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基于干性指数模型对肉瘤预后、免疫浸润和铁死亡调控的分析

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中国组织工程研究 2025年第19期29卷 4151-4160页

作者：魏婧娴孟莲孙皓张田田刘春霞石河子大学医学院病理学系/石河子大学第一附属医院病理科新疆维吾尔自治区石河子市832000 广州医科大学附属第二医院病理科广东省广州市510260

背景:干性指数可能与肉瘤预后、免疫浸润有关,但具体调控机制与特征基因尚不清楚。目的:利用基因干性指数模型探究肉瘤干细胞与患者预后和免疫浸润的关系,并识别肉瘤干细胞铁死亡特征基因。方法:从癌症基因组图谱(TCGA)中获取肉瘤RNA测... 详细信息

背景:干性指数可能与肉瘤预后、免疫浸润有关,但具体调控机制与特征基因尚不清楚。目的:利用基因干性指数模型探究肉瘤干细胞与患者预后和免疫浸润的关系,并识别肉瘤干细胞铁死亡特征基因。方法:从癌症基因组图谱(TCGA)中获取肉瘤RNA测序数据及相关临床信息。利用肉瘤干性指数,对获取的肉瘤RNA测序数据进行分组。利用生存数据进行组间预后情况分析,获取组间差异表达基因后进行通路富集和免疫浸润分析。获得铁死亡相关差异基因,构建蛋白互作网络并进行预后相关性分析。培养横纹肌肉瘤细胞系,分为贴壁细胞组和干细胞组,贴壁细胞组不予任何干预,干细胞组通过无血清培养处理以诱导横纹肌肉瘤干细胞富集,qRT-PCR验证干细胞相关标志物、铁死亡相关差异基因以及铁死亡相关标志物的mRNA表达。结果与结论:①以干性指数中位数为界将患者分成高干性指数组和低干性指数组,通过患病风险预测显示高干性指数组患者的无进展生存期低于低干性指数组,提示预后不佳;②GO、KEGG分析显示肉瘤高、低干性指数组差异表达基因参与不同的细胞通路;高干性指数组和低干性指数组之间免疫浸润存在差异;差异基因中有23个铁死亡相关基因,其中9个可构成相关性较强的蛋白互作网络,其中IDO1、IFNG、AQP5高表达的肉瘤患者预后更好,CA9高表达的肉瘤患者预后不佳;③qRT-PCR结果显示,与贴壁细胞组相比,干细胞组干细胞相关标志物NANOG、SOX2和OCT4 mRNA表达显著升高(P<0.05);与贴壁细胞组相比,干细胞组铁死亡相关标志物SLC7A11的mRNA表达显著降低(P<0.05),ACSL4、GPX4、FTH1和COX2的mRNA表达显著升高(P<0.05);与贴壁细胞组相比,干细胞组差异基因CA9的mRNA表达显著降低,IDO1、IFNG、AQP5的mRNA表达显著升高(P<0.05)。经上述生物信息学分析与实验验证,干细胞与肉瘤生存、铁死亡过程密切相关,CA9、IDO1、IFNG、AQP5在肉瘤干细胞中异常表达,可能成为肉瘤诊断标志物和治疗新靶点。

关键词：肉瘤干细胞干性指数铁死亡生存预后免疫浸润

The characteristic differences of tropical cyclones forming over the western North Pacific and the South China Sea

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Acta Oceanologica Sinica 2007年第4期26卷 29-43页

作者： YUAN Jinnan WANG Dongxiao liu chunxia HUANG Jian HUANG Huijun Key Open Laboratory for Tropical Monsoon Guangzhou Institute of Tropical and Marine Meteorology China Meteorological Administration Guangzhou 510080 China Laboratory for Tropical Marine Environmental Dynamics South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China

