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A preliminary study on the interaction between Asn-Gly-Arg(NGR)-modified multifunctional nanoparticles and vascular epithelial cells

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Acta Pharmaceutica Sinica B 2017年第3期7卷 361-372页

作者： chunxi liu Tingxian liu Xiaoyue Yu Yizhu Gu Department of Pharmacy Qilu HospitalShandong UniversityJi’nan 250012China School of Pharmaceutical Science Shandong UniversityJi’nan 250012China

Previously developed Asn-Gly-Arg(NGR) peptide-modified multifunctional poly(ethyleneimine)–poly(ethylene glycol)(PEI–PEG)-based nanoparticles(TPIC) have been considered to be promising carriers for the co-delivery of DNA and doxorubicin(DOX). As a continued effort, the aim of the present study was to further evaluate the interaction between TPIC and human umbilical vein endothelial cells(HUVEC) to better understand the cellular entry mechanism. In the present investigation,experiments relevant to co-localization, endocytosis inhibitors and factors influencing the internalization were performed. Without any treatment, there was no co-localization between aminopeptidase N/CD13(APN/CD13) and caveolin 1(CAV1). However, co-localization between CD13 and CAV1 was observed when cells were incubated with an anti-CD13 antibody or TPIC. As compared with antibody treatment,TPIC accelerated the speed and enhanced the degree of co-localization. TPIC entered HUVEC not only together with CD13 but also together with CAV1. However, this internalization was not dependent on the enzyme activity of CD13 but could be inhibited by methyl-β-eyclodextfin(MβCD), further identifying the involvement of caveolae-mediated endocytosis(CvME). This conclusion was also verified by endocytosis inhibitor experiments.

关键词： Asn-Gly-Arg peptide Aminopeptidase N/CD13 Caveolin 1 Caveolae-mediated endocytosis Endothelial cells Cellular entry Co-localization Doxorubicin

高迁移率金属氧化物半导体薄膜晶体管的研究进展

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液晶与显示 2024年第4期39卷 447-465页

作者：李强葛春桥陈露钟威平梁齐莹柳春锡丁金铎中山智隆新材料科技有限公司广东中山528459

基于金属氧化物半导体(MOS)的薄膜晶体管(TFT)由于较高的场效应迁移率(μFE)、极低的关断漏电流和大面积电性均匀等特点,已成为助推平板显示或柔性显示产业发展的一项关键技术。经过30余年的研究,非晶铟镓锌氧化物(a-IGZO)率先替代非晶... 详细信息

基于金属氧化物半导体(MOS)的薄膜晶体管(TFT)由于较高的场效应迁移率(μFE)、极低的关断漏电流和大面积电性均匀等特点,已成为助推平板显示或柔性显示产业发展的一项关键技术。经过30余年的研究,非晶铟镓锌氧化物(a-IGZO)率先替代非晶硅(a-Si)在TFT中得到推广应用。然而,为了同时满足显示产业对更高生产效益、更佳显示性能(如高分辨率、高刷新率等)和更低功耗等多元升级要求,需要迁移率更高的MOS TFTs技术。本文从固体物理学的角度,系统综述了MOS TFTs通过多元MOS材料实现高迁移率特性的研究进展,并讨论了迁移率与器件稳定性之间的关系。最后,总结展望了MOS TFTs的现状和发展趋势。

关键词：金属氧化物半导体薄膜晶体管场效应迁移率偏压稳定性

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山岭隧道富水破碎带突泥涌水处治技术研究

工程技术研究 2024年第13期9卷 13-15页

作者：李坪罗介池刘春希四川泸石高速公路有限责任公司

某高速公路高海拔山岭隧道穿越活动断层富水破碎带施工过程中，多次发生大面积突泥涌水。为安全有效处治并通过断层破碎带，结合既往施工技术经验，因地制宜，总结出“探、泄、固、挖”的总体思路，实施“帷幕注浆+水平旋喷桩+超前中管... 详细信息

某高速公路高海拔山岭隧道穿越活动断层富水破碎带施工过程中，多次发生大面积突泥涌水。为安全有效处治并通过断层破碎带，结合既往施工技术经验，因地制宜，总结出“探、泄、固、挖”的总体思路，实施“帷幕注浆+水平旋喷桩+超前中管棚+微台阶法开挖”的科学注浆开挖方式，取得了较好处治效果。文章研究内容可为类似隧道灾害处治提供经验。

