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Metal nanoparticles for cancer therapy:Precision targeting of DNA damage

Acta Pharmaceutica Sinica B 2024年第3期14卷 1132-1149页

作者： Qian Chen chunyan fang Fan Xia Qiyue Wang fangyuan Li Daishun Ling Institute of Pharmaceutics Hangzhou Institute of Innovative MedicineCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringNational Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China World Laureates Association(WLA)Laboratories Shanghai 201203China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Hangzhou 310009China

Cancer,a complex and heterogeneous disease,arises from genomic instability.Currently,DNA damage-based cancer treatments,including radiotherapy and chemotherapy,are employed in clinical practice.However,the efficacy and safety of these therapies are constrained by various factors,limiting their ability to meet current clinical demands.Metal nanoparticles present promising avenues for enhancing each critical aspect of DNA damage-based cancer therapy.Their customizable physicochemical properties enable the development of targeted and personalized treatment platforms.In this review,we delve into the design principles and optimization strategies of metal nanoparticles.We shed light on the limitations of DNA damage-based therapy while highlighting the diverse strategies made possible by metal nanoparticles.These encompass targeted drug delivery,inhibition of DNA repair mechanisms,induction of cell death,and the cascading immune response.Moreover,we explore the pivotal role of physicochemical factors such as nanoparticle size,stimuli-responsiveness,and surface modification in shaping metal nanoparticle platforms.Finally,we present insights into the challenges and future directions of metal nanoparticles in advancing DNA damage-based cancer therapy,paving the way for novel treatment paradigms.

关键词： DNA damage Metal nanoparticles Nucleus-targeting DNA repair inhibition Immune response Size optimization Stimuli-responsiveness Surface modification

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Effects of coronavirus disease 2019 vaccination on seizures in patients with epilepsy

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Chinese Medical Journal 2023年第5期136卷 571-577页

作者： Xiqin fang Shan Qiao Ranran Zhang Tingting Yang Zhihao Wang Qingxia Kong Meihua Sun Jianhong Geng chunyan fang Yanxiu Chen Yanping Sun Dongmei Zhang Lixing Qu Wei Shang Jianguo Wang Xuewu Liu Department of Neurology Qilu Hospital of Shandong UniversityJinanShandong 250000China Department of Neurology Institute of EpilepsyShandong UniversityJinanShandong 250000China Department of Neurology The First Affiliated Hospital of Shandong First Medical UniversityJinanShandong 250000China Department of Neurology Affiliated Hospital of Jining Medical CollegeJiningShandong 272000China Department of Neurology Tengzhou Central People’s HospitalJiningShandong 277599China Department of Neurology Affiliated Hospital of Weifang Medical CollegeWeifangShandong 261000China Department of Neurology Zhucheng People’s HospitalWeifangShandong 262200China Department of Neurology Liaocheng People’s HospitalLiaochengShandong 252000China Department of Neurology Affiliated Hospital of Qingdao UniversityQingdaoShandong 266000China Department of Neurology Linyi People’s HospitalLinyiShandong 276000China Department of Neurology Dezhou People’s HospitalDezhouShandong 253000China Department of Neurology Second Hospital of Shandong UniversityJinanShandong 250000China Department of Neurology Jinan Central HospitalJinanShandong 250000China.

