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Functional diversifications of Gh ERF1 duplicate genes after the formation of allotetraploid cotton

Journal of Integrative Plant Biology 2019年第1期61卷 60-74页

作者： chunxiao Liu tian Zhen Zhang National Key Laboratory of Crop Genetics & Germplasm Enhancement Cotton Research InstituteNanjing Agricultural University Crop Science Institute Agronomy DepartmentCollege of Agriculture and BiotechnologyZhejiang University

Whole genome duplication, a prevalent force of evolution in plants, results in massive genome restructuring in different organisms. Roles of the resultant duplicated genes are poorly understood both functionally and evolutionarily. In the present study, differentially expressed ethylene responsive factors(GhERF1 s), anchored on Chr-A07 and Chr-D07 were isolated from a high-yielding cotton hybrid(XZM2)and its parents. The GhERF1 was located in the B3 subgroup of the ethylene responsive factors subfamily involved in conferring tolerance to abiotic stress Nucleotide sequence analysis of 524 diverse accessions together with quantitative real-time polymerase chain reaction analysis, elucidated that de-functionalization of GhERF1-7 A occurred due to one base insertion following formation of the allotetraploid cotton. Our quantitative trait loci and association mapping analyses highlighted a role for GhERF1-7 A in conferring high boll number per plant in modern cotton cultivars. Overexpression of GhERF1-7 A in transgenic Arabidopsis resulted in a substantial increase in the number of siliques and total seed yield. Neo-functionalization of GhERF1-7 A was also observed in modern cultivars rather than in races and/or landraces, further supporting its role in the development of high-yielding cotton cultivars. Both de-and neofunctionalization occurred in one of the duplicate genes,thus providing new genomic insight into the evolution of allotetraploid cotton species.

关键词： Functional diversifications of Gh ERF1 duplicate genes after the formation of allotetraploid cotton

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Engineered macrophage-biomimetic versatile nanoantidotes for inflammation-targeted therapy against Alzheimer’s disease by neurotoxin neutralization and immune recognition suppression

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Bioactive Materials 2023年第8期26卷 337-352页

作者： Meng Cheng Caihua Ye Chunxiao Tian Dongju Zhao Haonan Li Zuhao Sun Yuyang Miao Qiang Zhang Junping Wang Yan Dou Department of Radiology and tianjin Key Laboratory of Functional Imaging Tianjin Medical University General HospitalTianjin300052PR China School of Biomedical Engineering and Technology Tianjin Medical UniversityTianjin300070PR China School of Life Sciences Tianjin UniversityTianjin300072PR China Department of Geriatrics Tianjin Medical University General HospitalTianjin Geriatrics InstituteTianjin300052PR China

Immune recognition of excessive neurotoxins by microglia is a trigger for the onset of neuroinflammation in the brain,leading to neurodegeneration in Alzheimer’s disease(AD).Blocking active recognition of microglia while removing neurotoxins holds promise for fundamentally alleviating neurotoxin-induced immune responses,but is very challenging.Herein,an engineered macrophage-biomimetic versatile nanoantidote(OT-Lipo@M)is developed for inflammation-targeted therapy against AD by neurotoxin neutralization and immune recognition suppression.Coating macrophage membranes can not only endow OT-Lipo@M with anti-phagocytic and inflammation-tropism capabilities to target inflammatory lesions in AD brain,but also efficiently reduce neurotoxin levels to prevent them from activating microglia.The loaded oxytocin(OT)can be slowly released to downregulate the expression of immune recognition site Toll-like receptor 4(TLR4)on microglia,inhibiting TLR4-mediated pro-inflammatory signalling cascade.Benefiting from this two-pronged immunosuppressive strategy,OT-Lipo@M exhibits outstanding therapeutic effects on ameliorating cognitive deficits,inhibiting neuronal apoptosis,and enhancing synaptic plasticity in AD mice,accompanied by the delayed hippocampal atrophy and brain microstructural disruption by in vivo 9.4T MR imaging.This work provides new insights into potential AD therapeutics targeting microglia-mediated neuroinflammation at the source.