关键词：山岭隧道富水破碎带突泥涌水帷幕注浆旋喷桩管棚

不同陶瓷颗粒表面处理对陶瓷/高铬铸铁复合材料微观界面的影响

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热加工工艺 2024年第5期53卷 142-146页

作者：汪勇余申卫刘春溪魏昂王成辉王惠梅中国船舶集团有限公司第十二研究所陕西兴平713102

采用传统的高铬铸铁制备电厂用磨煤机磨辊、磨盘已无法满足耐磨需求,陶瓷颗粒增强金属基耐磨复合材料成为替代传统耐磨材料的首选。本文研究了镀镍、镀钛表面处理对陶瓷/高铬铸铁复合材料微观界面的影响。结果表明,表面处理后陶瓷与高... 详细信息

采用传统的高铬铸铁制备电厂用磨煤机磨辊、磨盘已无法满足耐磨需求,陶瓷颗粒增强金属基耐磨复合材料成为替代传统耐磨材料的首选。本文研究了镀镍、镀钛表面处理对陶瓷/高铬铸铁复合材料微观界面的影响。结果表明,表面处理后陶瓷与高铬铸铁界面润湿性改善,可获得较好的铸渗效果。镀镍陶瓷颗粒与高铬铸铁复合材料没有明显的中间过渡层,二者之间的结合强度不高,陶瓷与高铬铸铁结合为机械结合。镀钛陶瓷颗粒与高铬铸铁复合材料的界面由于Ti元素的作用发生化学反应,形成明显的中间过渡层,界面结合强度高,陶瓷与高铬铸铁结合为冶金结合。

关键词：镀镍镀钛 ZTA陶瓷高铬铸铁界面结合

Effect of operating conditions on the performance of riser reactor for oxidative coupling of methane Author links open overlay panel

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Particuology 2024年第8期91卷 235-248页

作者： Min Cai Shuangzhu Kong Mengxi liu chunxi Lu State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China

Oxidative coupling of methane(OCM)is characterized by high temperature and strong heat released.A riser reactor is designed for the OCM process to improve gas-solid contacting and heat *** work illustrates the effect of hydrodynamic conditions and feed gas composition on the performance of an OCM riser *** findings suggest that oxidative reactions predominantly occur within the acceleration zone and developed flow ***,at the low superficial gas velocity accompanied by a high solid circulating rate,the C_(2)yield initially increases in the acceleration zone,followed by a decrease in the developed flow zone and deceleration *** optimal operating conditions are a specific region corresponding to the solids holdup ranges from 0.015 to ***,the C_(2)yield can be elevated using an appropriate feed mixture.

关键词： Oxidative coupling of methane Riser Hydrodynamics Solids holdup

Hydrodynamics and OCM reaction performance in a bubbling fluidized bed reactor and a riser reactor

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Particuology 2024年第3期86卷 188-204页

作者： Min Cai Shuangzhu Kong Sheng Chen Mengxi liu chunxi Lu State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China China Special Equipment Inspection and Research Institute Beijing102249China

The reasonable reactor design is of great importance for increasing the C_(2) yield(C2H4 and C2H6)of the oxidative coupling of methane(OCM),and the OCM reactor should remove the heat released in reactions quickly and efficiently and minimize the consecutive reaction of ethylene to carbon *** fluidized bed reactor is characterized by excellent heat transfer,superior mass transport,and large handling capacity,while fewer studies focused on large-scale fluidized bed reactors for the OCM ***,large cold-model experiments and computational fluid dynamics simulations were conducted to investigate hydrodynamics and the OCM reaction performance in a large-scale bubbling fluidized bed(BFB)and a large-scale *** the BFB reactor,consecutive reactions of ethylene are acute because of the strong gas back-mixing,high solids holdup,and non-uniform solids *** the consecutive reactions of ethylene are negligible due to the plug flow structure and low solids holdup in the riser ***,both reactors can achieve isothermal operation for the OCM *** C_(2) selectivity of 45.4% and C_(2) yield of 21.1% are obtained in the riser reactor,increasing by 20.3% and 5.8% individually than that in the BFB *** study provides useful information and reference to the OCM reactor designandcommercialization.

