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Epidemiology and control measures of an outbreak of neonatal echovirus 11 infections in Guangdong, China: A retrospective analysis

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生物安全与健康(英文) 2023年第4期5卷 227-232页

作者： chunxiao fang Xiaoming Zhang Xuemin Huang Fengqin Xu Danyang Zhao Department of Nosocomial Infection Control Guangzhou Women and Children’s Medical CenterGuangzhou 510623China Department of Nosocomial Infection Control Heyuan Women and Children’s Hospital and Health InstituteHeyuan 517000China Department of Nosocomial Infection Control Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

The objective of this study was to investigate the outbreak of echovirus 11 (ECHO 11) infection in newborns at a hospital in Guangdong Province, China, and to study the effectiveness of prevention and control measures to infer the epidemiological characteristics of ECHO 11 and explore the effective measures for its prevention and control. We performed retrospective analyses of hospital records and laboratory test data. In this outbreak, ten cases of ECHO 11 infection were identified, of which nine cases were nosocomial infections. Most of the cases (90%) were severe, and three died. The onset time interval of 10 patients was 1-4 days, most of which occur in 1-2 days. There were eight (80%) males and two females (20%). The gestational age of the patients was 31 to 40 weeks (mean, 35+4 weeks;median, 35+4 weeks). The onset time was 3-26 days (average 9 days;median 8 days). The birth weights of the patients ranged from 1,650 g to 3,450 g (mean 2,385 g;median 2,250 g). We concluded that neonatal infection with ECHO 11 will lead to serious symptoms and high mortality, and is prone to outbreaks of nosocomial infection. We speculate that ECHO 11 is most likely to spread via contact transmission;however, we do not rule out the possibility of droplet transmission. Prevention and control measures can effectively prevent and control hospital enteroviral infections.

关键词： Echovirus 11 Nosocomial infection Outbreak Epidemiology Control measures

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Dynamics of severe acute respiratory syndrome coronavirus 2 genome variants in the feces during convalescence

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Journal of Genetics and Genomics 2020年第10期47卷 610-617页

作者： Yi Xu Lu Kang Zijie Shen Xufang Li Weili Wu Wentai Ma chunxiao fang Fengxia Yang Xuan Jiang Sitang Gong Li Zhang Mingkun Li Department of Pediatrics Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou510623China Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesChina National Center for BioinformationBeijing101300China University of Chinese Academy of Sciences Beijing100049China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming650223China

In response to the current coronavirus disease 2019(COVID-19)pandemic,it is crucial to understand the origin,transmission,and evolution of severe acute respiratory syndrome coronavirus 2(SARS-Co V-2),which relies on close surveillance of genomic diversity in clinical samples.Although the mutation at the population level had been extensively investigated,how the mutations evolve at the individual level is largely unknown.Eighteen time-series fecal samples were collected from nine patients with COVID-19 during the convalescent phase.The nucleic acids of SARS-CoV-2 were enriched by the hybrid capture method.First,we demonstrated the outstanding performance of the hybrid capture method in detecting intra-host variants.We identified 229 intra-host variants at 182 sites in 18 fecal samples.Among them,nineteen variants presented frequency changes>0.3 within 1-5 days,reflecting highly dynamic intrahost viral populations.Moreover,the evolution of the viral genome demonstrated that the virus was probably viable in the gastrointestinal tract during the convalescent period.Meanwhile,we also found that the same mutation showed a distinct pattern of frequency changes in different individuals,indicating a strong random drift.In summary,dramatic changes of the SARS-CoV-2 genome were detected in fecal samples during the convalescent period;whether the viral load in feces is sufficient to establish an infection warranted further investigation.

