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2015-2022年深圳市龙岗区HIV/AIDS新发现病例流行趋势特征和灰色模型定量预测

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右江民族医学院学报 2024年第4期46卷 480-485,507页

作者：孙春云陈小燕龙清平叶伟雄广东省深圳市龙岗区疾病预防控制中心广东深圳518172

目的探讨HIV感染者/AIDS患者(HIV/AIDS)新发现病例流行特征和判定趋势、定量预测,为科学防控提供参考依据。方法对深圳市龙岗区2015—2022年新发现HIV/AIDS病例用描述流行病学方法进行特征分析,用缓冲算子建立灰色均值GM(1,1)模型进行... 详细信息

目的探讨HIV感染者/AIDS患者(HIV/AIDS)新发现病例流行特征和判定趋势、定量预测,为科学防控提供参考依据。方法对深圳市龙岗区2015—2022年新发现HIV/AIDS病例用描述流行病学方法进行特征分析,用缓冲算子建立灰色均值GM(1,1)模型进行趋势判定和病例数预测。结果2015—2022年龙岗区新发现HIV/AIDS病例共2722例(1611/1111),年均报告病例数(340±25)例。病例以男性(92.43%)、20~50岁(χ^(2)_(趋势)=25.241,P95%,可用于HIV/AIDS新发现病例数预测。结论龙岗区AIDS疫情态势平稳,但有中老年病例增加的趋势,病例发展到AIDS阶段因症状就诊发现的比例有增加趋势,应继续推行扩大检测策略及早发现病例,深入开展高危、重点人群综合干预防治措施,多渠道(尤其是在学校教育工作中)加强全民AIDS宣传教育和提高防护技能。灰色预测模型可有效判定AIDS疫情趋势和定量预测,对风险评估和疫情防控具有较好的指导意义。

关键词：获得性免疫缺陷综合征人类免疫缺陷病毒流行特征趋势灰色预测

Mutation N856K in spike reduces fusogenicity and infectivity of Omicron BA.1

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Signal Transduction and Targeted Therapy 2023年第3期8卷 908-911页

作者： chunyun sun Huiyu Wang Ji Yang Desheng Kong Yuning Chen Haiyue Wang Lingling sun Jianbo Lu Min Teng Liangzhi Xie Beijing Engineering Research Center of Protein and Antibody Sinocelltech Ltd.Beijing 100176China Beijing Key Laboratory of Monoclonal Antibody Research and Development Sino Biological Inc.Beijing 100176China Cell Culture Engineering Center Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China

Dear Editor,COVID-19 lung pathology is characterized by interstitial pneumonia with cell-cell fusion-induced syncytia and extensive tissue damage.1 The correlation between viral fusogenicity and pathogenicity has been reported in SARS-CoV-2 variants.2 Compared with the previous Delta or D614G variants,Omicron BA.1 has been proven to be less fusogenic and pathogenic.

关键词： lung pathology damage

An antibody cocktail with broadened mutational resistance and effective protection against SARS-CoV-2

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Science China(Life Sciences) 2023年第1期66卷 165-179页

作者： chunyun sun Hang Chi Fei Yuan Jing Li Ji Yang Aihua Zheng Fei Wang Lingling sun Yanjing Zhang Ping Hu Lihua Jiao Yongqiang Deng Liangzhi Xie Beijing Engineering Research Center of Protein and Antibody Sinocelltech Ltd.Beijing 100176China Department of Virology State Key Laboratory of Pathogen and BiosecurityBeijing Institute of Microbiology and EpidemiologyAcademy of Military Medical SciencesBeijing 100071China State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Key Laboratory of Monoclonal Antibody Research and Development Sino Biological Inc.Beijing 100176China Cell Culture Engineering Center Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China

Neutralizing antibodies have been proven to be highly effective in treating mild and moderate COVID-19 patients,but continuous emergence of SARS-CoV-2 variants poses significant *** cocktail treatments reduce the risk of escape mutants and *** this study,a new cocktail composed of two highly potent neutralizing antibodies(HB27 and H89Y)was developed,whose binding epitope is different from those cocktails that received emergency use *** cocktail showed more potent and balanced neutralizing activities(IC_(50)0.9–11.3 ng mL^(-1))against a broad spectrum of SARS-CoV-2 variants over individual HB27 or H89Y ***,the cocktail conferred more effective protection against the SARS-CoV-2 Beta variant in an aged murine model than *** was shown to prevent SARS-CoV-2 mutational escape in vitro and effectively neutralize 61 types of pseudoviruses harbouring single amino acid mutation originated from variants and escape strains of Bamlanivimab,Casirivimab and Imdevimab with IC_(50)of 0.6–65 ng mL^(-1).Despite its breadth of variant neutralization,the HB27+H89Y combo and EUA cocktails lost their potencies against Omicron *** results provide important insights that new antibody cocktails covering different epitopes are valuable tools to counter virus mutation and escape,highlighting the need to search for more conserved epitopes to combat Omicron.