关键词： Alzheimer’s disease Biomimetic nanomedicine Biological neutralization Immune recognition and response Neuroinflammation-targeted therapy 9.4T MR imaging

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Integrating reduced graphene oxides and PPy nanoparticles for enhanced electricity from water evaporation

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International Journal of Smart and Nano Materials 2023年第2期14卷 230-242页

作者： Bingkun tian Xiaofeng Jiang Weicun Chu chunxiao Zheng Wanlin Guo Zhuhua Zhang State Key Laboratory of Mechanics and Control for Aerospace Structures Key Laboratory for Intelligent Nano Materials and Devices of Ministry of Educationand Institute for Frontier ScienceNanjing University of Aeronautics and AstronauticsNanjingChina

Developing high-performance nanostructured materials is key to deliver the potential of hydrovoltaic technology into practical applications.As single-component materials have approached its limit in generating hydrovoltaic electricity,the development of multi-component hydrovoltaic materials has been necessary in continuously boosting the electricity output.Here,we report a hydrovoltaic material by integrating reduced graphene oxides and polypyrrole nanoparticles(rGO/PPy),where the rGO contributes improved conductivity and large specific surface area while PPy nanoparticles enable enhanced interaction with water.The device fabricated with this material generates a short-circuit current of 6μA as well as a maximum power density of over 1μW/cm3 from natural evaporation of water.And the substantial ion-PPy interaction enables robust voltage generation from evaporation of various salt solutions.Moreover,an outstanding scaling ability is demonstrated by connecting 10 devices in series that generate a sustainable voltage of up to~2.5 V,sufficing to power many commercial devices,e.g.LED bulb and LCD screen.

关键词： Hydrovoltaic generator water evaporation reduced graphene oxide Ppy nanoparticles

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Role of electrodes in study of hydrovoltaic effects

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Nano Research 2023年第8期16卷 11320-11325页

作者： chunxiao Zheng Sunmiao Fang Weicun Chu Jin Tan Bingkun tian Xiaofeng Jiang Wanlin Guo Key Laboratory for Intelligent Nano Materials and Devices of Ministry of Education State Key Laboratory of Mechanics and Control of Mechanical StructuresNanjing University of Aeronautics and AstronauticsNanjing 210016China Institute for Frontier Science of Nanjing University of Aeronautics and Astronautics Nanjing 210016China

The last decade has witnessed the emergence of hydrovoltaic technology,which can harvest electricity from different forms of water movement,such as raindrops,waves,flows,moisture,and natural evaporation.In particular,the evaporation-induced hydrovoltaic effect received great attention since its discovery in 2017 due to its negative heat emission property.Nevertheless,the influence of electrode reactions in evaporation-induced power generation is not negligible due to the chemical reaction between active metal electrodes and water,which leads to“exceptional”power generation.Herein,we designed a series of experiments based on air-laid paper devices with electrodes of different activities as the top and bottom electrodes.To verify the contribution of electrodes,we compared the output performance of different electrode combinations when the device was partially-wetted and fully-wetted.The device hydrophilicity,salt concentration,and acidity or basicity of solutions were also comprehensively investigated.It is demonstrated that the chemical reaction of active metals(Zn,Cu,Ag,etc.)with different aqueous solutions can generate considerable electrical energy and significantly distort the device performance,especially for Zn electrodes with an output voltage from~1.26 to~1.52 V and current from~1.24 to~75.69μA.To promote the long-term development of hydrovoltaic technology,we recommend use of inert electrodes in hydrovoltaic studies,such as Au and Pt,especially in water and moisture environment.