关键词： SARS-CoV-2 Intra-host variant Dynamics Mutation Hybrid capture

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Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China:A multicenter retrospective study

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Pediatric Investigation 2021年第3期5卷 188-194页

作者： Huili Hu Huiling Deng Jing Bi Yi Xu Shuangjie Li Yue Xie Xinrong Sun Dongmeng Wang Xufang Li Wenxian Ouyang Bing Hu Yufeng Zhang He Tang chunxiao fang Hui Zhang Lingyun Guo Chen Wang Tianyi Wang Fengxia Yang Tao Jiang Zhengde Xie Gang Liu Key Laboratory of Major Diseases in Children Ministry of EducationResearch Unit of Critical Infection in ChildrenChinese Academy of Medical ScienceDepartment of Infectious DiseasesBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Department of Infectious Diseases Xi’an Children’s HospitalXi’anShaanxiChina Department of Infectious Diseases Baoding Children’s HospitalBaodingHebeiChina Guangzhou Women and Children’s Medical Center GuangzhouGuangdongChina Hepatology Center Hunan Children’s HospitalChangshaHunanChina Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Importance:The clinical characteristics of infectious mononucleosis(IM)in Chinese children have not been evaluated in multicenter studies,and the effectiveness of antiviral treatment are controversial.Objective:To investigate the clinical characteristics of Chinese children with IM and current status of antiviral therapy for affected patients.Methods:Hospitalized patients with IM were enrolled between 2018 and 2020 in five children’s hospitals in China.The clinical characteristics were compared among four age groups:<3 years,3-<6 years,6-<10 years,and≥10 years.The clinical characteristics of IM and effectiveness of antiviral therapy were compared among patients receiving acyclovir(ACV),ganciclovir(GCV),and no antiviral therapy(i.e.,non-antiviral group).Results:In total,499 patients were analyzed;most patients were 3-<6 years of age.The most common symptoms and signs included fever(100%),lymphadenopathy(98.6%),pharyngitis(86.4%),eyelid edema(76.8%),and snoring(72.9%).There were significant differences in rash,hepatomegaly,and liver dysfunction among the four age groups.Patients aged<3 years had a lower incidence of liver dysfunction and a higher incidence of rash.Among the 499 patients,50.1%were treated with GCV,26.3%were treated with ACV,and 23.6%received no antiviral therapy.Compared with the non-antiviral group,patients in the ACV and GCV groups had longer durations of fever(P<0.001).There were no significant differences in the incidences of complications among the three treatment groups.Interpretation:The incidence of IM in Chinese children peaked at 3-<6 years of age.Clinical features of IM varied according to age.Patients receiving antiviral therapy exhibited more serious clinical manifestations than did patients without antiviral therapy.The effectiveness of antiviral therapy for IM requires further analysis.

关键词： Infectious mononucleosis Antiviral Ganciclovir Acyclovir

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老年重症肺炎病原学特点以及预后相关因素分析

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中国微生态学杂志 2019年第9期31卷 1043-1046,1051页

作者：张娜方春晓大连医科大学附属第一医院金普院区呼吸科辽宁大连116600

目的探讨老年重症肺炎病原学特点以及分析预后相关因素。方法选取我科住院的老年重症肺炎(SP)患者140例,分析患者病原菌感染的病原学特点,包括对患者痰液菌株的分离鉴定及药敏试验检测,并使用多因素logistic回归进行预后相关因素分析。... 详细信息

目的探讨老年重症肺炎病原学特点以及分析预后相关因素。方法选取我科住院的老年重症肺炎(SP)患者140例,分析患者病原菌感染的病原学特点,包括对患者痰液菌株的分离鉴定及药敏试验检测,并使用多因素logistic回归进行预后相关因素分析。结果共121株病原菌被分离,其中革兰阴性菌91株(75.20%),革兰阳性菌27株(22.31%),真菌3株(2.48%)。主要革兰阴性菌均对氨苄西林具有较高的耐药性(≥80%),对阿米卡星、环丙沙星耐药性稍低;主要革兰阳性菌对氨苄西林、头孢曲松耐药性较高(>70%),对头孢哌酮/舒巴坦耐药性稍低。住院时间(P=0.025)、机械通气(P=0.021)、MODS评分(P=0.019)与血浆白蛋白含量(P=0.013)是老年重症肺炎影响预后的独立危险因素。结论革兰阴性菌为老年重症肺炎主要致病菌,以鲍曼不动杆菌、铜绿假单胞菌为主,对氨苄西林耐药性较高。患者的预后与住院时间、机械通气、MODS评分和血浆白蛋白含量具有显著相关性。

