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A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

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Military Medical Research 2024年第2期11卷 228-267页

作者： Miguel A.Ortega Oscar Fraile-Martinez cielo garcía-montero Sergio Haro Miguel Ángel Álvarez-Mon Diego De Leon-Oliva Ana M.Gomez-Lahoz Jorge Monserrat Mar Atienza-Pérez David Díaz Elisa Lopez-Dolado Melchor Álvarez-Mon Department of Medicine and Medical Specialities University of Alcala28801 Alcala de HenaresSpain Ramón y Cajal Institute of Sanitary Research(IRYCIS) 28034 MadridSpain Department of Psychiatry and Mental Health Hospital Universitario Infanta Leonor28031 MadridSpain Service of Rehabilitation National Hospital for Paraplegic PatientsCarr.de la PeraledaS/N45004 ToledoSpain Immune System Diseases‑Rheumatology Service and Internal Medicine University Hospital Príncipe de Asturias(CIBEREHD)28806 Alcala de HenaresSpain

Spinal cord injury(SCI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage(secondary injury).The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after SCI,explaining the progression and detrimental consequences related to this condition.Psychoneuroimmunoendocrinology(PNIE)is a growing area of research aiming to integrate and explore the interactions among the different systems that compose the human organism,considering the mind and the body as a whole.The initial traumatic event and the consequent neurological disruption trigger immune,endocrine,and multisystem dysfunction,which in turn affect the patient's psyche and well-being.In the present review,we will explore the most important local and systemic consequences of SCI from a PNIE perspective,defining the changes occurring in each system and how all these mechanisms are interconnected.Finally,potential clinical approaches derived from this knowledge will also be collectively presented with the aim to develop integrative therapies to maximize the clinical management of these patients.

关键词： Spinal cord injury(SCI) Psychoneuroimmunoendocrinology(PNIE) Secondary injury Immunoinflammatory dysfunction Gut microbiota Translational opportunities

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迭层材料的光声与光热检测

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无损检测 1990年第5期12卷 147-149页

作者： P. cielo 陈焕林

光声和光热无损检测技术是一种用于检测某些工业材料的脱颖而出的方法。本文主要讨论宇航工业广泛应用的铝-环氧树脂和石墨-环氧树脂迭层以及冶金涂敷材料。这些材料在制作以后通常是应用超声波检测和射线照相技术检测分层的。光学技术... 详细信息

光声和光热无损检测技术是一种用于检测某些工业材料的脱颖而出的方法。本文主要讨论宇航工业广泛应用的铝-环氧树脂和石墨-环氧树脂迭层以及冶金涂敷材料。这些材料在制作以后通常是应用超声波检测和射线照相技术检测分层的。光学技术则是另一种方法,因为这种方法在大的表面上容易扫描,无需与检测表面接触,所以能在有害的和需遥控定位的环境下推广应用。本文描述了用光声和光热方法检测层状材料的一些应用。

关键词：光声检测光热检测迭层材料

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Evaluation of Self-Treatment of Acne Using Silk’n Blue Phototherapy System

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Journal of Cosmetics, Dermatological Sciences and Applications 2014年第3期4卷 179-184页

作者： Judith Hellman cielo A. Ramirez Mt. Sinai Hospital New York USA

Background: At-home phototherapy devices for the treatment of acne have emerged as an appealing treatment option and as an effective adjunct treatment to existing modalities. The principal goal of the study was to determine the changes in the number of inflammatory lesions in acne patients. Methods: Patients received instruction for daily at-home use of Silk’n Blue device for 12 weeks. Follow-up visits were conducted at 1 and 3 months to collect data. Results: Fifteen subjects with mild to severe cases experienced improvement over the course of the trial. The decrease in mean inflammatory acne counts (from 41.26 to 24.46) and mean percent reduction (41.8%) were statistically significant (p < 0.001). Some participants experienced percent reductions as great as 67%. No adverse events were recorded. Conclusions: The Silk’n Blue device is a safe and effective modality for at-home treatment of mild, moderate, and severe inflammatory acne vulgaris with proper use.

关键词： Acne Blue Light Therapy LED Phototherapy

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