关键词： hydrovoltaic effects electrodes water electrochemical reaction

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Role of lncRNA MALAT1 in UVA-induced corneal endothelial senescence

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Genes & Diseases 2023年第5期10卷 1795-1798页

作者： Yujie Qiao Bin Zhang Yani Wang tian Sang Shengqian Dou chunxiao Dong Qun Wang Qingjun Zhou State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyShandong Eye InstituteShandong First Medical University&Shandong Academy of Medical SciencesQingdaoShandong 266071China Qingdao Eye Hospital of Shandong First Medical University QingdaoShandong 266071China Qingdao University QingdaoShandong 266071China Eye Hospital of Shandong First Medical University(Shandong Eye Hospital) JinanShandong 250021China

The corneal endothelial monolayer is responsible for maintaining corneal transparency through its barrier and pump functions.Endothelial cells do not proliferate in vivo,and aging-related reductions in cell density make the endothelium fragile.1 However,the molecular mechanism associated with the aging corneal endothelium remains elusive.In this study,we used ultraviolet A(UVA)-light-induced senescence to mimic the degenerative endothelial changes during aging.MALAT1,the most abundant long non-coding RNA(lncRNA)gene in the cornea,was markedly down-regulated after UVA irradiation.The inhibition or activation of Malat1 expression genetically led to the aggravation or remission of the cellular aging phenotype after UVA irradiation.Furthermore,an in vitro model established by the human corneal endothelial cell line(HCEC)recapitulated the morphological and molecular changes during aging,encouraging the investigation of the underlying mechanisms.We observed changes in the mitochondrial bioenergetic profiles of HCECs accompanied by extensive cell aging and reduced reproductive capacity after MALAT1 was silenced by gene-targeting ASOs.Finally,Malat1 knockout(KO)aggravated mouse corneal endothelial senescence and dysfunction,which reinforced our conclusions.Our findings indicate that MALAT1 may contribute to the delay of aging processes involving endothelial cells and provide a new therapeutic target for treating aging-related corneal endothelium disorders.

关键词： MALAT1 corneal markedly

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组织变革视角下学校教育数字化转型的动力机制与构型——基于探索性双案例研究

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电化教育研究 2024年第5期45卷 27-34页

作者：侯春笑田爱丽华东师范大学教育学部上海200062

教育数字化转型是在学校及其次级组织中发生的系统性的进阶变革过程。为系统厘清学校教育数字化转型的驱动因素及实践形式,文章引入组织变革理论视角,扎根于典型案例探寻学校教育数字化转型的动因、构型,并挖掘学校教育数字化转型的机... 详细信息

教育数字化转型是在学校及其次级组织中发生的系统性的进阶变革过程。为系统厘清学校教育数字化转型的驱动因素及实践形式,文章引入组织变革理论视角,扎根于典型案例探寻学校教育数字化转型的动因、构型,并挖掘学校教育数字化转型的机理模型。结果表明:由内外部环境因素和利益相关者因素构成的情境动力,价值承诺因素和利益不满因素构成的触发动力,领导者能动因素和组织能动因素构成的使能动力,是三大驱动因素,不同因素交互协同,形成学校教育数字化转型的动力机制。依据技术指向和教育指向两个维度,学校教育数字化转型实践呈现出随动转向型、技术指向型、教育指向型、整体转向型四种构型。此外,教育数字化转型实践与学校组织变革有着共同的关键共演路径,呈现出双重优化的显著特征。

关键词：学校教育数字化转型动力机制构型双案例研究组织变革

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线上线下融合教育(OMO)发展的突破路径研究--基于路径依赖和路径创造的视角

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中国电化教育 2022年第1期 73-78,85页

作者：田爱丽侯春笑华东师范大学教育学部上海200062

线上线下融合教育(OMO)是人工智能时代教育改革发展的必然趋势,然而实践中主体的行为和路径依赖却是制约新实践持续推进的一大困境。该研究运用制度变迁中路径依赖与路径创造的理论,系统分析融合教育变革中路径依赖的原因,并提出推进融... 详细信息

线上线下融合教育(OMO)是人工智能时代教育改革发展的必然趋势,然而实践中主体的行为和路径依赖却是制约新实践持续推进的一大困境。该研究运用制度变迁中路径依赖与路径创造的理论,系统分析融合教育变革中路径依赖的原因,并提出推进融合教育发展路径创造的四大举措:发挥决策主体的主导作用,形成具有育人共识的决策共同体,完善融合教育发展的制度保障,强化评价深入落实融合教育等,进而助推线上线下融合教育的顺利实施。