The best track dataset of tropical cyclones in the western North Pacific （WNP） and the South China Sea （SCS） from 1977 to 2005 during the satellite era, the NCEP/NCAR reanalysis dataset and the extended reconstructed sea surface temperature dataset are employed in this study. The main climatological characteristics of tropical cyclone formation over the WNP and the SCS are compared. It is found that there is obviously different for the locations of tropical cyclone origins, achieving the lowest central pressure and termination points between over the WNP and over the SCS. The annual number of tropical cyclones forming over the SCS is obviously less than over the WNP, and there is a significant negative correlation with the correlation coefficient being - 0.36 at the 5% significance level between over the WNP and over the SCS. The mean speed of tropical cyclone moving is 6.5 m/s over the WNP and 4.6 m/s over the SCS. The mean lowest central pressure of tropical cyclones is obviously weaker over the SCS than over the WNP. The tropical cyclone days per year, mean total distance and total displacement of tropical cyclone traveled over the WNP are all obviously longer than those over the SCS. Tropical cyclone may intensify to Saffir - Simpson hurricane scale 5 over the WNP, but no tropical cyclone can intensify to Saffir - Simpson hurricane scale 3 over the SCS. The changing ranges of the radii （R15,R16） of the 15.4 m/s winds them and the 25.7 m/s winds over the WNP are obviously wider than those over the SCS, and the median values of the radii over the WNP are also larger than those over the SCS. For the same intensity of tropical cyclones, both radii have larger medians over the WNP than over the SCS. The correlations of annual mean tropical cyclone size parameters between over the WNP and over the SCS are not significant. At the same time, the asymmetric radii of tropical cyclones over the WNP are different from those over the SCS.

关键词： characteristic differences tropical cyclone western North Pacific and South China Sea

Evaluation of the Impact of Observations on Blended Sea Surface Winds in a Two-Dimensional Variational Scheme Using Degrees of Freedom

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Journal of Meteorological Research 2017年第6期31卷 1123-1132页

作者： Ting WANG Jie XIANG Jianfang FEI Yi WANG chunxia liu Yuanxiang LI Institute of Meteorology and Oceanography National University of Defense TechnologyNanjing 211101 Key Laboratory of Mesoscale Severe Weather of Ministry of Education Nanjing UniversityNanjing 210093 Guangdong Institute of Tropical and Marine Meteorology of China Meteorological Administration Guangzhou 510080 School of Aeronautics andAstronautics Shanghai Jiao Tong UniversityShanghai 200240

This paper presents an evaluation of the observational impacts on blended sea surface winds from a two- dimensional variational data assimilation （2D-Var） scheme. We begin by briefly introducing the analysis sensitivity with respect to observations in variational data assimilation systems and its relationship with the degrees of freedom for signal （DFS）, and then the DFS concept is applied to the 2D-Var sea surface wind blending scheme. Two meth- ods, a priori and a posteriori, are used to estimate the DFS of the zonal （u） and meridional （v） components of winds in the 2D-Var blending scheme. The a posteriori method can obtain almost the same results as the a priori method. Because only by-products of the blending scheme are used for the a posteriori method, the computation time is re- duced significantly. The magnitude of the DFS is critically related to the observational and background error statistics. Changing the observational and background error variances can affect the DFS value. Because the observation error variances are assumed to be uniform, the observational influence at each observational location is related to the background error variance, and the observations located at the place where there are larger background error variances have larger influences. The average observational influence of u and v with respect to the analysis is about 40%, implying that the background influence with respect to the analysis is about 60%.

关键词： sea surface wind blending sensitivity observational influence degrees of freedom for signal

Examining the evolution of tidal creeks in the Huanghe River delta using multi-temporal Landsat images

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Journal of Oceanology and Limnology 2024年第4期42卷 1061-1073页

作者： Zhen HAN Kai JIN Quanli ZONG Peng QIN chunxia liu Xiuzhi ZHU Xinyue LI College of Resources and Environment Qingdao Agricultural UniversityQingdao 266109China

Coastal tidal creeks are important channels for exchanges of material and energy between sea and land,and play an important role in the ecological protection of tidal *** tidal creeks have evolved differently in various regions,the evolutionary process of tidal creeks in the Huanghe(Yellow)River delta of China,one of the most active deltas worldwide,is not entirely ***,the evolution of tidal creeks in the delta from 1981 to 2021 was investigated by quantitatively analysing the tidal creeks and developing a standard for dividing their evolution *** interpretation and supervised classification methods were applied to the Landsat images to extract the tidal creek network,and 17 groups of tidal creek systems were *** indicate that Creek S 1 was the most developed creek for having 113 tidal creeks totaling 65.8 km in length,while Creek E 3 had the fastest growth rate for having average annual increase of 1.9 ***,the level of tidal creeks increased,the average and median lengths of tidal creeks increased,and the number of tidal creeks decreased since *** evolution of the tidal creek system could be divided into four stages,namely,rising,developing,stabilizing,and *** of a representative tidal creek show that there was no degenerated tidal creek during the rising period,with an increase in the number of 50 and a length increase of 57.9 km between 1981 and *** proportion of new tidal creeks in the developing period was more than 50%and the new tidal creeks in the stabilizing period were equal to the degraded tidal *** tidal creeks were greater than 50%during the degrading *** was no fixed order of tidal creek evolution in each period,and there may be a skip in *** findings provided a reference for studying the evolution of tidal creeks.

