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A cross-sectional study of the association between dietary inflammatory index and glaucoma prevalence in a US population

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 139-145页

作者： Wen-li Chen li-Xia Zhang Department of Ophthalmology Zhejiang Chinese Medical University Affiliated Wenzhou Hospital of Integrated Traditional Chinese and Western MedicineWenzhou 325000Zhejiang ProvinceChina Eye Hospital China Academy of Chinese Medical SciencesBeijing 100040China

AIM:To assess the relationship between dietary inflammatory index(DII)and prevalence of glaucoma among individuals aged 40y and above in the United ***:Participants were drawn from 2 cycles of the National Health and Nutrition Examination Survey(NHANES,2005-2008)for a cross-sectional *** was calculated from 24-hour dietary recall questionnaire conducted by experienced researchers and data analyzed in R according to the NHANES user guide,“Stratified Multi-stage Probability Sampling”.The relationship between DII and glaucoma was evaluated by multi-factor logistic regression analysis and the existence of a non-linear association examined by restricted cubic spline(RCS)***:A total of 5359 subjects were included and the cross-sectional analysis weighted to represent the US population of 109 *** was elevated in glaucoma patients(Pcient,r=-0.49).RCS analysis showed a linear relationship between DII and glaucoma risk(P of non-linear relationship=0.575).CONCLUSION:An increased DII is strongly associated with high risk of glaucoma and diet-induced inflammation should be controlled to delay glaucoma progression.

关键词： glaucoma risk factors dietar y inflammatory index National Health and Nutrition Examination Survey restricted cubic spline regression cross-sectional study

中国南瓜bHLH转录因子家族的鉴定与生物信息学分析

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生物技术通报 2025年第1期41卷 186-197页

作者：李彩霞李艺穆宏秀林俊轩白龙强孙美华苗妍秀山西农业大学园艺学院太谷030801 山西省设施蔬菜提质增效协同创新中心太谷030801

【目的】基于中国南瓜全基因组数据,鉴定中国南瓜bHLH转录因子家族成员并分析其理化性质和结构等,为中国南瓜bHLH转录因子家族的生物学功能研究提供理论支撑。【方法】利用NCBI和中国南瓜基因组数据库等对中国南瓜bHLH基因家族进行鉴定... 详细信息

【目的】基于中国南瓜全基因组数据,鉴定中国南瓜bHLH转录因子家族成员并分析其理化性质和结构等,为中国南瓜bHLH转录因子家族的生物学功能研究提供理论支撑。【方法】利用NCBI和中国南瓜基因组数据库等对中国南瓜bHLH基因家族进行鉴定,利用ExPASy ProtParam tool、DNAMAN和MAGA5.1等软件进行基本理化性质、系统进化、保守基序、启动子作用元件和表达模式等生物信息学分析。【结果】在中国南瓜全基因组中共鉴定出153个CmobHLHs基因,不均等地分布在20条染色体上。CmobHLH蛋白质含有91-897个氨基酸,理论等电点介于4.77-10.33;亚细胞定位预测表明有139个CmobHLH蛋白位于细胞核;系统进化分析将CmobHLH蛋白分为8个亚家族;保守基序(motif)预测结果表明,中国南瓜共含10条motif,其中motif1和motif2普遍存在于153个bHLH蛋白中。CmobHLHs在中国南瓜的各个部位均有表达,CmobHLH41、CmobHLH5、CmobHLH36和CmobHLH88分别在果实、叶片、茎和根中表达量最高;盐胁迫下,100个CmobHLHs基因表达量上调,49个CmobHLHs基因表达量下调。RT-q PCR结果表明盐胁迫下CmobHLH52和CmobHLH148基因表达量显著上调,而CmobHLH8、CmobHLH83、CmobHLH93和CmobHLH115基因表达量显著下调,与转录组结果基本一致。【结论】鉴定出153个CmobHLHs基因,家族成员在不同部位和盐胁迫下的表达模式存在差异,为挖掘南瓜bHLH转录因子在抗盐等方面的功能提供理论基础。