关键词： SARS-CoV-2 COVID-19 epitopes antibody cocktail mutational escape

A spike-trimer protein-based tetravalent COVID-19 vaccine elicits enhanced breadth of neutralization against SARS-CoV-2 Omicron subvariants and other variants

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Science China(Life Sciences) 2023年第8期66卷 1818-1830页

作者： Rui Wang Hongpeng Huang Chulin Yu chunyun sun Juan Ma Desheng Kong Yalong Lin Dandan Zhao Shaozheng Zhou Jianbo Lu Sai Cao Yanjing Zhang Chunxia Luo Xuefeng Li Yang Wang Liangzhi Xie Beijing Protein and Antibody R&D Engineering Center Sinocelltech Ltd.Beijing 100176China Cell Culture Engineering Center Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China

Multivalent vaccines combining crucial mutations from phylogenetically divergent variants could be an effective approach to defend against existing and future SARS-Co V-2 *** this study,we developed a tetravalent COVID-19 vaccine SCTV01E,based on the trimeric Spike protein of SARS-Co V-2 variants Alpha,Beta,Delta,and Omicron BA.1,with a squalenebased oil-in-water adjuvant *** the immunogenicity studies in na?ve BALB/c and C57BL/6J mice,SCTV01E exhibited the most favorable immunogenic characteristics to induce balanced and broad-spectrum neutralizing potencies against pre-Omicron variants(D614G,Alpha,Beta,and Delta)and newly emerging Omicron subvariants(BA.1,BA.1.1,BA.2,BA.3,and BA.4/5).Booster studies in C57BL/6J mice previously immunized with D614G monovalent vaccine demonstrated superior neutralizing capacities of SCTV01E against Omicron subvariants,compared with the D614G booster ***,SCTV01E vaccination elicited na?ve and central memory T cell responses to SARS-Co V-2 ancestral strain and Omicron spike ***,our comprehensive immunogenicity evaluation results indicate that SCTV01E could become an important COVID-19 vaccine platform to combat surging infections caused by the highly immune evasive BA.4/5 ***01E is currently being studied in a head-to-head immunogenicity comparison phase 3 clinical study with inactivated and m RNA vaccines(NCT05323461).

关键词： tetravalent SARS-CoV-2 vaccine Omicron subvariants broad neutralization

Rapeseed Breeding for Quality Character in Hunan Province

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Hunan Agricultural Science ＆ Technology Newsletter 2000年第3期1卷 12-13页

作者： Guan chunyun Li sun (Department of Agronomy, Hunan Agricultural University, Changsha, China, 410128) Department of Agronomy Hunan Agricultural University Changsha China 410128

Eight single-low or double-low rapeseed cultivars were bred from 1980 to 2000 in Hunan Province. In this paper, characters and breeding method of these cultivars are introduced.

关键词： Rapeseed Breeding for quality improvement Transgenic rapeseed line

Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China Life Sciences 2024年

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang chunyun Dai Shipeng Yan Kun Jiang Bingbing Song He Li Maomao Cao Dianqin sun Fan Yang Xinxin Yan Shaoli Zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Luoshan Center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer(GC) in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates(CIRs) of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic(atrophic gastritis/intestinal metaplasia) and neoplastic lesions(low-grade/high-grade dysplasia), respectively(Ptrend<0.001). Four predictors, including male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients(≥3 risk factors) with non-neoplastic lesions showed higher GC risks(adjusted HR=7.73, 95%CI: 4.29–13.92), and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions(aHR=3.07, 95%CI: 1.67–5.64) and high-risk patients with mild lesions(aHR=7.29, 95%CI: 3.58–14.86) showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