Background:Given that seizures may be triggered by vaccination,this study aimed to evaluate the risk and correlative factors of seizures in patients with epilepsy(PWE)after being vaccinated against coronavirus disease 2019(COVID-19).Methods:This study retrospectively enrolled PWE who were vaccinated against COVID-19 in the epilepsy centers of 11 hospitals in China.We divided the PWE into two groups as follows:(1)patients who developed seizures within 14 days of vaccination were assigned to the SAV(with seizures after vaccination)group;(2)patients who were seizure-free within 14 days of vaccination were assigned to the SFAV(seizure-free after vaccination)group.To identify potential risk factors for seizure reccurence,the binary logistic regression analysis was performed.Besides,67 PWE who had not been vaccinated were also included for elucidating the effects of vaccination on seizures recurrence,and binary logistic regression analysis was performed to determine whether vaccination would affect the recurrence rate of PWE who had drug reduction or withdrawal.Results:The study included a total of 407 patients;of which,48(11.8%)developed seizures within 14 days after vaccination(SAV group),whereas 359(88.2%)remained seizure-free(SFAV group).The binary logistic regression analysis revealed that duration of seizure freedom(P<0.001)and withdrawal from anti-seizure medications(ASMs)or reduction in their dosage during the peri-vaccination period were significantly associated with the recurrence of seizures(odds ratio=7.384,95%confidence interval=1.732–31.488,P=0.007).In addition,32 of 33 patients(97.0%)who were seizure-free for more than three months before vaccination and had a normal electroencephalogram before vaccination did not have any seizures within 14 days of vaccination.A total of 92(22.6%)patients experienced non-epileptic adverse reactions after vaccination.Binary logistic regression analysis results showed that vaccine did not significantly affect the recurrence rate of PWE who had the behavior of ASMs dose re

关键词： Coronavirus disease 2019 Electroencephalogram Seizure Vaccine

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学校劳动教育实施路径的历史审视——基于德国劳作学校与美国芝加哥大学实验学校的比较分析

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教育文化论坛 2024年第3期16卷 85-96页

作者：任平方纯燕林嘉雯广州大学教育学院广东广州510006

凯兴斯泰纳创立劳作学校的目标是培养和谐发展的公民,而杜威创办的芝加哥大学实验学校的目标是培养个性发展的儿童,二者都十分强调劳动教育在儿童成长过程中的重要作用,重视儿童的具身体验,认为劳动教育的关键在于让儿童参与到手脑并用... 详细信息

凯兴斯泰纳创立劳作学校的目标是培养和谐发展的公民,而杜威创办的芝加哥大学实验学校的目标是培养个性发展的儿童,二者都十分强调劳动教育在儿童成长过程中的重要作用,重视儿童的具身体验,认为劳动教育的关键在于让儿童参与到手脑并用的活动中。通过比较两所学校劳动教育的实践路径发现:在课程类型上,劳作学校设立了独立、必修的劳动课,实验学校则开设了大量符合儿童本能的劳动课程;在教学活动形式上,劳作学校开办了丰富多样的“实习工厂”,实验学校则强调“主动作业”;在教学内容的组织与编排上,劳作学校和实验学校分别呈现出“横向编排”与“纵向编排”的特点;在师资选择上,劳作学校强调“双师型教师”,实验学校则更倾向于“专家型教师”。二者对我国学校开展劳动教育的启示是:一是要选择具有教育性的劳动内容,通过多种形式发挥劳动的教育效能;二是要密切联系日常生活实践,完善劳动教育的软硬件配置;三是要建设一支专业化的师资队伍,将高校师范生培养、教师专修学校培训、转岗教师进修三大路径并行,在不同阶段发挥出各自优势。

关键词：劳动教育凯兴斯泰纳杜威德国劳作学校美国芝加哥大学实验学校

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黄山市临床护士情绪劳动与工作倦怠的关系——心理资本的中介作用

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齐齐哈尔医学院学报 2024年第2期45卷 196-201页

作者：高虹盛亚琳程丽芬方春艳黄山职业技术学院安徽黄山245000 黄山市人民医院安徽黄山245000 黄山首康医院安徽黄山245000

目的探讨黄山市临床护士情绪劳动、心理资本与工作倦怠之间的关系。方法于2022年12月—2023年2月,采用情绪劳动量表(ELS)、心理资本量表(PCQ-R)、工作倦怠量表(MBI-GS中文版),对黄山市几所影响力较大的医院481名临床一线护士进行调查。... 详细信息

