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Exploring conservative management for cervical intraepithelial neoplasia grade 2 in organised cervical cancer screening programmes:a multicentre study in Italy

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Family Medicine and Community Health 2024年第S2期12卷 1-7页

作者： Silvia Gori Helena Frayle Alessio Pagan Marika Soldà Cesare Romagnolo Egle Insacco Licia Laurino Mario Matteucci Giuseppe Sordi Enrico Busato Manuel Zorzi Tiziano Maggino Annarosa Del Mistro cin2 study working group Veneto Institute of Oncology IOV-IRCCS PadovaItaly Local Health Unit Marca Trevigiana TrevisoItaly Local Health Unit Serenissima VeneziaItaly Obstetrics and Gynecology Azienda Ospedale UniversitàPadovaItaly Local Health Unit Scaligera VeronaItaly Veneto Tumour Registry Azienda ZeroPadovaItaly 不详

Cervical intraepithelial neoplasia grade 2(cin2)lesions may regress spontaneously,offering an alternative to immediate treatment,especially for women of childbearing age(15–45 years).We conducted a prospective multicentre study on conservative cin2 management,with semiannual follow-up visits over 24 months,biomarkers’investigation and treatment for progression to cin3+or cin2 persistence for more than 12 ***,we assess women’s willingness to participate and adherence to the study *** study was set in population-based organised cervical cancer *** April 2019 to October 2021,640 cin2 cases were diagnosed in women aged 25–64 participating in the screening *** to our predefined inclusion and exclusion criteria,228(35.6%)women were not eligible;93(22.6%)of the 412 eligible refused,and 319(77.4%)were *** for personal reasons(ie,desire to become pregnant,anxiety,difficulty in complying with the study protocol)and external barriers(ie,residence elsewhere and language problems)accounted for 71%and 17%,*** 9%expressed a preference for *** primary ineligibility factor was the upper age limit of 45 *** enrolment,12(4%)women without evidence of progression requested treatment,125(39%)were lost to follow-up(mostly after 6–12 months)and 182(57%)remained ***,40%of enrolees did not fully adhere to the protocol,whereas only 5%(20/412)of the eligible women desired *** study demonstrates a good acceptance of conservative management for cin2 lesions by the women,supporting its implementation within cervical screening programmes.

关键词： cervical conservative centre

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Intraplaque injections of hyaluronic acid for the treatment of stable-phase Peyronie’s disease:a retrospective single-center experience

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Asian Journal of Andrology 2024年第3期26卷 268-271页

作者： Simone Cilio Roberto La Rocca Giuseppe Celentano Claudio Marino Massimiliano Creta Gianluigi Califano Celeste Manfredi Giorgio Ivan Russo Afonso Morgado Marco Falcone Marco Capece YAU working group Sexual and Reproductive Health Department of Neurosciences Reproductive Sciences and OdontostomatologyUrology UnitUniversity of Naples“Federico II”Naples 80131Italy Urology Unit Department of WomenChild and General and Specialized Surgery“Luigi Vanvitelli”UniversityNaples 80131Italy Urology Section Department of SurgeryUniversityof CataniaCatania 95131Italy Department of Urology Centro Hospitalar Universitário São JoãoPorto 4200-319Portugal Urology Clinic-A.O.U.“Cittàdella Salute edella Scienza”-Molinette Hospital University of TurinTurin 10100Italy 不详

Peyronie’s disease(PD)is a condition of penile connective tissue affecting up to 10%of men *** the complexity ofits management,nonsurgical treatments,such as intraplaque injections,are gaining *** current literature shows dataon the efficacy of intraplaque injections of hyaluronic acid(HA)mainly in acute-phase ***,data on injections of HA instable-phase PD are *** for this retrospective study were derived from a prospectively maintained database of privatepatients presenting at a private medical practice affiliated to the University of Naples“Federico II”(Naples,Italy)with stable-phasePD between January 2020 and March *** underwent a standard protocol of three injections,each administered at atwo-week *** the intervals,patients performed vacuum device therapy,penile stretching,and modeling *** compiled the Peyronie’s Disease Questionnaire(PDQ)and Global Assessment of Peyronie’s Disease(GAPD)at baselineand 2 weeks after the third injection.A penile Doppler ultrasound was performed 2 weeks after the last injection to record thefinal ***,we recruited 62 patients with stable-phase PD and a mean(±standard deviation[s.d.])curvature of52.7°(±9.7°).After 6 weeks,eight(12.9%)patients did not experience any curvature *** remaining 54 patientshad a final mean(±s.d.)curvature of 40.3°(±9.1°)with P<0.001,compared to that before *** found improvement inall PDQ domains(all P≤0.01),and 50(80.6%)patients reported subjective improvement of the penile curvature according to *** conclusion,we demonstrated that after three injections of HA administered according to the adopted protocol,patientswith stable-phase PD could experience significant improvements in penile curvature,and physical and psychological consequencesof the disease without significantly relevant side effects.

