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SYNTHESIS OF 1,2-ACEANTHRYLENEDIONE THROUGH ACYLATION OF ANTHRACENE WITH OXALYL CHLORIDE

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Chinese Journal of Reactive Polymers 2007年第Z1期 61-65页

作者： ZHANG chunyan CHEN Min yu Long JIANG Deli YAN Yongsheng School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China

Acylation of anthracene and oxalyl chloride in the presence of anhydrous AlCl3 was investigated. Pure 1,2-aceanthrylenedione, which is used as new functional macromolecule, was prepared by extraction and recrystallation. The structure of 1,2-aceanthrylenedione was identified by measure of melting point, GC/MS, FTIR and 1HNMR analyses. The influences of various parameters, such as solvent, dosage of catalyst, molar ratio of anthracene to oxalyl chloride, reaction temperature, and reaction time were studied. The anhydrous AlCl3 was found to catalyze the reaction with high yeild and good selectivity. When the reaction temperature is 303K, reaction time is 5h and molar ratio of anthracene to oxalyl chloride is 1:2, the yield and selectivity of 1,2-aceanthrylenedione is 83.8 % and 92.3% respectively.

关键词： Functional macromolecule intermediate 1,2-aeanthrylenedione Anthracene Acylation Anhydrous AlCl3.

Research on Simulation of Multi-agents Competition Model with Negotiation

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Research on Simulation of Multi-agents Competition Model wit...

Anisomycin suppresses Jurkat T cell growth by the cell cycle-regulating proteins

2010 International Conference on Life System Modeling and Simulation & 2010 International Conference on Intelligent Computing for Sustainable Energy and Environment

作者： Liqiao Wu, chunyan yu, Hongshu Wang, College of Mathematic and Computer Science, Fuzhou University 350108 Fuzhou, Fujian, China

To construct an artificial system with multi-Agents, it is obvious that some important factors, such as different agent's interests, limited resources and so on, will inevitably lead to conflict. To reduce conflict, it is found that effective competition with negotiation among multi-Agents can improve overall performance. Thence, this paper proposes a new Multi-Agents Competition Model with Negotiation, which improves the forecast accuracy of opponent's competing strategies with negotiation information and shortens negotiation time effectively depending on selecting strategies in probability to maximum interest.

关键词： Competition with negotiation Multi-Agents competition model Negotiation information Probability selection strategies.

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Anisomycin suppresses Jurkat T cell growth by the cell cycle...

Jagged-1–Deltex-1 signaling promotes the differentiation of Th17 cells via RORγt

第八届全国免疫学学术大会

作者： chunyan yu Zhengle Tang Christian Bronner Xijian Lu Jingfang Di Shan Zeng Jing Liu Feiyue Xing Institute of Tissue Transplantation and Immunology Department of ImmunobiologyJinan University

Background:Recent studies have shown that anisomycin significantly inhibits mammalian cell proliferation, but its mechanism remains *** this study, Jurkat T cells were used to first explore a relationship between effect of anisomycin on them and alteration of cell cycle-regulating ***:Cell colony formation, CCK-8 assay, Flow cytometry, RT-PCR and Western blot were employed to evaluate correlation of ten cell cycle-regulating proteins with suppression of the cell proliferation and arrest of the cell cycle by ***:Our data showed that anisomycin inhibited the colony-formation and proliferation of Jurkat T cells in a dose-dependent manner, and arrested the cells into S and G2/M phases with the production of sub-diploid *** levels of P21, P-P27 and P53/P-P53 reached to their peaks 4 h after anisomycin treatment, presenting a positive correlation with anisomycin concentration, and P16, P-P21, P27, P57, P73/P-P73 and P- Rb changed little with the exposure time or concentrations of *** the level of Rb protein was increased at 24 h after the treatment of *** expression of an inverted CCAAT box binding protein(ICBP90) in Jurkat T cells came to decrease 12 h after the treatment of anisomycin, presenting a negative correlation with anisomycin ***, the expression of P-CDK2 was also decreased at 24 h, presenting an obviously negative correlation, whereas P-CDK1 showed no differences among the differently treated Jurkat T ***, the level of P21 and P53 mRNA was increased with the enhanced concentrations of ***:The results indicate that anisomycin may mainly activate the P53/P21 signaling to decrease the expression of ICBP90, inhibit expression of P-CDK2 to block the cells into S and G2/M phases, and finally result in proliferation inhibition of Jurkat T cells.

关键词： Anisomycin P21 P53 ICBP90 CDK2 Jurkat T cell

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Jagged-1–Deltex-1 signaling promotes the differentiation of...

