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The difference of immunologic parameters between SARS patients of mild type and severe type

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Journal of Microbiology and Immunology 2005年第4期3卷 288-292页

作者： YONG JING CHENG ci bo huang GAO QIANG XIE QIAN WANG AI HUA LIU PEI LAI YING JUAN CHEN DE MIN HAN Rheumatology and Immunology Department Beifing Hospital Belting P. R. China Beijing Fuwai Hospital Beifing P. R. China Beijing board of Health Beifing P. R. China

The aim of this study is to study the difference of immunologic parameters between severe acute respiratory syndrome （SARS） patients of mild type and severe type. Data including white blood cell （WBC） count, lymphocyte count, CD3, CD4 and CD8 T lymphocyte count, levels of C3, C4, ESR （erythrocyte sedimentation rate） and CRP （C-reactive protein） from 1291 patients with SARS in each week from onset of illness were recorded. The clinical progress of each sign was analysed and the difference between mild type and severe type was compared. Lymphocyte count, CD8 T lymphocyte count declined in the first two weeks and recovered from the third week, while CRP and CA- levels rose in the first week and then recovered gradually. Lymphocyte count and CD8 T lymphocyte count of severe cases were much lower than that of mild type （P 〈 0.01）, while CRP and CA- levels in severe type were much higher than that of mild type （P 〈 0.01）. Lymphocyte count, CD8 T lymphocyte count, CRP and CA- levels are useful signs for the diagnosis of SARS of severe type and are valuable for the evaluation of its severity.

关键词： Severe acute respiratory syndrome (SARS) Lymphocyte count CD8 T lymphocyte count CRP CA

Application of the improved dung beetle optimizer,muti-head attention and hybrid deep learning algorithms to groundwater depth prediction in the Ningxia area,China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 18-23页

作者： Jiarui Cai bo Sun Huijun Wang Yi Zheng Siyu Zhou Huixin Li Yanyan huang Peishu Zong Collaborative Innovation Center on forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjingChina Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiChina China Meteorological Administration Key Laboratory of Transportation MeteorologyNanjingChina Jiangsu Meteorological Observatory NanjingChina

Due to the lack of accurate data and complex parameterization,the prediction of groundwater depth is a chal-lenge for numerical *** learning can effectively solve this issue and has been proven useful in the prediction of groundwater depth in many *** this study,two new models are applied to the prediction of groundwater depth in the Ningxia area,*** two models combine the improved dung beetle optimizer(Dbo)algorithm with two deep learning models:The Multi-head Attention-Convolution Neural Network-Long Short Term Memory networks(MH-CNN-LSTM)and the Multi-head Attention-Convolution Neural Network-Gated Recurrent Unit(MH-CNN-GRU).The models with Dbo show better prediction performance,with larger R(correlation coefficient),RPD(residual prediction deviation),and lower RMSE(root-mean-square error).Com-pared with the models with the original Dbo,the R and RPD of models with the improved Dbo increase by over 1.5%,and the RMSE decreases by over 1.8%,indicating better prediction *** addition,compared with the multiple linear regression model,a traditional statistical model,deep learning models have better prediction performance.

关键词： Groundwater depth Multi-head attention Improved dung beetle optimizer CNN-LSTM CNN-GRU Ningxia

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen Wen bo Zeng Xiaofeng Zhang Zichao huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

Unraveling the impacts of intermolecular interaction on morphology evolution for highly efficient organic solar cells and modules

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Science China Chemistry 2025年第01期 264-272页

作者： Xueqing Ma Yingying Cheng Yuqiang Liu Xinming Zheng Guangliu Ran Hongxiang Li Xinyue Cui Andong Zhang Wenkai Zhang Pei Cheng Wenchao huang Zhishan bo Beijing Key Laboratory of Energy Conversion and Storage Materials College of Chemistry Beijing Normal University College of Textiles and Clothing State Key Laboratory of Bio-fibers and Eco-textiles Qingdao University Key State Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and EngineeringWuhan University of Technology Department of Physics and Applied Optics Beijing Area Major Laboratory Center for Advanced Quantum Studies Beijing Normal University State Key Laboratory of Polymer Materials Engineering College of Polymer Science and Engineering Sichuan University

Understanding the effect of intermolecular interaction on the growth dynamic of active layers is critical for advancing organic solar cells(OSCs). However, the diverse structure of donors and acceptors makes the research challenging. Additives with customizable structures and properties could simplify this complexity. Herein, we meticulously tailor two additives of 3,4-ethylenedioxythiophene(EDOT) and 2,5-dibromo-3,4-ethylenedioxythiophene(DBEDOT), possessing distinct intermolecular interaction features to elaborate the inherent relationship. It is found that varied interaction strengths can alter film formation processes. The enhanced intermolecular interaction between the DBEDOT and non-fullerene acceptor BTP-e C9-4F results in pre-aggregation and longer crystallization duration of BTP-e C9-4F, facilitating the formation of films with compact molecular packing and decent phase separation. Thus, exciton dissociation and charge transport become more efficient. Finally, devices processed with DBEDOT exhibit a remarkable power conversion efficiency of 19.35% in small-area OSCs and 14.11% in bladecoated 5 cm × 5 cm organic solar mini-modules. Especially, OSCs can maintain 80% of their initial efficiency after continuous annealing at 85 °C for over 2,100 h.

