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Aspirin in hepatocellular carcinoma:Is it an out-of-date or promising treatment?

iLIVER 2022年第1期1卷 55-64页

作者： Xun Qiu Fengqiang Gao Kai Wang Zhensheng Zhang chuxiao shao Xiao Xu Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryAffiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou310006China Westlake Laboratory of Life Sciences and Biomedicine Hangzhou310024China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou310003China Institute of Organ Transplantation Zhejiang UniversityHangzhou310003China Department of Hepatobiliary and Pancreatic Surgery Affiliated Lishui HospitalZhejiang University School of MedicineLishui323000China

Hepatocellular carcinoma(HCC)is one of the most aggressive human malignancies with a dismal survival *** strategies can effectively prevent the occurrence of *** immunotherapy has significantly improved HCC-related survival in recent years,this systemic therapy is very expensive and lays a heavy burden on most HCC ***,which is currently one of the most widely used medications in analgesic and cardiovascular diseases,is reported to have anti-tumor effects on *** importantly,long-term administration of low-dose aspirin does not significantly increase the risk of gastrointestinal *** to its costeffectiveness and wide use,aspirin can be easily applied as an HCC treatment and is affordable for a wide range of ***,deeper understanding and more attention are needed to extend the frontline of aspirin's preventive and therapeutic potential into cancer research and *** this review,we discuss the preventive effect of aspirin on HCC in the context of different etiological factors,including hepatitis B or hepatitis C virus infection,non-alcoholic fatty liver disease,and alcohol-associated liver *** therapeutic role of aspirin in resectable or unresectable HCC management is also ***,the mechanisms underlying the anti-cancer effects of aspirin on HCC are fully reviewed and discussed in the following two aspects:the effect of aspirin on multi-oncogenic signaling pathways in HCC(e.g.,AMPK,Wnt/β-catenin,NF-κB)and aspirinmediated immunometabolic responses in liver *** findings indicate aspirin is a promising agent for populations at risk and HCC patients to prevent or treat HCC.

关键词： Hepatocellular carcinoma Aspirin Chemoprevention Cancer therapy Oncogenic signaling Immunometabolic response

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Extrahepatic organs in the development of non-alcoholic fatty liver disease in liver transplant patients

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 400-411页

作者： Renyi Su Xuyong Wei Qiang Wei Di Lu Zuyuan Lin Shuo Wang chuxiao shao Xiao Xu Department of Hepatobiliary and Pancreatic Surgery Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouChina NHC Key Laboratory of Combined Multi-Organ Transplantation HangzhouChina Department of Hepatobiliary and Pancreatic Surgery Shu Lan HospitalShu Lan International Medical College of Zhejiang Shuren UniversityHangzhouChina Department of Hepatobiliary and Pancreatic Surgery Affiliated Lishui HospitalZhejiang University School of MedicineLishuiChina

Background and Objective:Non-alcoholic fatty liver disease(NAFLD)is highly prevalent in patients who undergo liver transplantation(LT).Whereas there is huge data on NAFLD,little is known about NAFLD in *** this review,we aim to explore extrahepatic organs and their potential mechanisms in the development of NAFLD in LT patients and discuss current limitations in preclinical and clinical scenarios with suggestions for future ***:The following keywords,such as NAFLD,NASH,liver transplant,therapy,pathogenesis and biomarkers,were set for literature *** articles which were published articles in English till 25th June 2020 in PubMed database were included,and there is no limit for the study design *** Content and Findings:Following LT,there are significant shifts in the microbiota and farnesoid X receptor may be a potential therapeutic target for NAFLD in LT *** roles of probiotics and diet on NALFD remain inconclusive in LT ***,the adipokines and cytokines disorder and local insulin resistance of adipose tissue may contribute to NAFLD *** surgeries are promising in controlling de novo and recurrent NAFLD with significant reduction in abdominal adipose tissue,despite the optimal timing is inconclusive in LT ***,circumstantial evidence indicates that miRNA-33a may function as a mediator bridging sarcopenia and NAFLD of post-LT.β-Hydroxy-β-Methyl-Butyrate treatment could improve muscle status in graft recipients and shows protective potential for NAFLD in LT ***:Gut,adipose tissue and muscle are intricately intertwined in promoting NAFLD in LT *** animal studies are needed to deepen our understanding of mechanisms in multi-organ *** quality clinical trials are warrant for making guidelines and developing management strategies on NAFLD after LT.

