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剑桥大学生物医药方向创业教育探究

生物学杂志 2024年第5期41卷 126-130页

作者：卫春祥洪磊鲁红典胡坤宏合肥大学能源材料与化工学院合肥230601 合肥大学生物食品与环境学院合肥230601

深入探讨剑桥大学依托“课程体系优化-创业机构支持-产业集群共建”三位一体的体系建设,成功推动生物医药领域成果的高效转化及人才培养。通过跨学科课程体系的优化和创业思维的培养,强化学生的创新实践能力;依托Cambridge Enterprise平... 详细信息

深入探讨剑桥大学依托“课程体系优化-创业机构支持-产业集群共建”三位一体的体系建设,成功推动生物医药领域成果的高效转化及人才培养。通过跨学科课程体系的优化和创业思维的培养,强化学生的创新实践能力;依托Cambridge Enterprise平台,剑桥大学有效管理和商业化科研成果;同时,剑桥生物医药产业集群(CBC)的建设,促进产学研深度融合,为创业人才提供独特的生态环境。这些成功经验为中国高校在生物医药领域的创业教育提供宝贵借鉴,旨在提升科研成果转化率,培养适应市场需求的高素质人才,推动生物医药产业的创新发展。

关键词：剑桥大学生物医药创业教育成果转化产业集群

Synthesis of Bio-based Epoxy Containing Phosphine Oxide as a Reactive Additive Toward Highly Toughened and Fire-retarded Epoxy Resins

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Chinese Journal of Polymer Science 2023年第11期41卷 1733-1746,I0007页

作者： chunxiang wei Tianyu Gao Yu Xu Wenjie Yang Guangjian Dai Ruiting Li SanE Zhu Richard K.K.Yuen wei Yang Hongdian Lu School of Energy Materials and Chemical EngineeringHefei UniversityHefei 230601China Yusuf Hamied Department of Chemistry University of CambridgeCambridge CB21EWU.K. Department of Architecture and Civil Engineering City University of Hong KongHong Kong 999077China

The integration of high mechanical toughness,impact strength as well as excellent flame-retardant properties toward epoxy resins(EPs)have always been a *** inadequate overall performance of EPs severely restricts their sustainable utilization in engineering aspects over ***,a new bio-based agent(diglycidyl ether of magnolol phosphine oxide,referred as DGEMP)derived from magnolol(classified as lignan),extracted from natural plants Magnolia officinalis,was successfully synthesized and further employed as a flameretardant reactive additive to diglycidyl ether of bisphenol A(DGEBA).As demonstration,the composite resin,DGEBA/15DGEMP(15 wt%DGEMP),achieved an Underwriters Laboratories-94 V-0 rating with a high limiting oxygen index(LOI)value(41.5%).In cone calorimeter tests,it showed that heat release and smoke production were effectively inhibited during combustion,wherein the peak heat release rate(PHRR)value of DGEBA/15DGEMP was reduced by 50%compared to neat ***,it exhibited a superior tensile strength(82.8 MPa),toughness(5.11MJ/m^(3))and impact strength(36.5 k J/m^(2)),much higher than that of neat DGEBA(49.7 MPa,2.05 MJ/m^(3)and 20.9 k J/m^(2)).Thus,it is highly anticipated that DGEMP imparts significantly improved mechanical and fire-retarded properties to conventional EPs,which holds a great potential to address the pressing challenges in EP thermosets industry.

关键词： Epoxy resin Magnolol Phosphine oxide Toughness Flame retardant

Influence of surface acidity and chemical valence on low temperature activity over Pt-HSiW/CeO_(2) for catalytic combustion of chlorobenzene

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Journal of Rare Earths 2024年第9期42卷 1693-1703,I0002页

作者： Zhongxian Song Zepeng Liu Xuejun Zhang Yanli Mao wei Liu chunxiang Gao Haiyang Li Xia Zhang Changrui Han Zhenzhen Huang Key Laboratory of Carbon Emission Reduction and Combined Air Pollution Control Technology Faculty of Environmental and Municipal EngineeringHenan University of Urban ConstructionPingdingshan467036China College of Environmental and Safety Engineering Shenyang University of Chemical TechnologyShenyang110142China

Pt-HSiW/CeO_(2) catalysts were prepared for chlorobenzene(CB) catalytic combustion by hydrothermal method at different calcination temperatures,and the effects of the surface acidity and chemical valence on the catalytic activity were *** results show that the catalyst calcined at 450℃(Cat-B)exhibits the outstanding catalytic performance,and the Cat-B catalyst possesses 90% conversion of CB at148℃.The excellent catalytic activity of Cat-B is attributed to more Ce^(3+)/(Ce^(3+)+Ce^(4+)),Pt~0/(Pt^(0)+Pt^(2+)),O_(ads)/(O_(latt)+O_(ads)) and Lewis acid *** degradation mechanism is proposed based on the analysis of the intermediates with the following reaction pathway:chlorobenzene→phenates/benzoquinone→acetate→maleate→CO_(2)+H_(2)O.