关键词： hyaluronic acid intraplaque injection Peyronie’s disease stable-phase therapy

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Report on Childhood Obesity in China (1) Body Mass Index Reference for Screening Overweight and Obesity in Chinese School-age Children

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Biomedical and Environmental Sciences 2005年第6期18卷 390-400页

作者： COOPERATIVE study ON CHILDHOOD OBESITY working group ON OBESITY IN CHINA (WGOC) Institute of Child and Adolescent Health

Purpose To establish and propose a national body mass index （BMI） reference for screening overweight and obesity in Chinese school-age children and adolescents. Methods 2000 CNSSCH （Chinese National Survey on Students Constitution and Health） data, including 216 620 primary and secondary school students aged 7 to 18 years old, were used as a reference population. Compared with those of the NCHS intematioanl reference, three temporary sets of cut-off BMI were proposed by testing different combinations of P85, P90, and P95. When physiological and biochemical measures between and among “obesity” “overweight”, and “normal weight” groups were taken into consideration, set Ⅱ was selected to be the most appropriate one. The sex-age-specific curves were then plotted and smoothed by using B-spline method. Results Based on the samples from costal developed metropolis, the BMI curves successfully overcame the shortcomings of lower and level-off tendency of the Chinese total population. Temporary set H, composed by cut-offs of P85 for overweight and P95 for obesity, was finally selected by its sensitivity and peculiarity. BMI 24 and 28 were used as cut-offs for overweight and obesity for both males and females aged 18 years old. These cut-offs, consistent with Chinese Adult＇s Reference, was proposed as the Body mass index reference for screening overweight and obesity in Chinese school-age children and adolescents. Conehlsion The new reference clearly showed its superiorty in both prospectivity and actuality. The proposed reference minimized the gaps of the BMI curve between Chinese adolescents and the international reference. Most importantly was that it was consistent with the Eastern Asia ethnic characteristics of body fatness growth. It was therefore proposed by the working group on Obesity in China （WGOC） to use it as an nationwide reference for screening overweight and obesity of school-age children and adolescents in China.

关键词： Body mass index, Chinese school-age children Overweight Reference

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Predictive Values of Body Mass Index and Waist Circumference for Risk Factors of Certain Related Diseases in Chinese Adults - study on Optimal Cut-off Points of Body Mass Index and Waist Circumference in Chinese Adults

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Biomedical and Environmental Sciences 2002年第1期15卷 83-96页

作者： ZHOU BEI-FAN2Cooperative Meta-Analysis group of the working group on Obesity in China Cooperative Meta-Analysis group of the working group on Obesity in China

Objective For prevention of obesity in Chinese population, it is necessary to definethe optimal range of healthy weight and the appropriate cut-off points of BMI and waistcircumference for Chinese adults. The working group on Obesity in China under the supportof International Life Sciences Institute Focal Point in China organized a meta-analysis on therelation between BMI, waist circumference and risk factors of related chronic diseases (e. g.,high diabetes, diabetes mellitus, and lipoprotein disorders). Methods 13 population studiesin all met the criteria for enrollment, with data of 239 972 adults (20-70 year) surveyed inthe 1990s. Data on waist circumference was available for 111411 persons and data on serumlipids and glucose were available for more than 80 000. The study populations located in21provinces, municipalities and autonomous regions in China's Mainland as well as inTaiwan. Each enrolled study provided data according to a common protocol and uniformformat. The Center for data management in Department of Epidemiology, Fu Wai Hospitalwas responsible for statistical analysis. Results and conclusion The prevalence ofhypertension, diabetes, dyslipidemia and clustering of risk factors all increased withincreasing levels of BMI or waist circumference. BMI at 24 with best sensitivity andspecificity for identification of the risk factors, was recommended as the cut-off point foroverweight, BMI at 28 which may identify the risk factors with specificity around 90 % wasrecommended as the cut-off point for obesity. Waist circumference beyond 85 cm for menand beyond 80 cm for women were recommended as the cut-off points for central *** of population attributable risk percent illustrated that reducing BMI to normalrange (<24) could prevent 45%-50% clustering of risk factors. Treatment of obese persons(BMI≥28)with drugs could prevent 15%-17% clustering of risk factors. The waistcircumference controlled under 85 cm for men and under 80 cm for women

