检索结果-南通市图书馆

China CDC weekly 2024年第33期6卷 834-840页

作者： Minrui Ren Keli Li Yan Li chunxiang fan Yuyang Xu Lina Zhang Yuan Li Lei Cao Wenzhou Yu Zundong Yin National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) National Immunization ProgrammeChinese Center for Disease Control and PreventionBeijingChina Department of Expanded Programme on Immunization Hangzhou Center for Disease Control and PreventionHangzhou CityZhejiang ProvinceChina

Introduction The Haemophilus influenzae type b(Hib)conjugate vaccine is widely administered in *** We extracted data on Hib vaccine doses administered and adverse events following immunization(AEFI)reported between 2010 and 2021 from the Chinese National Immunization Information System(CNIIS).A descriptive analysis was conducted to examine the characteristics and incidence rates of AEFI with the Hib *** In China,between 2010 and 2021,a total of 52,910 AEFIs with the Hib vaccine were reported,resulting in an overall AEFI reporting rate of 38.10 per 100,000 ***(typically minor)and rare(potentially serious)vaccine reactions occurred at rates of 34.71 and 2.78 per 100,000 doses,*** the common vaccine reactions,the incidences of fever(axillary temperature≥38.6℃),injection site redness and swelling(>2.5 cm in diameter),and injection site induration(>2.5 cm in diameter)were 11.93,9.69,and 3.38 per 100,000 doses,*** vaccine reactions included anaphylactic rash,angioedema,and febrile convulsion with reported incidences of 2.42,0.10,and 0.05 per 100,000 doses,*** incidence of serious rare vaccine reactions was 0.16 per 100,000 *** The reported incidence of AEFI with the Hib vaccine was low,with the occurrence of serious rare adverse reactions also being markedly low throughout the period 2010–2021 in China.

关键词： doses markedly injection

Thirty Years of Experience of Acute Flaccid Paralysis Surveillance for Polio — China, 1993–2022

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China CDC weekly 2024年第16期6卷 344-349页

作者： Hong Yang Ning Wen chunxiang fan Fuzhen Wang Yong Zhang Lei Cao Shuangli Zhu Lixin Hao Dongmei Yan Lei Wang Quanwei Song Miao Wang Yifan Song Chao Ma Zhijie An Lance ERodewald Huaqing Wang Zundong Yin National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) BeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Introduction:Detecting poliovirus infections proves to be highly challenging due to their asymptomatic nature and infectious potential,highlighting the crucial importance of effective detection methods in the context of polio eradication *** many countries,including China,the primary approach for identifying polio outbreaks has been through acute flaccid paralysis(AFP)*** this study,we conducted an evaluation spanning three decades(1993–2022)to assess the effectiveness of AFP surveillance in ***:Data on all AFP cases identified since 1993 and national-level AFP surveillance system quality indicators aligned with the World Health Organization(WHO)standards were collected for *** quality indicators assess surveillance sensitivity,completeness,timeliness of detection notification,case investigation,and laboratory *** sensitivity is determined by the non-polio AFP(NPAFP)detection rate among children under 15 years of ***:Between 1993 and 2022,a total of 150,779 AFP cases were identified and *** this pool,surveillance identified 95 cases of wild poliovirus(WPV)and 24 cases due to vaccinederived *** 1995 onwards,the detection rate of NPAFP cases consistently adhered to the WHO and national standards of≥1 case per 100,000,falling between 1.38 and *** in 1997,all timeliness indicators consistently achieved the criteria of 80%,apart from the consistency in meeting standards set for the rate of positive specimens sent to the national ***:AFP surveillance has been instrumental in China’s accomplishment of maintaining a polio-free *** ongoing adherence to key performance indicators,ensuring sensitivity and prompt specimen collection,demonstrates that AFP surveillance is proficient in detecting poliovirus in *** we move into the post-eradication phase,AFP surveillance remains crucial for the sustained absence of polioviruses in the long term.

关键词： sustained prompt surveillance

Risk Assessments for Type 1 Wild Poliovirus and Type 2 Vaccine-Derived Poliovirus Importation and Transmission—China,2023

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China CDC weekly 2024年第42期6卷 1098-1104,I0007,I0008页

作者： Wei Kang chunxiang fan Yifan Song Zhaonan Zhang Xiaoqi Wang Miao Wang Jing Ma Mulei Chen Yuzhen Yang Yi Wen Lei Cao Lance Rodewald Fuzhen Wang Zundong Yin Ning Wen Hong Yang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionBeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Education and Training of Chinese Center for Disease Control and Prevention BeijingChina