关键词： Pt-HSiW/CeO_(2) Catalytic combustion Chlorobenzene Acid sites Rare earths

利用几何画板实现高中物理力学和运动学的深度教学

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科教导刊 2019年第34期 139-140页

作者：魏春翔自贡成都外国语学校四川自贡643000

"几何画板"是一款常用的物理、数学多媒体教学软件,其带有丰富的创造功能,可方便教师按照自己的设计思想编写出所需的教学课件.它既能创设静态的几何图形,又能动态的保持几何关系,很容易开发出配合数学、物理等课程的课件,已成为制作中... 详细信息

"几何画板"是一款常用的物理、数学多媒体教学软件,其带有丰富的创造功能,可方便教师按照自己的设计思想编写出所需的教学课件.它既能创设静态的几何图形,又能动态的保持几何关系,很容易开发出配合数学、物理等课程的课件,已成为制作中学物理教学课件的主要创作平台之—.在高中物理的力学与运动学部分经常会遇到动态问题,而传统教学中教师凭借粉笔和黑板仅能绘制出静态图像,学生很难想像变化的物理过程.文章介绍了利用几何画板开发力学与运动学课件的过程,这些课件能较好的展示动态的物理过程,从而提高教学效率.论文的结尾部分讨论了几何画板教学的有效性及作者对软件教学应用的体会.

关键词：几何画板高中物理力的合成运动学

Leukocyte-Specific Morrbid Promotes Leukocyte Differentiation and Atherogenesis

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Research 2024年第2期2023卷 123-137页

作者： Di Xiang Lei Jiang Qiong Yuan Yang Yu Ruiming Liu Meiting Chen Zheng Kuai Wendy Zhang Fan Yang Tingting Wu Zhiyu He Zuhui Ke Wanzi Hong Pengcheng He Ning Tan Yeying Sun Zhen Shi Xuebiao wei Jianfang Luo Xiaoqiu Tan Yuqing Huo Gangjian Qin chunxiang Zhang Department of Cardiology Key Laboratory of Medical ElectrophysiologyMinistry of EducationInstitute of Cardiovascular ResearchThe Affiliated Hospital of Southwest Medical UniversitySouthwest Medical UniversityLuzhouSichuan 646000China Department of Biomedical Engineering School of Medicine The University of Alabama at BirminghamBirminghamAL 35233USA Department of Cardiology.Guangdong Cardiovascular Institute Guangdong Provincial Key Laboratory of Coronary Heart Disease PreventionGuangdong Provincial Institute of Geriatric MedicineGuangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510100China Vascular Biology Center Medical College of GeorgiaAugusta UniversityAugustaGA 30912USA

Monocyte-to-M0/M1 macrophage differentiation with unclear molecular mechanisms is a pivotal cellular event in many cardiovascular diseases including *** non-coding RNAs(lncRNAs)are a group of protein expression regulators;however,the roles of monocyte-lncRNAs in macrophage differentiation and its related vascular diseases are still *** study aims to investigate whether the novel leukocyte-specific lncRNA Morrbid could regulate macrophage differentiation and *** identified that Morrbid was increased in monocytes and arterial walls from atherosclerotic mouse and from patients with *** cultured monocytes,Morrbid expression was markedly increased during monocyte to M0 macrophage differentiation with an additional increase during M0 macrophage-to-M1 macrophage *** differentiation stimuli-induced monocyte-macrophage differentiation and the macrophage activity were inhibited by Morrbid ***,overexpression of Morrbid alone was sufficient to elicit the monocyte-macrophage *** role of Morrbid in monocyte-macrophage differentiation was also identified in vivo in atherosclerotic mice and was verified in Morrbid knockout *** identified that PI3-kinase/Akt was involved in the up-regulation of Morrbid expression,whereas s100a10 was involved in Morrbid-mediated effect on macrophage *** provide a proof of concept of Morrbid in pathogenesis of monocyte/macrophage-related vascular disease,we applied an acute atherosclerosis model in *** results revealed that overexpression of Morrbid enhanced but monocyte/macrophage-specific Morrbid knockout inhibited the monocytes/macrophages recruitment and atherosclerotic lesion formation in *** results suggest that Morrbid is a novel biomarker and a modulator of monocyte-macrophage phenotypes,which is involved in atherogenesis.