关键词： Chinese adults Overweight Obesity BMI Waist circumference

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Associations between cardiac arrhythmia,incident disability in activities of daily living and physical performance:the ILSA study

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Journal of Geriatric Cardiology 2020年第3期17卷 127-132,I0002-I0004页

作者： Marianna Noale Nicola Veronese Lee Smith Andrea Ungar Stefano Fumagalli Stefania Maggi the Italian Longitudinal study on Aging working group National Research Council(CNR) Neuroscience InstituteAging BranchVia Giustiniani 235128 PaduaItaly Azienda ULSS 3 Serenissima Primary Care DepartmentDistrict 3VeniceItaly The Cambridge Centre for Sport and Exercise Sciences Department of Life SciencesAnglia Ruskin UniversityCambridge CB11PTUK Geriatrics and Intensive Care Unit Department of Experimental and Clinical MedicineUniversity of Florence and AOU CareggiFlorenceItaly 不详

Background Cardiac arrhythmias are common conditions in older ***,there is limited literature on associations between cardiac arrhythmias and physical performance or *** therefore aimed to prospectively investigate associations between cardiac arrhythmias and changes in disability and physical performance during 8 years of follow-up,using data from the Italian Longitudinal study on Aging(ILSA).Methods Cardiac arrhythmias diagnosis was posed through a screening phase,confirmed by a *** onset of disability in activities of daily living(ADL)and the changes in several physical performance tests during follow-up were considered as ***-adjusted and propensity-score Cox Proportional Hazard models and mixed models were used for exploring associations between cardiac arrhythmia and the outcomes of *** The prevalence of cardiac arrhythmia at baseline was 23.3%.People reporting cardiac arrhythmia at the baseline were significantly older,more frequently male,smokers and reported a higher presence of all medical conditions investigated(hypertension,heart failure,angina,myocardial infarction,diabetes,stroke),but no difference in dementia,Parkinsonism,cognitive or mood *** arrhythmia at baseline was significantly associated with the incidence of disability in ADL(HR=1.23;95%:CI:1.01–1.50;P=0.0478 in propensity score analyses;HR=1.28;95%CI:1.01–1.61;P=0.0401 in fully adjusted models).Cardiac arrhythmia at baseline was also associated with a significant worsening in balance test(P=0.0436).Conclusions The presence of cardiac arrhythmia at baseline was associated with a significant higher risk of disability and of worsening in some physical performance tests,particularly those relating to *** and frequently assessing physical performance in older people affected by cardiac arrhythmia can be important to prevent a loss of physical performance,with further,potential,complications of medical managemen

关键词： Atrial fibrillation Cardiac arrhythmia Disability Physical activity Physical performance

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胆道恶性肿瘤全程规范化管理中国专家共识(2023)

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中华外科杂志 2024年第6期62卷 504-513页

作者：中华医学会外科学分会胆道外科学组中国医师协会外科医师分会胆道外科专家工作组全志伟刘青光程南生龚伟李江涛李富宇耿智敏曾永毅吴向嵩杨自逸于源泉不详上海交通大学医学院附属新华医院普外科上海200092 西安交通大学第一附属医院肝胆外科西安710031 四川大学华西医院胆道外科成都610041 上海交通大学医学院附属新华医院浙江大学医学院附属第二医院四川大学华西医院西安交通大学第一附属医院福建医科大学孟超肝胆医院

胆道恶性肿瘤早期诊断困难,多数患者首诊时已处于进展期,肿瘤根治性切除率低、综合治疗手段有限、患者预后差。目前我国胆道系统疾病专科诊疗及多学科协作机制构建尚不完善,而胆道恶性肿瘤的诊疗模式日趋复杂。为了更好地对胆道恶性肿... 详细信息

胆道恶性肿瘤早期诊断困难,多数患者首诊时已处于进展期,肿瘤根治性切除率低、综合治疗手段有限、患者预后差。目前我国胆道系统疾病专科诊疗及多学科协作机制构建尚不完善,而胆道恶性肿瘤的诊疗模式日趋复杂。为了更好地对胆道恶性肿瘤患者进行规范化诊治,切实提升全国各级医疗机构对胆道恶性肿瘤的全程化管理能力,中华医学会外科学分会胆道外科学组、中国医师协会外科医师分会胆道外科专家工作组基于现有循证医学证据,组织相关领域专家充分讨论后制定了《胆道恶性肿瘤全程规范化管理中国专家共识(2023)》,共识内容涵盖了胆道恶性肿瘤的筛查、诊断、治疗及随访等环节,希望为胆道恶性肿瘤患者的规范化全程化管理提供指导性建议。

