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Robotic in situ bioprinting for cartilage tissue engineering

International Journal of Extreme Manufacturing 2023年第3期5卷 118-142页

作者： Yaxin Wang Rúben F Pereira Chris Peach Boyang Huang cian vyas Paulo Bartolo Department of Mechanical Aerospace and Civil EngineeringUniversity of ManchesterManchester M139PLUnited Kingdom Instituto de Ciências Biomédicas Abel Salazar Universidade do Porto4050-313PortoPortugal Instituto de Investigacao e Inovaao em Saúde Universidade do Porto4200-135PortoPortugal Instituto de Engenharia Biomédica Universidade do Porto4200-135PortoPortugal Manchester University NHS Foundation Trust ManchesterUnited Kingdom Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore639798Singapore

Articular cartilage damage caused by trauma or degenerative pathologies such as osteoarthritis can result in significant pain,mobility issues,and *** surgical treatments have a limited capacity for efficacious cartilage repair,and long-term patient outcomes are not ***-dimensional bioprinting has been used to fabricate biochemical and biophysical environments that aim to recapitulate the native microenvironment and promote tissue ***,conventional in vitro bioprinting has limitations due to the challenges associated with the fabrication and implantation of bioprinted constructs and their integration with the native cartilage *** situ bioprinting is a novel strategy to directly deliver bioinks to the desired anatomical site and has the potential to overcome major shortcomings associated with conventional *** this review,we focus on the new frontier of robotic-assisted in situ bioprinting surgical systems for cartilage *** outline existing clinical approaches and the utilization of robotic-assisted surgical *** and robotic-assisted in situ bioprinting techniques including minimally invasive and non-invasive approaches are defined and ***,we discuss the challenges and potential future perspectives of in situ bioprinting for cartilage applications.

关键词： in situ bioprinting cartilage tissue engineering robotic in situ bioprinting minimally invasive surgery bioinks

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