关键词：重症肺炎老年病原学预后相关因素

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水下天空偏振图像天顶区域光矢量叠加航向解算

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Journal of Measurement Science and Instrumentation 2024年第2期15卷 157-165页

作者：房政郭银景孔芳吕雪杜春晓阮耀煌山东科技大学电子信息工程学院山东青岛266590 青岛智海牧洋科技有限公司山东青岛266590 山东科技大学电气与自动化工程学院山东青岛266590

水下天空光偏振图像可以用于航向测量,具有抗干扰、无累积误差等优点。本文提出了一种基于天顶区域光矢量叠加的水下偏振图像航向解算方法,以获取水下环境中的航向角。该方法首先分析水下天空光偏振图像,并结合姿态信息提取出天顶区域... 详细信息

水下天空光偏振图像可以用于航向测量,具有抗干扰、无累积误差等优点。本文提出了一种基于天顶区域光矢量叠加的水下偏振图像航向解算方法,以获取水下环境中的航向角。该方法首先分析水下天空光偏振图像,并结合姿态信息提取出天顶区域的偏振信息。然后,利用叠加运算将天顶区域内的水下折射光偏振矢量与大气偏振光偏振矢量进行合成。通过对偏振矢量的最优解算,可以精确地获取水下目标的航向角。实验结果显示,该方法在水箱实验中航向角的均方根误差(RMSE)为0.30°,海洋实验航向角的RMSE为0.41°;并分别在0.98米,4.89米和5.94米深的海洋中解算出太阳方位角的RMSE分别为1.10°, 2.03°和3.04°。

关键词：偏振图像航向测量天顶区域矢量叠加

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Exothermic Performance of the Calcined Limestone Determined by Exothermic Temperature under Fluidization during CaCO_(3)/CaO Energy Storage Cycles

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Journal of Thermal Science 2023年第5期32卷 1784-1796页

作者： fang Yi ZHAO Jianli ZHANG chunxiao LI Yingjie Shandong Engineering Laboratory for High-Efficiency Energy Conservation and Energy Storage Technology&Equipment School of Energy and Power EngineeringShandong UniversityJi'nan 250061China

Thermochemical energy storage based on CaO/CaCO_(3)cycles has obtained significant attention as an alternative energy storage solution for concentrated solar power plants.In view of the applicability of fluidized bed reactors for CaO/CaCO_(3)heat storage,it is imperative to study the factors related to the heat release performance of CaO.This work presents an exothermic experiment on calcined limestone under fluidization,exploring the impact of initial temperature,CO_(2)concentration,particle size,superficial gas velocity,and number of cycles on the exothermic performance of CaO.The result indicates that CaO with high initial temperature leads to higher exothermic temperature,with better exothermic stability under cycles.An optimal initial temperature range of 600℃-650℃exists with an actual CaO conversion rate deviating merely 2%from theoretical conversion.Higher CO_(2)concentration augments the exothermic temperature and rate of CaO,while also improves the effective conversion of CaO.Nevertheless,high CO_(2)concentrations exacerbate the sintering and deactivation of CaO.High superficial gas velocity and small particle size shorten the exothermic time by increasing heat dissipation,but has minimal effect on the exothermic properties.Finally,the exothermic properties of CaO under fluidized and static conditions are studied.The result shows that exothermic temperature and exothermic rate of CaO under fluidization are enhanced,displaying higher heat storage performance than that under static state.This study provides valuable insights for optimizing the exothermic performance of CaO in fluidized bed reactors,contributing to advanced thermochemical energy storage for concentrated solar power plants.