关键词：胆道肿瘤诊断肿瘤治疗方案全程化管理规范化专家共识

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Developing Whole-Process People’s Democracy and Ensuring the People Run the Country

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求是:英文版 2023年第4期15卷 62-69页

作者： Core Theoretical study Team of the CPC Leadership group for the working Bodies of the National People's Congress Standing Committee Core Theoretical study Team of the CPC Leadership group for the working Bodies of the National People's Congress Standing Committee

Since the 18th National Congress of the Communist Party of China (CPC) held in 2012, President Xi Jinping has comprehensively reviewed achievements and experiences in building China’s socialist democracy, deepened understanding of the laws governing the development of democracy, and put forward a key concept of whole-process people’s democracy. This concept has further enriched Marxist democratic theory and represents a historic achievement and landmark in the development of democracy in China in the new era.

关键词： Whole comprehensive Communist

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中国颈动脉内膜剥脱术现状和地区差异

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中国循环杂志 2024年第3期39卷 228-233页

作者：国家心血管系统疾病医疗质量控制中心血管外科工作组舒畅罗明尧不详中国医学科学院阜外医院

近年来,中国颈内动脉内膜剥脱术(CEA)不断完善和发展,但是仍然存在一些问题。本研究利用2021年医院质量监测系统(HQMS)的数据,对全国各地区开展的共10783例CEA进行了统计分析。结果显示,CEA患者的平均年龄为(65.8±7.9)岁,男性占比82%,... 详细信息

近年来,中国颈内动脉内膜剥脱术(CEA)不断完善和发展,但是仍然存在一些问题。本研究利用2021年医院质量监测系统(HQMS)的数据,对全国各地区开展的共10783例CEA进行了统计分析。结果显示,CEA患者的平均年龄为(65.8±7.9)岁,男性占比82%,女性占比18%。85%患者通过门诊途径入院,14%患者通过急诊途径入院。92%手术在三级医院完成,8%手术在二级医院完成。东部地区手术量占全国的66%,中部地区占23%,西部地区占11%。CEA患者常见的合并症有高血压7499例(70%)和糖尿病3436例(32%)。中国CEA有关数据存在一定的地区差异,应加大对术者和围术期管理团队的培训。此外,中国CEA整体规模尚小,还有很大的发展空间。

关键词：颈动脉内膜剥脱颈动脉狭窄医疗资源医疗质量

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A GEOLOGICAL TIME SCALE OF CHINA

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Chinese Science Bulletin 1988年第22期33卷 1879-1881页

作者： working group ON GEOLOGICAL TIME SCALE OF CHINA Ministry of Geology and Mineral Resources

From 1980 to 1985, we carried out a systematical study on boundary ages of rocks of various periods and the ages of important geological events in all geological time in China. Based on the results of the study and on... 详细信息

关键词： boundary age stratigraphic column isotopic analysis

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Association between tea consumption and cognitive function in cognitively healthy older adults and older adults with mild cognitive impairment

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General Psychiatry 2021年第4期34卷 44-50页

作者： Hua Xu Alexandra J Fiocco Xiaohua Liu Tao Wang Guanjun Li Shifu Xiao the research group of Shanghai Brain Aging study Department of Psychiatry Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Alzheimer’s Disease and Related Disorders Center Shanghai Jiao Tong UniversityShanghaiChina Department of Psychology Ryerson UniversityTorontoOntarioCanada Department of Geriatric Psychiatry Shanghai Mental Health CenterShanghai Jiao Tong UniversityShanghaiChina 不详

Background Prospective studies suggest that tea consumption may decrease the risk for cognitive impairment in late ***,little research has examined the association between tea consumption and cognitive performance across multiple *** addition,no research has examined the benefit of tea consumption on cognitive performance among older adults with existing *** The current study examined the association between tea consumption and performance on tasks of global cognitive function,episodic memory and executive function in cognitively healthy(CH)older adults and older adults with mild cognitive impairment(MCI).Methods The analytical sample included 1849 community-dwelling older adults from the Shanghai Brain Aging study(65.6%female,mean age of 69.50(8.02)years).Following ascertainment of cognitive function,816 were categorised as *** addition to completion of a demographics questionnaire,participants reported their tea consumption and completed a battery of tests to measure global cognitive function,episodic memory and working *** Independent analyses of covariance revealed a significant association between tea consumption and measures of episodic memory;however,these associations were restricted to CH older adults but not older adults with *** consumption was not associated with working memory *** The current study suggests that the benefit of tea consumption is restricted to cognitively healthy older adults and does not extend to older adults with MCI.

关键词： impairment function cognitive

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