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Immunoglobulin G-mediated food intolerance and metabolic syndrome influence the occurrence of reflux esophagitis in Helicobacter pylori-infected patients

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World Journal of Gastroenterology 2024年第8期30卷 855-862页

作者： Li-Hui Wang Bin-Bin Su Sheng-Shu Wang Guan-Chao sun Kun-Ming Lv Yi Li Hui Shi Qian-Qian Chen College Chinese PLA General HospitalBeijing 100853China Department of Gastroenterology Second Medical Center of Chinese PLA General HospitalBeijing 100853China Institute of Geriatrics The 2nd Medical CenterBeijing Key Laboratory of Aging and GeriatricsNational Clinical Research Center for Geriatrics DiseasesSecond Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Gastroenterology First Medical Center of Chinese PLA General HospitalBeijing 100853China

BACKGROUND Reflux esophagitis has an increasing prevalence and complex and diverse *** its risk factors is crucial to understanding the etiology,prevention,and management of the *** occurrence of reflux esophagitis may be associated with food reactions,Helicobacter pylori(***)infection,and metabolic *** To investigate the risk factors for reflux esophagitis and analyze the effects of immunoglobulin(Ig)G-mediated food intolerance,*** infection,and metabolic syndrome on reflux *** Outpatients attending the Second Medical Center of the PLA General Hospital between 2017 and 2021 were retrospectively *** patients’basic information,test results,gastroscopy results,*** test results,and IgG-mediated food intolerance results were *** logistic regression analysis was used to analyze risk factors for reflux *** mediation analysis was used to evaluate the effects of IgG-mediated food intolerance and metabolic syndrome on *** infection affecting reflux *** A total of 7954 outpatients were included;the prevalence of reflux esophagitis,IgG-mediated food intolerance,*** infection,and metabolic syndrome were 20.84%,61.77%,35.91%,and 60.15%,*** analysis showed that the independent risk factors for reflux esophagitis included IgG-mediated food intolerance(OR=1.688,95%ci:1.497-1.903,Pci:1.030-1.317,P=0.01484),and the independent protective factor for reflux esophagitis was *** infection(OR=0.400,95%ci:0.351-0.456,Pciated with reduced occurrence of reflux esophagitis(P=0.0200).Metabolic syndrome had a partially negative mediating effect on *** infection and reduced the occurrence of reflux esophagitis(P=0.0220).CONCLUSION Patients with IgG-mediated food intol

关键词： Gastroesophageal reflux Esophagitis Food intolerance Metabolic syndrome Helicobacter pylori Chemokines

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基于大数据的哈尔滨城市空间活力分布特征及提升策略研究

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低温建筑技术 2024年第7期46卷 37-42页

作者：王作为赵婧马超慈醒孙琦哈尔滨工业大学城市规划设计研究院有限公司哈尔滨150000

城市活力作为衡量一个城市发展质量的重要指标和要素,成为城市空间规划研究中的重要议题。随着大数据技术的发展和广泛的应用,利用大数据精准识别城市空间活力分布特征,对于城市空间活力的提升具有重要的指导意义。文中以哈尔滨主城区... 详细信息

城市活力作为衡量一个城市发展质量的重要指标和要素,成为城市空间规划研究中的重要议题。随着大数据技术的发展和广泛的应用,利用大数据精准识别城市空间活力分布特征,对于城市空间活力的提升具有重要的指导意义。文中以哈尔滨主城区为研究范围,通过对百度热力图数据、POI数据、人口数据的识别与分析,划分出哈尔滨市主城区的活力强区、活力中区、活力弱区,再对活力强区和活力弱区中的活力要素进行对比分析,探寻空间活力的影响因素,从而总结哈尔滨城市空间活力存在的问题,并有针对性提出哈尔滨城市空间活力的提升策略,为城市空间活力的构建提供理论依据。

关键词：城市空间活力 POI数据城市空间规划

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加速康复外科理念管理下行手术治疗食管癌患者出院准备度现状及影响因素分析

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中西医结合护理（中英文） 2024年第7期10卷 108-110页

作者：孙聪聪张文文慈利凤山东大学齐鲁医院山东济南250000

目的探讨加速康复外科理念(ERAS)管理下行手术治疗食管癌患者出院准备度现状及影响因素。方法选取2021年2月至2022年5月期间于山东大学齐鲁医院胸外科行手术治疗的82例食管癌患者为研究对象,采用基本资料调查问卷收集患者的临床资料,并... 详细信息