关键词： Oxidative coupling of methane Bubbling fluidized bed reactor Riser reactor Hydrodynamics Isothermal operation

SUS441不锈钢/Al金属间化合物微叠层复合板的界面结构与力学性能

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有色金属材料与工程 2024年第1期45卷 59-65页

作者：黄蔚泓袁文铮吴宇星刘淳熙满达魏振雄祖国胤东北大学材料科学与工程学院辽宁沈阳110819

采用“表面预处理—交替层叠—热轧复合—热处理”的工艺流程制备了SUS441不锈钢/Al金属间化合物微叠层复合板。利用光学显微镜、X射线衍射仪、扫描电子显微镜等检测与表征方法研究了热处理温度对复合板界面形貌、微观组织、物相组成、... 详细信息

采用“表面预处理—交替层叠—热轧复合—热处理”的工艺流程制备了SUS441不锈钢/Al金属间化合物微叠层复合板。利用光学显微镜、X射线衍射仪、扫描电子显微镜等检测与表征方法研究了热处理温度对复合板界面形貌、微观组织、物相组成、维氏硬度、拉伸性能的影响。结果表明:复合板界面结合良好;热处理后,固–液反应界面氧化严重,易导致界面分层而开裂;固–固、固–半固、固–液热处理后,金属间化合物层由均匀层和两相层组成,均匀层的物相组成为Fe_(2)A_(15),两相层的物相组成为Fe_(4)Al_(13)和Al_(13)Cr_(2),且两相层具有韧性特征,固–半固反应所得到的复合板的综合力学性能最佳。

关键词： SUS441不锈钢/Al 微叠层复合板热轧复合合金化界面

Research on a New Control Strategy of Three Phase Inverter for Unbalanced Loads

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Journal of Electromagnetic Analysis and Applications 2010年第1期2卷 39-44页

作者： Wenhua HU Weiming Ma chunxi liu 不详

One of the very important functions of three-phase inverter is to maintain the symmetric three-phase output voltage when the three-phase loads are unbalanced. Although the traditional symmetrical component decomposing and superimpose theory can keep the voltage balance through compensating the positive-, negative- and zero-sequence components of the output voltage of inverter, however, this method is time-consuming and not suitable for control. Aiming at high power medium frequency inverter source, a P+Resonant (Proportion and Resonant) controller which ensured a balanced three phase output voltage under unbalanced load is proposed in this paper. The regulator was proved to be applicable to both three-phase three-wire system and three-phase four-wire system and developed two methods of realization. The simulation results verified that this method can suppressed effectively the output voltage distorted caused by the unbalanced load and attained a high quality voltage waveforms.

关键词： Three-Phase Inverter Unbalanced Load the Three-Phase Output Voltage Symmetric Medium Frequency P+Resonant Controller

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数字SPWM方法对系统延时的影响

电力自动化设备 2013年第6期33卷 75-80页

作者：刘春喜孙驰高姬辽宁工程技术大学电气与控制学院辽宁葫芦岛125105 海军工程大学舰船综合电力技术国防科技重点实验室湖北武汉430033

首先定量分析了对称规则采样和不对称规则采样正弦脉宽调制(SPWM)方法引入的延时,然后介绍了3种改进的SPWM方法:改进的不对称规则采样法、多次采样固定更新法和多次采样立即更新法,并对每种方法引入的延时进行了分析。最后,采用DSP和现... 详细信息

首先定量分析了对称规则采样和不对称规则采样正弦脉宽调制(SPWM)方法引入的延时,然后介绍了3种改进的SPWM方法:改进的不对称规则采样法、多次采样固定更新法和多次采样立即更新法,并对每种方法引入的延时进行了分析。最后,采用DSP和现场可编程门阵列(FPGA),以同一个正弦信号为参考,同时生成了5种方法的SPWM波形,得到了各个波形基波分量与参考信号的相位差。从相位差可得到各种方法相对于参考信号的延时,与理论分析相一致,证明了所提的3种改进的SPWM方法可以有效地减小延时。

关键词：延时逆变器 SPWM 对称规则采样不对称规则采样