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Triptolide inhibits TGF-β-induced matrix contraction and fibronectin production mediated by human Tenon fibroblasts

International Journal of Ophthalmology(English edition) 2018年第7期11卷 1108-1113页

作者： Yang Liu Ping-Ping Liu Lei Liu Xiao-Shuo Zheng Hui Zheng Cheng-Cheng Yang ci-ren luobu Ye Liu Department of Ophthalmology the Fifth Affiliated Hospital Sun Yat-sen University Department of Ophthalmology the First Hospital of Jilin University Department of Pathology the Fifth Affiliated Hospital Sun Yat-sen University

AIM： To determine if triptolide influences the contractility and fibronectin production in human Tenon fibroblasts（HTFs）. METHODS： HTFs were cultured in type I collagen gels with or without transforming growth factor beta（TGF-β） and/or triptolide. The diameter of the collagen gel was used to measure contraction. Immunoblot analysis was used to quantify myosin light chain（MLC） phosphorylation and integrin expression. Laser confocal fluorescence microscopy was used to monitor the formation of actin stress fibers. Fibronectin production was measured with an enzyme immunoassay. RESULTS： Triptolide inhibition of contraction in TGF-β-induced collagen gel mediated by HTFs was dosedependent and statistically significant at 3 nmol/L（P〈0.05） and maximal at 30 nmol/L and significantly time dependent at 2 d（P〈0.05）. Triptolide reduced TGF-β-induced expression of integrins α5 and β1, phosphorylation of MLC, and formation of stress fibers in HTFs. Furthermore, the inhibition of triptolide on the attenuated TGF-β-induced production of fibronectin by HTFs was concentration-dependent and significant at 1 nmol/L（P〈0.05） and maximal at 30 nmol/L. CONCLUSION： Triptolide suppress the contractility of HTFs induced by TGF-β and the production of fibronectin by these cells. It is promising that triptolide treatment may possibly inhibit scar formation after glaucoma filtration surgery.

关键词： Tenon fibroblast triptolide transforming growth factor β wound healing fibronectin

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Ecological vulnerability analysis of Tibetan towns with tourism-based economy： a case study of the Bayi District

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Journal of Mountain Science 2018年第5期15卷 1101-1114页

作者： KAN Ai-ke LI Guo-qing YANG Xiao ZENG Ye-long TESren luobu HE Jie College of Geophysics Chengdu University of Technology Chengdu 610059 China State Key Laboratory of Resource and Environmental Information System Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China School of Resources and Environmental Engineering Ludong University Yantai 264025 China College of Forestry Guizhou University Guiyang 550025 China Institute of Science & Technology Information of Tibet Autonomous Region Lhasa 850000 China College of Tourism and Urban-RuraI Planning Chengdu University of Technology Chengclu 610059 China

This paper provides a generalizable mode for the ecological vulnerability evaluation for tourism planning and development in high mountain *** Bayi District located in southeastern Tibet is taken as a typical town to study the conflict between the protection of natural ecological environment and the exploitation of tourism resources. Based on the Sensitivity-Recovery-Pressure(SRP) framework, a set of vulnerability evaluation systems for plateau tourism regions were developed. The spatial principal component analysis(SPCA), remote sensing and GIS technologies were integrated to apply for spatial quantification of evaluation index system. The ecological vulnerability of the Bayi District was divided into five levels: potential, mild, moderate,severe, and extreme, and our results showed that significantly severe and extreme vulnerability areas were mainly distributed throughout the southwestern and central northern alpine pasture and glacial *** and mild vulnerability areas were mainly distributed in the vicinity of the Yarlung Zangbo River tributary basin. Then three tourism development and environmental protection zones were classified and appropriate measures for the protection were proposed. It also provides a reference for the spatial distribution of a range of areas that require different protection measures according to ecological vulnerability classification.

关键词： Ecological vulnerability Tourism area Tibet Spatial principal component analysis (SPCA) Moran's I model

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A Study on the Transfer of Rural Surplus Labor in Nyingchi city

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Asian Agricultural Research 2017年第5期9卷 36-38页

作者： luobu Dunzhu Yan HE Xizang Agriculture and Animal Husbandry College

This paper studies the surplus labor transfer in Nyingchi city,obtains the first-hand information of the surplus labor transfer through the typical survey,and analyzes the current situation and characteristics of surplus labor transfer. From " transfer channel", " transfer industry" and " transfer space",this paper analyzes the factors affecting the transfer of local surplus farming and animal husbandry labor,discusses the obstacles to surplus farming and animal husbandry labor in Nyingchi city,and finally makes some recommendations for the transfer of rural surplus labor in Nyingchi city.

