检索结果-南通市图书馆

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin dai Lei Ye Tao Song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

在线全文

学校读者我要写书评

暂无评论

加快我国可再生能源数据信息平台建设

中外能源 2012年第2期17卷 23-28页

作者：代春艳张希良陶冶唐松林刘贞刘建东清华大学能源环境经济研究所北京100084 国家发改委能源研究所可再生能源中心北京100038 重庆理工大学重庆400067

有效的可再生能源数据信息平台是进行新能源发展战略制定、规划、决策的基础。相比可再生能源的迅速发展,我国可再生能源信息收集和统计工作相对滞后,并缺乏一个集中的信息发布和共享服务平台。我国迫切需要建立和完善可再生能源信息收... 详细信息

有效的可再生能源数据信息平台是进行新能源发展战略制定、规划、决策的基础。相比可再生能源的迅速发展,我国可再生能源信息收集和统计工作相对滞后,并缺乏一个集中的信息发布和共享服务平台。我国迫切需要建立和完善可再生能源信息收集平台,构建基于系统科学的数据信息分析系统。美国能源信息署(EIA)、美国可再生能源实验室(REL)、丹麦可再生能源实验室(Risoe)、国际能源署(IEA)、亚太经合组织(APEC)在能源和可再生能源数据信息平台建设方面积累了丰富的经验,代表了国际先进水平,可为我国可再生能源数据信息平台的建设提供重要的参考与借鉴。它们的经验包括人财物组织、数据收集方式、数据管理、数据监测、数据分析等方面。为加快我国可再生能源数据信息平台建设、建议有关部门应做好以下几项工作:加大对国家可再生能源数据信息平台建设的支持力度;加强国际交流合作,充分利用各国和有关国际组织的研究成果;严格数据定义,统一数据标准;建立高质量的数据收集体系;建立数据核查与评价机制;建立可再生能源数据信息平台标准手册制度;实现数据信息平台建设和运营管理的"天缝"衔接。

关键词：可再生能源信息平台模型数据收集数据核查

Ultralight and superelastic MXene/reduced graphene oxide aerogels for electromagnetic interference shielding

在线全文

学校读者我要写书评

暂无评论

Nano Research 2025年第1期18卷 1-9页

作者： Xinfeng Zhou Yang dai Guoyao Yue Yiman Zhang Lulu Li Zhong-Zhen Yu Peng Min Hao-Bin Zhang 21 State Key Laboratory of Organic-Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Advanced Functional Polymer Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Present address:BOE Technology Innovation Center BOE Technology Group Co.Ltd.Beijing 100176China Xi’an Modern Chemistry Research Institute Xi’an 710065China

Lightweight aerogels feature multifunctionality and a high porosity,yet accompanied with poor structure recovery under large strain *** this work,we develop an air bubble-ice crystal dual template and annealing strategy to integrate low density and high resilience for the conductive transition metal carbides/nitrides(MXene)composite *** air bubbles and ice crystals synergistically exclude the nanosheets to the gas-liquid interfaces,thereby constructing unique Y-shaped junctions and robust *** annealing process greatly enhances the interlayer *** external load,the Yshaped structures prevent the stress concentration at the junctions by transferring the forces to the skeleton for maintaining structural *** addition,the wrinkled and thick cell walls,together with the enhanced interlayer interactions,endow the aerogel with exceptional structural stability and *** a result,the MXene/reduced graphene oxide(RGO)composite aerogels exhibit superelasticity with reversible compressive strains of up to 95%.In addition,the electron bridging effect of the RGO sheets affords the aerogel to deliver excellent electromagnetic interference shielding performance,as high as 46.3 dB at 2.5 ***,the remarkable reshapeability of the aerogels allows for precise regulation of structure and performance(33.5-75.1 dB)by a simple wetting compression *** summary,this work offers helpful inspirations for developing lightweight and superelasticity aerogels for extensive applications.

