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Biomarkers for neuromyelitis optica:a visual analysis of emerging research trends

Neural Regeneration Research 2024年第12期19卷 2735-2749页

作者： Xiangjun li Jiandong Zhang Siqi Zhang Shengling Shi Yi’an Lu Ying Leng chunyan li Department of Ophthalmology Affiliated Hospital of Beihua UniversityJilinJilin ProvinceChina Department of Ophthalmology Changchun Bright Eye HospitalChangchunJilin ProvinceChina Departemt of Endocrinology Affiliated Hospital of Beihua UniversityJilinJilin ProvinceChina

Neuromyelitis optica is an inflammatory demyelinating disease of the central nervous system that differs from multiple sclerosis.Over the past 20 years,the search for biomarke rs for neuromyelitis optica has been ongoing.Here,we used a bibliometric approach to analyze the main research focus in the field of biomarkers for neuromyelitis optica.Research in this area is consistently increasing,with China and the United States leading the way on the number of studies conducted.The Mayo Clinic is a highly reputable institution in the United States,and was identified as the most authoritative institution in this field.Furthermore,Professor Wingerchuk from the Mayo Clinic was the most authoritative expe rt in this field.Keyword analysis revealed that the terms "neuro myelitis optica"(261 times), "multiple sclerosis"(220 times), "neuromyelitis optica spectrum disorder"(132 times), "aquaporin4"(99 times),and "optical neuritis"(87 times) were the most frequently used keywords in literature related to this field.Comprehensive analysis of the classical literature showed that the majority of publications provide conclusive research evidence supporting the use of aquaporin-4-IgG and neuromyelitis optica-IgG to effectively diagnose and differentiate neuromyelitis optica from multiple sclerosis.Furthermore,aquaporin-4-IgG has emerged as a highly specific diagnostic biomarker for neuromyelitis optica spectrum disorder.Myelin oligodendrocyte glycoprotein-IgG is a diagnostic biomarke r for myelin oligodendrocyte glycoprotein antibody-associated disease.Recent biomarkers for neuromyelitis optica in clude cerebrospinal fluid immunological biomarkers such as glial fibrillary acidic protein,serum astrocyte damage biomarkers like FAM19A5,serum albumin,and gammaaminobutyric acid.The latest prospective clinical trials are exploring the potential of these biomarkers.Preliminary results indicate that glial fibrillary acidic protein is emerging as a promising candidate biomarker for neuromyelitis optica spectrum disorder.The ultimate goal of

关键词： aquaporin-4 autoantibody multiple sclerosis myelin oligodendrocyte glycoprotein antibody-associated disease neuromyelitis optica neuromyelitis optica spectrum disorder optical coherence tomography

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Anti-vascular endothelial growth factor drugs combined with laser photocoagulation maintain retinal ganglion cell integrity in patients with diabetic macular edema: study protocol for a prospective, non-randomized, controlled clinical trial

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Neural Regeneration Research 2024年第4期19卷 923-928页

作者： Xiangjun li chunyan li Hai Huang Dan Bai Jingyi Wang Anqi Chen Yu Gong Ying Leng Department of Ophthalmology Affiliated Hospital of Beihua University Department of Endocrinology Affiliated Hospital of Beihua University

The integrity of retinal ganglion cells is tightly associated with diabetic macular degeneration that leads to damage and death of retinal ganglion cells,affecting vision.The major clinical treatments for diabetic macular edema are anti-vascular endothelial growth factor drugs and laser photocoagulation.However,although the macular thickness can be normalized with each of these two therapies used alone,the vision does not improve in many patients.This might result from the incomplete recovery of retinal ganglion cell injury.Therefore,a prospective,non-randomized,controlled clinical trial was designed to investigate the effect of anti-vascular endothelial growth factor drugs combined with laser photocoagulation on the integrity of retinal ganglion cells in patients with diabetic macular edema and its relationship with vision recovery.In this trial,150 patients with diabetic macular edema will be equally divided into three groups according to therapeutic methods,followed by treatment with anti-vascular endothelial growth factor drugs,laser photocoagulation therapy,and their combination.All patients will be followed up for 12 months.The primary outcome measure is retinal ganglion cell-inner plexiform layer thickness at 12 months after treatment.The secondary outcome measures include retinal ganglion cell-inner plexiform layer thickness before and 1,3,6,and 9 months after treatment,retinal nerve fiber layer thickness,best-corrected visual acuity,macular area thickness,and choroidal thickness before and 1,3,6,9,and 12 months after treatment.Safety measure is the incidence of adverse events at 1,3,6,9,and 12 months after treatment.The study protocol hopes to validate the better efficacy and safety of the combined treatment in patients with diabetic macula compared with the other two monotherapies alone during the 12-month follow-up period.The trial is designed to focus on clarifying the time-effect relationship between imaging measures related to the integrity of retinal ganglion cells and best-corrected visual acuity.