目的探讨黄山市临床护士情绪劳动、心理资本与工作倦怠之间的关系。方法于2022年12月—2023年2月,采用情绪劳动量表(ELS)、心理资本量表(PCQ-R)、工作倦怠量表(MBI-GS中文版),对黄山市几所影响力较大的医院481名临床一线护士进行调查。结果黄山市临床护士情绪劳动处于中等水平[(52.02±10.20)分],心理资本处于中等偏上水平[(101.47±15.37)分],工作倦怠处于中等水平[(54.49±11.50)分];临床护士的情绪劳动与工作倦怠呈显著正相关(r=0.290,P<0.01)、与心理资本呈负相关(r=-0.103,P<0.05),心理资本与工作倦怠成显著负相关(r=-0.550,P<0.01)。情绪劳动可以通过心理资本的中介作用对工作倦怠产生影响,心理资本的中介效应占总效应约29.5%。结论黄山市临床护士情绪劳动不仅能够直接预测工作倦怠,也可以通过心理资本的中介作用对工作倦怠产生间接影响。加强情绪劳动管理,提升心理资本,对降低工作倦怠水平具有积极作用。

关键词：临床护士情绪劳动心理资本工作倦怠

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淫羊藿苷对男性生殖系统的药理作用研究进展及文献可视化分析

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医药导报 2024年第1期43卷 96-105页

作者：张静益李俊君方春燕蒲诗云张凤杨薆黎俞旭君成都中医药大学临床医学院成都610075 成都中医药大学附属医院代谢性疾病中医药调控四川省重点实验室成都610075 成都市第五人民医院/成都中医药大学附属第五人民医院第二临床医学院成都611137

淫羊藿苷是传统补益中草药淫羊藿的主要活性成分,属黄酮类化合物。现代研究表明,淫羊藿苷在男性生殖系统中作用广泛,具有调控细胞增殖与凋亡、抗氧化、促进睾酮生成、改善勃起功能、抑制前列腺癌细胞迁移与侵袭和调控细胞周期等多种药... 详细信息

淫羊藿苷是传统补益中草药淫羊藿的主要活性成分,属黄酮类化合物。现代研究表明,淫羊藿苷在男性生殖系统中作用广泛,具有调控细胞增殖与凋亡、抗氧化、促进睾酮生成、改善勃起功能、抑制前列腺癌细胞迁移与侵袭和调控细胞周期等多种药理活性,在男科及辅助生殖领域具有研究价值及应用前景。该文综述了淫羊藿苷在男性生殖系统的药理作用及其分子机制,并结合文献可视化分析探讨目前研究现状及热点,为淫羊藿苷在男性生殖健康领域的药用价值开发及临床应用提供参考。

关键词：淫羊藿苷男性生殖系统信号通路分子机制文献计量学可视化分析

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High nitrogen fertilizer input enhanced the microbial network complexity in the paddy soil

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Soil Ecology Letters 2024年第2期6卷 97-109页

作者： Yanan Chen Yan Li Tianyi Qiu Haoran He Ji Liu Chengjiao Duan Yongxing Cui Min Huang chunyan Wu Linchuan fang The Research Center of Soil and Water Conservation and Ecological Environment Chinese Academy of Sciences and Ministry of EducationYangling712100China State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Institute of Soil and Water Conservation CAS and MWRYangling712100China University of Chinese Academy of Sciences Beijing100049China Institute of Environment Resource and Soil Fertilizer Zhejiang Academy of Agricultural SciencesHangzhou310021China College of Natural Resources and Environment Northwest A&F UniversityYangling712100China Hubei Province Key Laboratory for Geographical Process Analysis and Simulation Central China Normal UniversityWuhan430079China Department of Ecohydrology Leibniz Institute of Freshwater Ecology and Inland FisheriesBerlin12587Germany Sino-French Institute for Earth System Science College of Urban and Environmental SciencesPeking UniversityBeijing100871China College of Resources and Environmental Engineering Wuhan University of TechnologyWuhan430070China CAS Center for Excellence in Quaternary Science and Global Change Xi’an710061China