关键词： Agricultural and pastoral areas Surplus labor Transfer

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Dynamic Changes in Per Capita Net Income of Rural Residents in Nyingchi city of Tibet

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Asian Agricultural Research 2017年第3期9卷 20-23页

作者： luobu Dunzhu Weilian ZENG Tibet Agricultural and Animal Husbandry College

Through an in-depth analysis of the per capita net income of rural residents in Nyingchi city,it was known that the per capita net income of rural residents in Nyingchi city was increasing at high speed in recent 10 years. However,the wage income,household operating income,and agricultural income gap constitute the major factors influencing the gap of the per capita net income of rural residents in Nyingchi city. Finally,it came up with recommendations including promoting the reasonable flow of labor to the secondary and tertiary industries,increasing the wage income and transfer income of rural residents,accelerating the construction of small towns in rural areas,promoting the development of rural cooperatives,implementing the strategy of " benefiting farmers and strengthening tourism",promoting integration of agriculture and eco-tourism,promoting the development of modern agriculture,and expanding diversified production income of farmers.

关键词： Dynamic changes Per capita net income of rural residents Nyingchi city of Tibet

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A successful mountain rescue operation in Yushu Earthquake

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Engineering Sciences 2012年第1期10卷 2-7页

作者： Wu Tianyi Li Suzhi Hou Shike Ouzhu luobu High Altitude Medical Research Institute Xining 810012 China Tibet Military General Hospital of PLA Lhasa 850007 China Chinese International Search and Rescue Team Beijing 100039 China Tibet University Medical College Lhasa 850002 China

On April 14, 2010, an earthquake reaching 7.1 Richter scale struck Jiegu Town of Yushu. More than 2 698 people were confirmed dead, and 12 135 were injured, of which 1 434 were severely injured. Rescue operation was carried out soon after the disaster; however, the rescue teams face great challenges of altitude hypoxia, freezing temperature and very bad weather. Thus, 1 434 severe injuries were rapidly transported airlifted to hospitals in Xining and neighboring provinces for effective treatment. The extremity trauma （49.9 % ） was the most common patteru of injuries. Asphyxia （40.8 % ） was by far the most important reason for death. A high incidence of acute altitude illness in the lowland rescuers was a special medical problem during the highest earthquake in Yushu. We have learned more lessons from Yushu Earthquake.

关键词： Yushu Earthquake mountain rescue medical emergency acute altitude illness

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Study on the efficiency of the underground muon detectors in YangBaJing Hybrid Array

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Radiation Detection Technology and Methods 2019年第3期3卷 101-105页

作者： Zhen Wang Youliang Feng Cheng Liu Yiqing Guo Hongbo Hu Tianlu Chen Danzeng luobu Jiancheng He Yuhua Yao Yi Zhang Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Physics Department of Science School Tibet UniversityLhasa 850000China College of Physical Science and Technology Sichuan UniversityChengdu 610064SichuanChina

Purpose Theγ-ray astronomy at 100 TeV is important to unravel the puzzles related to the origin and acceleration of the Galactic cosmic rays up to PeV *** YangBaJing Hybrid Array(YBJ-HA),about 2%the scale of LHAASO-KM2A,is such a kind of detection instrument capable of detecting 100 TeVγ-*** the muon detection efficiency stability of the MD array in YBJ-HA is crucial for high qualityγ-ray *** measure and monitor the muon detection efficiency,we develop a method in this *** We develop a muon bundle method to measure and monitor the efficiency of each muon *** this method,muon detection efficiency of the target MD unit is calculated based on the surrounding MD units and the MC *** The average actual muon detection efficiency of the 16 MD units is up to 83.4%during 4 years’*** The muon detection efficiency of each MD unit is found to be stable during 4 years’*** the future,a similar method may be applicable to the muon detection efficiency study for LHAASO.

关键词： Detection efficiency Muon detector EAS

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青藏高原那曲中部土壤温湿分布特征

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冰川冻土 2021年第6期43卷 1704-1717页

作者：卓嘎罗布巴桑曲珍中国气象局成都高原气象研究所拉萨分部西藏拉萨850000 西藏高原大气环境科学研究所西藏拉萨850000 高原与盆地暴雨旱涝灾害四川省重点实验室四川成都610072 西藏自治区气象台西藏拉萨850000 林芝市气象局西藏林芝860000

青藏高原土壤水热状况对气候变化和植被退化方面的研究具有重要意义,土壤湿度的准确刻画还会影响到数值预报模式对当地及其下游地区降水的模拟能力。为此,采用中国科学院那曲高寒气候环境观测研究站安多观测点2014年1—12月的土壤温度... 详细信息

