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肠道病毒性脑炎的患儿T细胞活化亚群和细胞因子的变化

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中华实验和临床病毒学杂志 2016年第2期30卷 171-174页

作者：方春艳邹小杰袁哲峰黄明海高峰浙江大学医学院附属儿童医院杭州310000 浙江省湖州市中心医院湖州313000 宁波市妇女儿童医院 315000

目的通过对肠道病毒性脑炎（Enterovirus Encephalitis,EVE）的患儿T细胞活化亚群、细胞因子的检测,探讨其在EVE发病机制中的可能作用.方法选择2014年6月至2015年7月浙江大学医学院附属儿童医院神经科病房收住院的24例脑脊液肠道病毒... 详细信息

目的通过对肠道病毒性脑炎（Enterovirus Encephalitis,EVE）的患儿T细胞活化亚群、细胞因子的检测,探讨其在EVE发病机制中的可能作用.方法选择2014年6月至2015年7月浙江大学医学院附属儿童医院神经科病房收住院的24例脑脊液肠道病毒阳性的EVE患儿为病例组,其中14例予活化T细胞亚群检测,24例均予细胞因子流式测定,同期门诊体检的49例健康儿童为对照组.通过流式细胞术检测两组外周血CD25 ＋/CD3＋ CD4＋、CD69 ＋/CD3＋CD4＋、HLA-DR/CD3＋ CD4＋、CD25 ＋/CD3＋ CD8＋、CD69 ＋/CD3＋ CD8＋、HLA-DR/CD3＋ CD8＋,及IL-2、IL-4、IL-6、IL-10、TNF-α、INF-γ水平.结果病例组外周血CD69/CD3＋ CD4＋、CD69/CD3＋ CD8＋的表达含量（1.193％ ±2.849％,0.696％±1.242％）低于对照组（Z=-2.722,P=0.006;Z=-3.321,P=0.001）.外周血病例组IL-2的表达水平（3.342±1.089 pg/ml）低于对照组（Z=-2.722,P=0.019）;而IL-6,TNF-α的表达水平（123.046±355.349;3.367±1.717 pg/ml）,与对照组相比,有所增加,差异有统计学意义（Z=-3.471,P=0.001;Z=-4.803,P＜0.001）.结论 EVE患儿存在一定程度的免疫功能紊乱,T细胞活化亚群和细胞因子可能参与了EVE的发病过程.

关键词：肠道病毒性脑炎脑脊液肠道病毒DNA阳性 T-淋巴细胞细胞因子类

基于Uni-app框架的高中物理实验App设计——以加速度传感器为例

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物理实验 2024年第9期44卷 55-59,63页

作者：方春艳余孝源李丰果华南师范大学物理学院广东广州510006 华南师范大学物理国家级实验教学示范中心(华南师范大学) 广东广州510006

基于Uni-app框架自主开发了高中物理实验App软件,详细阐述了基于手机传感器的App开发流程,并基于此实现了电梯加速度测量实验,讨论了气垫导轨测量重力加速度的实验过程,实验结果与理论值相符.与Phyphox软件进行对比发现:二者采集的实验... 详细信息

基于Uni-app框架自主开发了高中物理实验App软件,详细阐述了基于手机传感器的App开发流程,并基于此实现了电梯加速度测量实验,讨论了气垫导轨测量重力加速度的实验过程,实验结果与理论值相符.与Phyphox软件进行对比发现:二者采集的实验数据吻合度较高.该自主软件的开发流程和实验过程描述,将为基于智能手机实验的App开发提供技术参考.

关键词：实验应用程序传感器加速度气垫导轨实验

PICC置管患者导管相关皮肤损伤的调查及影响因素分析

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健康研究 2023年第5期43卷 579-583,588页

作者：蔡恩旦牟春雨方春燕杭州市第九人民医院输液室浙江杭州311225

目的对中心静脉导管(PICC)置管患者导管相关皮肤损伤(CASI)情况进行调查,分析影响PICC置管患者导管相关皮肤损伤的危险因素,提出针对性预防措施。方法选取行PICC置管的539例患者为研究对象,记录患者发生CASI情况,以是否发生皮肤损伤分为... 详细信息

