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A pair of nuclear factor Y transcription factors act as positive regulators in jasmonate signaling and disease resistance in Arabidopsis

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Journal of Integrative Plant Biology 2024年第9期66卷 2042-2057页

作者： chuyu lin Chenghao Lan Xiaoxiao Li Wei Xie Fucheng lin Yan Liang Zeng Tao Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects Institute of BiotechnologyZhejiang UniversityHangzhou 310058China State Key Laboratory for Managing Biotic and Chemical Treats to the Quality and Safety of Agro‐products Institute of BiotechnologyZhejiang UniversityHangzhou 311400China

The plant hormone jasmonate(JA)regulates plant growth and immunity by orchestrating a genome-wide transcriptional *** the resting stage,JASMONATE-ZIM DOMAIN(JAZ)proteins act as main repressors to regulate the expression of JA-responsive genes in the JA signaling ***,the mechanisms underlying de-repression of JA-responsive genes in response to JA treatment remain ***,we report two nuclear factor Y transcription factors NF-YB2 and NF-YB3(thereafter YB2 and YB3)play key roles in such de-repression in ***2 and YB3 function redundantly and positively regulate plant resistance against the necrotrophic pathogen Botrytis cinerea,which are specially required for transcriptional activation of a set of JA-responsive genes following ***,YB2 and YB3 modulated their expression through direct occupancy and interaction with histone demethylase Ref6 to remove repressive histone ***,YB2 and YB3 physically interacted with JAZ repressors and negatively modulated their abundance,which in turn attenuated the inhibition of JAZ proteins on the transcription of JA-responsive genes,thereby activating JA response and promoting disease ***,our study reveals the positive regulators of YB2 and YB3 in JA signaling by positively regulating transcription of JA-responsive genes and negatively modulating the abundance of JAZ proteins.

关键词： histone demethylase jasmonate response JAZ repressor necrotrophic resistance nuclear factor

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A pair of nuclear factor Y transcription factors act as positive regulators in jasmonate signaling and disease resistance in Arabidopsis

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Journal of Integrative Plant Biology 2024年第09期 2042-2057页

作者： chuyu lin Chenghao Lan Xiaoxiao Li Wei Xie Fucheng lin Yan Liang Zeng Tao Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects Institute of Biotechnology Zhejiang University State Key Laboratory for Managing Biotic and Chemical Treats to the Quality and Safety of Agro-products Institute of BiotechnologyZhejiang University

The plant hormone jasmonate(JA) regulates plant growth and immunity by orchestrating a genomewide transcriptional reprogramming. In the resting stage, JASMONATE-ZIM DOMAIN(JAZ) proteins act as main repressors to regulate the expression of JA-responsive genes in the JA signaling ***, the mechanisms underlying de-repression of JA-responsive genes in response to JA treatment remain elusive. Here, we report two nuclear factor Y transcription factors NF-YB2 and NF-YB3(thereafter YB2 and YB3) play key roles in such de-repression in Arabidopsis. YB2 and YB3 function redundantly and positively regulate plant resistance against the necrotrophic pathogen Botrytis cinerea, which are specially required for transcriptional activation of a set of JA-responsive genes following ***, YB2 and YB3 modulated their expression through direct occupancy and interaction with histone demethylase Ref6 to remove repressive histone modifications. Moreover, YB2 and YB3physically interacted with JAZ repressors and negatively modulated their abundance, which in turn attenuated the inhibition of JAZ proteins on the transcription of JA-responsive genes, thereby activating JA response and promoting disease resistance. Overall, our study reveals the positive regulators of YB2 and YB3 in JA signaling by positively regulating transcription of JA-responsive genes and negatively modulating the abundance of JAZ proteins.