关键词： choroidal thickness diabetic macular edema laser photocoagulation retinal ganglion cell-inner plexiform layer thickness retinal ganglion cells retinal nerve fiber layer thickness thickness of the macular area vascular endothelial growth factor visual acuity

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Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

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Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy G.White chunyan li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurological damage.While pharmacological interventions have demonstrated initial potential in addressing CSDs,a standardized treatment approach has not yet been established.The objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSDs,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

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Effect of transcranial direct current stimulation on postoperative sleep disturbance in older patients undergoing lower limb major arthroplasty:a prospective,double-blind,pilot,randomised controlled trial

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General Psychiatry 2024年第2期37卷 224-233页

作者： Jie Yang Mingshu Tao Rongguang liu Jiaxing Fang chunyan li Dexian Chen Qi Wei Xingyu Xiong Wenxin Zhao Wen Tan Yuan Han Hongxing Zhang He liu Song Zhang Junli Cao Department of Anesthesiology The Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsuChina Department of Anesthesiology Hospital of Chengdu University of Traditional Chinese Medicine&Traditional Chinese Medicine Hospital of Sichuan ProvinceChengduSichuanChina NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs&Jiangsu Province Key Laboratory of Anesthesiology&Jiangsu Key Laboratory of Applied Technology of Anesthesia and Analgesia Xuzhou Medical UniversityXuzhouJiangsuChina Department of Anesthesiology Eye&ENT Hospital of Fudan UniversityShanghaiChina Department of Anesthesiology&Clinical Research Center for Anesthesia and Perioperative Medicine&Huzhou Key Laboratory of Basic Research and Clinical Translation for Neuromodulation The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University||Huzhou Central Hospital||The Affiliated Huzhou HospitalZhejiang University School of Medicine||Affiliated Central Hospital Huzhou UniversityHuzhouZhejiangChina Department of Anesthesiology Renji Hospital School of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background Postoperative sleep disturbance(PSD)is a common and serious postoperative complication and is associated with poor postoperative outcomes.Aims This study aimed to investigate the effect of transcranial direct current stimulation(tDCS)on PSD in older patients undergoing lower limb major arthroplasty.Methods In this prospective,double-blind,pilot,randomised,sham-controlled trial,patients 65 years and over undergoing lower limb major arthroplasty were randomly assigned to receive active tDCS(a-tDCS)or sham tDCS(s-tDCS).The primary outcomes were the objective sleep measures on postoperative nights(N)1 and N2.Results 116 inpatients were assessed for eligibility,and a total of 92 patients were enrolled;47 received a-tDCS and 45 received s-tDCS.tDCS improved PSD by altering the following sleep measures in the a-tDCS and s-tDCS groups;the respective comparisons were as follows:the promotion of rapid eye movement(REM)sleep time on N1(64.5(33.5-105.5)vs 19.0(0.0,45.0)min,F=20.10,plight sleep and REM sleep on N1 and N2(plimb major arthroplasty,a single session of anodal tDCS over the left dorsolateral prefrontal cortex showed a potentially prophylactic effect in improving postoperative short-term objective sleep measures.However,this benefit was temporary and was not maintained over time.

关键词： sleep stimulation postoperative

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RDX crystals with high sphericity prepared by resonance acoustic mixing assisted solvent etching technology

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Defence Technology（防务技术） 2023年第10期28卷 23-32页

作者： Dongjie liao Qian liu chunyan li Ning liu Mingchang Wang Chongwei An North University of China Taiyuan 030051China Yichang Testing Technique R&D Institute Yichang 443099China Xi'an Modern Chemistry Research Institute Xi'an 710065China