关键词： CaO/CaCO_(3)heat storage cycles exothermic temperature fluidization exothermic performance

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基于有机酸和多酚组成的贵州5种特色水果酿酒特性评价

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食品科学 2024年第10期45卷 158-166页

作者：陈秋竹谢菡怡何娇娇吴芳王春晓贵州大学酿酒与食品工程学院贵州省发酵工程与生物制药重点实验室贵州贵阳550025 华南理工大学生物科学与工程学院广东广州510006

为评价贵州特色水果的发酵潜力,本研究以水晶葡萄、刺葡萄、猕猴桃、金刺梨和蓝莓为原料开展实验室发酵实验,分析果汁与果酒中有机酸与多酚含量变化,并与商业果酒中相应物质含量进行对比分析。结果表明,5种水果之间有机酸和多酚含量差... 详细信息

为评价贵州特色水果的发酵潜力,本研究以水晶葡萄、刺葡萄、猕猴桃、金刺梨和蓝莓为原料开展实验室发酵实验,分析果汁与果酒中有机酸与多酚含量变化,并与商业果酒中相应物质含量进行对比分析。结果表明,5种水果之间有机酸和多酚含量差异显著,其中金刺梨汁有机酸(72.30g/L)、总酚(2457.16mg/L)和单宁(1112.84mg/L)质量浓度最高,而水晶葡萄汁质量浓度最低(有机酸7.63g/L、总酚8.52mg/L、单宁7.45mg/L)。发酵过程改变了有机酸和多酚含量,所有果酒总有机酸含量明显降低,蓝莓酒和刺葡萄酒总酚和花色苷含量增加,猕猴桃酒和金刺梨酒总酚和单宁含量都有不同程度下降,水晶葡萄酒变化不明显。只有商业红葡萄酒和商业蓝莓酒中检测出了少量白藜芦醇,质量浓度在0.29~5.98mg/L之间。对比商业果酒,实验室酿造金刺梨酒和猕猴桃酒有机酸含量偏高,金刺梨酒总酚和单宁偏高,实验室酿造刺葡萄酒花色苷含量最高,是所有商业果酒的2~3倍。贵州特色水果具有各自有机酸和多酚组成特征,呈现不同的发酵变化,本研究为贵州特色果酒加工过程中工艺方法的选择如浸渍、复合果酒酒体设计等提供理论研究基础。

关键词：果酒有机酸白藜芦醇花色苷单宁

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水下天空偏振光视频采集实验装置设计与应用

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实验室研究与探索 2024年第1期43卷 67-72页

作者：郭银景杜春晓孔芳阮耀煌石浩辰山东科技大学电子信息工程学院山东青岛266590 山东科技大学电气与自动化工程学院山东青岛266590

水下天空偏振信息的获取是水下潜航器实现偏振光导航的重要基础,为此搭建一种水下偏振相机采集天空偏振分布的实验装置,用于采集天空光经过水面折射后的水下偏振分布。实验装置分为防水外壳和偏振光传感器两部分。防水外壳的设计主要从... 详细信息

水下天空偏振信息的获取是水下潜航器实现偏振光导航的重要基础,为此搭建一种水下偏振相机采集天空偏振分布的实验装置,用于采集天空光经过水面折射后的水下偏振分布。实验装置分为防水外壳和偏振光传感器两部分。防水外壳的设计主要从材质、质量和密闭性考虑,偏振光传感器的核心是通过程序实现工控机控制偏振相机拍摄0°、45°、90°、135°的偏振图像和斯托克斯的4个矢量图像。结合计算机技术,利用相关算法计算偏振角、偏振度和偏振方位角。结果表明,偏振度和偏振角在太阳子午线上呈对称分布,太阳附近的偏振度最小,并以环状向外增大。该装置采集的数据能够有效提取太阳的方位信息。

