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Comparing the efficacy and safety of low,medium,and high dosages of selexipag for treating pulmonary hypertension:A systematic review and meta-analysis

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Animal Models and Experimental Medicine 2024年第1期7卷 56-70页

作者： Shang Wang Yi Yan Jian Zhang Ping Yuan ci-jun luo Hong-Ling Qiu Hui-Ting Li Jian Xu Lan Wang Tian-Lan Li Rong Jiang Department of Cardio-Pulmonary circulation Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina Heart Center and Shanghai Institute of Pediatric Congenital Heart Disease Shanghai Children's Medical CenterNational Children's Medical CenterShanghai Jiaotong University School of MedicineShanghaiChina Department of Respiratory and Critical Care Medicine The 416 Hospital of Nuclear IndustryThe Second Affiliated Hospital of Chengdu Medical CollegeChengduChina Department of Hematology The Affiliated Hospital of Qingdao UniversityQingdaoChina

Background:The maintenance dosage of selexipag is categorized as low,medium or *** order to assess the efficacy and safety of different dosages of selexipag for the risk stratification of pulmonary arterial hypertension(PAH),we performed a sys-tematic review and ***:Studies assessing PAH risk stratification indices,such as the World Health Organization functional class(WHO-FC),six-minute walk distance(6MWD),N-terminal pro-B-type natriuretic peptide(NT-proBNP)level,right atrial pressure(RAP),cardiac index(ci)and mixed venous oxygen saturation(SvO2),were ***:Thirteen studies were *** led to improvements in the 6MWD(MD:24.20 m,95%ci:10.74-37.67),NT-proBNP(SMD:-0.41,95%ci:-0.79-0.04),ci(MD:0.47 L/min/m^(2),95%ci:0.17-0.77)and WHO-FC(OR:0.564,95%ci:0.457-0.697).Subgroup analysis demonstrated that all three dosages improved the 6MWD.A moderate dosage led to improvements in the ci(MD:0.30 L/min/m^(2),95%ci:0.15-0.46)and WHO-FC(OR:0.589,95%ci:0.376-0.922).Within 6 months of treatment,only the WHO-FC and ci were significantly improved(OR:0.614,95%ci:0.380-0.993;MD:0.30 L/min/m^(2),95%ci:0.16-0.45,respectively).More than 6 months of treatment significantly improved the 6MWD,WHO-FC and NT-proBNP(MD:40.87 m,95%ci:10.97-70.77;OR:0.557,95%ci:0.440-0.705;SMD:-0.61,95%ci:-1.17-0.05,respectively).Conclusions:Low,medium,and high dosages of selexipag all exhibited good *** treatment lasted for more than 6 months,selexipag exerted obvious effects,even in the low-dosage *** finding is important for guiding individualized treatments.

关键词： individualized treatments meta-analysis prostacyclin receptor agonist risk stratification systematic review

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Genomics,transcriptomics,and peptidomics of the greater wax moth Galleria mellonella neuropeptides and their expression in response to lead stress

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Insect Science 2024年第3期31卷 773-791页

作者： Li-Lin luo Yang Lin jun-Hong Linghu Wei Gong Yuan-Hong luo Man Liu Dao-Chao Jin Guy Smagghe Tong-Xian Liu Shun-Hua Gui Tian-ci Yi Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous Region Institute of EntomologyGuizhou UniversityGuiyangGuizhouChina Guizhou Institute of Biology Guizhou Academy of SciencesGuiyangChina Institute of Plant Health and Medicine Guizhou UniversityGuiyangChina

Neuropeptides are crucial in regulation of a rich variety of developmental,physiological,and behavioral functions throughout the life cycle of *** an integrated approach of multiomics,we identified neuropeptide precursors in the greater wax moth Galleria mellonella,which is a harmful pest of honeybee hives with a worldwide ***,a total of 63 and 67 neuropeptide precursors were predicted and annotated in the *** genome and transcriptome,in which 40 neuropeptide precursors were confirmed in the *** ***,we identified 12 neuropeptide precursor genes present in *** but absent in honeybees,which may be potential novel pesticide target *** hives were contaminated with heavy metals such as lead,enabling its bioaccumulation in *** bodies through the food chain,we performed transcriptome sequencing to analyze the effects of Pb stress on the mRNA expression level of *** neuropeptide *** treatment by Pb,the expression of neuropeptide F1 was found to be significantly downregulated,implying that this neuropeptide might be associated with responding to the heavy metal stress in *** study comprehensively identified neuropeptide precursors in ***,and discussed the effects of heavy metals on insect neuropeptides,with the example of *** results are valuable for future elucidation of how neuropeptides regulate physiological functions in *** and contribute to our understanding of the insect's environmental plasticity and identify potential new biomarkers to assess heavy metal toxicity in insects.