In order to obtain high-quality spherical RDX crystal particles,the RDX crystals were suspended in a mixed solvent of cyclohexanone and cyclohexane,subsequently a solvent etching study was carried out under the action of vibration/acoustic flow coupled flow field,which generated by resonance acoustic mixing.The effects of solvent ratio,temperature,acceleration and experiment time on morphology as well as particle size of RDX crystals were studied.Not only were the morphology,particle size distribution and crystal form of RDX crystals determined,but also the thermal decomposition performance and mechanical sensitivity of spherical RDX were examined and discussed.Results indicated that under the process of solvent/non-solvent volume ratio at 1:2,temperature of 40℃,acceleration of 40 g and experiment time of 4 h,α-type RDX crystal with sphericity of 0.92 can be obtained.Furthermore,the median particle size(D_(50))of spherical RDX crystals is 215.8 μm with a unimodal particle size distribution(size span 1.34).For one thing,the thermal decomposition peak temperature of spherical RDX is about 2.5℃ higher than that of raw RDX,and apparent activation energy reaches 444.68 kJ/mol.For another thing,impact sensitivity and friction sensitivity of spherical RDX are 18.18% and 33.33% lower than that of raw RDX,respectively.It demonstrates that safety of spherical RDX under thermal,impact and friction stimuli has been improved.

关键词： Resonance acoustic mixing Solvent etching RDX Sphericial explosive

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Structure-based insights into recognition and regulation of SAM-sensing riboswitches

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Science China(life Sciences) 2023年第1期66卷 31-50页

作者： Luqian Zheng Qianqian Song Xiaochen Xu Xin Shen chunyan li Hongcheng li Hao Chen Aiming Ren Department of Gastroenterology Department of Cardiology of the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310058China life Sciences Institute Zhejiang UniversityHangzhou 310058China The Eighth Affiliated Hospital Sun Yat-sen UniversityShenzhen 518033China

Riboswitches are highly conserved RNA elements that located in the 5’-UTR of m RNAs,which undergo real-time structure conformational change to achieve the regulation of downstream gene expression by sensing their cognate ligands.S-adenosylmethionine(SAM)is a ubiquitous methyl donor for transmethylation reactions in all living organisms.SAM riboswitch is one of the most abundant riboswitches that bind to SAM with high affinity and selectivity,serving as regulatory modules in multiple metabolic pathways.To date,seven SAM-specific riboswitch classes that belong to four families,one SAM/SAH riboswitch and one SAH riboswitch have been identified.Each SAM riboswitch family has a well-organized tertiary core scaffold to support their unique ligand-specific binding pocket.In this review,we summarize the current research progress on the distribution,structure,ligand recognition and gene regulation mechanism of these SAM-related riboswitch families,and further discuss their evolutionary prospects and potential applications.

关键词： riboswitches SAM SAH tertiary structures sensing domain expression platform

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Roles of interleukins in antibacterial immune defense of the brood pouch in the lined seahorse Hippocampus erectus

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Journal of Oceanology and limnology 2022年第1期40卷 235-244页

作者： Han JIANG chunyan li Bo ZHANG Yongli WU Qiang liN CAS Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Guangdong Provincial Key Laboratory of Applied Marine Biology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China University of Chinese Academy of Sciences Beijing 100049China

Seahorse embryos are brooded in the enclosed nutrient-rich environment of the male brood pouch,which may be prone to bacterial infection.The immune responses of interleukin(IL)genes in the brood pouch have not been well studied.We identifi ed 13 interleukins in the lined seahorse Hippocampus erectus.Tissue-specifi c expression analysis revealed increased mRNA expression levels of il-1β,il-18,and il-8 in the brood pouch.When challenged with lipopolysaccharide or Vibrio parahaemolyticus,il-1βand il-18 were active as part of the acute and chronic infl ammatory responses,respectively.Importantly,il-8 may be involved in powerful antibacterial immune responses and may be induced by il-1βand il-18 via a process involving the nuclear factor-κB signaling pathway.These results suggest that il-1β,il-18,and il-8 may play key roles in the antibacterial immune defense of the brood pouch in male seahorses.