目的探讨加速康复外科理念(ERAS)管理下行手术治疗食管癌患者出院准备度现状及影响因素。方法选取2021年2月至2022年5月期间于山东大学齐鲁医院胸外科行手术治疗的82例食管癌患者为研究对象,采用基本资料调查问卷收集患者的临床资料,并通过出院准备度量表(RHDS)对患者的出院准备度现状进行分析。采用多元线性回归分析食管癌手术患者出院准备度的影响因素。结果82例行手术治疗的食管癌患者的RHDS总均分为(92.78±12.12)分,出院准备度处于较高水平。单因素分析结果显示,家庭人均月收入、年龄、文化程度、住院时间及婚姻状况均与行手术治疗食管癌患者的出院准备度有关(P均<0.05)。Pearson相关性分析结果显示,行手术治疗的食管癌患者出院准备度与出院指导质量呈正相关(P<0.05)。多元线性回归分析结果显示,文化程度、年龄、住院时间和出院指导质量量表得分均是行手术治疗食管癌患者出院准备度的影响因素(P均<0.05)。结论ERAS管理下行手术治疗的食管癌患者出院准备度处于较高水平。年龄、文化程度、住院时间和QDTS得分均是影响其出院准备度的影响因素。医护人员可根据患者的个体差异性为其提供针对性、个体化护理方案。

关键词：食管癌手术加速康复外科理念出院准备度影响因素

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KCNQ1 rs2237895 gene polymorphism increases susceptibility to type 2 diabetes mellitus in Asian populations

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World Journal of Diabetes 2024年第3期15卷 552-564页

作者： Dong-Xu Li Li-Ping Yin Yu-Qi Song Nan-Nan Shao Huan Zhu Chen-Sen He Jiang-Jie sun First Clinical Medical College Anhui Medical UniversityHefei 230032Anhui ProvinceChina School of Mental Health and Psychological Sciences Anhui Medical UniversityHefei 230032Anhui ProvinceChina School of Clinical Medicine Anhui Medical UniversityHefei 230031Anhui ProvinceChina School of Health Care Management Anhui Medical UniversityHefei 230032Anhui ProvinceChina

BACKGROUND The association of single nucleotide polymorphism of KCNQ1 gene rs2237895 with type 2 diabetes mellitus(T2DM)is currently *** is unknown whether this association can be gene realized across different *** To determine the association of KCNQ1 rs2237895 with T2DM and provide reliable evidence for genetic susceptibility to *** We searched PubMed,Embase,Web of Science,Cochrane Library,Medline,Baidu Academic,China National Knowledge Infrastructure,China Biomedical Literature Database,and Wanfang to investigate the association between KCNQ1 gene rs2237895 and the risk of T2DM up to January 12,*** Manager 5.4 was used to analyze the association of the KCNQ1 gene rs2237895 polymorphism with T2DM and to evaluate the publication bias of the selected *** Twelve case–control studies(including 11273 cases and 11654 controls)met our inclusion *** the full population,allelic model[odds ratio(OR):1.19;95%confidence interval(95%ci):1.09–1.29;Pci:1.11–1.29;Pci:1.14–1.42;Pci:1.15–1.60;P=0.0003)(OR:1.22;95%ci:1.10–1.36;P=0.0002)indicated that the KCNQ1 gene rs2237895 polymorphism was significantly correlated with susceptibility to *** stratified analysis,this association was confirmed in Asian populations:allelic model(OR:1.25;95%ci:1.13–1.37;Pci:1.11–1.49;P=0.0007),dominant model(OR:1.35;95%ci:1.20–1.52;Pci:1.22–1.81;Pci:1.16–1.36;Pciation was not significant:Allelic model(OR:1.06,95%ci:0.98–1.14;P=0.12),recessive model(OR:1.04;95%ci:0.75–1.42;P=0.83),dominant model(OR:1.06;95%ci:0.98–1.15;P=0.15),codominant model(OR:1.08;95%ci:0.82–1.42;P=***:1.15;95%ci:0.95–1.39;P=0.14).CONCLUSION KCNQ1 gene rs2237895 was significantly associated with susceptibility to T2DM

关键词： Type 2 diabetes mellitus KCNQ1 rs2237895 Single nucleotide polymorphism Asian populations

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Two different autorefractors for vision screening in children and adolescents

