检索结果-南通市图书馆

Protein translation:biological processes and therapeutic strategies for human diseases

Signal Transduction and Targeted Therapy 2024年第3期9卷 1048-1064页

作者： Xuechao Jia Xinyu He chuntian huang Jian Li Zigang Dong Kangdong Liu Department of Pathophysiology School of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan 450000China China-US(Henan)Hormel Cancer Institute ZhengzhouHenan 450000China Department of Pathology and Pathophysiology Henan University of Chinese MedicineZhengzhouHenan 450000China Tianjian Laboratory of Advanced Biomedical Sciences ZhengzhouHenan 450052China Research Center for Basic Medicine Sciences Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052 HenanChina Provincial Cooperative Innovation Center for Cancer Chemoprevention Zhengzhou UniversityZhengzhouHenan 450000China State Key Laboratory of Esophageal Cancer Prevention and Treatment Zhengzhou UniversityZhengzhouHenan 450000China The Collaborative Innovation Center of Henan Province for Cancer Chemoprevention ZhengzhouHenan 450000China

Protein translation is a tightly regulated cellular process that is essential for gene expression and protein *** deregulation of this process is increasingly recognized as a critical factor in the pathogenesis of various human *** this review,we discuss how deregulated translation can lead to aberrant protein synthesis,altered cellular functions,and disease *** explore the key mechanisms contributing to the deregulation of protein translation,including functional alterations in translation factors,tRNA,mRNA,and ribosome *** translation leads to abnormal protein expression,disrupted cellular signaling,and perturbed cellular functions-all of which contribute to disease *** development of ribosome profiling techniques along with mass spectrometry-based proteomics,mRNA sequencing and single-cell approaches have opened new avenues for detecting diseases related to translation ***,we highlight recent advances in therapies targeting translation-related disorders and their potential applications in neurodegenerative diseases,cancer,infectious diseases,and cardiovascular ***,the growing interest lies in targeted therapies aimed at restoring precise control over translation in diseased cells is *** conclusion,this comprehensive review underscores the critical role of protein translation in disease and its potential as a therapeutic *** in understanding the molecular mechanisms of protein translation deregulation,coupled with the development of targeted therapies,offer promising avenues for improving disease outcomes in various human ***,it will unlock doors to the possibility of precision medicine by offering personalized therapies and a deeper understanding of the molecular underpinnings of diseases in the future.

关键词： translation offering precise

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exploring the Roles of Single Atom in Hydrogen Peroxide Photosynthesis

引用

Nano-Micro Letters 2024年第2期16卷 32-67页

作者： Kelin He Zimo huang Chao Chen chuntian Qiu Yu Lin Zhong Qitao Zhang International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518000China Queensland Micro‑and Nanotechnology Centre School of Environment and ScienceGriffith UniversityNathanQLD 4222Australia Institute for Sustainable Transformation School of Chemical Engineering and Light IndustryGuangdong University of TechnologyGuangzhou 51006China ZJU‑Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311215China

This comprehensive review provides a deep exploration of the unique roles of single atom catalysts(SACs)in photocatalytic hydrogen peroxide(H_(2)O_(2))*** offer multiple benefits over traditional catalysts such as improved efficiency,selectivity,and flexibility due to their distinct electronic structure and unique *** review discusses the critical elements in the design of SACs,including the choice of metal atom,host material,and coordination environment,and how these elements impact the catalytic *** role of single atoms in photocatalytic H_(2)O_(2)production is also analysed,focusing on enhancing light absorption and charge generation,improving the migration and separation of charge carriers,and lowering the energy barrier of adsorption and activation of *** these advantages,several challenges,including H_(2)O_(2)decomposition,stability of SACs,unclear mechanism,and low selectivity,need to be *** towards the future,the review suggests promising research directions such as direct utilization of H_(2)O_(2),high-throughput synthesis and screening,the creation of dual active sites,and employing density functional theory for investigating the mechanisms of SACs in H_(2)O_(2)*** review provides valuable insights into the potential of single atom catalysts for advancing the field of photocatalytic H_(2)O_(2)production.

关键词： Single atom catalysts H_(2)O_(2)photosynthesis Catalyst design and optimization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

花生红衣中反式白藜芦醇对HEK293T细胞抗氧化的影响

引用

中国食品学报 2024年第5期24卷 150-160页

作者：孙畅周春田岳玉兰吕呈蔚李云飞黄威李铁柱胡济美吉林省农业科学院农产品加工研究所长春130033 包头轻工职业技术学院内蒙古包头014035 中国国际工程咨询有限公司北京100048

目的:分析花生红衣中的白藜芦醇成分,探究其主要成分反式白藜芦醇(RES)对人胚胎肾细胞293(HEK293T)抗氧化的影响及其潜在的分子机制。方法:采用超声波辅助酶法提取花生红衣中的白藜芦醇,采用高效液相色谱-质谱联用(HPLC-MS)技术分析花... 详细信息