目的对中心静脉导管(PICC)置管患者导管相关皮肤损伤(CASI)情况进行调查,分析影响PICC置管患者导管相关皮肤损伤的危险因素,提出针对性预防措施。方法选取行PICC置管的539例患者为研究对象,记录患者发生CASI情况,以是否发生皮肤损伤分为CASI组和无CASI组,收集患者的临床相关资料,采用单因素和多因素Logistic回归,分析影响皮肤损伤的独立危险因素。结果539例PICC置管患者中有183例出现CASI,发生率为33.95%,其中机械性损伤98例(53.55%),接触性皮炎51例(26.23%),压力性损伤15例(8.20%),穿刺点渗液12例(6.56%),局部感染10例(5.46%)。CASI组患者年龄61~74岁、使用刺激性药物、在夏冬季置管、PICC置管时间≥5月、导管维护周期≥7 d、存在导管正压接头压迫、使用3M敷贴、皮肤敏感体质者的占比,均高于无CASI组,血清Alb及Hb均低于无CASI组,差异有统计学意义(P60岁(OR=18.102)、导管维护周期≥7 d(OR=23.430)、存在导管正压接头压迫(OR=19.787)、低水平血清Alb(OR=10.433),是影响PICC置管患者发生CASI的独立危险因素(均P60岁、导管维护周期≥7 d、存在导管正压接头压迫、低水平血清Alb的患者。

关键词：中心静脉导管皮肤损伤危险因素

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鉴江流域特枯条件下水量应急调度方案

广东水利水电 2020年第8期 21-25,39页

作者：吕超寅房春艳周佳伟广东省西江流域管理局广东珠海519082 中山大学水资源与环境研究中心广东广州510275 华南地区水循环和水安全重点实验室广东广州510275 中山大学土木工程学院广东珠海519082

近年来,鉴江流域经济社会快速发展,对鉴江水资源的需求不断增加,接近流域水资源承载能力,尤其是枯水期,容易出现大范围、长时间的干旱。流域供水得不到保障,将严重影响茂名和湛江的城乡生活用水和社会经济发展,需要统一的水量调度机制... 详细信息

近年来,鉴江流域经济社会快速发展,对鉴江水资源的需求不断增加,接近流域水资源承载能力,尤其是枯水期,容易出现大范围、长时间的干旱。流域供水得不到保障,将严重影响茂名和湛江的城乡生活用水和社会经济发展,需要统一的水量调度机制。该文在分析鉴江流域水文资料、用水、水利工程建设情况的基础上,从调度原则、供水对象、调度工程、调水线路等方面,研究并制订了鉴江流域水量应急调度预案。方案有助于应对流域枯季干旱缺水的问题,更好地保障流域供水安全。

关键词：用水短缺枯水期水量应急调度鉴江

WHITE NOISE ESTIMATION FOR DISCRETE-TIME SYSTEMS WITH RANDOM DELAY AND PACKET DROPOUT

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Journal of Systems Science & Complexity 2014年第3期27卷 476-493页

作者： WANG Wei HAN chunyan HE fang School of Control Science and Engineering Shandong University School of Electrical Engineering University of Jinan

This paper is concerned with the optimal and suboptimal deconvolution problems for discrete-time systems with random delayed observations. When the random delay is known online, i.e., time stamped, the random delayed system is reconstructed as an equivalent delay-free one by using measurement reorganization technique, and then an optimal input white noise estimator is presented based on the stochastic Kahnan filtering theory. However, tb_e optimal white-noise estimator is timevarying, stochastic, and doesn＇t converge to a steady state in general. Then an alternative suboptimal input white-noise estimator with deterministic gains is developed under a new criteria. The estimator gain and its respective error covariance-matrix information are derived based on a new suboptimal state estimator. It can be shown that the suboptimal input white-noise estimator converges to a steady-state one under appropriate assumptions.

关键词： Discrete-time system packet dropout random delay white-noise estimators.