关键词： tidal creek evolution pattern remote sensing Huanghe(Yellow)River delta

Injectable decellularized extracellular matrix hydrogel loaded with exosomes encapsulating curcumin for prevention of cardiac fibrosis after myocardial infarction

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Journal of Materials Science & Technology 2023年第36期167卷 50-58页

作者： Yuanyuan Wang Jingjing Wang chunxia liu Jingjing Li Kunyan Lu Qian Yu Yanxia Zhang Zhenya Shen Department of Cardiovascular Surgery of the First Affiliated Hospital and Institute for Cardiovascular Science Suzhou Medical College of Soochow UniversitySoochow UniversitySuzhou 215007China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

Excessive cardiac fibrosis impairs cardiac repair after myocardial infarction(MI).In this work,an in-jectable composite hydrogel integrating natural biomaterials,exosomes,and bioactive molecules is de-veloped to prevent or alleviate cardiac ***,a natural molecule with antifibrotic activity,is encapsulated in the exosomes that are isolated from bone marrow-derived mesenchymal stem cells to enhance its water solubility and *** composite exosomes are efficiently internalised by fibroblasts and effectively inhibit their transition to myofibroblasts in *** porcine cardiac extracellular matrix(dECM)hydrogel is used as the carrier for delivering these composite exosomes to the infarcted myocardium,not only improving the retention of exosomes but also providing mechani-cal support and structural *** of this hydrogel into the infarcted heart of a mouse MI model leads to a decrease in collagen deposition,alleviation of fibrosis,a reduction in infarct size,and an improvement in cardiac *** reported composite hydrogel comprising natural materials and biomolecules exhibits good biocompatibility and ***,this study demonstrates that the dECM hydrogel is a suitable platform for the local delivery of antifibrotic biomolecule-encapsulating exo-somes to prevent myocardial fibrosis after MI and have great potential for the treatment of MI in clinical settings.

关键词： Myocardial fibrosis Myocardial infarction Decellularized extracellular matrix Exosomes Curcumin

Evaluation of the Global and Regional Assimilation and Prediction System for Predicting Sea Fog over the South China Sea

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Advances in Atmospheric Sciences 2019年第6期36卷 623-642页

作者： Huijun HUANG Bin HUANG Li YI chunxia liu Jing TU Guanhuan WEN Weikang MAO Institute of Tropical and Marine Meteorology China Meteorological Administration National Meteorological Centre Ocean University of China Guangdong Meteorological Observatory

In the South China Sea, sea fog brings severe disasters every year, but forecasters have yet to implement an effective seafog forecast. To address this issue, we test a liquid-water-content-only(LWC-only) operational sea-fog prediction method based on a regional mesoscale numerical model with a horizontal resolution of about 3 km, the Global and Regional Assimilation and Prediction System(GRAPES), hereafter GRAPES-3 km. GRAPES-3 km models the LWC over the sea, from which we infer the visibility that is then used to identify fog. We test the GRAPES-3 km here against measurements in 2016 and 2017 from coastal-station observations, as well as from buoy data, data from the Integrated Observation Platform for Marine Meteorology, and retrieved fog and cloud patterns from Himawari-8 satellite data. For two cases that we examine in detail, the forecast region of sea fog overlaps well with the multi-observational data within 72 h. Considering forecasting for0–24 h, GRAPES-3 km has a 2-year-average equitable threat score(ETS) of 0.20 and a Heidke skill score(HSS) of 0.335,which is about 5.6%(ETS) and 6.4%(HSS) better than our previous method(GRAPES-MOS). Moreover, the stations near the particularly foggy region around the Leizhou Peninsula have relatively high forecast scores compared to other sea ***, the results show that GRAPES-3 km can roughly predict the formation, evolution, and dissipation of sea fog on the southern China coast.