关键词： lightweight superelasticity MXene aerogel electromagnetic interference shielding reshapeability

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

某碱性铀矿石微生物柱浸试验

有色金属（矿山部分） 2014年第4期66卷 18-21页

作者：代春艳孙占学王学刚陈功新陈剑朝东华理工大学江西抚州344000

采用普通酸法对碱性铀矿进行堆浸时存在耗酸大、周期长、易板结等问题,不利于工业生产,因此选用微生物浸出法对碱性铀矿石进行室内柱浸试验,初步探究细菌在试验柱中的适应性、液计铀浸出率、耗酸率和翻柱效果。试验结果显示,柱中细菌生... 详细信息

采用普通酸法对碱性铀矿进行堆浸时存在耗酸大、周期长、易板结等问题,不利于工业生产,因此选用微生物浸出法对碱性铀矿石进行室内柱浸试验,初步探究细菌在试验柱中的适应性、液计铀浸出率、耗酸率和翻柱效果。试验结果显示,柱中细菌生长状况良好,浸出周期170d,液计铀浸出率为76.75%,耗酸率为9.14%,微生物浸出以及通过翻柱减轻板结程度均利于提高液计铀浸出率。通过室内研究得出相应参数,为碱性铀矿的规模化生产提供依据。

关键词：碱性铀矿微生物柱浸液计铀浸出率耗酸率

MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1431-1444页

作者： Yuehua Cui Xiaokuang Ma Jing Wei Chang Chen Neha Shakir Hitesch Guirram Zhiyu dai Trent Anderson Deveroux Ferguson Shenfeng Qiu Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZUSA Department of Medicine University of Arizona College of Medicine-PhoenixPhoenixAZUSA

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse *** have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine *** investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing *** found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection *** findings are further corroborated by increased synaptic activity and transient generation of immature silent *** MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and *** data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult *** findings may have implications for regenerative therapy in aging and neurodegeneration conditions.

关键词： aging circuit connectivity cortical circuits molecular mechanisms neural regeneration neurodegeneration synapses

右美托咪定辅助腰硬阻滞麻醉对老年骨折患者术后应激反应及认知功能的影响

在线全文

学校读者我要写书评

暂无评论

中国社区医师 2021年第29期37卷 20-21页

作者：戴春燕刘海健马国平赵邦娥黄成泉上海健康医学院附属周浦医院麻醉科上海201318

目的:探究右美托咪定辅助腰硬阻滞麻醉对老年骨折患者术后应激反应及认知功能的影响。方法:2019年6月-2020年6月收治接受骨折手术治疗的老年患者168例,随机分为两组,各84例。对照组给予腰硬阻滞麻醉;试验组在腰硬阻滞麻醉基础上加用右... 详细信息

目的:探究右美托咪定辅助腰硬阻滞麻醉对老年骨折患者术后应激反应及认知功能的影响。方法:2019年6月-2020年6月收治接受骨折手术治疗的老年患者168例,随机分为两组,各84例。对照组给予腰硬阻滞麻醉;试验组在腰硬阻滞麻醉基础上加用右美托咪定。比较两组患者麻醉前(T_(0))、手术结束时(T_(1))、手术结束后6 h(T_(2))血清去甲肾上腺素(NE)、肾上腺素(E)水平以及术前1天、术后第7天简易精神状态量表(MMSE)评分。结果:两组T_(0)时NE及E水平比较,差异无统计学意义(P>0.05);试验组T_(1)、T_(2)时NE及E水平均低于对照组,差异有统计学意义(P0.05);试验组术后第7天MMSE评分高于对照组,差异有统计学意义(P<0.05)。结论:采用腰硬阻滞麻醉辅以右美托咪定对老年骨折患者进行麻醉,能够减轻对患者认知功能的影响,并减轻应激反应。

关键词：右美托咪定腰硬阻滞麻醉应激反应认知功能

在线全文

学校读者我要写书评

暂无评论

磺化杯[8]芳烃的合成表征及热性能研究

广东化工 2015年第13期42卷 11-13页

作者：戴春燕王倩罗怡韩傲雪高杰谭佳朱林华海南师范大学化学与化工学院海南海口571158 浙江树人大学生物与环境工程学院浙江杭州310015

本文以对叔丁基苯酚和甲醛为原料,通过缩醛反应、去烷基化反应以及磺化反应合成了磺化杯[8]芳烃,并通过红外光谱和核磁共振谱对其进行结构表征,通过热重分析研究其热性能。热分析结果表明,磺化杯[8]芳烃的热重分为四个阶段,分别是室温-... 详细信息