关键词： Non-alcoholic fatty liver disease(NAFLD) liver transplant sarcopenia lipid gut

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Bladder microenvironment actuated proteomotors with ammonia amplification for enhanced cancer treatment

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Acta Pharmaceutica Sinica B 2023年第9期13卷 3862-3875页

作者： Hao Tian Juanfeng Ou Yong Wang Jia Sun Junbin Gao Yicheng Ye Ruotian Zhang Bin Chen Fei Wang Weichang Huang Huaan Li Lu Liu chuxiao shao Zhili Xu Fei Peng Yingfeng Tu NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Pharmacy Zhujiang HospitalSouthern Medical UniversityGuangzhou 510282China Key Laboratory of Joint Diagnosis and Treatment of Chronic Liver Disease and Liver Cancer of Lishui Central Laboratory of Lishui People’s HospitalThe Sixth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000China Department of Ultrasound Institute of Ultrasound in Musculoskeletal Sports MedicineGuangdong Second Provincial General HospitalGuangzhou 510317China School of Materials Science and Engineering Sun Yat-Sen UniversityGuangzhou 510275China

Enzyme-driven micro/nanomotors consuming in situ chemical fuels have attracted lots of attention for biomedical ***,motor systems composed by organism-derived organics that maximize the therapeutic efficacy of enzymatic products remain ***,swimming proteomotors based on biocompatible urease and human serum albumin are constructed for enhanced antitumor therapy via active motion and ammonia *** decomposing urea into carbon dioxide and ammonia,the designed proteomotors are endowed with self-propulsive capability,which leads to improved internalization and enhanced penetration in *** a glutamine synthetase inhibitor,the loaded L-methionine sulfoximine further prevents the conversion of toxic ammonia into non-toxic glutamine in both tumor and stromal cells,resulting in local ammonia *** intravesical instillation,the proteomotors achieve longer bladder retention and thus significantly inhibit the growth of orthotopic bladder tumor in vivo without adverse *** envision that the as-developed swimming proteomotors with amplification of the product toxicity may be a potential platform for active cancer treatment.

关键词： Swimming proteomotors Enhanced diffusion Glutamine synthetase Ammonia amplification Biocompatibility Penetration Retention Bladder microenvironment

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A novel nomogram for prognosis stratification in salvage liver transplantation:a national-wide study with propensity score matching analysis in China

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 854-867,I0006-I0009页

作者： Kai Wang Fengqiang Gao Siyi Dong Jialu Ding Libin Dong chuxiao shao Zhoucheng Wang Xun Qiu Xuyong Wei Zhengxin Wang Jiayin Yang Qiang Xia Shusen Zheng Xiao Xu Department of Hepatobiliary and Pancreatic Surgery Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouChina Institute of Organ Transplantation Zhejiang UniversityHangzhouChina Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouChina NHC Key Laboratory of Combined Multi-organ Transplantation HangzhouChina Zhejiang University School of Medicine HangzhouChina Department of Hepatobiliary and Pancreatic Surgery Affiliated Lishui HospitalZhejiang University School of MedicineLishuiChina National Center for Healthcare Quality Management in Liver Transplant HangzhouChina Graduate School Nanjing University of Chinese MedicineNanjingChina Department of General Surgery Huashan HospitalFudan UniversityShanghaiChina Liver Transplantation Center Department of Liver SurgeryWest China Hospital of Sichuan UniversityChengduChina Department of Liver Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of Hepatobiliary and Pancreatic Surgery Shulan Hospital of HangzhouHangzhouChina