关键词：中国南瓜 bHLH 理化性质系统进化树组织表达模式盐胁迫表达模式

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Visual outcomes and corneal biomechanical evaluation between LASIK and LASIK combined with accelerated corneal crosslinking

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International Journal of Ophthalmology(English edition) 2025年第3期18卷 496-503页

作者： li Zhang Yue-Hua Zhou Xiao-Rui Wang Yan Zheng Cai-Yun Fu xiu-Mei Song Ya-Bin Hu Yue Wang Chang-Bin Zhai Beijing Tongren Eye Center Beijing Tongren Hospital Affiliated to Capital Medical UniversityBeijing Ophthalmology&Visual Science Key LabBeijing 100730China Beijing Ming Vision&Ophthalmology Beijing 100191China College of Ophthalmology Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina School of Optometry and Vision Sciences Cardiff UniversityCardiffCF244HQUK

AIM:To assess the visual outcomes and corneal biomechanical properties of myopia patients between laser in situ keratomileusis(LASIK)and LASIK combined with accelerated corneal crosslinking(LASIK Xtra).METHODS:This prospective study analyzed 52 consecutive myopia patients treated with LASIK Xtra and 45 consecutive myopia patients treated with *** the right eyes in the two groups were *** uncorrected distance visual acuity(UDVA),keratometry values,postoperative central corneal thickness(CCT),corneal demarcation line depth,the corneal compensated intraocular pressure(IOPcc),Goldmann-correlated IOP(IOPg),corneal resistance factor(CRF)and corneal hysteresis(CH)from Ocular Response Analyzer(ORA)were ***,the correlation between the demarcation line depth and ORA-related biomechanical parameters were ***:No significant differences in UDVA,postoperative CCT,or mean K values were found between the 2 groups at 1 to 12mo postoperative follow-up(all P>0.05).The changes of CRF was significantly lower in the LASIK Xtra group compared to the LASIK group(all P0.05).Out of 52 cases in the LASIK Xtra group,the demarcation line was present in 40 eyes(77%).The average depth of the demarcation was 220.73±42.70μm(136 to 288μm).No significant correlation was observed between the depth of the demarcation line and any of the ORA-related biomechanical parameters such as IOPcc,IOPg,CRF and CH at 12mo(all P>0.05).CONCLUSION:Both procedures demonstrate comparable outcomes in terms of visual acuity,refraction and ablation *** study confirms that corneal biomechanical properties of the included patients weakened after both procedures,but the cornea after LASIK Xtra are stiffer than conventional LASIK.

关键词： myopia femto-laser in situ keratomileusis laser in situ keratomileusis combined with accelerated corneal crosslinking corneal biomechanics

Screening cervical lesions with Fourier transform infrared spectroscopy

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Chinese Science Bulletin 2001年第3期46卷 213-216页

作者： GAO Tiyu li Jun ci Yunxiang DONG Jianqiang KAN xiu QUO Zhenquan Department of Chemistry Peking UniversityBeijing 100871China Gansu Chinese Traditional Medical College Lanzhou 730000China Department of Pathology Beijing Medical UniversityBeijing 100044China Department of Biology Peking UniversityBeijing 100871China

The screening results were reported based on the Fourier transform infrared spectroscopy (FTIR) analysis of the samples of exfoliated cervical cells from 354 women. Their spectra can be sorted into two types based on the emerging or not of the absorption bands near 970 cm-1 and 1170 cnT1: Tl (83.1%) type without emerging, and T2 (16.9%) type with obviously emerging. All of the samples assigned to Tl were cytologicaily diagnosed as normal or within normal limits (Pap I). 28.9% and 71.1% of samples exhibiting T2 profile, were cytologicaily evaluated as Pap I and abnormal respectively. 3 women in the abnormal group were diagnosed as to have cervical cells with changes associated with high grade of inflammation, cervical scar and cervical erosion. Furthermore, based on the progressive change of the relative intensities of the absorption bands, both T1 and T2 profiles can be categorized into 6 subtypes. The observed heterogeneous spectra and the progressive changes in the absorption frequencies and the

关键词： infrared spectral feature exfoliated cervical cells screening of cervical lesions.