Linear-Quadratic Pareto Cooperative Game for Mean-Field Backward Stochastic System

第八届全国免疫学学术大会

作者： Zhengle Tang yuan Wang Hui Zhang chunyan yu Jingfang Di Shan Zeng Jing Liu Feiyue Xing Institute of Tissue Transplantation and Immunology Department of ImmunobiologyJinan University

Background:Notch signaling plays an important role in regulating Th17 ***, little is known as to its detailed ***:In this study, a soluble recombinant Jagged-1/Fc chimera protein(Jagged-1), a RING finger ubiquitin ligase(Deltex-1)-targeting siRNA, and hairy and enhancer of split(Hes)-1-targeting siRNA were employed to explore effect of Jagged-1-Deltex-1 signaling from a CSL(CBF1, Su(H) and LAG-1)-independentroute on differentiation of CD4+ T cells into Th17 *** and Results:Jagged-1 promoted the expressions of both Deltex-1 and Hes-1 in CD4+ T ***-1-siRNA down-regulated the expression of Deltex-1, whereas presented no influence on Hes-1 in CD4+ Tcells with the suppressed generation of IL-17- producing CD4+ T *** Hes-1-siRNA showed the opposite ***, Deltex-1-siRNA down-regulated retinoic acid-related orphan receptor γt( RORγt) mRNA and protein levels as well as its DNA binding activity in the *** the in situ expression of RORγt was mainly localized in the cytoplasm of the *** the contrary, Deltex-1-siRNA up-regulated Foxp3, GATA3 mRNA and protein levels as well as their DNA binding *** in situ expressions of them were mainly distributed in the cytoplasm and nuclei of the *** it showed no influence on T-bet, *** expressions of IL-17 A, IL-6, TNF-α, IFN-γ and TGF-β1 produced by the cells were also diminished by Deltex-1-siRNA, but the production of IL-10 was ***:Together, these results indicate that Jagged-1-Deltex-1 signaling promotes CD4+ T cells to differentiate into Th17 cells, whereas Jagged-1-Hes-1 signaling exerts an opposite action.

关键词： Jagged-1 Deltex-1 Th17 differentiation

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Journal of Systems Science & Complexity 2024年第3期37卷 947-964页

作者： WANG yu School of Control Science and Engineering Shandong UniversityJinan 250061China

This paper focuses on a Pareto cooperative differential game with a linear mean-field backward stochastic system and a quadratic form cost functional. Based on a weighted sum optimality method, the Pareto game is equivalently converted to an optimal control problem. In the first place,the feedback form of Pareto optimal strategy is derived by virtue of decoupling technology, which is represented by four Riccati equations, a mean-field forward stochastic differential equation(MF-FSDE),and a mean-field backward stochastic differential equation(MF-BSDE). In addition, the corresponding Pareto optimal solution is further obtained. Finally, the author solves a problem in mathematical finance to illustrate the application of the theoretical results.

关键词： Backward stochastic differential equation linear-quadratic control mean-field Pareto optimality

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基于单列深度时空卷积神经网络的人群计数

激光与光电子学进展 2021年第8期58卷 135-143页

作者：鱼春燕徐岩缑丽莎南哲锋兰州交通大学电子与信息工程学院甘肃兰州730070

突发性人群聚集会给人们的人身安全带来隐患,因此,对高风险区域进行有效的人群计数具有重要意义。针对多列神经网络结构臃肿、冗余信息多及耗时长等问题,提出了一种基于单列深度时空卷积神经网络的人群计数模型,并对模型进行改进,以满... 详细信息

突发性人群聚集会给人们的人身安全带来隐患,因此,对高风险区域进行有效的人群计数具有重要意义。针对多列神经网络结构臃肿、冗余信息多及耗时长等问题,提出了一种基于单列深度时空卷积神经网络的人群计数模型,并对模型进行改进,以满足视频图像计数的需要。首先,在全卷积神经网络(FCN)中加入空洞卷积和跳级连接特征融合,以提高网络提取特征的能力。然后,为了减少视频监控产生的角度畸变对计数结果的影响,在长短期记忆(LSTM)网络结构中加入空间变换模块;为了提高网络计数结果的精确性,用残差连接方式连接改进的FCN和关联时序的LSTM网络。最后,在UCSD、Mall和自建人群数据集上分别进行测试,结果表明,相比其他模型,本模型的人群计数准确性和鲁棒性更好。