Introduction:All countries face the potential threat of imported polioviruses,including both wild type and circulating vaccine-derived *** response,we conducted a province-level assessment in China to evaluate the risk of importation and transmission of type 1 wild poliovirus(WPV1)and type 2 vaccine-derived poliovirus(VDPV2).Methods:Distinct risk assessment tools for WPV1 and VDPV2 were employed,incorporating three primary indicators—population immunity,poliovirus surveillance,and importation ***1 was assessed using 13 secondary indicators,whereas VDPV2 utilized 21 secondary *** used comprehensive provincial data from the preceding five ***(S-values)were derived from the secondary indicators’criteria and ratings,and used to classify the provincial-level administrative divisions(PLADs)into three risk categories:high,medium,and *** top 10%of PLADs were designated as highrisk,with the remaining provinces equally distributed into medium-and low-risk ***:In 2023,Xizang,Qinghai,and Xinjiang PLADs faced the highest risk of WPV1 importation and transmission;Xizang,Shaanxi,and Hainan PLADs were at the greatest risk for VDPV2 importation and ***:Risk assessment for VDPV2 importation and transmission has identified a distinct set of high-risk provinces compared to those identified by WPV1 risk *** and proactive response measures tailored to the specific risks should be implemented to maintain China’s polio-free status.

关键词： immunity maintain utilized

2017-2022年中国急性弛缓性麻痹病例监测质量评价

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国疫苗和免疫 2024年第4期30卷 403-408页

作者：周洁樊春祥宋祎凡王淼温宁杨宏中国疾病预防控制中心中国现场流行病学培训项目北京100050 传染病溯源预警与智能决策全国重点实验室中国疾病预防控制中心北京102206 中国疾病预防控制中心免疫规划中心北京100050 新疆维吾尔自治区疾病预防控制中心新疆乌鲁木齐830002

目的评价中国急性弛缓性麻痹(Acute flaccid paralysis,AFP)病例监测质量和维持无脊髓灰质炎(脊灰)状态。方法通过中国AFP病例报告管理系统收集2017-2022年<15岁儿童非脊灰AFP个案信息,分析AFP监测敏感性和及时性指标。结果2017-2022年... 详细信息

目的评价中国急性弛缓性麻痹(Acute flaccid paralysis,AFP)病例监测质量和维持无脊髓灰质炎(脊灰)状态。方法通过中国AFP病例报告管理系统收集2017-2022年<15岁儿童非脊灰AFP个案信息,分析AFP监测敏感性和及时性指标。结果2017-2022年中国<15岁儿童非脊灰AFP病例年均报告发病率为2.08/10万(29116例),各年报告发病率在1.79/10万-2.33/10万之间;总调查及时率、合格粪便标本采集率分别为99.34%、92.12%,各年分别在98.79%-99.74%、91.48%-92.74%之间。在完成粪便标本检测的28765例AFP病例中,脊灰病毒和非脊灰肠道病毒分离率分别为0.55%(157例)、5.19%(1492例)。在检出脊灰病毒病例中,Ⅰ型、Ⅲ型、Ⅰ+Ⅲ型疫苗相似株分别为39例、70例、36例,Ⅲ型疫苗高变异脊灰病毒3例;Ⅰ型、Ⅱ型、Ⅲ型疫苗衍生脊灰病毒分别为2例、1例、6例,未发现脊灰野病毒。结论2017-2022年中国AFP病例监测质量总体良好,继续维持无脊灰状态。

关键词：脊髓灰质炎急性弛缓性麻痹脊髓灰质炎病毒监测质量

益肠抗癌方对结肠癌术后化疗患者疗效、免疫功能及肠黏膜屏障的影响

在线全文

学校读者我要写书评

暂无评论

中医药临床杂志 2024年第3期36卷 528-532页

作者：尚东方杨秋敏范春香河南省商丘市第一人民医院河南商丘476100

目的:探究结肠癌术后化疗患者应用益肠抗癌方对肠黏膜屏障及免疫功能的影响。方法:选取商丘市第一人民医院2020年12月—2022年12月82例结肠癌术后患者作为研究对象,采用随机数字表法进行分组,对照组给予化疗方案,观察组加用益肠抗癌方,... 详细信息