丹参药材干燥动力学研究及其干燥过程有效成分动态变化

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中国中药杂志 2025年第1期50卷 128-138页

作者：李玉琴沙秀秀张喆宿树兰倪亮郭盛严辉钱大玮段金廒南京中医药大学江苏省中药资源产业化过程协同创新中心中药资源产业化与方剂创新药物国家地方联合工程研究中心国家中医药管理局中药资源循环利用重点研究室江苏省方剂高技术研究重点实验室江苏南京210023 南京中医药大学附属医院江苏南京210029

研究丹参药材干燥动力学特征,建立适宜的干燥动力学模型,并进一步评价不同干燥方法及其干燥过程中有效成分动态变化,以期为建立丹参药材适宜的干燥加工方法及其质量控制提供科学依据。通过干燥曲线、干燥速率、水分有效扩散系数以及干... 详细信息

研究丹参药材干燥动力学特征,建立适宜的干燥动力学模型,并进一步评价不同干燥方法及其干燥过程中有效成分动态变化,以期为建立丹参药材适宜的干燥加工方法及其质量控制提供科学依据。通过干燥曲线、干燥速率、水分有效扩散系数以及干燥活化能等指标评价丹参药材干燥动力学特征,建立适宜的干燥动力学模型;采用热风干燥、红外干燥、微波干燥等不同干燥方法评价丹参适宜的干燥加工方法,并应用UPLC-TQ-MS联用技术分析干燥过程10种丹酚酸类成分和6种丹参酮类成分的动态变化,通过TOPSIS综合评价法研究不同干燥方法的丹参药材品质。结果表明,丹参的干燥速率和水分有效扩散系数随着干燥温度的升高而升高,不同干燥方法的最大干燥速率排序为微波干燥>红外干燥>热风干燥,切片>整根,干燥速率随着温度的升高和干燥时间的延长逐步降低;热风干燥法丹参的干燥活化能大于红外干燥。丹参干燥过程最适宜的动力学模型为Page模型;结合TOPSIS评价结果,50℃红外干燥为丹参药材最佳干燥方法。干燥过程丹参药材有效成分动态变化分析结果表明,在干燥过程中随着失水率的不断增加,丹酚酸类成分含量均不同程度的增加,其中丹酚酸B增加幅度最大,与新鲜药材相比,丹酚酸B含量增加了44倍。丹参酮类成分在丹参新鲜药材中亦存在,在干燥过程中均有不同程度的增加,其中丹参酮ⅡA含量干燥后增加了3倍。研究结果为丹参药材产地适宜干燥加工方法的建立及质量控制提供了科学依据和重要支撑。

关键词：丹参干燥动力学 Page模型丹酚酸

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小学语文教师专业发展研究

教育教学论坛 2025年第06期 33-36页

作者：蒯秀丽商丘师范学院教师教育学院

强国必先强教，强教必先强师。教师是教育发展的第一资源，是立教之本、兴教之源。高素质的教师是优质基础教育发展的基石，要致力于培养具备创新能力、专业化素养的新时代中小学师资队伍，夯实基础教育基础。语文是掌握其他学科的基础... 详细信息

强国必先强教，强教必先强师。教师是教育发展的第一资源，是立教之本、兴教之源。高素质的教师是优质基础教育发展的基石，要致力于培养具备创新能力、专业化素养的新时代中小学师资队伍，夯实基础教育基础。语文是掌握其他学科的基础，作为小学语文教师，要具备更高的专业素养。以弘扬教育家精神为纽带，以促进学生核心素养发展为目的，以语文实践活动为主线，探讨教育家精神在语文课堂教学中的渗透，以期展现小学语文教师能力的多样化，推动教师专业持续地发展。