关键词： Galleria mellonella genomics heavy metal stress neuropeptide peptidomics transcriptomics

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A Simple Proof of ACC for Minimal Log Discrepancies for Surfaces

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Acta Mathematica Sinica,English Series 2024年第2期40卷 425-434页

作者： Jing jun HAN Yu Jie luo Shanghai Center for Mathematical Sciences Fudan UniversityJiangwan CampusShanghai 200438P.R.China Department of Mathematics Johns Hopkins UniversityBaltimoreMD 21218USA

Following Shokurov's idea,we give a simple proof of the ACC conjecture for minimal log discrepancies for surfaces.

关键词： Ascending chain condition minimal log discrepancies minimal model program surface

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Progress in research on the exploration and evaluation of deep geothermal resources in the Fujian-Guangdong-Hainan region,China

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Energy Geoscience 2024年第2期5卷 1-13页

作者： Herong Zheng jun luo Petroleum Exploration and Production Research Institute SINOPECBeijing 102206China

Deep geothermal resources in the Fujian-Guangdong-Hainan region,China,offer significant potential for sustainable *** diverse igneous rock formations along the southeast coast present intricate geological challenges that impede exploration and evaluation *** this study,we address critical concerns related to the Fujian-Guangdong-Hainan region's deep geothermal resources,encompassing heat source composition,formation conditions,strategic favorable areas,and exploration *** methods involve the analysis of regional geothermal reservoirs and cap *** findings include:the primary heat sources in the Fujian-Guangdong-Hainan region consist of the radioactive heat generation from granites in the crust,heat conduction in the mantle,and,in specific areas like Yangjiang and Shantou,melts within the middle and lower crust;the deep,high-temperature geothermal resources in the region predominantly reside in basins'depressed *** areas are characterized by the confluence of triple heat sources:heat from the Earth's crust,mantle,and other supplementary sources;our analysis led to the identification of three strategic areas favorable for deep geothermal resources in the Fujian-Guangdong-Hainan *** are the Beibu Gulf Basin's continental area,the Yuezhong Depression,and the Fuzhou-Zhangzhou area.

关键词： Deep geothermal resources Geology of geothermal energy Strategic selection

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Emerging delivery systems based on aqueous two-phase systems:A review

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Acta Pharmaceutica Sinica B 2024年第1期14卷 110-132页

作者： Yaowen Zhang Yankun luo Jingqi Zhao Wenzhuo Zheng jun Zhan Huaping Zheng Feng luo State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China School of StomatologySichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610041China Department of Dermatology Rare Diseases CenterInstitutes for Systems GeneticsFrontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

The aqueous two-phase system(ATPS)is an all-aqueous system fabricated from two immiscible aqueous *** is spontaneously assembled through physical liquid-liquid phase separation(LLPS)and can create suitable templates like the multicompartment of the intracellular *** structures containing multiple compartments make it possible to endow materials with advanced *** to the properties of ATPSs,ATPS-based drug delivery systems exhibit excellent biocompatibility,extraordinary loading efficiency,and intelligently controlled content release,which are particularly advantageous for delivering drugs in ***,we will systematically review and evaluate ATPSs as an ideal drug delivery *** on the basic mechanisms and influencing factors in forming ATPSs,the transformation of ATPSs into valuable biomaterials is ***,we concentrate on the most recent cutting-edge research on ATPS-based delivery ***,the potential for further collaborations between ATPS-based drug-carrying biomaterials and disease diagnosis and treatment is also explored.