Background:Salvage liver transplantation(SLT)has been reported to be an efficient treatment option for patients with recurrent hepatocellular carcinoma(HCC)after liver resection(LR).However,for recipients who underwent liver transplantation(LT)due to recurrent HCC after LR in China,the selection criteria are not well ***:In this study,data from the China Liver Transplant Registry(CLTR)of 4,244 LT performed from January 2015 to December 2019 were examined,including 3,498 primary liver transplantation(PLT)and 746 SLT *** score matching(PSM)analysis was used to minimize between-group *** overall survival(OS)and disease-free survival(DFS)between PLT and SLT in recipients fulfilling the Milan or Hangzhou criteria were compared based on the multivariate analysis,nomograms were plotted to further classify the SLT group into low-and high-risk ***:In this study,the 1-,3-and 5-year OS and DFS of SLT recipients fulfilling Milan criteria(OS,P=0.01;DFS,P<0.001)or Hangzhou criteria(OS,P=0.03;DFS,P=0.003)were significantly reduced when compared to that of PLT group after PSM *** risk factors,including preoperative transarterial chemoembolization(TACE),alpha fetoprotein(AFP)level,tumor maximum size and tumor total diameter were selected to draw a prognostic *** low-risk SLT recipients(1-year,95.34%;3-year,84.26%;5-year,77.20%)showed a comparable OS with PLT recipients fulfilling Hangzhou criteria (P=0.107). Conclusions: An optimal nomogram model for prognosis stratification and clinical decision guidance of SLT was established. The low-risk SLT recipients based on the nomograms showed comparable survival with those fulfilling Hangzhou criteria in PLT group.

关键词： Salvage liver transplantation(SLT) nomogram primary liver transplantation(PLT) overall survival(OS) disease-free survival(DFS)

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原发性肝癌早期诊断的研究进展

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中华肝胆外科杂志 2014年第9期20卷 689-693页

作者：张健邵初晓温州医科大学附属第一医院肝胆胰外科 325000 温州医科大学附属五院肝胆胰外科丽水323000

原发性肝细胞癌（HCC,以下简称肝癌）是最常见的恶性肿瘤之一.其发病隐匿,无特异性临床表现,往往发现时已进展到晚期,错过了最好的治疗时机,因此预后较差.早期诊断能明显提高患者的生存率,对肝癌患者的治疗至关重要.随着影像学技术和分... 详细信息

原发性肝细胞癌（HCC,以下简称肝癌）是最常见的恶性肿瘤之一.其发病隐匿,无特异性临床表现,往往发现时已进展到晚期,错过了最好的治疗时机,因此预后较差.早期诊断能明显提高患者的生存率,对肝癌患者的治疗至关重要.随着影像学技术和分子生物学的不断发展,影像学检查在肝癌诊断中作用越发重要,多种新的肝癌标志物也相继被发现.本文介绍了肝癌早期诊断的最新进展,并结合既往诊断方法,对肝癌的早期诊断进行综合阐述.

关键词：肝细胞癌早期诊断影像学肿瘤标志物

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髂静脉压迫综合征的研究进展

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中国普通外科杂志 2015年第6期24卷 880-884页

作者：张杰邵初晓温州医科大学附属第五医院普通外科浙江丽水323000

髂静脉压迫综合征是导致下肢静脉高压的重要因素,常表现为下肢静脉曲张、下肢深静脉血栓形成。随着医学诊断技术及认识的提高,越来越多的髂静脉压迫患者被识别。目前关于髂静脉压迫综合征合并有下肢静脉曲张或下肢深静脉血栓形成的治疗... 详细信息

髂静脉压迫综合征是导致下肢静脉高压的重要因素,常表现为下肢静脉曲张、下肢深静脉血栓形成。随着医学诊断技术及认识的提高,越来越多的髂静脉压迫患者被识别。目前关于髂静脉压迫综合征合并有下肢静脉曲张或下肢深静脉血栓形成的治疗,存在一定分歧。笔者对髂静脉压迫综合征的新认识、诊断方法及治疗进展进行综述。