关键词：图像处理神经网络人群计数深度时空网络空洞卷积空间变换

虚拟环境中基于二级2D投影图的动态碰撞检测机制

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中国机械工程 2005年第9期16卷 805-810页

作者：侯宏仑余春艳吴明晖潘云鹤浙江大学杭州310027

一种良好的动态碰撞检测机制应该遵循实时性、用户透明性、用户空间认知度等准则。基于这些准则,提出了一种基于二级2D平面投影图的水平动态碰撞检测机制TMBHD CD,阐述了其具体实现及体系结构。二级平面投影图Free Space Map 和Detail P... 详细信息

一种良好的动态碰撞检测机制应该遵循实时性、用户透明性、用户空间认知度等准则。基于这些准则,提出了一种基于二级2D平面投影图的水平动态碰撞检测机制TMBHD CD,阐述了其具体实现及体系结构。二级平面投影图Free Space Map 和Detail ProjectionMap在不同阶段提供化身的空间信息;该机制将碰撞检测处理分为碰撞判定、碰撞避免和路径修复三个阶段,提出动态障碍物碰撞预警域、碰撞互斥域及碰撞互斥带的概念,结合DetailProjection Map进行碰撞判定、避免和修正。

关键词：碰撞检测二级2D投影图碰撞判定碰撞避免路径修复

Thiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2132-2142页

作者： Xinglong Han Lina Qu Miao yu Lingqun Ye Liujia Shi Guangfu Ye Jingsi Yang Yaning Wang Hao Fan Yong Wang Yingjun Tan chunyan Wang Qi Li Wei Lei Jianghai Chen Zhaoxia Liu Zhenya Shen Yinghui Li Shijun Hu Department of Cardiovascular Surgery of the First Affiliated Hospital&Institute for Cardiovascular Science State Key Laboratory of Radiation Medicine and ProtectionSuzhou Medical CollegeSoochow UniversitySuzhouChina State Key Laboratory of Space Medicine China Astronaut Research and Training CenterBeijingChina Department of Hand Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

During spaceflight,the cardiovascular system undergoes remarkable adaptation to microgravity and faces the risk of cardiac ***,the effects and mechanisms of microgravity on cardiac morphology,physiology,metabolism,and cellular biology need to be further *** China started constructing the China Space Station(CSS)in 2021,we have taken advantage of the Shenzhou-13 capsule to send human pluripotent stem cell-derived cardiomyocytes(hPSC-CMs)to the Tianhe core module of the *** this study,hPSC-CMs subjected to space microgravity showed decreased beating rate and abnormal intracellular calcium *** and transcriptomic analyses revealed a battery of metabolic remodeling of hPSC-CMs in spaceflight,especially thiamine *** microgravity condition blocked the thiamine intake in *** decline of thiamine utilization under microgravity or by its antagonistic analog amprolium affected the process of the tricarboxylic acid *** decreased ATP production,which led to cytoskeletal remodeling and calcium homeostasis imbalance in *** importantly,in vitro and in vivo studies suggest that thiamine supplementation could reverse the adaptive changes induced by simulated *** study represents the first astrobiological study on the China Space Station and lays a solid foundation for further aerospace biomedical *** data indicate that intervention of thiamine-modified metabolic reprogramming in human cardiomyocytes during spaceflight might be a feasible countermeasure against microgravity.

关键词： programming battery modified

溶胶-凝胶法载银SiO_2杂化膜的制备及性能研究

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材料导报 2011年第24期25卷 80-83,106页

作者：杨靖于春雁刘华华西安工程大学环境与化学工程学院西安710048 华能沁北发电有限责任公司济源454664

采用溶胶-凝胶法,在甲基化改性的SiO2溶胶中掺杂硝酸银,制备Ag/M-SiO2杂化膜。通过XRD、XPS、紫外-可见吸收谱、N2吸附-脱附以及气体渗透性能测试等方法,考察了银掺杂对杂化膜结构和性能的影响。结果表明,Ag/M-SiO2膜中的银元素完全为... 详细信息

采用溶胶-凝胶法,在甲基化改性的SiO2溶胶中掺杂硝酸银,制备Ag/M-SiO2杂化膜。通过XRD、XPS、紫外-可见吸收谱、N2吸附-脱附以及气体渗透性能测试等方法,考察了银掺杂对杂化膜结构和性能的影响。结果表明,Ag/M-SiO2膜中的银元素完全为纳米金属银,具有面心立方结构。金属银的掺杂对Ag/M-SiO2膜的化学结构基本没有影响,但使其孔径和总孔体积略微增大。与未载银的SiO2膜相比,Ag/M-SiO2膜具有更大的H2渗透速率和更好的H2/CO2选择性。金属银的引入增强了H2的表面扩散作用,促进了H2在膜中的传递,提高了SiO2膜的水汽稳定性。

关键词：溶胶-凝胶法银掺杂甲基化改性水汽稳定性