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淤地坝溃坝风险性评估综述

灾害学 2025年第1期40卷 123-128,134页

作者：黄波张耀南中国科学院西北生态环境资源研究院兰州甘肃730000 中国科学院大学北京1000493 国家冰川冻土沙漠科学数据中心兰州甘肃730000 甘肃省科学数据总中心兰州甘肃730000

淤地坝作为一种关键的防灾减灾设施,对于粮食生产、水资源保持和洪水控制等方面发挥着至关重要的作用。上世纪六七十年代修建的大部分淤地坝面临淤满失效问题,突发的暴雨、地震等自然灾害将极大概率引起溃决,从而导致引发更为严重的次... 详细信息

淤地坝作为一种关键的防灾减灾设施,对于粮食生产、水资源保持和洪水控制等方面发挥着至关重要的作用。上世纪六七十年代修建的大部分淤地坝面临淤满失效问题,突发的暴雨、地震等自然灾害将极大概率引起溃决,从而导致引发更为严重的次生灾害。该文通过梳理黄土高原淤地坝溃坝风险性评价文献,总结了现有淤地坝溃坝风险性评价方法。结果表明,传统淤地坝风险性评价方法对影响因素数据的依赖程度很高;选取评价因子及其权重赋予存在较强的主观经验性;缺乏大范围的风险评估。因此,该文建议整合数据驱动模型的研究思路,利用多源数据,区域尺度上开展淤地坝溃坝风险性评价,为相关部门提供更可靠的决策支持,及具有提高防灾减灾能力实践意义。

关键词：淤地坝溃坝数据工程风险性评价

Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-Jun Zhang Wen-Wei Wang Jing-Shui Zhen bo-Cheng Li De-Cheng Cai Yang-Yang Du Hui huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

Developing stages and causes of desertification in the Mu Us sandland

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Chinese Science Bulletin 1999年第9期44卷 845-849页

作者： bo Wu Longjun ci Chinese Acad Forestry Chinese Res & Dev Ctr Combating Desertificat Beijing 100091 Peoples R China

Based on historical aerial photography of three periods and together with field investigation, the status of desertification development after the 1950s in the Mu Us sandland was analyzed, the difference of the desertification developing speed at two stages was compared, and its possible causes were explored. The results show that the developing speed of desertification from the late 1970s to the early 1990s is apparently slowed down, compared with that from the late 1950s to the late 1970s and there exists an obvious recovery trend at the second stage. The difference between the two stages accounts for severely over-reclaiming, over-grazing and unrestricted cutting during the first stage, which are the main causes of desertification development in the semi-arid steppe and arid desert steppe areas.

关键词： Mu Us sandland desertification developing stage over-reclaiming over-grazing unrestricted cutting.

Big spatial data for urban and environmental sustainability

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Geo-Spatial Information Science 2020年第2期23卷 125-140页

作者： bo huang Jionghua Wang Department of Geography and Resource Management The Chinese University of Hong KongHong KongChina

Eighty percent of big data are associated with spatial information,and thus are Big Spatial Data(BSD).BSD provides new and great opportunities to rework problems in urban and environmental sustainability with advanced BSD *** fully leverage the advantages of BSD,it is integrated with conventional data(*** sensing images)and improved methods are *** paper introduces four case studies:(1)Detection of polycentric urban structures;(2)Evaluation of urban vibrancy;(3)Estimation of population exposure to PM2.5;and(4)Urban land-use classification via deep *** results provide evidence that integrated methods can harness the advantages of both traditional data and ***,they can also improve the effectiveness of big data ***,this study makes three key recommendations for the development of BSD with regards to data fusion,data and predicting analytics,and theoretical modeling.

关键词： Big spatial data analytics review spatial modeling data fusion

Laminarin and Laminarin Oligosaccharides Originating from Brown Algae:Preparation,Biological Activities,and Potential Applications

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Journal of Ocean University of China 2021年第3期20卷 641-653页

作者： huang Yi JIANG Hong MAO Xiangzhao ci Fangfang College of Food Science and Engineering Ocean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Qingdao 266237China

Brown algae is one of the three major types of marine algae and includes approximately 2000 *** is widely dis-tributed in various seas around the *** algae contain a plethora of active substances,such as polysaccharides,polyphe-nols,omega-3 fatty acids,and ***,a type of storage carbohydrate found abundantly in brown algae,is mainly formed by glucose monomers linked byβ-1,3-glucosidic bonds and partialβ-1,6-glucosidic *** and laminarin oligo-saccharides,which contain 2-10 saccharide units,have extensive biological activities,such as antitumor,antioxidant,anti-inflam-matory,and prebiotic ***,both laminarin and laminarin oligosaccharides can be considered as ideal substrates for bioethanol production because they are composed of abundant glucose ***,brown algae-derived laminarin and lami-narin oligosaccharides have various potential applications in the food,medicine,cosmetics,and bioenergy *** paper reviews the preparation methods of laminarin and laminarin oligosaccharides,as well as their biological activities and potential applications.

关键词： brown algae laminarin laminarin oligosaccharides biological activities potential applications