目的:探究结肠癌术后化疗患者应用益肠抗癌方对肠黏膜屏障及免疫功能的影响。方法:选取商丘市第一人民医院2020年12月—2022年12月82例结肠癌术后患者作为研究对象,采用随机数字表法进行分组,对照组给予化疗方案,观察组加用益肠抗癌方,比较2组患者疗效、免疫功能免疫球蛋白M、免疫球蛋白G免疫球蛋白A及肠黏膜屏障血管内皮生长因子、转化生长因子-β1、血浆内毒素含量、尿乳果糖/甘露醇比值及不良反应。结果:治疗8周后,观察组患者免疫球蛋白G、A、M水平高于对照组(P<0.05);观察组内毒素水平及尿乳果糖/甘露醇比值低于对照组(P<0.05),血管内皮生长因子、转化生长因子-β1水平低于对照组(P<0.05);观察组总有效率63.41%高于对照组41.46%(P<0.05);观察组发生胃肠道反应、周围神经病变及肝功能异常例数均低于对照组(P<0.05)。结论:应用益肠抗癌方治疗结肠癌术后化疗患者效果明显,可改善患者肠黏膜屏障功能及免疫功能,并减少化疗引起的不良反应,值得临床参考应用。

关键词：结肠癌化疗免疫功能肠黏膜屏障

2021-2022年中国疑似预防接种异常反应监测

在线全文

学校读者我要写书评

暂无评论

中国疫苗和免疫 2024年第4期30卷 470-484页

作者：张丽娜李媛李克莉李燕樊春祥任敏睿余文周曹雷尹遵栋传染病溯源预警与智能决策全国重点实验室中国疾病预防控制中心北京102206 中国疾病预防控制中心免疫规划中心北京100050

目的分析中国2021-2022年疑似预防接种异常反应(Adverse event following immunization,AEFI)监测数据。方法通过中国疾病预防控制信息系统收集2021-2022年上市疫苗(不含紧急使用和附条件上市疫苗)接种后报告的AEFI个案信息和接种剂次数... 详细信息

目的分析中国2021-2022年疑似预防接种异常反应(Adverse event following immunization,AEFI)监测数据。方法通过中国疾病预防控制信息系统收集2021-2022年上市疫苗(不含紧急使用和附条件上市疫苗)接种后报告的AEFI个案信息和接种剂次数,描述性分析AEFI发生特征和报告发生率。结果2021-2022年中国41种疫苗AEFI总报告发生率为32.52/10万剂(323627例),其中严重AEFI报告发生率为0.15/10万剂(1468例,0.45%);一般反应、异常反应报告发生率分别为31.07/10万剂(309163例,95.53%)、1.14/10万剂(11381例,3.52%);严重异常反应报告发生率为0.08/10万剂次(759例,0.23%)。在异常反应中,过敏性皮疹、血管性水肿、血小板减少性紫癜/血小板减少症报告发生率分别为0.96/10万剂(9528例)、0.02/10万剂(232例)、0.02/10万剂(230例)。结论2021-2022年中国AEFI报告发生率略有下降,以一般反应为主,严重异常反应极其罕见。

关键词：疫苗疑似预防接种异常反应监测

中医综合疗法结合康复运动训练治疗脑卒中后肩痛的临床观察

在线全文

学校读者我要写书评

暂无评论

基层中医药 2024年第6期3卷 46-53页

作者：王琦王宇卉鲁婵婵李鹏帆范春香上海交通大学医学院附属仁济医院浦南分院中医科上海200125 复旦大学附属浦东医院中医科上海201399

目的观察一种操作简单、易于推广的中医综合治疗方法结合康复运动训练对治疗脑卒中后肩痛的临床疗效。方法收集2021年7月—2022年12月间上海交通大学医学院附属仁济医院浦南分院中医科收治的脑卒中肩痛患者共80例,随机分配入组,最终脱... 详细信息

目的观察一种操作简单、易于推广的中医综合治疗方法结合康复运动训练对治疗脑卒中后肩痛的临床疗效。方法收集2021年7月—2022年12月间上海交通大学医学院附属仁济医院浦南分院中医科收治的脑卒中肩痛患者共80例,随机分配入组,最终脱落剔除6例,观察组36例,对照组38例。观察组予针刺、中药熏蒸、拔罐的中医综合疗法结合常规康复运动训练治疗,对照组予常规康复运动训练治疗,疗程为4周。主要观察两组病例的肩关节被动关节活动度(PROM)、视觉模拟评分法(VAS)评分;次要观察两组病例的上肢Fugl-Meyer运动及日常生活活动能力(Barthel指数)。结果治疗后,两组的肩关节PROM、VAS评分、BI评分均较治疗前改善(P0.05)。治疗后,观察组在后伸、外旋2个方向疗效均优于对照组(P0.05)。结论中医综合疗法结合康复运动训练对治疗脑卒中后肩痛确有疗效,且在止痛及后伸、外旋方向的肩关节活动方面疗效优于单用基础治疗方案治疗,因其操作简单,可应用于临床推广。

关键词：脑卒中肩痛中风针刺中药熏蒸拔罐康复运动训练

Cases of Residual Paralysis in an Acute Flaccid Paralysis Surveillance System--China,2001−2010