关键词：水下天空偏振信息偏振相机偏振角偏振度

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先天性胆汁酸合成障碍2型血浆氨基酸谱分析

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临床儿科杂志 2023年第6期41卷 470-474页

作者：佘兰辉李旭芳叶家卫谭丽梅杨花梅房春晓廖凯丽徐翼广州市妇女儿童医疗中心广东广州510120

目的探讨先天性胆汁酸合成障碍2型(CBAS2)患儿血浆氨基酸谱改变及临床意义。方法回顾性分析2016年1月至2021年6月就诊的婴儿胆汁淤积症患儿的临床资料。患儿根据病因分为CBAS2组、citrin缺陷导致的婴儿肝内胆汁淤积症(NICCD)组以及不明... 详细信息

目的探讨先天性胆汁酸合成障碍2型(CBAS2)患儿血浆氨基酸谱改变及临床意义。方法回顾性分析2016年1月至2021年6月就诊的婴儿胆汁淤积症患儿的临床资料。患儿根据病因分为CBAS2组、citrin缺陷导致的婴儿肝内胆汁淤积症(NICCD)组以及不明原因婴儿肝内胆汁淤积症(INH)组,比较三组22种血浆氨基酸的差异。结果纳入婴儿胆汁淤积症患儿85例,男58例、女27例,中位年龄2.3(2.0~4.0)月。中位总胆红素为134.9(103.1~181.7)μmol/L,中位直接胆红素79.0(62.2~110.6)μmol/L。CBAS2组12例患儿中11例(91.7%)有≥3种氨基酸改变,11例(91.7%)支链氨基酸(BCAA,包括亮氨酸、异亮氨酸、缬氨酸)在正常范围;INH组23例患儿中17例(73.9%)有≥3种氨基酸改变;NICCD组50例患儿均有≥3种氨基酸改变。与INH组相比,CBAS2和NICCD组的天冬酰胺、丝氨酸、苏氨酸、酪氨酸水平较高;与NICCD组相比,CBAS2组谷氨酰胺、丙氨酸、色氨酸、亮氨酸、丙氨酸/瓜氨酸水平较高,瓜氨酸、精氨酸、蛋氨酸、碱性氨基酸、苏氨酸/丝氨酸水平较低,差异均有统计学意义(P<0.05)。结论CBAS2患儿血浆氨基酸谱变化广泛。CBAS2患儿血浆氨基酸谱变化与NICCD、INH患儿不同,这对CBAS2的诊断及鉴别诊断有重要意义。

关键词：先天性胆汁酸合成障碍2型胆汁淤积氨基酸

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多因素logistic回归模型分析产程时限对新生儿结局的影响因素研究

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重庆医学 2020年第S2期49卷 62-65页

作者：方春晓浙江省金华市人民医院 321000

目的借助多因素logistic回归模型对产程时限与新生儿结局的关系及影响因素进行分析。方法选取2018年1-12月该院收治的头胎、单胎、足月住院分娩孕妇3279例,根据新生儿结局分为不良组(165例),正常组(3114例),对两组孕妇新旧活跃期时间、... 详细信息

目的借助多因素logistic回归模型对产程时限与新生儿结局的关系及影响因素进行分析。方法选取2018年1-12月该院收治的头胎、单胎、足月住院分娩孕妇3279例,根据新生儿结局分为不良组(165例),正常组(3114例),对两组孕妇新旧活跃期时间、第二产程时间、胎头拨露至胎儿娩出时间、新生儿Apgar评分进行统计,并采用logistic回归模型行多因素分析。结果正常组新产程活跃期、第二产程时间、胎头拨露至胎儿娩出时间均明显低于不良组,差异均有统计学意义(P<0.05);新生儿Apgar评分与第二产程时间、胎头拨露至胎儿娩出时间呈负相关;新生儿Apgar评分、新产程活跃期、第二产程时间、胎头拨露至胎儿娩出时间均为新生儿结局的主要危险因素。结论新生儿Apgar评分、新产程活跃期、第二产程时间、胎头拨露至胎儿娩出时间均可对新生儿结局造成不良影响,为此必须密切观察产程变化。

关键词：产程时限新生儿结局 logistic回归模型分析

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