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 331-338页

作者： Xiao-Jun Chen Lin-Jie Liu Bing sun Dan-Dan Jiang Shu-Shu Zuo Yan-Hui Wang Chun-Hua Zhang Yan-Yan Chen School of Optometry and Ophthalmology Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To compare the consistency of two autorefractors(Tianle RM-9000 and Topcon KR-800)for school-age myopia children,and to provide a basis for largescale data analysis and ***:The refractive error in 909 subjects(age 4–18y)were measured using both autorefractors without *** data were analyzed using Fourier decomposition and the correlation coefficients,intraclass correlation coefficients(ICC),and Bland-Altman limits of agreement(LoA)for each parameter were ***:There was a strong correlation between the spherical equivalent(SE),sphere diopter(DS),and cylinder diopter(DC)readings of the Tianle RM-9000 and those of the Topcon KR-800,with correlation coefficient values of 0.98,0.98 and 0.83 and ICC values of 0.99,0.99 and 0.93,***,the correlation coefficients and ICC values of J0 and J45 were unreliable(R=-0.004,-0.034;both ICCci:-1.00,1.10;J45 SD:0.52;95%ci:-1.00,1.00).CONCLUSION:The two autorefractors are consistent with each other,as the differences in SE,DS,and DC were within the clinically acceptable *** can compare the data measured by either device in different studies and use the two devices in the same study to generate a dataset that can be analyzed ***,the J0 and J45 vectors are unreliable and should not be used to assess astigmatism.

关键词： refractive error autorefractors school-age myopia children

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Neoadjuvant camrelizumab(an anti-PD-1 antibody)plus chemotherapy or apatinib(a VEGFR-2 inhibitor)for initially unresectable stage II–III non-small-cell lung cancer:a multicentre,two-arm,phase 2 exploratory study

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3015-3023页

作者： Haoran Xia Han Zhang Zheng Ruan Huibiao Zhang Liangdong sun Hezhong Chen Yongxin Zhou Lele Zhang Dongliang Bian Xinsheng Zhu Jing Zhang Fenghuan sun Huansha Yu Nan Song Xiaogang Liu Yuming Zhu Haiping Zhang Wenxin He Jian Chen Jie Yang Guohan Chen Shiliang Xie Dongfang Tang Xiaomiao Zhang Liang Duan Deping Zhao Qinchuan Li Peng Zhang Gening Jiang Department of Thoracic Surgery Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Department of Thoracic Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Thoracic Surgery Huadong Hospital Affiliated to Fudan UniversityShanghaiChina Department of Thoracic Surgery Changhai HospitalNaval Medical UniversityShanghaiChina Department of Thoracic-Cardiovascular Surgery Tongji HospitalTongji University School of MedicineShanghaiChina Central Laboratory Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Experimental Animal Center Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Department of Oncology Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Department of Thoracic Surgery Shanghai East HospitalTongji University School of MedicineShanghaiChina

This multicentre,two-arm,phase 2 study aimed to explore the efficacy and safety of neoadjuvant camrelizumab plus chemotherapy or apatinib in patients with initially unresectable stage II–III non-small-cell lung cancer(NSCLC).Eligible patients regardless of PD-L1 expression received neoadjuvant camrelizumab 200 mg and platinum-doublet chemotherapy every 3 weeks(arm A)or those with PD-L1-positive tumors received neoadjuvant camrelizumab and apatinib 250 mg once daily(arm B),for 2–4 cycles,followed by *** primary endpoint was major pathological response(MPR)*** patients in arm A and 21 in arm B were *** rates were 50.0%(15/30)in arm A and 42.9%(9/21)in arm B,with all patients achieving R0 *** these patients,the MPR and pathological complete response rates were both 20.0%(95%ci 4.3–48.1)in arm A and were 55.6%(95%ci 21.2–86.3)and 11.1%(95%ci 0.3–48.2)in arm B,*** corresponding objective response rates were 33.3%(95%ci 11.8–61.6)and 55.6%(95%ci 21.2–86.3).With a median follow-up of 22.4 months(95%ci 19.0–26.0),the median event-free survival was not reached(NR;95%ci 13.6-NR)in arm A and 16.8 months(95%ci 8.6-NR)in arm *** 3 or above treatment-related adverse events occurred in eight(26.7%)patients in arm A and three(14.3%)in arm *** analysis showed baseline TYROBP expression was predictive of treatment response in arm *** camrelizumab plus chemotherapy or apatinib exhibits preliminary efficacy and manageable toxicity in patients with initially unresectable stage II–III NSCLC.

