生对语气词“吧”的掌握最好,对“啊”和“呢”的掌握有待加强。学生最容易对“啊”和“呢”之间用法产生混淆,最不容易对“吧”和“呢”产生混淆。学生有较强的使用语气词“啊”的倾向,尤其在句内误代“吧”,以及在陈述句末尾误代“吧”和“呢”。在陈述句末尾,学生有一定的回避使用“呢”的倾向。学生产生的偏误主要可分为四种偏误类型,即误代、误加、遗漏以及结构的偏误,其中误代偏误的比例最高。进过分析,本文认为学生偏误形成的主要原因有:语气词用法复杂,不容易全面掌握;忽视影响语气词使用的因素;母语负迁移的作用。为减少偏误的产生,我们认为在教授“啊”“吧”“呢”在非疑问句中的用法时,教师应该有意识地:运用翻译法时提醒学生注意汉语和印尼语语气词的差异;提醒学生注意使用语气词的格式、以及副词等影响语气词使用的因素;除了课文意外,补充日常生活、学习的语境操练语气词;讲解语气词之间的区别,有针对性地进行操练。我们也在本文的第五章中对相关教学设想举例说明。

关键词：语气词偏误研究印尼学生

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

省际间人口迁移流动及原因探析

人口学刊 2009年第5期31卷 50-53页

作者：王化波 C. cindy Fan 吉林大学东北亚研究院吉林长春130012 加州大学洛杉矶分校地理系

按照户籍人力资本净流入和非户籍人力资本净流入的正负,把全国31个省、市、自治区分为四种类型,每一种类型的地区都有着各自的特点。多元回归分析的结果表明,人均国内生产总值增长率和每千人卫生技术人员数对户籍人力资本净流入有显著影... 详细信息

按照户籍人力资本净流入和非户籍人力资本净流入的正负,把全国31个省、市、自治区分为四种类型,每一种类型的地区都有着各自的特点。多元回归分析的结果表明,人均国内生产总值增长率和每千人卫生技术人员数对户籍人力资本净流入有显著影响,城镇职工平均工资对非户籍人力资本净流入和总人力资本净流入影响显著,而外商直接投资及其他投资又是决定职工平均工资的主要因素。

关键词：户籍非户籍人力资本净流入

Essentials of medical transcription : a modular approach 2nd ed.

在线全文

学校读者我要写书评

暂无评论

Active Learning Improves Nursing Student Clinical Performance in an Academic Institution in Macao

2004年

作者： Destafano cindy.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Chinese Nursing Research 2015年第3期2卷 108-115页

作者： cindy Sin U Leong Lynn B.Clutter School of Health Sciences Macao Polytechnic Institute School of Nursing Colleqe of Health Saence The University of Tulsa

Objective： To assess the outcome of the application of active learning during practicum among nursing students using clinical assessment and evaluation scores as a measurement. Methods： Nursing students were instructed on the basics of active learning prior to the initiation of their clinical experience. The participants were divided into 5groups of nursing students （ n = 56） across three levels （years 2-4） in a public academic institute of a bachelor degree program in Macao. Final clinical evaluation was averaged and compared between groups with and without intervention. Results： These nursing students were given higher appraisals in verbal and written comments than previous students without interventian. The groups with the invention achieved higher clinical assessment and evaluation scores on average than comparable groups without the active learning intervention. One group of sophomore nursing students （year 2） did not receive as high of evaluations as the other groups, receiving an average score of above 80. Conclusions＂ Nursing students must engage in active learning to demonstrate that they are willing to gain knowledge of theory, nursing skills and communication skills during the clinical practicum.

关键词： Active learning Clinical competence Nursing students

Comparison between empirical prokinetics, Helicobacter test-and-treat and empirical endoscopy in primary-care patients presenting with dyspepsia: A one-year study

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第31期12卷 5010-5016页

作者： Wayne HC Hu SK Lam cindy LK Lam WM Wong KF Lam KC Lai YH Wong Benjamin CY Wong Annie OO Chan CK Chan Gabriel M Leung WM Hui Department of Medicine University of Hong Kong Hong Kong China Department of Statistics and Actuarial Science University of Hong Kong Hong Kong China Department of Community Medicine University of Hong Kong Hong Kong China

瞄准：调查最佳的策略在主要照顾对待消化不良的病人。方法：介绍给主要照顾门诊病人诊所的消化不良的病人随机被分到：(1 ) 实验内视镜检查法，(2 ) H pylori test-and-treat，并且(3 ) 实验专业版有 cisapride 的运动治疗。如果病人们... 详细信息

瞄准：调查最佳的策略在主要照顾对待消化不良的病人。方法：介绍给主要照顾门诊病人诊所的消化不良的病人随机被分到：(1 ) 实验内视镜检查法，(2 ) H pylori test-and-treat，并且(3 ) 实验专业版有 cisapride 的运动治疗。如果病人们在 2 wk 以后仍然保持征兆，早内视镜检查法被安排。症状严厉， quality-of-life (SF-36 ) 以及耐心的偏爱和满足被估计。所有病人由 wk 经历了内视镜检查法 6。病人们被跟随在上面为一年。结果：二百和三十四个病人被招募(163 女、吝啬的年龄 49 ) 。46% 是 H pylori 积极。测试的 26% H pylori 和运动病人显示出的 25% 实验专业版在 wk 的没有改进 2 后续和需要的早内视镜检查法。收到实验 cisapride 的 15% 病人对治疗作出回应很好，但是消化性溃疡是最后的诊断。症状分辨率和 quality-of-life 在这些组之中是类似的。为三策略的费用是每病人的 HK 美元 4343，美元 1771 和美元 1750。66% 病人喜欢有早内视镜检查法。结论：三策略是同等地有效的。实验专业版运动治疗是最不昂贵的，但是消化性溃疡可以与这治疗被错过。H pylori test-and-treat 是最划算的选择。

关键词：幽门螺杆菌内窥镜消化不良实验治疗