关键词：髂静脉静脉曲张静脉血栓形成综述文献

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综合性护理干预对肝硬化合并上消化道出血治疗效果的影响

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中国现代医生 2014年第11期52卷 89-91页

作者：杨海燕邵初晓浙江省绍兴市第六人民医院内科浙江绍兴312000 浙江省丽水市中心医院内科浙江丽水323000

目的探讨综合性护理干预对肝硬化合并上消化道出血治疗效果的影响.方法选择我院2010年1月～2013年1月间收治的肝硬化合并上消化道出血患者60例,根据护理方法随机分为干预组和对照组,各30例,对照组予以常规对症护理,干预组实施综合性... 详细信息

目的探讨综合性护理干预对肝硬化合并上消化道出血治疗效果的影响.方法选择我院2010年1月～2013年1月间收治的肝硬化合并上消化道出血患者60例,根据护理方法随机分为干预组和对照组,各30例,对照组予以常规对症护理,干预组实施综合性护理干预,比较两组的疗效、止血时间、住院时间、并发症及护理满意度.结果干预组患者治疗有效率达90.0％,对照组有效率达73.3％,两组差异存在显著性（P＜0.05）.干预组患者的止血时间、住院时间短于对照组,组间比较差异存在显著性（P＜0.05）.干预组治疗期间并发症发生率达10％,对照组并发症发生率达36.7％,组间比较差异存在显著性（P＜0.05）.干预组的护理满意度达96.7％,明显高于对照组,组间比较差异存在显著性（P＜0.05）.结论对肝硬化合并上消化道出血患者在积极有效治疗的同时实施综合性的护理干预措施,可以明显提高疗效,缩短住院时间,减少并发症发生,提高护理满意度.

关键词：肝硬化上消化道出血综合性护理干预并发症满意度

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肝细胞肝癌免疫治疗外周血生物标志物的研究进展

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国际外科学杂志 2022年第12期49卷 848-853页

作者：陈枫峰涂朝勇邵初晓温州医科大学附属第五医院肝胆胰外科温州323000 丽水市中心医院肝胆胰外科丽水323000 丽水市人民医院肝胆胰外科丽水323000

肝细胞肝癌(HCC)是全球第六大最常见的恶性疾病,也是导致癌症相关死亡的主要原因之一。目前对于晚期HCC患者的治疗手段十分有限,而作为近年来晚期癌症治疗方案的重要研究方向,免疫治疗已取得了较好的研究成果。截至当前,学者们已经试验... 详细信息

肝细胞肝癌(HCC)是全球第六大最常见的恶性疾病,也是导致癌症相关死亡的主要原因之一。目前对于晚期HCC患者的治疗手段十分有限,而作为近年来晚期癌症治疗方案的重要研究方向,免疫治疗已取得了较好的研究成果。截至当前,学者们已经试验了多种免疫治疗方法,利用免疫检查点抑制剂(ICIs)治疗晚期癌症的方案取得了不小的进展。ICIs通过抑制免疫检查点,增强抗肿瘤免疫,为晚期癌症患者的治疗提供了新的思路。然而,免疫治疗仍无法彻底治愈肝癌,且仅适用于一小部分患者。在当前肝癌大环境的背景下,肿瘤学的一个重点研究方向是了解预测免疫治疗临床反应的生物标志物,借此改善患者选择,以最大限度地发挥临床效益,并避免不必要的毒性。相较肿瘤及周围组织生物标志物,外周血生物标志物依靠其无创检测的优势,在临床研究及使用方面具有独特的作用。在这篇综述中总结了对HCC患者免疫治疗临床反应及预后疗效起关键预测作用的外周血生物标志物,以期为临床提供参考。

关键词：癌,肝细胞免疫抑制剂生物标志物外周血免疫治疗

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肝细胞癌中HIF-1α与PHD2的表达及临床意义

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中国组织化学与细胞化学杂志 2013年第6期22卷 533-538页

