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Metal nanoparticles for cancer therapy:Precision targeting of DNA damage

Acta Pharmaceutica Sinica B 2024年第3期14卷 1132-1149页

作者： Qian Chen chunyan fang Fan Xia Qiyue Wang fangyuan Li Daishun Ling Institute of Pharmaceutics Hangzhou Institute of Innovative MedicineCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringNational Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China World Laureates Association(WLA)Laboratories Shanghai 201203China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Hangzhou 310009China

Cancer,a complex and heterogeneous disease,arises from genomic ***,DNA damage-based cancer treatments,including radiotherapy and chemotherapy,are employed in clinical ***,the efficacy and safety of these therapies are constrained by various factors,limiting their ability to meet current clinical *** nanoparticles present promising avenues for enhancing each critical aspect of DNA damage-based cancer *** customizable physicochemical properties enable the development of targeted and personalized treatment *** this review,we delve into the design principles and optimization strategies of metal *** shed light on the limitations of DNA damage-based therapy while highlighting the diverse strategies made possible by metal *** encompass targeted drug delivery,inhibition of DNA repair mechanisms,induction of cell death,and the cascading immune ***,we explore the pivotal role of physicochemical factors such as nanoparticle size,stimuli-responsiveness,and surface modification in shaping metal nanoparticle ***,we present insights into the challenges and future directions of metal nanoparticles in advancing DNA damage-based cancer therapy,paving the way for novel treatment paradigms.

关键词： DNA damage Metal nanoparticles Nucleus-targeting DNA repair inhibition Immune response Size optimization Stimuli-responsiveness Surface modification

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Effects of coronavirus disease 2019 vaccination on seizures in patients with epilepsy

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Chinese Medical Journal 2023年第5期136卷 571-577页

作者： Xiqin fang Shan Qiao Ranran Zhang Tingting Yang Zhihao Wang Qingxia Kong Meihua Sun Jianhong Geng chunyan fang Yanxiu Chen Yanping Sun Dongmei Zhang Lixing Qu Wei Shang Jianguo Wang Xuewu Liu Department of Neurology Qilu Hospital of Shandong UniversityJinanShandong 250000China Department of Neurology Institute of EpilepsyShandong UniversityJinanShandong 250000China Department of Neurology The First Affiliated Hospital of Shandong First Medical UniversityJinanShandong 250000China Department of Neurology Affiliated Hospital of Jining Medical CollegeJiningShandong 272000China Department of Neurology Tengzhou Central People’s HospitalJiningShandong 277599China Department of Neurology Affiliated Hospital of Weifang Medical CollegeWeifangShandong 261000China Department of Neurology Zhucheng People’s HospitalWeifangShandong 262200China Department of Neurology Liaocheng People’s HospitalLiaochengShandong 252000China Department of Neurology Affiliated Hospital of Qingdao UniversityQingdaoShandong 266000China Department of Neurology Linyi People’s HospitalLinyiShandong 276000China Department of Neurology Dezhou People’s HospitalDezhouShandong 253000China Department of Neurology Second Hospital of Shandong UniversityJinanShandong 250000China Department of Neurology Jinan Central HospitalJinanShandong 250000China.

Background:Given that seizures may be triggered by vaccination,this study aimed to evaluate the risk and correlative factors of seizures in patients with epilepsy(PWE)after being vaccinated against coronavirus disease 2019(COVID-19).Methods:This study retrospectively enrolled PWE who were vaccinated against COVID-19 in the epilepsy centers of 11 hospitals in *** divided the PWE into two groups as follows:(1)patients who developed seizures within 14 days of vaccination were assigned to the SAV(with seizures after vaccination)group;(2)patients who were seizure-free within 14 days of vaccination were assigned to the SFAV(seizure-free after vaccination)*** identify potential risk factors for seizure reccurence,the binary logistic regression analysis was ***,67 PWE who had not been vaccinated were also included for elucidating the effects of vaccination on seizures recurrence,and binary logistic regression analysis was performed to determine whether vaccination would affect the recurrence rate of PWE who had drug reduction or ***:The study included a total of 407 patients;of which,48(11.8%)developed seizures within 14 days after vaccination(SAV group),whereas 359(88.2%)remained seizure-free(SFAV group).The binary logistic regression analysis revealed that duration of seizure freedom(P<0.001)and withdrawal from anti-seizure medications(ASMs)or reduction in their dosage during the peri-vaccination period were significantly associated with the recurrence of seizures(odds ratio=7.384,95%confidence interval=1.732–31.488,P=0.007).In addition,32 of 33 patients(97.0%)who were seizure-free for more than three months before vaccination and had a normal electroencephalogram before vaccination did not have any seizures within 14 days of vaccination.A total of 92(22.6%)patients experienced non-epileptic adverse reactions after *** logistic regression analysis results showed that vaccine did not significantly affect the recurrence

关键词： Coronavirus disease 2019 Electroencephalogram Seizure Vaccine

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滩地植被化复式河槽的水流阻力特性试验

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重庆交通大学学报（自然科学版） 2013年第4期32卷 668-672页

作者：房春艳罗宪中山大学水资源与环境研究中心广州510275 重庆交通大学信息科学与工程学院重庆400074

利用室内变坡水槽试验研究了复式河槽中滩地植被对水流阻力的影响,采用声学多普勒测速仪(ADV)观测了不同垂线、不同测点的垂线流速分布,分别讨论了水深、植被密度、淹没与非淹没植被对滩地阻力系数的影响。分析发现:滩地种有植被后,复... 详细信息

利用室内变坡水槽试验研究了复式河槽中滩地植被对水流阻力的影响,采用声学多普勒测速仪(ADV)观测了不同垂线、不同测点的垂线流速分布,分别讨论了水深、植被密度、淹没与非淹没植被对滩地阻力系数的影响。分析发现:滩地种有植被后,复式河槽的水流流速不再满足对数分布,在垂向可以认为是一个常数,且其值随植被密度的增加而减小;阻力系数在滩地无植被时受水深的影响很小,在有植被的工况中,阻力系数会随水深的增加而显著增大,其值与植被密度满足线性关系;滩地植被淹没后,虽然滩地阻力系数也随水深的增加而增大,但其增幅较非淹没植被工况中要小。

关键词：复式河道植物流速分布阻力系数

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