关键词： Aqueous two-phase systems Drug delivery systems Biomaterials Microcapsules Microparticles Cell therapy Cancer treatment Organ regeneration

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Experimental study of the damage characteristics of rocks containing non-penetrating cracks under cyclic loading

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International Journal of Mining Science and Technology 2024年第2期34卷 197-210页

作者： jun Xu Xiaochun Xiao Lu Ma Sen luo Jiaxu Jin Baijian Wu School of Mechanics and Engineering Liaoning Technical UniversityFuxin 123000China School of civil Engineering Liaoning Technical UniversityFuxin 123000China Department of Engineering Mechanics Southeast UniversityNanjing 211189China

The damage evolution process of non-penetrating cracks often causes some unexpected engineering *** specimens containing non-penetrating crack(s)are used to study the damage evolution and characteristics under cyclic *** results show that under cyclic loading,the relationship between the number of non-penetrating crack(s)and the characteristic parameters(cyclic number,peak stress,peak strain,failure stress,and failure strain)of the pre-cracked specimens can be represented by a decreasing linear *** damage evolution equation is fitted by calibrating the accumulative plastic strain for each cycle,and the damage constitutive equation is proposed by the concept of effective ***,non-penetrating cracks are more likely to cause uneven stress distribution,damage accumulation,and local failure of *** local failure can change the stress distribution and relieve the inhibition of non-penetrating crack extension and eventually cause a dramatic destruction of the ***,the evolution process caused by non-penetrating cracks can be regarded as one of the important reasons for inducing *** results are expected to improve the understanding of the process of spalling formation and rockburst and can be used to analyze the stability of rocks or rock structures.

关键词： Damage characteristics Constitutive model Fissured rocks Non-penetrating crack Cyclic loading

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Microstructure evolution of Ti_(48)Zr_(27)Cu_(6)Nb_(5)Be_(14)amorphous alloy after semi-solid isothermal treatment

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China Foundry 2024年第3期21卷 287-294页

作者： Xin-hua Huang Jing-wen Pu Yong-xin luo Yue-jun Ouyang School of Material Electricity and Intelligent ManufacturingHuaihua UniversityHuaihua 330031HunanChina Hunan Renewable Aluminum Innovation Research Center Huaihua UniversityHuaihua 330031HunanChina

The as-cast amorphous Ti_(48)Zr_(27)Cu_(6)Nb_(5)Be_(14)composites,comprising in situ formedβ-Ti ductile crystalline precipitates,were prepared by water cooled copper mold suction ***,the semi-solid composites were obtained after the as-cast composites were treated by semi-solid isothermal *** microstructure evolution and kinetics of the composites were *** show that the microstructures of both the as-cast and semi-solid composites comprise ofβ-Ti crystal phases and amorphous matrix *** and after treatment,the crystals evolve from fine granular or fine dendritic crystals to coarse *** the treatment temperature increasing or the time prolonging,the average crystal size gradually increases and the surface morphology of the crystals gradually becomes *** studying the microstructural evolution and dynamics during the isothermal treatment process,it is found that the final morphology ofβ-Ti crystals is influenced by the isothermal treatment temperature and time(t),and theβ-Ti evolution rate increases with an increase in treatment *** addition,a linear relationship was observed between the size of cubicβ-Ti crystals(D^(3))and t;the growth kinetics factor K is 3.8μm^(3)·s^(-1).As the K value closes to 4μm^(3)·s^(-1),it is inferred the morphology evolution ofβ-Ti crystals is a coarsening behavior controlled by the diffusion of solute elements.

关键词： Ti_(48)Zr_(27)Cu_(6)Nb_(5)Be_(14) amorphous matrix composites semi-solid as-cast microstructure

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Asymmetrical Fault Current Calculation Method and Influencing Factors Analysis of Droop-Controlled Inverters

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 562-573页

作者： Huimin Zhao Zhikang Shuai jun Ge An luo Weimin Wu Z.John Shen College of Electrical and Information Engineering Hunan UniversityChangsha 410006China Electrical Engineering Department Shanghai Maritime UniversityShanghai 201306China Department of Electrical and Computer Engineering Ilinois Institute of TechnologyChicagoIL 60616 USA