关键词： Surgery chemotherapy treatment

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基于骨骼特征点的跌倒检测方法

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内江师范学院学报 2024年第2期39卷 52-57页

作者：侯相军陈亚军孙超越肖慈西华师范大学电子信息工程学院四川南充637009

针对现有跌倒检测方法中利用时空图卷积网络(ST-GCN)进行行为检测的准确率有待提高、时间信息利用不够充分等问题,提出了一种基于轻量级YOLO v3人体目标检测模型结合人体骨骼特征点的跌倒检测方法.本方法利用AlphaPose算法实时得到人体... 详细信息

针对现有跌倒检测方法中利用时空图卷积网络(ST-GCN)进行行为检测的准确率有待提高、时间信息利用不够充分等问题,提出了一种基于轻量级YOLO v3人体目标检测模型结合人体骨骼特征点的跌倒检测方法.本方法利用AlphaPose算法实时得到人体的骨骼特征点信息,在此基础上结合改进的ST-GCN模型提取了强化后的行为时空信息,从而对跌倒进行更加准确的检测.在通用数据集及自建数据集上的测试结果表明,该方法在跌倒检测中具有良好的效果.

关键词：计算机视觉跌倒行为检测目标检测骨骼特征点时空图卷积

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Inetetamab combined with pyrotinib and oral vinorelbine for patients with human epidermal growth factor receptor 2 positive advanced breast cancer:A single-arm phase 2 clinical trial

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Cancer Pathogenesis and Therapy 2024年第1期2卷 31-37页

作者： Nan Jin Yi Xu Siqi Wang Chunxiao sun Xueqi Yan Fan Yang Yan Liang Weiwei Chen Xiang Huang Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Pathology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Radiology Department The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Oncology Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu 210000China

Background Human epidermal growth factor receptor 2(HER2)-targeted agents have significantly improved the outcomes of patients with HER2-positive breast cancer;however,a large proportion of patients still develop resistance to *** this study,we investigated the efficacy and safety of inetetamab,another anti-HER2 antibody,combined with pyrotinib and oral vinorelbine in patients with HER2-positive advanced breast cancer so as to provide new ideas for the *** In this prospective,single-arm,phase 2 trial,patients with HER2-positive advanced breast cancer with disease progression after trastuzumab were *** received a combination of inetetamab(loading dose of 8 mg/kg and subsequent doses of 6 mg/kg intravenously once every 3 weeks),pyrotinib(400 mg orally once daily),and vinorelbine(60 mg/m^(2)orally once weekly)until disease progression or intolerable *** primary endpoint was progression-free survival(PFS).The secondary endpoints included objective response rate(ORR),overall survival(OS),disease control rate(DCR),and *** Between February 13,2022 and December 25,2022,30 patients were screened and enrolled in this *** median age of the patients at enrollment was 54 years,12 patients(40.0%)had hormone-receptor-positive disease and 23 patients(76.7%)had visceral *** median PFS was 8.63 months(95%confidence interval[ci]4.15-13.12 months).The median OS was not *** ORR was 53.3%(16/30)and the DCR was 96.7%(29/30).The most common Grade III/IV adverse events were leukopenia(n=5,16.7%),neutropenia(n=4,13.3%),and diarrhea(n=3,10%).No treatment-related serious adverse events or deaths *** The combination regimen of inetetamab,pyrotinib,and oral vinorelbine showed encouraging efficacy and favorable safety in patients with HER2-positive advanced breast cancer and could be considered as an alternative treatment option for the patients.

关键词： Human epidermal growth factor receptor 2 Breast cancer Inetetamab Pyrotinib Vinorelbine

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Comparison of ocular biometric parameters between two swept-source optical coherence tomography devices and Scheimpflug tomography in patients with cataract

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1437-1446页

作者： Shan Ma Cheng Li Jing sun Jun Yang Kai Wen Xi-Teng Chen Fang-Yu Zhao Rong-Yu Gao Fang Tian Tianjin Key Laboratory of Retinal Functions and Diseases Tianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300380China Zhengda Guangming Eye Group Weifang 261000Shandong ProvinceChina Binzhou Polytechnic Binzhou 256603Shandong ProvinceChina