作者：林巧妹尉建锋王伟林邵初晓浙江大学医学院附属第一医院肝胆胰外科杭州310003 浙江省丽水市中心医院肝胆外科丽水323000

目的研究HIF-1α和PHD2在肝细胞癌(HCC)组织中的表达,并分析其与临床病理特征间的相关性及临床意义。方法应用免疫组化Envision法检测103例HCC组织、14例癌旁组织及13例正常肝组织中HIF-1α和PHD2的表达。结果在HCC、癌旁组织、正常组织... 详细信息

目的研究HIF-1α和PHD2在肝细胞癌(HCC)组织中的表达,并分析其与临床病理特征间的相关性及临床意义。方法应用免疫组化Envision法检测103例HCC组织、14例癌旁组织及13例正常肝组织中HIF-1α和PHD2的表达。结果在HCC、癌旁组织、正常组织中HIF-1α阳性表达率分别为63.1%、35.7%、0%,差异显著(P≤0.05),其阳性表达与肿瘤大小、脉管瘤栓、分化程度、TNM分期均有显著差异(P<0.05)。PHD2在HCC组织中表达阳性率明显低于正常肝组织(P≤0.05)。HCC中PHD2表达水平下调与肿瘤大小、分化程度、TNM分期的差异有统计学意义(P<0.05)。生存分析显示HIF-1α阳性组与阴性组2年生存率分别为53.8%(35/65)、81.6%(31/38),差异有统计学意义(P<0.05)。Cox多因素分析显示肿瘤大小、脉管瘤栓、HBsAg阳性及HIF-1α的表达是影响HCC的独立预后因素。HIF-1α和PHD2表达呈正相关(r=0.219,P<0.05)。结论 HIF-1α和PHD2的异常表达与HCC的一些恶性进展临床病理特征相关,提示其可能参与肝癌的发生、发展、侵袭,有助于肿瘤的预后分析。

关键词：肝细胞癌 HIF-1α PHD2 预后

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阿司匹林联合偏瘫活络片治疗脑血栓临床效果及对D-二聚体水平的影响

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新中医 2019年第6期51卷 131-134页

作者：张杰王剑吴丹邵初晓浙江大学丽水医院血管外科浙江丽水323000 浙江大学丽水医院疼痛诊疗中心浙江丽水323000 浙江大学丽水医院普外科浙江丽水323000

目的:观察阿司匹林联合偏瘫活络片治疗脑血栓的临床效果及对D-二聚体水平的影响。方法:将收治的脑血栓患者148例采用随机数字法分为2组各74例,对照组采用单一的阿司匹林进行治疗,研究组在此基础上联合偏瘫活络片进行治疗,对2组患者的临... 详细信息

目的:观察阿司匹林联合偏瘫活络片治疗脑血栓的临床效果及对D-二聚体水平的影响。方法:将收治的脑血栓患者148例采用随机数字法分为2组各74例,对照组采用单一的阿司匹林进行治疗,研究组在此基础上联合偏瘫活络片进行治疗,对2组患者的临床治疗效果、治疗前后动脉斑块情况、神经功能缺损评估量表(NIHSS)评分和Barthel指数、D-二聚体以及血浆N端前脑钠肽(NT-proBNP)的水平。结果:治疗后,研究组总有效率为93.2%,对照组为84.5%,2组比较,差异有统计学意义(P 0.05)。经治疗,2组动脉斑块面积及颈动脉内膜厚度较前改善(P 0.05)。经治疗,2组NIHSS评分、Barthel指数较前改善(P 0.05)。经治疗,2组D-二聚体、血浆NT-proBNP较前改善(P <0.05)。治疗3个月后,2组间D-二聚体、血浆NT-proBNP比较,差异有统计学意义(P <0.05)。结论:对脑血栓患者采用阿司匹林联合偏瘫活络片进行治疗,可提高临床治疗效果,改善相关指标水平。

关键词：脑血栓偏瘫活络片阿司匹林 D-二聚体中西医结合疗法

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