黄山市临床护士情绪劳动与工作倦怠的关系——心理资本的中介作用

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齐齐哈尔医学院学报 2024年第2期45卷 196-201页

作者：高虹盛亚琳程丽芬方春艳黄山职业技术学院安徽黄山245000 黄山市人民医院安徽黄山245000 黄山首康医院安徽黄山245000

目的探讨黄山市临床护士情绪劳动、心理资本与工作倦怠之间的关系。方法于2022年12月—2023年2月,采用情绪劳动量表(ELS)、心理资本量表(PCQ-R)、工作倦怠量表(MBI-GS中文版),对黄山市几所影响力较大的医院481名临床一线护士进行调查。... 详细信息

目的探讨黄山市临床护士情绪劳动、心理资本与工作倦怠之间的关系。方法于2022年12月—2023年2月,采用情绪劳动量表(ELS)、心理资本量表(PCQ-R)、工作倦怠量表(MBI-GS中文版),对黄山市几所影响力较大的医院481名临床一线护士进行调查。结果黄山市临床护士情绪劳动处于中等水平[(52.02±10.20)分],心理资本处于中等偏上水平[(101.47±15.37)分],工作倦怠处于中等水平[(54.49±11.50)分];临床护士的情绪劳动与工作倦怠呈显著正相关(r=0.290,P<0.01)、与心理资本呈负相关(r=-0.103,P<0.05),心理资本与工作倦怠成显著负相关(r=-0.550,P<0.01)。情绪劳动可以通过心理资本的中介作用对工作倦怠产生影响,心理资本的中介效应占总效应约29.5%。结论黄山市临床护士情绪劳动不仅能够直接预测工作倦怠,也可以通过心理资本的中介作用对工作倦怠产生间接影响。加强情绪劳动管理,提升心理资本,对降低工作倦怠水平具有积极作用。

关键词：临床护士情绪劳动心理资本工作倦怠

Efficient and simple synthesis of B_(2)O_(3)-Al_(2)O_(3)nanocomposites assisted by deep eutectic solvent for production of 5-hydroxymethylfurfural from glucose

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Nano Research 2025年第1期18卷 236-248页

作者： Yuchen Wang Kai Rong Shanlei Chang Youxing fang Shaojun Dong State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China College of Chemistry Jilin UniversityChangchun 130012China

The catalytic conversion of glucose to high valueadded platform chemical 5-hydroxymethylfurfural(HMF)is a promising biorefinery process,and alumina-boria catalysts are considered to be green and mild solid acid catalysts for this catalytic ***,compared to the common synthesis methods with complicated steps,we reported a simple and efficient strategy to prepare B_(2)O_(3)-Al_(2)O_(3)nanocomposites by calcining cost-effective glucose-urea deep eutectic solvent(DES)solution containing the *** prepared B_(2)O_(3)-Al_(2)O_(3)nanocomposites exhibited an open three-dimensional skeleton and two-dimensional porous lamellar substructure,endowing them with a high specific surface area(228.27 m2/g).The introduction of boron changed the ratios of different aluminum species(AlⅣ,AlⅤ,and AlⅥ)and borate species(BO3 and BO4),thus further affecting the acidity and the types of acid sites of the *** prepared B_(2)O_(3)-Al_(2)O_(3)bifunctional acid catalysts possessing abundant Lewis acid sites and adjustable Brønsted acid sites showed complete glucose conversion and 55.38%of HMF yield under the optimum *** study proposed a concise method to synthesize alumina-boria solid acid catalysts assisted by glucose-urea *** hope to extend the application and prospect of this efficient and simple synthesis strategy.

关键词： 5-hydroxymethylfurfural(HMF) deep eutectic solvent glucose alumina-boria acid catalyst

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng Lin Tianyuan fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

Receding Horizon Estimation for Linear Discrete-time Systems with Multi-channel Observation Delays

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IEEE/CAA Journal of Automatica Sinica 2019年第2期6卷 478-484页

作者： chunyan Han Chaochao Li fang He Yue Liu the School of Electrical Engineering University of Jinan

This paper investigates the receding horizon state estimation for the linear discrete-time system with multi-channel observation delays. The receding horizon estimation is designed by the reorganized observation technique and the linear unbiased estimation method. The estimation gains are developed by solving a set of Riccati equations, and a stability result about the state estimation is shown. Finally, an example is given to illustrate the efficiency of the receding horizon state estimation.

关键词： Multi-channel observation delays receding horizon estimation reorganized observation stability analysis