本文以对叔丁基苯酚和甲醛为原料,通过缩醛反应、去烷基化反应以及磺化反应合成了磺化杯[8]芳烃,并通过红外光谱和核磁共振谱对其进行结构表征,通过热重分析研究其热性能。热分析结果表明,磺化杯[8]芳烃的热重分为四个阶段,分别是室温-100℃,230-250℃,430-465℃以及705-752℃,同时温度在800℃时,磺化杯芳烃的质量保持率在63%,显示其具有较好的热性能。

关键词：磺化杯芳烃合成热降解

住院缺血性脑卒中病人医学应对方式及其影响因素研究

在线全文

学校读者我要写书评

暂无评论

全科护理 2019年第29期17卷 3597-3600页

作者：董玉静殷海燕王爱红杜世正陈冬戴春燕南京中医药大学护理学院 210023 江苏省中医院 210029

[目的]探讨住院缺血性脑卒中病人医学应对方式及其影响因素。[方法]采用便利抽样法选择2017年3月—2017年6月在南京市某三级甲等综合性医院神经内科病房住院且入院天数在3 d及以上的70例缺血性脑卒中病人为研究对象。采用一般资料调查表... 详细信息

[目的]探讨住院缺血性脑卒中病人医学应对方式及其影响因素。[方法]采用便利抽样法选择2017年3月—2017年6月在南京市某三级甲等综合性医院神经内科病房住院且入院天数在3 d及以上的70例缺血性脑卒中病人为研究对象。采用一般资料调查表、Essen卒中风险评分表、日常生活能力问卷、医学应对问卷对病人进行调查,采用t检验、单因素方差分析及相关分析探讨影响病人医学应对方式的因素。[结果]面对维度得分为(14.74±4.14)分,回避维度得分为(13.53±2.80)分,屈服维度得分为(8.83±4.03)分。本组病人面对、回避维度得分低于国内常模(P0.05)。各维度影响因素分析:①面对维度。文化程度高、入院天数长的病人更倾向于采取面对策略。②回避维度。无功能障碍的病人更易采取回避策略。③屈服维度。小学及以下文化程度、经济状况差及有功能障碍的病人更倾向于采用屈服应对方式。其他因素如发病情况、性别、年龄、ESRS得分等因素对医学应对方式无影响。[结论]住院缺血性脑卒中病人的应对水平较低;文化程度、经济状况、入院天数、是否存在功能障碍是医学应对方式的影响因素。首次发病还是复发对病人的医学应对方式无影响,提示上一次的发病经历并没有帮助病人正确认识和应对疾病,也凸显了医院健康教育的不足。

关键词：脑卒中医学应对影响因素

Estimation of Extreme Marine Hydrodynamic Variables in Western Laizhou Bay

在线全文

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2015年第3期14卷 425-432页

作者： dai Yanchen QIAO Lulu XU Jishang ZHOU chunyan DING Dong BI Wei Key Lab of Submarine Sciences & Prospecting Techniques MOE Ocean University of China China Petroleum & Chemical Corporation Shengli Oilfield Branch College of Marine Geosciences Ocean University of China State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University Qingdao Meteorological Bureau

Laizhou Bay and its adjacent waters are of great importance to China＇s marine oil and gas development. It is therefore crucial to estimate retttrn-period values of marine environmental variables in this region to ensure the safety and success of maritime engineering and maritime exploration. In this study, we used numerical simulations to estimate extreme wave height, sea current velocity and sea-level height in westem Laizhou Bay. The results show that the sea-level rise starts at the mouth of the bay, increases toward west/southwest, and reaches its maximum in the deepest basin of the bay. The 100-year return-period values of sea level rise can reach 3.4-4.0m in the western bay. The elevation of the western part of the Qingdong Oil Field would remain above the sea sur- face during extreme low sea level, while the rest of the oil field would be 1,6-2.4m below the sea surface. The return-period value of wave height is strongly affected by water depth; in fact, its spatial distribution is similar to the isobath＇s. The 100-year return-period values of effective wave height can be 6m or higher in the central bay and be more than 1 m in the shallow water near shore. The 100-year return-period values of current velocity is about 1.2-1.8 ms-1 in the Qingdong Oil Field. These results provide scientific basis for ensuring construction safety and reducing construction cost,

关键词： Laizhou Bay extreme value current velocity wave surface elevation return period