关键词： lined seahorse brood pouch interleukin antibacterial immunity

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Mixed Aleatory-epistemic Uncertainty Modeling of Wind Power Forecast Errors in Operation Reliability Evaluation of Power Systems

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Journal of Modern Power Systems and Clean Energy 2022年第5期10卷 1174-1183页

作者： Jinfeng Ding Kaigui Xie Bo Hu Changzheng Shao Tao Niu chunyan li Congcong Pan Powerand Energy Reliability Research Center State Key Laboratory of Power Transmission Equipment&System Security and New TechnologyChongqing UniversityChongqing400044China

As the share of wind power in power systems continues to increase, the limited predictability of wind power generation brings serious potential risks to power system reliability. Previous research works have generally described the uncertainty of wind power forecast errors(WPFEs) based on normal distribution or other standard distribution models, which only characterize the aleatory uncertainty. In fact, epistemic uncertainty in WPFE modeling due to limited data and knowledge should also be addressed. This paper proposes a multi-source information fusion method(MSIFM) to quantify WPFEs when considering both aleatory and epistemic uncertainties. An extended focal element(EFE) selection method based on the adequacy of historical data is developed to consider the characteristics of WPFEs. Two supplementary expert information sources are modeled to improve the accuracy in the case of insufficient historical data. An operation reliability evaluation technique is also developed considering the proposed WPFE model. Finally,a double-layer Monte Carlo simulation method is introduced to generate a time-series output of the wind power. The effectiveness and accuracy of the proposed MSIFM are demonstrated through simulation results.

关键词： Wind power forecast error(WPFE) epistemic uncertainty multi-source information fusion method(MSIFM) operation reliability extended focal element(EFE) double-layer Monte Carlo simulation

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Research on Influence of Motor Parameters on the Negative-Salient Permanent Magnet Synchronous Motor

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CES Transactions on Electrical Machines and Systems 2022年第1期6卷 77-86页

作者： Fei Guo Qiu Chu chunyan li Tao Meng Department of Mechanical and Electrical Engineering Heilongjiang University IEEE

The d-axis inductance(Ld)of the negative-salient permanent magnet synchronous motor(NSPMSM)is larger than the q-axis inductance(Lq).Compared with the traditional motor,the NSPMSM has the characteristics of a high overload capacity,wide speed range,and preventing permanent magnet demagnetization.Positive d-axis current(id)is applied to control positive reluctance torque when running at base speed.When the motor is running at high speed,a relatively small id can achieve speed expansion and effectively expand the motor flux-weakening range.The use of a magnetic bridge to increase the Ld and a W-type permanent magnet to reduce the Lq is proposed in this article as a novel NSPMSM rotor structure.Firstly,the working principle of the NSPMSM was determined according to the equivalent magnetic circuit.Secondly,using the finite element method,the influence of motor structure on torque and speed performance of NSPMSM was analyzed,and the motor structure was optimized.Thirdly,the effect of the internal power factor angle on the performance of the two motors is analyzed.Finally,the short circuit simulation and analysis verified that the NSPMSM has a stronger short circuit current suppression ability without sacrificing overload ability.

关键词： Speed range inner power factor angle flux weakening torque short-circuit current

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Effect of stratification on current hydrodynamics over Louisiana shelf during Hurricane Katrina

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Water Science and Engineering 2017年第2期10卷 154-165页

作者： Mohammad Nabi Allahdadi chunyan li Department of Oceanography and Coastal Sciences College of the Coast and Environment Louisiana State University Baton Rouge 70803 USA

Numerical experiments were conducted using the finite volume community ocean model(FVCOM) to study the impact of the initial density stratification on simulated currents over the Louisiana shelf during Hurricane Katrina. Model results for two simulation scenarios, including an initially stratified shelf and an initially non-stratified shelf, were examined. Comparison of two simulations for two-dimensional(2D) currents,the time series of current speed, and variations of cross-shore currents across different sections showed that the smallest differences between simulated currents for these two scenarios occurred over highly mixed regions within 1 radius of maximum wind(RMW) under the hurricane.For areas farther from the mixed zone, differences increased, reaching the maximum values off Terrebonne Bay. These large discrepancies correspond to significant differences between calculated vertical eddy viscosities for the two scenarios. The differences were addressed based on the contradictory behavior of turbulence in a stratified fluid, as compared to a non-stratified fluid. Incorporation of this behavior in the MellorYamada turbulent closure model established a Richardson number-based stability function that was used for estimation of the vertical eddy viscosity from the turbulent energy and macroscale. The results of this study demonstrate the necessity for inclusion of shelf stratification when circulation modeling is conducted using three-dimensional(3D) baroclinic models. To achieve high-accuracy currents, the parameters associated with the turbulence closures should be calibrated with field measurements of currents at different depths.

关键词： Hurricane Katrina Louisiana shelf Hydrodynamics Baroclinic and barotropic models Stratification

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