关键词：小学语文教师高质量专业发展

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浅析矿山企业质量风险管理

有色矿冶 2025年第1期41卷 56-58页

作者：滕秀丽抚顺红透山矿业有限公司

近年来，企业采用ISO9001标准对企业进行质量管理已成为一种普遍趋势，从2015年标准换版后，纳入了基于风险的管理理念，从质量风险的识别、评估和控制等几方面，阐述和分析了矿山企业质量风险管理工作，从而阐明了质量风险管理在矿山... 详细信息

近年来，企业采用ISO9001标准对企业进行质量管理已成为一种普遍趋势，从2015年标准换版后，纳入了基于风险的管理理念，从质量风险的识别、评估和控制等几方面，阐述和分析了矿山企业质量风险管理工作，从而阐明了质量风险管理在矿山企业发展和管理上的必要性和意义。

关键词：质量风险管理风险识别风险评估风险控制

An assessment model for efficacy of autologous CD19 chimeric antigen receptor T-cell therapy and relapse or refractory diffuse large B-cell lymphoma risk

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中华医学杂志(英文版) 2025年第1期138卷 108-110页

作者： Xue Bin liu Yifan Zhang Min Xiao Gangfeng Luo xiu Zhou lili Ye Shiguang Lu Yan Qian Wenbin Wang li li Ping liang Aibin Department of Hematology Shanghai Tongji Hospital Tongji University School of Medicine Shanghai China Department of Hematology Ningbo No.Hospital Ningbo Zhejiang China Department of Hematology The Second Affiliated Hospital College of Medicine Zhejiang University Hangzhou Zhejiang China Department of Hematology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China

Different Acupuncture Therapies for Postherpetic Neuralgia:An Overview of Systematic Reviews and Meta-analysis

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Chinese Journal of Integrative Medicine 2025年第1期31卷 55-67页

作者： XIA Yun-fan SUN Ruo-han li Shi-min WANG Yi-yi li Rong-rong FANG Jian-qiao The Third Clinical Medical College of Zhejiang Chinese Medical University Hangzhou310000China Department of Rehabilitation Medicine Hangzhou Third People’s Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhou310000China Department of Acupuncture the Third Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310000China

Background: Postherpetic neuralgia(PHN) is the most common complication of herpes zoster infection and affects patients' quality of life. Acupuncture therapy is regarded as a competitive method of treatment for analgesia. Objective: To summarize evidence from systematic reviews(SRs) and evaluate the effectiveness and safety of different acupuncture therapies for treating PHN. Methods: Eight electronic databases were searched from their inception to August 5, 2022, including 4 international electronic databases(PubMed, EMBASE, the Cochrane library, and Web of Science) and 4 Chinese databases(Chinese Biomedical Database, China National Knowledge Infrastructure, VIP Database and Wanfang Database).Methodological quality was assessed by A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2).The Risk of Bias in Systematic Review(ROBIS) tool was used to assess the risk of bias in SRs. Evidence level was assessed by the Grading of Recommendations Assessment, Development, and Evaluation(GRADE)approach. Results: Totally, 7 SRs were included, including 128 studies and 9,792 patients. In AMSTAR 2, most of the SRs were of low or critically low levels since they had more than 1 critical deficiency. In ROBIS, 1 SR(14.29%)was rated as high risk, and the other 6(85.71%) were rated as low risk. In the GRADE system, 9 outcomes(28.13%)were valued as high level, 5(15.63%) as moderate level, 1(3.13%) as low, and 17(53.13%) as very low. In the effectiveness of acupuncture therapy, the group "moxibustion vs. original medical treatment" [mean difference(MD)=–1.44, 95% confidence interval(ci): –1.80 to –1.08, I2=99%, Pci: –3.14 to –2.46, I2=0, P<0.00001)was of the lowest heterogeneity. Six SRs have reported the safety of their studies and no serious events were shown in the treatment and control groups. Conclusions: Acupuncture therapy seems to be effective in treating PH

关键词： acupuncture postherpetic neuralgia systematic review Chinese medicine