N fertilizer altered bacterial community compositions by changing soil nutrients.•Bacterial ammonia oxidation became predominated with the increasing N rate.•Excessive N input caused the information of a more complex microbial network.•Intensified microbial competition by excessive N was due to negative link increase.Nitrogen(N)fertilization drives the structure and function of soil microbial communities,which are crucial for regulating soil biogeochemical cycling and maintaining ecosystem stability.Despite the N fertilizer effects on soil microbial composition and diversity have been widely investigated,it is generally overlooked that ecosystem processes are carried out via complex associations among microbiome members.Here,we examined the effects of five N fertilization levels(0,135,180,225,and 360 kg N ha−1)on microbial co-occurrence networks and key functional taxa such as ammonia-oxidizers in paddy soils.The results showed that N addition altered microbial community composition,which were positively related to soil total N and available phosphorus(P)contents.The abundance of ammonia-oxidizing archaea(AOA)significantly decreased after N addition,whereas ammonia-oxidizing bacteria(AOB)increased in N360 treatment.Compared with low-N group(N0 and N135),the high-N group(N225 and N360)shaped more complex microbial webs and thus improved the stability of the microbial community.Partial least squares path modeling further revealed that N fertilizer had a higher effect on microbial network complexity in the high-N group(0.83)than the low-N group(0.49).Although there were more positive links across all microbial networks,the proportion of negative links significantly increased in the high-N network,suggesting that excess N addition aggravated the competition among microbial species.Disentangling these interactions between microbial communities and N fertilization advances our understanding of biogeochemical processes in paddy soils and their effects on nutrient supply to rice production.Our findings highlighted that h

关键词： nitrogen fertilizer paddy soil co-occurrence network microbial interaction

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Effect of transcranial direct current stimulation on postoperative sleep disturbance in older patients undergoing lower limb major arthroplasty:a prospective,double-blind,pilot,randomised controlled trial

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General Psychiatry 2024年第2期37卷 224-233页

作者： Jie Yang Mingshu Tao Rongguang Liu Jiaxing fang chunyan Li Dexian Chen Qi Wei Xingyu Xiong Wenxin Zhao Wen Tan Yuan Han Hongxing Zhang He Liu Song Zhang Junli Cao Department of Anesthesiology The Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsuChina Department of Anesthesiology Hospital of Chengdu University of Traditional Chinese Medicine&Traditional Chinese Medicine Hospital of Sichuan ProvinceChengduSichuanChina NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs&Jiangsu Province Key Laboratory of Anesthesiology&Jiangsu Key Laboratory of Applied Technology of Anesthesia and Analgesia Xuzhou Medical UniversityXuzhouJiangsuChina Department of Anesthesiology Eye&ENT Hospital of Fudan UniversityShanghaiChina Department of Anesthesiology&Clinical Research Center for Anesthesia and Perioperative Medicine&Huzhou Key Laboratory of Basic Research and Clinical Translation for Neuromodulation The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University||Huzhou Central Hospital||The Affiliated Huzhou HospitalZhejiang University School of Medicine||Affiliated Central Hospital Huzhou UniversityHuzhouZhejiangChina Department of Anesthesiology Renji Hospital School of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background Postoperative sleep disturbance(PSD)is a common and serious postoperative complication and is associated with poor postoperative outcomes.Aims This study aimed to investigate the effect of transcranial direct current stimulation(tDCS)on PSD in older patients undergoing lower limb major arthroplasty.Methods In this prospective,double-blind,pilot,randomised,sham-controlled trial,patients 65 years and over undergoing lower limb major arthroplasty were randomly assigned to receive active tDCS(a-tDCS)or sham tDCS(s-tDCS).The primary outcomes were the objective sleep measures on postoperative nights(N)1 and N2.Results 116 inpatients were assessed for eligibility,and a total of 92 patients were enrolled;47 received a-tDCS and 45 received s-tDCS.tDCS improved PSD by altering the following sleep measures in the a-tDCS and s-tDCS groups;the respective comparisons were as follows:the promotion of rapid eye movement(REM)sleep time on N1(64.5(33.5-105.5)vs 19.0(0.0,45.0)min,F=20.10,p<0.001)and N2(75.0(36.0-120.8)vs 30.0(1.3-59.3)min,F=12.55,p<0.001);the total sleep time on N1(506.0(408.0-561.0)vs 392.0(243.0-483.5)min,F=14.13,p<0.001)and N2(488.5(455.5-548.5)vs 346.0(286.5-517.5)min,F=7.36,p=0.007);the deep sleep time on N1(130.0(103.3-177.0)vs 42.5(9.8-100.8)min,F=24.4,p<0.001)and N2(103.5(46.0-154.8)vs 57.5(23.3-106.5)min,F=8.4,p=0.004);and the percentages of light sleep and REM sleep on N1 and N2(p<0.05 for each).The postoperative depression and anxiety scores did not differ significantly between the two groups.No significant adverse events were reported.Conclusion In older patients undergoing lower limb major arthroplasty,a single session of anodal tDCS over the left dorsolateral prefrontal cortex showed a potentially prophylactic effect in improving postoperative short-term objective sleep measures.However,this benefit was temporary and was not maintained over time.