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融合LBP和卷积神经网络的摩尔纹检测

现代电子技术 2023年第9期46卷 73-77页

作者：孙春云李祥祥孙甜甜昌吉学院信息工程学院新疆昌吉831100

摩尔纹是一种由数字网格重叠引起的不规则混叠干扰条纹。屏摄类图像中摩尔纹的出现不仅降低了图像质量,并会对后续的图像处理任务产生不良的影响。为了有效、快速、准确地检测这种摩尔纹,文中提出一种利用局部二值模式(LBP)和多输入卷... 详细信息

摩尔纹是一种由数字网格重叠引起的不规则混叠干扰条纹。屏摄类图像中摩尔纹的出现不仅降低了图像质量,并会对后续的图像处理任务产生不良的影响。为了有效、快速、准确地检测这种摩尔纹,文中提出一种利用局部二值模式(LBP)和多输入卷积神经网络(CNN)结合的检测模型。LBP特征计算速度快且能很好地描述摩尔纹纹理,该方法首先使用LBP提取特征,并将提取特征后的图像与原始图像一起送入设计好的多输入卷积神经网络。实验结果证明,将经过LBP特征提取的图像作为摩尔纹纹理的强化信息与原始图像一起送入网络,比单独将原始图像送入网络的网络收敛速度更快、准确率更高,可以达到99.6%,比经典的Inception V3分类模型准确率提高了4%。

关键词：摩尔纹检测 LBP 卷积神经网络检测模型特征提取收敛速度

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停课对托幼机构手足口病暴发疫情控制效果评价

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中国学校卫生 2016年第8期37卷 1203-1204页

作者：段利娜李刚刘凤仁叶伟雄孙春云广东省深圳市福田区疾病预防控制中心 518040 深圳市龙岗区疾病预防控制中心

目的探讨停课措施对托幼机构手足口病暴发疫情的控制效果,为提供科学、经济的疫情控制策略提供依据。方法收集2005—2014年龙岗区手足口病暴发疫情材料,按照初始报告病例数和初始波及班级数,进行1∶1匹配,比较停课组和非停课组疫情的新... 详细信息

目的探讨停课措施对托幼机构手足口病暴发疫情的控制效果,为提供科学、经济的疫情控制策略提供依据。方法收集2005—2014年龙岗区手足口病暴发疫情材料,按照初始报告病例数和初始波及班级数,进行1∶1匹配,比较停课组和非停课组疫情的新增病例数、新增班级数、终末罹患率、措施介入至疫情结束时间间隔。结果停课组新增病例中位数为2.00人;新增班级中位数为0个;终末罹患率中位数为6.97%,停课至疫情结束时间间隔中位数为5.50 d。非停课组新增病例中位数为1.00人;新增班级中位数为0.50个;终末罹患率中位数为6.24%,控制措施至疫情结束时间间隔中位数为4.00 d。停课组与非停课组新增病例数、新增班级数、终末罹患率、措施介入至疫情结束时间间隔差异均无统计学意义。结论停课措施对手足口病暴发疫情控制效果不明显。

关键词：综合预防手足口病疾病暴发流行学生

肘关节骨折术后早期康复治疗对功能恢复的影响

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中外医学研究 2018年第16期16卷 107-109页

作者：黄丰郭春云孙永建魏波广东医科大学研究生学院广东湛江524000 南方医科大学第五附属医院广东医科大学附属医院

目的:观察早期康复治疗对肘关节骨折术后肘关节功能恢复的影响。方法:选取42例肘关节骨折术后患者,将其随机分成对照组和观察组。对照组单纯采用手术治疗,观察组在手术治疗的基础上,术后3 d开始联合康复治疗。比较两组患者术后6个月肘... 详细信息

目的:观察早期康复治疗对肘关节骨折术后肘关节功能恢复的影响。方法:选取42例肘关节骨折术后患者,将其随机分成对照组和观察组。对照组单纯采用手术治疗,观察组在手术治疗的基础上,术后3 d开始联合康复治疗。比较两组患者术后6个月肘关节活动度(Rom),肘关节Mayo评分、骨折愈合时间及术后并发症发生情况。结果:42例患者术后均获得随访,随访时间7～12个月,平均(8.7±1.2)个月。(1)术后6个月,对照组患者肘关节活动度(98.14±10.52)°,小于观察组的(105.2±15.34)°,差异有统计学意义(t=2.135,P0.05)。结论:肘关节骨折术后早期康复治疗能促进骨折愈合,患者可获得良好的肘关节活动性,提高肘关节运动功能的恢复程度,临床上值得推广。

关键词：肘关节骨折手术后康复治疗功能恢复