在线全文

学校读者我要写书评

暂无评论

China CDC weekly 2020年第50期2卷 962-967页

作者： Ning Wen Qiru Su chunxiang fan Haibo Wang Yong Zhang Lei Cao Wei Xia Zhijie An Huiming Luo Chinese Center for Disease Control and Prevention BeijingChina Shenzhen Children’s hospital ShenzhenGuangdongChina Clinical Research Institute Peking UniversityBeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Background:China has been polio-free since 2000 and maintains an acute flaccid paralysis(AFP)surveillance *** paralysis(RP)in children with acute flaccid paralysis can be caused by Sabinstrain poliovirus(PV)and non-polio enteroviruses(NPEV).Methods:The national AFP surveillance data was analyzed to describe AFP cases with RP in the mainland of China during 2001 to *** patterns and virus detection of AFP cases with RP were ***:Annual incidence of AFP with RP among children aged<15 years old ranged between 0.22-0.35 cases per 100,*** peak age for AFP with RP and PV was 2 to 4 *** cases with viral Sabinstrain viral isolates,types Ⅱ and Ⅲ were the most common.A summer season peak in RP cases was similar to cases with NPEV *** and Implications for Public Health Practice:The first ten years after polio eradication of AFP surveillance data for the occurrence of RP can serve as a baseline rate for poliovirus vaccine changes in the routine immunization system to help detect vaccine safety signals in a timely manner and to support the routine polio immunization program switch in China.

关键词： routine vaccine acute

上海浦东某地脑卒中患者的中医分型特点及治疗情况分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

临床医学研究与实践 2024年第5期9卷 105-109页

作者：王琦舒适鲁婵婵李鹏帆赵江范春香上海交通大学医学院附属仁济医院浦南分院上海200125

目的分析上海浦东某地脑卒中患者的中医分型特点及治疗情况,为该地区中医药防治脑卒中提供参考依据。方法收集2020年10月至2021年9月我院中医科的284例脑卒中患者为研究对象。对研究对象脑卒中进行中医辨证诊断,并依据证型给予辨证论治... 详细信息

目的分析上海浦东某地脑卒中患者的中医分型特点及治疗情况,为该地区中医药防治脑卒中提供参考依据。方法收集2020年10月至2021年9月我院中医科的284例脑卒中患者为研究对象。对研究对象脑卒中进行中医辨证诊断,并依据证型给予辨证论治。分析脑卒中患者的中医证型及治疗效果。结果浦东某地男性脑卒中患者多于女性(P0.05)。284例患者的中医证型由多到少依次为风痰阻络证、阴虚风动证、气虚血瘀证、痰湿蒙窍证、痰火闭窍证、肝阳暴亢证及痰热腑实证。治疗后,风痰阻络证、阴虚风动证的美国国立卫生院卒中量表(NIHSS)评分低于治疗前(P<0.05);治疗后,风痰阻络证的Barthel指数(BI)评分高于治疗前(P<0.05)。脑卒中患者的治疗总有效率为91.55%。结论浦东某地脑卒中男性患者多于女性,患病年龄小于女性,偏瘫部位与性别无关,中医证型诊断风痰阻络证型最多。现代医学规范化治疗方案结合中医药辨证论治对卒中预后有明显干预作用,中医治疗使用祛风化痰通络之法最多。

关键词：脑卒中中医分型风痰阻络证

TGF-βsignaling in health,disease,and therapeutics

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第4期9卷 1466-1505页

作者： Ziqin Deng Tao fan Chu Xiao He Tian Yujia Zheng chunxiang Li Jie He Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

ransforming growth factor(TGF)-βis a multifunctional cytokine expressed by almost every tissue and cell *** signal transduction of TGF-βcan stimulate diverse cellular responses and is particularly critical to embryonic development,wound healing,tissue homeostasis,and immune homeostasis in *** dysfunction of TGF-βcan play key roles in many diseases,and numerous targeted therapies have been developed to rectify its pathogenic *** the past decades,a large number of studies on TGF-βsignaling have been carried out,covering a broad spectrum of topics in health,disease,and ***,a comprehensive overview of TGF-βsignaling is required for a general picture of the studies in this *** this review,we retrace the research history of TGF-βand introduce the molecular mechanisms regarding its biosynthesis,activation,and signal *** also provide deep insights into the functions of TGF-βsignaling in physiological conditions as well as in pathological ***-β-targeting therapies which have brought fresh hope to the treatment of relevant diseases are *** the summary of previous knowledge and recent updates,this review aims to provide a systematic understanding of TGF-βsignaling and to attract more attention and interest to this research area.

关键词： homeostasis healing wound