目的:分析花生红衣中的白藜芦醇成分,探究其主要成分反式白藜芦醇(RES)对人胚胎肾细胞293(HEK293T)抗氧化的影响及其潜在的分子机制。方法:采用超声波辅助酶法提取花生红衣中的白藜芦醇,采用高效液相色谱-质谱联用(HPLC-MS)技术分析花生红衣中白藜芦醇粗提液的组成成分。通过测定细胞活力,检测RES对HEK293T细胞的最高毒性。通过荧光素酶报告基因试验及免疫印迹试验检测其对Keap1-Nrf2-ARE抗氧化信号通路的影响,以DPPH自由基清除率评价其体外抗氧化能力。结果:HPLC-MS结果表明,花生红衣中含有白藜芦醇苷、白皮杉醇和RES。由于白藜芦醇在自然界中主要以反式白藜芦醇形式存在,因此选择RES进行后续试验。细胞存活力检测结果表明,RES对HEK293T细胞的最高无毒浓度为50μmol/L,体外抗氧化作用呈浓度依赖性。荧光素酶报告基因分析表明,RES显著诱导了ARE介导的转录激活。免疫印迹结果显示,RES能诱导Nrf2介导的3个抗氧化蛋白表达【血红素氧合酶1(HO-1)、醌氧化还原酶1(NQO1)和谷氨酸半胱氨酸连接酶(GCLM)】表达。此外,DPPH自由基清除率测定结果表明,RES能有效清除DPPH自由基,具有体外抗氧化能力。结论:花生红衣中白藜芦醇的主要成分RES对HEK293T细胞有抗氧化作用,可通过Keap1-Nrf2-ARE信号通路激活潜在的抗氧化活性。

关键词：花生红衣白藜芦醇 HEK293T 高效液相色谱-质谱联用 Keap1-Nrf2-ARE信号通路抗氧化

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

汽车玻璃升降器轻量化的设计

引用

汽车零部件 2016年第11期 46-49页

作者：黄春田上海实业交通电器有限公司上海200030

实施轻量化的途径一般是应用新材料、优化结构、减少冗余功能等方式。针对一款传统绳轮式汽车玻璃升降器,通过设计一款新型轴销螺钉,改变系统的受力方式,从而使铝镁合金材料得以应用,达到轻量化设计目标;同时为紧固件与铝合金板材的压... 详细信息

实施轻量化的途径一般是应用新材料、优化结构、减少冗余功能等方式。针对一款传统绳轮式汽车玻璃升降器,通过设计一款新型轴销螺钉,改变系统的受力方式,从而使铝镁合金材料得以应用,达到轻量化设计目标;同时为紧固件与铝合金板材的压铆工艺提供了参考。

关键词：汽车玻璃升降器轴销螺钉铝合金汽车轻量化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

汽车塑料零件孔隙率的检测及控制方法

引用

汽车零部件 2017年第9期 54-56页

作者：黄春田上海实业交通电器有限公司上海200030

铝合金材料代替钢材、塑料代替钢材是新的常用轻量化方法。采用注塑加工的塑料零件,零件内部易出现孔隙,这些孔隙会影响零件的机械强度。通过几个汽车玻璃升降器塑料零件的开发,介绍塑料零件孔隙率的检测方法及控制方法,为以塑代钢的轻... 详细信息

铝合金材料代替钢材、塑料代替钢材是新的常用轻量化方法。采用注塑加工的塑料零件,零件内部易出现孔隙,这些孔隙会影响零件的机械强度。通过几个汽车玻璃升降器塑料零件的开发,介绍塑料零件孔隙率的检测方法及控制方法,为以塑代钢的轻量化零件的开发应用提供参考。

关键词：塑料零件孔隙率检测方法控制方法汽车轻量化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

矸石电厂粉煤灰的化学激发及活化机理研究

引用

非金属矿 2013年第6期36卷 25-27页

作者：陈杰石莹黄庆享李思琼黄纯田西安科技大学材料学院陕西西安710054 西安科技大学能源学院陕西西安710054

以矸石电厂粉煤灰为研究对象,采用工业石灰、石膏、硫酸钠激活其火山灰活性,研究了激活剂掺量对矸石电厂粉煤灰活性的影响。通过正交实验研究了复合活化粉煤灰以及陈腐工艺对水泥胶砂试样不同龄期抗压强度影响规律,并通过扫描电镜(SEM)... 详细信息

以矸石电厂粉煤灰为研究对象,采用工业石灰、石膏、硫酸钠激活其火山灰活性,研究了激活剂掺量对矸石电厂粉煤灰活性的影响。通过正交实验研究了复合活化粉煤灰以及陈腐工艺对水泥胶砂试样不同龄期抗压强度影响规律,并通过扫描电镜(SEM)对胶砂试样28 d龄期的微观结构进行了表征,揭示了活化机理。结果表明,化学活化能有效激发矸石电厂粉煤灰的早期活性,成本低廉,工艺简单。活化剂作用于矸石电厂粉煤灰,存在最佳掺量,正交实验得到活化剂复配比为:氧化钙5%,石膏1%,硫酸钠4%。陈腐工艺有利于粉煤灰的化学活化,对胶砂试样28d抗压强度有一定程度提高。