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Polycomb Repressive Complex 2-Mediated H3K27 Trimethylation Is Required for Pathogenicity in Magnaporthe oryzae

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Rice science 2022年第4期29卷 363-374页

作者： WU Zhongling QIU Jiehua SHI Huanbin lin chuyu YUE Jiangnan LIU Zhiquan XIE Wei Naweed INAQVI KOU Yanjun TAO Zeng Ministry of Agriculture and Rural Affairs Key Laboratory of Molecular Biology of Crop Pathogens and Insects Institute of BiotechnologyZhejiang UniversityHangzhou 310058China State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhou 311400China Temasek Life Sciences Laboratory and Department of Biological Sciences 1 Research LinkNational University of SingaporeSingapore 117604Singapore

Polycomb repressive complex 2(PRC2)contributes to catalyze the methylation of histone H3 at lysine 27 and plays vital roles in transcriptional silencing and growth development in various *** Magnaporthe oryzae,histone H3K27 is found to associate with altered transcription of in planta induced ***,it is still unknown whether and how H3K27me3 modification is involved in pathogenicity to rice and stress *** this study,we found that core subunits of PRC2,Kmt6-Suz12-Eed,were required for fungal pathogenicity to rice in ***6-Suz12-Eed localized in the nuclei and was necessary for the establishment of H3K27me3 *** ChIP-seq analysis,9.0%of genome regions enriched with H3K27me3 occupancy,which corresponded to 1033 genes in ***,deletion of Kmt6,Suz12 or Eed altered genome-wide transcriptional expression,while the de-repression genes in theΔkmt6 strain were highly associated with H3K27me3 ***,plenty of genes which encode effectors and secreted enzymes,secondary metabolite synthesis genes,and cell wall stress-responsive genes were directly occupied with H3K27me3 modification and de-repression in theΔkmt6 *** results elaborately explained how PRC2 was required for pathogenicity,which is closely related to effector modulated host immunity and host environment adaption.

关键词： rice blast H3K27me3 transcriptional regulation pathogenicity Polycomb repressive complex 2

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Combination of methylthio-chemistry with living crystallization-driven self-assembly toward uniformπ-conjugated nanostructures with antibacterial activity,surface tailorability,tunable morphology and dimension

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Science China Chemistry 2024年第7期67卷 2341-2352页

作者： chuyu Duan Binbin Xu Ruru Li Xiaoyu Huang Shaoliang lin Chun Feng Shanghai Key Laboratory of Advanced Polymeric Materials School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

Living crystallization-driven self-assembly(CDSA)provides robust access to uniformπ-conjugated nanostructures(CNSs)from block copolymers(BCPs)containing a crystallineπ-conjugated segment with controlled dimension,morphology and composition,which show appealing applications in biomedicine,photocatalysis and *** further expand the application spectrum of these CNSs,the development of facile strategies toward diverse CNSs with varying structures/functionalities is highly ***,BCPs consisting of oligo(p-phenylene ethynylene)-b-poly(polypropyl-3-methanethiol acrylate)(OPE_(9)-bPMTPA35and OPE_(9)-b-PMTPA_(58);the subscript represents the number of repeat unit of each block)consisting of a crystallineπ-conjugated core-forming OPE_(9)segment and a corona-forming PMTPA block are *** efficient“click-type”alkylation of methylthio groups,OPE_(9)-b-PMTPA with varying contents of sulfonium unit is *** ribbon-like micelles with different widths and lengths can then be generated in a controlled manner via the self-seeding approach of living ***,negatively charged polymeric and Ag nanoparticles can be immobilized on sulfonium/methylthio-containing shells by taking advantage of electrostatic attraction and coordination interaction,***,the ribbon-like micelles with positively charged shells exhibit antibacterial activity against *** the ease of modification of PMTPA-based shell and attractive opto-electronic/photocatalytic properties ofπ-conjugated units,the combination of methylthio-chemistry and living CDSA opens a new avenue to generate multi-functional CNSs for widespread applications from biomedicine to photocatalysis.

关键词： crystallization-driven self-assembly block copolymer π-conjugated nanostructure methylthio-chemistry

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浅析室内装修污染

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当代化工研究 2018年第5期 117-118页

作者：林楚育山东省莱山第一中学山东264000

室内是人们生活的重要场所,人们越来越多的时间是在室内度过的,对室内环境要求也越来越高,不仅要求舒适更要求安全。室内装修对环境影响很大,容易造成污染,威胁人们的身体健康。本文简述了室内装修污染的概念、污染物类型和危害、治理措... 详细信息

室内是人们生活的重要场所,人们越来越多的时间是在室内度过的,对室内环境要求也越来越高,不仅要求舒适更要求安全。室内装修对环境影响很大,容易造成污染,威胁人们的身体健康。本文简述了室内装修污染的概念、污染物类型和危害、治理措施,希望能够引起公众对装修污染的重视,在讲求装潢美观的同时,更注重居住环境的安全问题。