关键词： sea fog operational GRAPES model southern China coast forecast evaluation

Management and nursing strategies for different patterns of adverse events in patients with urological cancer treated with immune checkpoint inhibitors

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Current Urology 2024年第3期18卷 212-217页

作者： Xiaojuan Huang Xiaolei Li Lulin Ma chunxia liu Department of Urology Peking University Third HospitalBejingChina

Background This study aimed to explore the patterns of treatment-related adverse events(AEs)associated with immune checkpoint inhibitor(ICI)monotherapy and in combination with chemotherapy or tyrosine kinase inhibitor(TKI)therapy and to summarize the corresponding management and nursing *** and methods A total of 69 patients with malignant urological tumors who received ICI treatment between June 2019 and October 2022 were retrospectively analyzed,and AEs that occurred during treatment were observed and *** on the different types of treatment,the patients were divided into ICI monotherapy,ICI plus chemotherapy,and ICI plus TKI therapy *** analysis was *** incidence,distribution,and severity of AEs in the different subgroups were *** A total of 138 AEs occurred in 69 patients,among which grade 1 plus 2,and grade 3 plus 4 AEs accounted for 78.99%and 21.01%,*** incidence of AEs per patient in the ICI-TKI therapy group was the highest(3.75 times/person),followed by the ICI-chemotherapy(2.33 times/person)and ICI monotherapy(0.82 times/person)*** AEs,such as fatigue,nausea,and myelosuppression,were much more common in the ICI-gemcitabine and cisplatin group,whereas renal injury,skin lesions,and diarrhea were most common ones in the ICI-TKI *** Immune checkpoint inhibitors are new treatment options for advanced urological tumors and renal cell *** AE patterns were observed among the different treatment ***,strict and meticulous clinical management and nursing measures are required to ensure the safety of patients receiving ICI treatment.

关键词： Immune checkpoint inhibitor Immunotherapy Adverse events Nursing Urological tumor

Biomaterials based cardiac patches for the treatment of myocardial infarction

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Journal of Materials Science & Technology 2021年第35期94卷 77-89页

作者： Tianqi Chang chunxia liu Kunyan Lu Yong Wu Mingzhu Xu Qian Yu Zhenya Shen Tingbo Jiang Yanxia Zhang Department of Cardiovascular Surgery of the First Affiliated Hospital&Institute for Cardiovascular Science Soochow University.Suzhou 215006China Department of Cardiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

Myocardial infarction(MI)is one of the common cardiovascular diseases that occurs with a blockage in one or more of the coronary arteries to lead to the damage of the myocardium,resulting in a lifethreatening *** repair the damaged myocardium in MI,researchers are looking forwards to new ways to postpone the progression of myocardial *** patches,the scaffolds layered on the heart surface,can provide mechanical support for the infarction site and improve cardiac function by delivering various bioactive factors or cells,showing considerable curative effect in the treatment of *** with certain biocompatibility and mechanical properties have received widespread attention for the application in cardiac *** this review,we focus on the recent progress on these biomaterialsbased cardiac patches,which could be categorized into two types according to the sources of materials including(ⅰ)natural materials and(ⅱ)synthetic *** major advantages and current challenges of each type are discussed and a brief perspective on the future research directions is presented.

关键词： Biomaterials Cardiac patches Myocardial infarction

Spatial patterns and driving forces of urban vegetation greenness in China:A case study comprising 289 cities

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Geography and Sustainability 2024年第3期5卷 370-381页

作者： Yansong Jin Fei Wang Quanli Zong Kai Jin chunxia liu Peng Qin College of Resources and Environment Qingdao Agricultural UniversityQingdao 266109China College of Soil and Water Conservation Science and Engineering Northwest A&F UniversityYangling 712100China Institute of Soil and Water Conservation Chinese Academy of Sciences and Ministry of Water ResourcesYangling 712100China

Urban vegetation in China has changed substantially in recent decades due to rapid urbanization and dramatic climate ***,the spatial differentiation of greenness among major cities of China and its evolution process and drivers are still poorly *** study examined the spatial patterns of vegetation greenness across 289 cities in China in 2000,2005,2010,2015,and 2018 by using spatial autocorrelation analysis on the Normalized Difference Vegetation Index(NDVI);then,the influencing factors were analyzed by using the optimal parameters-based geographical detector(OPGD)model and 18 natural and anthropogenic *** findings demonstrated a noticeable rise in the overall greenness of the selected cities during *** cities in northwest China and east China exhibited the rapidest and slowest greening,respectively,among the six sub-regions.A significant positive spatial correlation was detected between the greenness of the 289 cities in different periods,but the correlation strength weakened over *** hot and very hot spots in southern and eastern China gradually shifted to the *** the spatial pattern of urban greenness in China is primarily influenced by wind speed(WS)and precipitation(PRE),the interaction between PRE and gross domestic product(GDP)has the highest explanatory *** explanatory power of most natural factors decreased and,conversely,the influence of anthropogenic factors generally *** findings emphasize the variations in the influence strength of multiple factors on urban greenness pattern,which should be taken into account to understand and adapt to the changing urban ecosystem.

关键词： Vegetation greenness Spatial heterogeneity Influencing factors Geographical detector Urban areas