关键词： sleep stimulation postoperative

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Microbe-induced gene silencing explores interspecies RNAi and opens up possibilities of crop protection

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Science China(Life Sciences) 2024年第3期67卷 626-628页

作者： Rongxiang fang State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of Sciencesand National Plant Gene Research CenterBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

In most eukaryotes, small RNA(sRNA)-mediated RNA silencing(or RNA interference, RNAi) is an evolutionarily conserved mechanism that regulates gene expression in a sequence-specific manner.Generally, s RNAs are produced by the RNase III enzymes Dicers and then incorporated into Argonaute(AGO) proteins to regulate gene expression by mRNA degradation.

关键词： protection conserved manner

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Life forms affect beta-diversity patterns of larch forests in China

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Plant Diversity 2024年第1期46卷 49-58页

作者： Wenjing fang Qiong Cai Chengjun Ji Jiangling Zhu Zhiyao Tang Jingyun fang School of Ecology and Environmental Science Yunnan UniversityKunming 650091China Department of Ecology College of Urban and Environmental Sciencesand Key Laboratory for Earth Surface Processes of the Ministry of EducationPeking UniversityBeijing 100871China

Beta-diversity reflects the spatial changes in community species composition which helps to understand how communities are assembled and biodiversity is formed and maintained. Larch(Larix) forests, which are coniferous forests widely distributed in the mountainous and plateau areas in North and Southwest China, are critical for maintaining the environmental conditions and species diversity. Few studies of larch forests have examined the beta-diversity and its constituent components(species turnover and nestedness-resultant components). Here, we used 483 larch forest plots to determine the total betadiversity and its components in different life forms(i.e., tree, shrub, and herb) of larch forests in China and to evaluate the main drivers that underlie this beta-diversity. We found that total betadiversity of larch forests was mainly dependent on the species turnover component. In all life forms,total beta-diversity and the species turnover component increased with increasing geographic, elevational, current climatic, and paleoclimatic distances. In contrast, the nestedness-resultant component decreased across these same distances. Geographic and environmental factors explained 20%-25% of total beta-diversity, 18%-27% of species turnover component, and 4%-16% of nestedness-resultant component. Larch forest types significantly affected total beta-diversity and species turnover component. Taken together, our results indicate that life forms affect beta-diversity patterns of larch forests in China, and that beta-diversity is driven by both niche differentiation and dispersal limitation. Our findings help to greatly understand the mechanisms of community assemblies of larch forests in China.

关键词： Beta-diversity Species turnover Nestedness-resultant Geographic distance Climatic distance Larch forest

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Pancreatic panniculitis as the first presentation of pancreatic ductaladenocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 106-108页

作者： Wei-fang Zhu Shan fang Jian-Jun Qiao Department of Dermatology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

To the Editor:Pancreatic panniculitis,also known as pancreatic fat necrosis or enzymatic panniculitis,is a rare type of panniculitis that occurs in 0.3%−3%of patients with pancreatic disease such as acute or chronic pancreatitis and pancreatic carcinoma,especially acinar cell carcinoma[1,2].The clinical manifestations are nonspecific erythema tender nodules.

关键词： Pancreatic acute adenocarcinoma

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