关键词：室内装修污染物治理措施

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Graphene-based all-optical modulators

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Frontiers of Optoelectronics 2020年第2期13卷 114-128,F0004页

作者： chuyu ZHONG Junying LI Hongtao lin Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province College of Information Science and Electronic EngineeringZhejiang UniversityHangzhou 310027China School of Microelectronics Zhejiang UniversityHangzhou 310027China College of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China

All-optical devices,which are utilized to process optical signals without electro-optical conversion,play an essential role in the next generation ultrafast,ultralow power-consumption optical information processing *** satisfy the performance requirement,nonlinear optical materials that are associated with fast response,high nonlinearity,broad wavelength operation,low optical loss,low fabrication cost,and integration compatibility with optical components are *** is a promising candidate,particularly considering its electrically or optically tunable optical properties,ultrafast large nonlinearity,and high integration compatibility with various *** far,three all-optical modulation systems utilize graphene,namely free-space modulators,fiber-based modulators,and on-chip *** paper aims to provide a broad view of state-of-the-art researches on the graphene-based all-optical modulation *** performances of different devices are reviewed and compared to present a comprehensive analysis and perspective of graphene-based all-optical modulation devices.

关键词： graphene saturable absorption low power consumption all-optical modulation

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Free-spectral-range-free filters with ultrawide tunability across the S+C+L band

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Photonics Research 2021年第6期9卷 1013-1018页

作者： CHUNLEI SUN chuyu ZHONG MAOLIANG WEI HUI MA YE LUO ZEQUN CHEN RENJIE TANG JIAlinG JIAN HONGTAO lin LAN LI Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province School of EngineeringWestlake UniversityHangzhou 310024China Institute of Advanced Technology Westlake Institute for Advanced StudyHangzhou 310024China Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province College of Information Science and Electronic EngineeringZhejiang UniversityHangzhou 310027China School of Microelectronics Zhejiang UniversityHangzhou 310027China

Optical filters are essential parts of advanced optical communication and sensing *** them,the ones with an ultrawide free spectral range(FSR)are especially *** are promising to provide access to numerous wavelength channels highly desired for large-capacity optical transmission and multipoint multiparameter *** schemes for wide-FSR filters either suffer from limited cavity length or poor fabrication tolerance or impose an additional active-tuning control *** theoretically and experimentally demonstrate a filter that features FSR-free operation capability,subnanometer optical bandwidth,and acceptable fabrication *** one single deep dip within a record-large waveband(S+C+L band)is observed by appropriately designing a side-coupled Bragg-grating-assisted Fabry–Perot filter,which has been applied as the basic sensing unit for both the refractive index and temperature *** such basic units are also cascaded in series to demonstrate a multichannel *** work provides a new insight to design FSR-free filters and opens up a possibility of flexible large-capacity integration using more wavelength channels,which will greatly advance integrated photonics in optical communication and sensing.

关键词： free desired insight

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广州抗逆转录病毒治疗后低水平HIV-1病毒载量感染者基因型耐药特征分析

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国际病毒学杂志 2024年第2期31卷 145-149页

作者：凌雪梅林雅晴李凌华李俊彬李全敏曾琨张楚瑜兰芸广州医科大学附属市八医院感染病中心 510440 广州医科大学附属市八医院传染病研究所 510440

目的分析广州市抗逆转录病毒治疗(antiretroviral therapy,ART)后HIV-1病毒载量介于50~200 copies/mL的感染者基因型耐药发生特征。方法募集2023年1月至7月广州医科大学附属市八医院感染门诊接受ART满6个月,且HIV-1病毒载量介于50~200 c... 详细信息