青藏高原土壤水热状况对气候变化和植被退化方面的研究具有重要意义,土壤湿度的准确刻画还会影响到数值预报模式对当地及其下游地区降水的模拟能力。为此,采用中国科学院那曲高寒气候环境观测研究站安多观测点2014年1—12月的土壤温度、土壤湿度观测资料以及同期安多气象站观测数据,分析了青藏高原那曲中部不同深度土壤温湿度的分布特征及其与气温、降水量等气象要素的关系。结果表明:土壤温度在浅层为正弦曲线,随着土壤深度的增加,曲线逐渐接近直线。土壤升温迅速而降温过程缓慢。封冻和解冻日期随土壤深度的增加而推迟,封冻期逐渐缩短。不同层次土壤湿度日内变化较小。月变化呈单峰型结构,峰值和谷值基本出现在8月和12月。土壤湿度上升速率较下降速率缓慢。区域尺度上GLDAS-NOAH资料显示出类似的变化特征。土壤温湿度在一年中的变化不一致,但土壤温湿度呈显著正相关。浅层土壤的温度梯度明显大于深层;浅层土壤湿度最大,中间层较大,深层土壤湿度最小。随着干季向湿季的转换,由于太阳辐射的增加,非绝热加热呈增加的趋势。土壤湿度与气象要素在不同时段的相关性存在一些差异,但总体上土壤湿度与气温、降水量和相对湿度呈正相关,与风速、日照时数相关性不显著。

关键词：青藏高原土壤温湿度分布特征

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20世纪中叶门隅社会村社组织层级疏略——述《门隅水羊清册》所涉及的社会村社组织

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西藏大学学报（社会科学版） 2014年第1期29卷 100-105,120页

作者：巴桑罗布西藏自治区人民代表大会常务委员会西藏拉萨850000

《门隅水羊清册》是迄今记载西藏门隅人口、土地、税制等最为详尽的《清册》,也是极具参考价值的第一手原始资料。文章根据《门隅水羊清册》及其相关文献资料的记载,对门隅地区的社会村社组织层级,即措(定)及以下村社组织层级进行了梳... 详细信息

《门隅水羊清册》是迄今记载西藏门隅人口、土地、税制等最为详尽的《清册》,也是极具参考价值的第一手原始资料。文章根据《门隅水羊清册》及其相关文献资料的记载,对门隅地区的社会村社组织层级,即措(定)及以下村社组织层级进行了梳理和评述。研究发现,门隅各措(定)都设佐根、定本(首领、首要责任人)1名,配有阔米(听差)和佐列或者公差各1名。佐根和定本由各措、定酝酿,从有威望的中年以上村民中,定期轮流推举上报后,照例尼玛三措的佐根由达旺"六联"审查批准;其他措(定)的佐根和定本,由达旺"四联"和"六联"委派的税收员或者各小宗宗堆(宗本)批准任命。各措下辖的噶尔琼(定)和参等村社组织的首领,大都称阔米,由各措(定)自行选派、委任或指定。

关键词：《门隅水羊清册》门隅社会村社组织层级措

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医学机能学实验教学实践与思考

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基础医学与临床 2014年第10期34卷 1450-1452页

作者：罗布占堆西藏大学医学院实验中心西藏拉萨850000

目的提高医学机能学实验教学的效果。方法通过对医学机能学实验教学方面的文献进行收集与整理,然后对医学机能学实验教学中存在的问题进行归纳总结,最后提出解决措施。结果通过对收集到的资料进行分析,目前医学机能学实验教学中还存在... 详细信息

目的提高医学机能学实验教学的效果。方法通过对医学机能学实验教学方面的文献进行收集与整理,然后对医学机能学实验教学中存在的问题进行归纳总结,最后提出解决措施。结果通过对收集到的资料进行分析,目前医学机能学实验教学中还存在很多问题,这些问题在很大程度上影响了医学机能学实验教学的效果,这需要有关教学工作者必须要进一步加强医学机能学实验教学实践与思考。结论医学机能学实验教学能够将理论与实际联系在一起,教学方式更加贴近实际,能够有效引导学生积极地自己动手,从实验中学习和巩固理论知识,具有十分明显的教学效果。

关键词：医学机能学实验教学问题对策

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福音客栈、马帮传播与新教伦理:藏文《拉达克信使报》在西喜马拉雅地区的传播创新与内容生产

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新闻界 2022年第5期 27-39页

作者：韩鸿巴桑罗布电子科技大学公共管理学院四川成都611730 西藏日喀则市第一职业学校西藏日喀则857012

《拉达克信使报》(1937-1947)是西喜马拉雅地区毗邻西藏的拉达克创办时间最长的藏文报纸,本文作者于2019年在英国伦敦摩拉维亚教会档案馆发现该报原件,其报名是对出版于1908-1910年的同名报纸的继承。该报在《拉达克新闻报》(1904-1907... 详细信息

《拉达克信使报》(1937-1947)是西喜马拉雅地区毗邻西藏的拉达克创办时间最长的藏文报纸,本文作者于2019年在英国伦敦摩拉维亚教会档案馆发现该报原件,其报名是对出版于1908-1910年的同名报纸的继承。该报在《拉达克新闻报》(1904-1907)的基本版式和办报理念基础上,在内容生产上可视化增强,报道地域和题材范围窄化,布道纸特征明显,社教内容增加,媒介倡导色彩强烈。作者认为,该报内容生产的核心逻辑在于摩拉维亚教派的新教伦理。通过福音客栈的空间生产和马帮传播,该报扩大发行范围并最终实现了在西藏本土的传播,在早期藏文报刊发展史上具有重要意义。

关键词：《拉达克信使报》藏文报纸马帮传播新教伦理

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