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中国口腔医学继续教育杂志 2019年第6期22卷 368-375页

作者： cibele Nasri-Heri Diana Shigdar Deyaaeddin.Alnaas Olga Anna Korczeniewska Rotem Eliav Gary M.Heir 赵伟威(译) 韩莹(审) 不详北京大学口腔医院北京市海淀区100081

原发性灼口综合征(primary burning mouth syndrome,BMS)是一种慢性灼伤性疼痛,影响舌头和口腔黏膜。目前,还没有明确的诊断标准;因此,诊断是通过排除潜在的局部和系统的可以导致烧灼感的原因。原发性BMS的病因尚不清楚;然而,原发性BMS... 详细信息

原发性灼口综合征(primary burning mouth syndrome,BMS)是一种慢性灼伤性疼痛,影响舌头和口腔黏膜。目前,还没有明确的诊断标准;因此,诊断是通过排除潜在的局部和系统的可以导致烧灼感的原因。原发性BMS的病因尚不清楚;然而,原发性BMS与神经性疼痛相关是最易被接受的理论。本文综述了BMS的诊断、机制和治疗,重点介绍了BMS与疼痛模型的关系。初步数据表明,原发性BMS和一个错误的抑制疼痛系统之间存在联系。

关键词：灼口综合征疼痛模型诊断标准神经性疼痛口腔黏膜初步数据文献综述 BMS

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Meat Quality Parameters and the Effects of Stress: A Review

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Journal of Agricultural Science and Technology(B) 2019年第5期9卷 305-315页

作者： Tatiany Carvalho dos Santos Richard Stephen Gates Cecília de Fátima Souza Ilda de Fátima Ferreira Tinoco Márcia Gabrielle Lima Candidoand Letícia cibele da Silva Ramos Freitas Department of Agricultural Engineering Federal University of VicosaVicosaMinas Gerais 36570-9000Brazil Department of Agricultural and Biological Engineering University of Illinois at Urbana-ChampaignUrbanaIllinois 61801United States

The objective of this review was to address the stress effects on meat quality considering the main attributes that involve meat *** protein production has been increasing with global demand for meat with meat quality a major concern,especially for more demanding consumers who are looking for quality products to meet their *** quality of the meat is the result of what happened to the animal throughout the production chain,that is,good rearing conditions result in a better meat *** types of stress can be harmful to animals due to inadequate or improper animal handling on farms,inadequate transport conditions,poorly maintained trucks and roads,and conditions that agitate animals can lead to bruising,thermal *** stress in animals occurs when they are in adverse conditions and can significantly compromise meat quality *** an example,stress can significantly affect meat quality parameters as drip loss(DL),meat color,change ultimate pH and cause meat *** the main parameters of evaluation used for meat quality are color,characterized by luminosity(L^*,a^*,b^*),lipid and protein oxidation,pH,water holding capacity(WHC)and *** and processing high-quality meat is a challenge since it is necessary to apply methods that promote comfort in a complete sense,in a way that minimizes inducing significant *** on the results presented it is remarkable that stress alters the meat quality,compromising the main attributes that involve it,like color,pH,WHC,Warner-Bratzler shear force(WBSF),lipid oxidation,among others andis necessary to avoid or reduce stress caused during the production of the animals to ensure a high-quality meat,resulting in greater profitability for the producer.

关键词： Animal stress drip loss farm buildings meat quality tenderness

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Tropical Isabella Grape Juices： Bioactive Compounds and Antioxidant Power Depends on Harvest Season

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Journal of Food Science and Engineering 2013年第2期3卷 64-70页

作者： Cinthia Bau Betim Cazarin Luiz Claudio Correa Juliana Kelly da Silva Angela Giovana Batista cibele Priscila Busch Furlan Aline Camarao Telles Biasoto Giuliano Elias Pereira Ana Cecilia Poloni Rybka Mairio Roberto Marostica Junior Department of Food and Nutrition University of Campinas Campinas Sao Paulo 13083-862 Brazil Brazilian Agricultural Research Corporation Embrapa Tropical Semi-arid Petrolina Pernambuco 56302-970 Brazil Brazilian Agricultural Research Corporation Embrapa Grape & Wine/Tropical Semi-arid Petrolina Pernambuco 56302-970Brazil

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Antidepressant Drugs Modulate Differentially Anti-inflammatory Lithium＇s Property： An in Vitro and in Vivo Study

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Journal of Pharmacy and Pharmacology 2018年第4期6卷 287-304页

作者： Femanda Barbisan Pedro Antonio Schmidt do Prado-Lima Veronica Farina Azzolin Maiquidieli Dal Berto Claudia Giuliano Bica cibele Ferreira Teixeira Dianni Capeleto Ivo Emilio da Cruz Jung Euler Esteves Ribeiro Marta Maria Medeiros Frescura Duarte Ivana Beatrice Manica da Cruz Graduate Program in Pharmacology Federal University of Santa Maria Santa Maria-RS 97105900 Brazil Brain Institute Catholic University of Rio Grande do Sul Porto Alegre-RS 91410000 Brazil Graduate Program in Pathology Federal University of Health Sciences of Porto Alegre Porto Alegre-RS 90050170 Brazil Open University of the Third Age State University of Amazonas Manaus-AM 69029040 Brazil Lutheran University of Brazil Santa Maria-RS 97030080 Brazil

Li (lithium), a mood stabilizer has anti-inflammatory effect. However, in clinical practice, Li can be administered together with other antidepressants drugs, such as FLX (fluoxetine), IMI (imipramine), NOR (nortriptyline) and ESC (escitalopram). As interaction between Li and these antidepressant drugs on inflammatory modulation has not been investigated yet, we performed an in vitro protocol using a non-human macrophage cell line. Oxidative and inflammatory markers, as well as cell cycle analysis and cytokine gene expressions were compared among treatments. An IR (inflammatory ratio) was calculated based on the following oxidative-inflammatory variables: nitric oxide, superoxide anion, reactive oxygen molecules, cytokines IL-1β, IL-6, TNF-α and IL-10. The in vitro calculated IR data were validated through an in vivo analysis of 154 human subjects with similar IR. Li and control cells presented similar IR values. FLX, NOR and IMI increased slightly IR values indicating some proinflammatory effect, whereas ESC decreased IR values indicating some anti-inflammatory effect. However, cells exposed to Li + ESC triggered a proinflammatory response on macrophages. Thus, IR comparison results suggest that the Li anti-inflammatory effect is not universal and could be influenced by both basal macrophage-inflammatory state and interaction of other psychiatric drugs. These results could be useful to understand some inconsistencies observed in human studies involving Li and other psychiatric drugs.

关键词：抗抑郁剂 Vivo cytokines 性质调制学习巨噬细胞锂

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