关键词： inhibited Mor markedly

阿立哌唑与氯氮平对精神分裂症患者生活质量影响的对照研究

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四川精神卫生 2007年第2期20卷 80-82页

作者：魏月玲韩鹏魏春香山东省济宁精神病防治院精神科一病房272151

目的探讨阿立哌唑对精神分裂症患者生活质量的影响。方法对90例精神分裂症患者随机分为两组,分别给予阿立哌唑、氯氮平治疗6个月。用阳性症状与阴性症状量表(PANSS)评定精神症状,用世界卫生组织编制的生活质量量表(WHOQOL-100)评定生活... 详细信息

目的探讨阿立哌唑对精神分裂症患者生活质量的影响。方法对90例精神分裂症患者随机分为两组,分别给予阿立哌唑、氯氮平治疗6个月。用阳性症状与阴性症状量表(PANSS)评定精神症状,用世界卫生组织编制的生活质量量表(WHOQOL-100)评定生活质量,用TESS评定药物不良反应。结果治疗6个月后,两组对患者的生活质量均有改善。阿立哌唑组对WHOQOL-100各领域中,除精神支柱领域外,在生理、心理、独立性、社会关系和环境等领域的改善均明显优于氯氮平组;而氯氮平组仅明显改善心理领域。两组PANSS总分较疗前均有极显著性差异(P<0.01),两组间比较无显著性差异,但阿立哌唑对阴性症状的改善优于氯氮平。阿立哌唑比氯氮平的不良反应少且轻。结论阿立哌唑对精神分裂症患者生活质量的改善优于氯氮平,有利于患者重返社会。

关键词：阿立哌唑氯氮平精神分裂症生活质量

钯催化烯烃杂环化反应制备[60]富勒烯二氢呋喃化合物

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有机化学 2021年第5期41卷 2082-2090页

作者：朱三娥豆礼锋张建辉吴缨杨伟鲁红典卫春祥邓崇海董强合肥学院能源材料与化工学院合肥230601

富勒烯二氢呋喃衍生物在光电、医药等领域具有较好的应用前景,近年来已成为研究热点.以氯化钯为催化剂,三氟甲烷磺酸铜为氧化剂,烯烃衍生物和[60]富勒烯为原料,通过C—H键活化和杂环化反应,合成了一系列单取代和双取代的富勒烯二氢呋喃... 详细信息

富勒烯二氢呋喃衍生物在光电、医药等领域具有较好的应用前景,近年来已成为研究热点.以氯化钯为催化剂,三氟甲烷磺酸铜为氧化剂,烯烃衍生物和[60]富勒烯为原料,通过C—H键活化和杂环化反应,合成了一系列单取代和双取代的富勒烯二氢呋喃化合物.利用1H NMR、13C NMR、IR和HRMS等对产物的结构进行了表征.通过设计对照实验,对反应机理进行了研究,提出了可能的反应机理.

关键词：烯烃 C60 富勒烯二氢呋喃氯化钯三氟甲烷磺酸铜

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利用ANSYS软件分析滚动轴承接触问题

制造技术与机床 2013年第10期 56-58页

作者：韦春翔李伟伟黄志平叶冬上海三一精机有限公司上海201200

轴承作为现代机械传动中重要的一环,其工况的好坏直接影响整机的运行。利用有限元分析软件ANSYS,建立滚动轴承接触分析的三维有限元模型,并进行工况加载,模拟得到承载过程中的应力和变形分布趋势。并利用Labview软件对轴承在载荷下的信... 详细信息

轴承作为现代机械传动中重要的一环,其工况的好坏直接影响整机的运行。利用有限元分析软件ANSYS,建立滚动轴承接触分析的三维有限元模型,并进行工况加载,模拟得到承载过程中的应力和变形分布趋势。并利用Labview软件对轴承在载荷下的信息进行了采集,验证ANSYS分析轴承接触问题的准确性。

关键词： ANSYS 滚动轴承有限元接触问题

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复合纤维的相关标准及鉴别技术进展

合成纤维工业 2021年第2期44卷 75-79页

作者：魏纯香倪冰选苏州中纺联检验技术服务有限公司江苏苏州215200 中纺协东莞检验技术服务有限公司广东东莞523900

简述了复合纤维的结构类型、性能特点及应用领域,概述了复合纤维的有关标准方法,综述了复合纤维的鉴别方法以及鉴别技术进展,复合纤维的鉴别方法中重点介绍了热分析方法和光谱法。指出复合纤维的鉴别方法除了常规的燃烧法、显微镜观察... 详细信息

简述了复合纤维的结构类型、性能特点及应用领域,概述了复合纤维的有关标准方法,综述了复合纤维的鉴别方法以及鉴别技术进展,复合纤维的鉴别方法中重点介绍了热分析方法和光谱法。指出复合纤维的鉴别方法除了常规的燃烧法、显微镜观察法、溶解法外,还需要同时利用热分析技术和光谱分析技术进行分析,才能准确鉴别复合纤维的结构和类型,为复合纤维的研究和生产应用提供技术支撑。

关键词：复合纤维皮芯结构鉴别光谱技术热分析技术燃烧法显微镜观察法溶解法