关键词：融合教育路径依赖路径创造

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“互联网+”背景下智慧居家养老模式的发展现状——以河南省信阳市为例

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漯河职业技术学院学报 2023年第3期22卷 9-14页

作者：田平翟春晓信阳职业技术学院护理学院河南信阳464000

我国目前已经处于国家人口层次变化的关键时节,老龄人口比例的不断上涨,带动社会整体养老压力的进一步加剧,也引发了社会关于养老模式的大讨论。随着“互联网+”理念的进一步深入,智慧居家养老开始成为现阶段养老问题解决的可行办法。... 详细信息

我国目前已经处于国家人口层次变化的关键时节,老龄人口比例的不断上涨,带动社会整体养老压力的进一步加剧,也引发了社会关于养老模式的大讨论。随着“互联网+”理念的进一步深入,智慧居家养老开始成为现阶段养老问题解决的可行办法。通过对智慧社区居家养老背景的简要概述,针对当前信阳市智慧社区居家养老服务面临的供给需求不平衡、人力资源不足、科技支撑不足、覆盖率低等问题,提出推进智慧社区建设、夯实技术支撑、鼓励多元主体共同参与、贯彻以人为本的服务理念等对策建议,以期促进信阳市乃至河南省养老产业的健康发展。

关键词：互联网+ 智慧养老居家养老模式

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基于老年人需求的智慧养老服务平台的优化研究——以河南省信阳市为例

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商丘职业技术学院学报 2023年第3期22卷 45-51页

作者：田平翟春晓信阳职业技术学院河南信阳464000

目前,我国人口老龄化规模大、程度高,在此背景之下,以智能信息化技术为基础,大力发展智慧养老,使分散的养老资源能够进行集中化、准确化和高效化的供给,是有效应对我国人口老龄化的举措。对信阳市智慧养老服务平台认知水平和使用情况进... 详细信息

目前,我国人口老龄化规模大、程度高,在此背景之下,以智能信息化技术为基础,大力发展智慧养老,使分散的养老资源能够进行集中化、准确化和高效化的供给,是有效应对我国人口老龄化的举措。对信阳市智慧养老服务平台认知水平和使用情况进行梳理,并从产品性能优化、政府政策完善等角度展开研究,进一步明确现阶段老年人群体的实际需求,有效解决现阶段国内智慧养老服务设施、服务体系、服务产品层面存在的不足,同时为后续研究的开展提供一定基础和思路。

关键词：智慧养老平台建设研究现状

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具非局部源的非线性高阶抛物型方程解的全局存在性与非全局存在性

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数学进展 2022年第5期51卷 907-916页

作者：杨春晓李亚红田清西安建筑科技大学理学院西安陕西710055 保定理工学院艺术与外语学院保定河北071000

本文考虑一类具非局部源的高阶抛物型方程u_(t)=-(-Δ)^(m)u+(∫_(R^(n))|u|^(1+σ)dy)^((p-1)/(1+σ))|u|^(r)的Cauchy问题.近年来,我们已给出这一方程的Fujita临界指标p_(c)=1+((2m-n(r-1))(1+σ))/(nσ),即当1 p_(c)时,存在非全局解也存在全局解,这取决于初值的大小.本文进一步确定了这一方程的第二临界指标a^(*)=(2m+(n(p-1))/(1+σ))/(p+r-2),用于在p>p_(c)这一全局解与非全局解的共存区域内鉴别初值的大小.我们发现:(1)与具局部源|u|^(p)的高阶抛物型方程的第二临界指标a^(*)=2/(p-m)不同的是,这里与空间维数n有关;(2)非局部源中参数σ的增大有利于扩大解的全局存在区域.

关键词：临界指标高阶抛物型方程的初值问题非局部源全局解爆破

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