目的分析广州市抗逆转录病毒治疗(antiretroviral therapy,ART)后HIV-1病毒载量介于50~200 copies/mL的感染者基因型耐药发生特征。方法募集2023年1月至7月广州医科大学附属市八医院感染门诊接受ART满6个月,且HIV-1病毒载量介于50~200 copies/mL的感染者。用0.5 mL血浆于4℃超速离心浓缩病毒后提取RNA,经逆转录和巢式PCR扩增HIV-1 pol基因片段。获得基因序列经COMET HIV-1进行分型,并用Mega 11构建系统邻接法进化树验证亚型。经斯坦福HIV耐药数据库解析耐药发生情况。结果共随访11799例感染者,发现415例(3.5%)低水平病毒载量感染者。从完成检测的297例感染者中扩增获得154条pol基因片段序列(52.0%)。主要基因亚型为CRF01-AE(34.4%,53/154)和CRF07-BC(31.2%,48/154)。耐药相关突变(drug resistance mutations,DRMs)发生率为37.0%(57/154),最常见的DRMs为非核苷类逆转录酶抑制剂(NNRTIs)突变V179E(11.7%,18/154)和核苷类逆转录酶抑制剂(NRTIs)突变S68G(6.5%,10/154)和M184V(5.2%,8/154)。对任一药物耐药发生率为17.5%(27/154),其中NVP耐药率为11.7%(18/154),EFV耐药率为11.0%(17/154),RPV耐药率为10.4%(16/154)。结论广州ART后低水平病毒载量感染者耐药相关突变发生率较高(18.2%~37.0%),对我国常用的一线抗病毒药物存在不同程度耐药。应加强治疗后低病毒载量感染者的耐药监测,以优化治疗方案、改善临床结果。

关键词：人免疫缺陷病毒抗逆转录病毒治疗低病毒载量基因型耐药

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深圳市三级医院静脉用药调配中心的现状与服务效能:基于13家医院的横断面调研

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儿科药学杂志 2024年第8期30卷 28-31页

作者：甘金芳李楚玉邱文涛林哲思刘妙娜郭惠娟国家感染性疾病临床医学研究中心深圳市第三人民医院南方科技大学第二附属医院广东深圳518112 深圳市宝安区妇幼保健院广东深圳518133

目的:调研广东省深圳市三级医院静脉用药调配中心(PIVAS)的现状,为PIVAS的建设和发展提供参考。方法:设计问卷,对广东省深圳市三级医院的PIVAS进行多中心横断面调研,包含PIVAS开展时间、PIVAS数量、床位数目、面积、设备配备、人员模式... 详细信息

目的:调研广东省深圳市三级医院静脉用药调配中心(PIVAS)的现状,为PIVAS的建设和发展提供参考。方法:设计问卷,对广东省深圳市三级医院的PIVAS进行多中心横断面调研,包含PIVAS开展时间、PIVAS数量、床位数目、面积、设备配备、人员模式、成本和收益等数据,分析各医疗机构中PIVAS建设的差异。结果:收集问卷13份,回复率为100%。PIVAS运行时间1~10年不等(中位数5年);建筑面积135~760 m^(2),其中≤500 m^(2)占53.85%(7/13),>500 m^(2)占46.15%(6/13);日均调配输液量≤500袋占53.85%(7/13),501~1000袋占15.38%(2/13),1001~2000袋占30.77%(4/13);PIVAS人员模式方面,采用药学管理占84.62%(11/13),药护管理占15.38%(2/13)。有84.62%机构认为PIVAS目前的普通药物与抗生素配置费收取不合理,100%认为PIVAS目前的抗肿瘤药物配置费、肠外营养配置费收取不合理。结论:近年来,广东省深圳市三级医院PIVAS逐步发展壮大,新开的PIVAS增加了许多信息化、智能化设备投入,成本也随之增加。因PIVAS工作人员紧缺,大部分医疗机构仅开展了部分液体调配,无法开展全院区的全医嘱调配。目前,总体的配置费标准偏低,一定程度上影响了PIVAS发展。

关键词：静脉用药调配中心成本收费调研

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Distributed constrained optimization with nonconvex communication and input constraints

Distributed constrained optimization with nonconvex communic...

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第32届中国过程控制会议(CPCC2021)

作者： Peng lin chuyu Zeng School of Automation Central South University

The aim of this paper is to study distributed constrained optimization with nonconvex communication and input constraints when nonuniform gradient gains,nonuniform convex state constraints and jointly-strongly-connected switching graphs are *** to the existence of nonconvex communication and input constraints and the optimization of the local objective functions,the edge weights are equivalent to be multiplied with time-varying factors,and the interaction balance is destroyed,resulting in the invalidness of the existing *** is shown that the optimization problem can be solved if the communication graphs are ***,a numerical example is given to illustrate the theoretical results.

关键词： Distributed optimization Nonconvex communication and input constraints Nonuniform gradient gains Nonuniform convex constraints

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