Since the fault dynamic of droop-controlled inverter is different from synchronous generators (SGs), protection devices may become invalid, and the fault overcurrent may damage power electronic devices and threaten the safety of the microgrid. Therefore, it is imperative to conduct a comprehensive fault analysis of the inverter to guide the design of protection schemes. However, due to the complexity of droop control strategy, existing literatures have simplified asymmetric fault analysis of droop-controlled inverters to varying degrees. Therefore, accurate fault analysis of a droop-controlled inverter is needed. In this paper, by analyzing the control system, an accurate fault model is established. Based on this, a calculation method for instantaneous asymmetrical fault current is proposed. In addition, the current components and current characteristics are analyzed. It was determined that fault currents are affected by control loops, fault types, fault distance and nonlinear limiters. In particular, the influences of limiters on the fault model, fault current calculation and fault current characteristics were analyzed. Through detailed analysis, it was found that dynamics of the control loop cannot be ignored, the fault type and fault distance determine fault current level, and part of the limiters will totally change the fault current trend. Finally, calculation and experimental results verify the correctness of the proposed method.

关键词： Asymmetrical fault analysis droop control fault current calculation method limiter transient fault characteristics

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Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting

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CHINESE JOURNAL OF POLYMER SciENCE 2024年第8期42卷 1067-1076页

作者： Zhang, Chun-Peng Gao, Si-Jia luo, Ying Zou, Lei Zhang, Yong-jun Tiangong Univ Sch Mat Sci & Engn State Key Lab Separat Membranes & Membrane Proc Tianjin 300387 Peoples R China Tiangong Univ Sch Pharmaceut Sci State Key Lab Separat Membranes & Membrane Proc Tianjin 300387 Peoples R China Tiangong Univ Cangzhou Inst Cangzhou 061000 Peoples R China Nankai Univ Inst Hepatobiliary Dis Tianjin Key Lab Extracorporeal Life Support Crit D Affiliated Ctr Hosp 3 Tianjin 300170 Peoples R China

Glucose-sensitive membrane has potential application in self-regulating insulin release. Phenylboronic acid (PBA) is a well-known glucose reporter. Unfortunately, most PBA-based glucose-sensitive materials are expansion-type, which are not suitable as chemical valves in membrane pores for self-regulating insulin release. According to a new glucose-sensitive mechanism, we synthesized PBA-based contraction-type glucose-sensitive liner polymer and microgels. Herein, a glucose-sensitive membrane was prepared by grafting PBA-based contraction-type glucose-sensitive linear polymer on the membrane surface. Through adjusting the chain length and chain density, the glucose-sensitivity of the membrane was optimized. The membrane can reversibly regulate insulin release at physiologically relevant glucose concentrations in simulates body fluids and fetal bovine serum. The membrane also has good stability, anti-fouling and biocompatibility. It has potential application in self-regulating insulin release.

关键词： Phenylboronic acid Glucose-sensitive Membrane Surface grafting Insulin PHENYLBORONIC AciD BRUSHES DENSITY CHAINS LENGTH FILM

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Controllable Condensation of Aromatics and Its Mechanisms in Carbonization

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 34-46页

作者： Fan Xi Wang Chunlu luo Yang Ren Qiang Shen Haiping Long jun Sinopec Research Institute of Petroleum Processing Co. Ltd.Beijing 100083China

In order to obtain liquefied products with higher yields of aromatic molecules to produce mesophase pitch,a good understanding of the relevant reaction mechanisms is *** molecular dynamics simulations were used to study the thermal reactions of pyrene,1-methylpyrene,7,8,9,10-tetrahydrobenzopyrene,and mixtures of pyrene with 1-octene,cyclohexene,or *** reactant conversion rates,reaction rates,and product distributions were calculated and compared,and the mechanisms were analyzed and *** results demonstrated that methyl and naphthenic structures in aromatics might improve the conversion rates of reactants in hydrogen transfer processes,but their steric hindrances prohibited the generation of high *** naphthenic structures could generate more free radicals and presented a more obvious inhibition effect on the condensation of polymers compared with the methyl side *** was discovered that when different olefins were mixed with pyrene,1-octene primarily underwent pyrolysis reactions,whereas cyclohexene mainly underwent hydrogen transfer reactions with pyrene and styrene,mostly producing superconjugated biradicals through condensation reactions with *** the mixture systems,the olefins scattered aromatic molecules,hindering the formation of pyrene trimers and higher *** to the reactive molecular dynamics simulations,styrene may enhance the yield of dimer and enable the controlled polycondensation of pyrene.

关键词： carbonization controllable condensation aromatics mechanisms molecular simulation

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