AIM:To assess and compare the variations and agreements across different ocular biometric parameters using swept-source optical coherence tomography(SS-OCT)and Scheimpflug tomography in patients diagnosed with ***:This prospective case series was conducted at Tianjin Medical University Eye *** total,212 eyes from 212 patients scheduled for phacoemulsification were *** were evaluated preoperatively using two SSOCT devices(IOLMaster700 and CASIA2)and Scheimpflug tomography(Pentacam).Central corneal thickness(CCT),anterior chamber depth(ACD),aqueous depth(AQD),white-to-white distance(WTW),flat simulated keratometry(Kf),steep simulated keratometry(Ks),mean keratometry(Km),and total corneal keratometry(TKm)were *** correlation coefficient(ICC),95%confidence intervals(ci)and limits of agreement(LoA)widths were conducted to assess differences and correlations between ***:All parameters,except for Ks,were significantly *** comparison revealed no significant differences between keratometry obtained by IOLMaster 700 and *** widths of all paired comparisons for Ks were>0.80 *** for WTW between IOLMaster 700 and CASIA2 and between CASIA2 and Pentacam,other Pearson’s coefficients between devices showed a strong correlation(all r>0.95).The ICC of WTW(ICC=0.438,95%ci 0.167-0.625)showed poor *** reliability of CCT,ACD,and AQD was excellent(all ICC>0.95),whereas that of TKm was good(ICC=0.827,95%ci 0.221-0.939).A significant linear correlation was also observed among ***:The ocular parameters derived from the use of IOLMaster700,CASIA2,and Pentacam exhibit significant discrepancies;as such,measurements from these devices should not be deemed as interchangeable.

关键词： ocular parameters swept-source optical coherence tomography cataract

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Effect of autologous bone marrow stem cells-scaffold transplantation on the ongoing pregnancy rate in intrauterine adhesion women:a randomized,controlled trial

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Science China(Life Sciences) 2024年第1期67卷 113-121页

作者： Hui Zhu Taishun Li Peizhen Xu Lijun Ding Xianghong Zhu Bin Wang Xiaoqiu Tang Juan Li Pengfeng Zhu Huiyan Wang Chenyan Dai Haixiang sun Jianwu Dai Yali Hu Department of Obstetrics and Gynecology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Department of Biostatistics Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Department of Gynecology Changzhou Maternal and Child Health Care HospitalChangzhou Medical CenterNanjing Medical UniversityChangzhou 213004China Clinical Center for Stem Cell Research Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Department of Hematology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100190China

Intrauterine adhesion is a major cause of female reproductive *** we and others uncontrolled pilot studies showed that treatment with autologous bone marrow stem cells made a few patients with severe intrauterine adhesion obtain live birth,no large sample randomized controlled studies on this therapeutic strategy in such patients have been reported so *** verify if the therapy of autologous bone marrow stem cells-scaffold is superior to traditional treatment in moderate to severe intrauterine adhesion patients in increasing their ongoing pregnancy rate,we conducted this randomized controlled clinical *** 195 participants with moderate to severe intrauterine adhesion were screened and 152 of them were randomly assigned in a 1:1 ratio to either group with autologous bone marrow stem cells-scaffold plus Foley balloon catheter or group with only Foley balloon catheter(control group)from February 2016 to January *** per-protocol analysis included 140 participants:72 in bone marrow stem cells-scaffold group and 68 in control *** ongoing pregnancy occurred in 45/72(62.5%)participants in the bone marrow stem cells-scaffold group which was significantly higher than that in the control group(28/68,41.2%)(RR=1.52,95%ci 1.08–2.12,P=0.012).The situation was similar in live birth rate(bone marrow stem cells-scaffold group 56.9%(41/72)*** group 38.2%(26/68),RR=1.49,95%ci 1.04–2.14,P=0.027).Compared with control group,participants in bone marrow stem cells-scaffold group showed more menstrual blood volume in the 3rd and 6th cycles and maximal endometrial thickness in the 6th cycle after hysteroscopic *** incidence of mild placenta accrete was increased in bone marrow stem cells-scaffold group and no severe adverse effects were *** conclusion,transplantation of bone marrow stem cells-scaffold into uterine cavities of the participants with moderate to severe intrauterine adhesion increased their ongoing pregnancy and

关键词： intrauterine adhesion Asherman’s syndrome uterine infertility autologous bone marrow stem cells transplantation endometrial regeneration ongoing pregnancy rate

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