关键词：矸石电厂粉煤灰化学活化活化机理陈腐

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

湖南省新田县富锶岩溶水矿物饱和指数特征,Sr^(2+)、SO_(4)^(2-)来源及开发潜力

引用

中国地质 2024年第3期51卷 1046-1058页

作者：赵光帅苏春田黄奇波朱义年杨杨罗飞李小盼桂林理工大学环境科学与工程学院广西桂林541004 中国地质科学院岩溶地质研究所广西桂林541004 自然资源部/广西壮族自治区岩溶动力学重点实验室广西桂林541004 联合国教科文组织国际岩溶研究中心/岩溶动力系统与全球变化国际联合研究中心广西桂林541004 广西平果喀斯特生态系统国家野外科学观测研究站广西平果531406 中国地质大学(武汉) 湖北武汉430074

【研究目的】湖南新田县发现大型富锶矿泉水田,然而锶元素来源及锶矿泉开发利用潜力研究相对薄弱,此外探究富锶岩溶水水化学特征及锶元素来源可为岩溶区寻找富锶地下水提供一定的理论支撑。【研究方法】通过开展水文地质调查,富锶地下... 详细信息

【研究目的】湖南新田县发现大型富锶矿泉水田,然而锶元素来源及锶矿泉开发利用潜力研究相对薄弱,此外探究富锶岩溶水水化学特征及锶元素来源可为岩溶区寻找富锶地下水提供一定的理论支撑。【研究方法】通过开展水文地质调查,富锶地下水水化学指标检测分析,利用PHREEQC软件、水化学计量法、端元法、水文地质参数等揭示富锶岩溶水矿物饱和指数特征,Sr^(2+)、SO_(4)^(2-)来源及富锶地下水开发潜力。【研究结果】方解石在下降泉和机井中均主要处于饱和状态,白云石由下降泉中未饱和状态转为机井中的饱和状态,菱锶矿在机井中出现饱和状态,石膏在下降泉和机井中均为未饱和状态。下降泉中矿物饱和指数随泉水溶解性总固体增加而升高,两者呈较好的正相关关系,但在机井中两者相关性较差。下降泉SO_(4)^(2-)和大气降水SO_(4)^(2-)具有较好的拟合关系,根据Ca^(2+)、Mg^(2+)、Sr^(2+)、HCO_(3)^(-)、SO_(4)^(2-)化学计量关系,机井中SO_(4)^(2-)可能来源于石膏溶解。下降泉中Sr^(2+)主要来源于石灰岩中以类质同像置换钙的锶,机井中Sr^(2+)较大可能来源于含水层中菱锶矿。研究区85.2%水点的地下水符合国家生活饮用水卫生标准,超标水点多为单指标超标。经计算,枯水年富锶地下水天然补给资源量、可开采资源量和地下水资源潜力分别为3.83×10^(7)m^(3)/a、1.05×10^(7)m^(3)/a、7.28×10^(6)m^(3)/a。【结论】新田县富锶地下水中锶主要来源于泥盆系佘田桥组地层含锶矿物(类质同像置换钙的锶和菱锶矿)的溶解,富锶地下水资源量及资源潜力可观,具有较大的开发利用潜力与价值。

关键词：富锶岩溶水矿物饱和指数 Sr^(2+)和SO_(4)^(2-) 开发潜力水文地质调查工程新田县湖南省

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Self-supported porous heterostructure WC/WO_(3−x)ceramic electrode for hydrogen evolution reaction in acidic and alkaline media

引用

Journal of Advanced Ceramics 2022年第8期11卷 1208-1221页

作者： Feihong WANG Binbin DONG Junwei WANG Nianwang KE chuntian TAN Anding huang Yutong WU Luyuan HAO Liangjun YIN Xin XU Yuxi XIAN Simeon AGATHOPOULOS CAS Key Laboratory of Materials for Energy Conversion Department of Materials Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China School of Materials Science and Engineering Henan Key Laboratory of Special Protective MaterialsLuoyang Institute of Science and TechnologyLuoyang 471023China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China School of Energy Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China CAS Key Laboratory of Mechanical Behaviors and Design of Materials Department of Modern MechanicsUniversity of Science and Technology of ChinaHefei 230026China Department of Materials Science and Engineering University of IoanninaIoannina GR-45110Greece

Tungsten carbide(WC)-based materials are widely considered as the hydrogen evolution reaction(HER)process catalysts due to their“Pt-like”electronic ***,traditional powder electrodes have a high cost,and display problems related to the process itself and the poor stability over operation *** paper presented a self-supported asymmetric porous ceramic electrode with WO_(3-x)whiskers formed in situ on the walls of the finger-like holes and membrane surface,which was prepared by combining phase inversion tape-casting,pressureless sintering,and thermal treatment in a CO_(2) *** optimized ceramic electrode displayed good catalytic HER activity and outstanding stability at high current *** specifically,it demonstrated the lowest overpotentials of 107 and 123 mV and the lowest Tafel slopes of 59.3 and 72.4 mV·dec^(-1)at 10 mA·cm^(-2)in acidic and alkaline media,*** superior performance was ascribed to the structure of the ceramic membrane and the charge transfer efficiency,which was favored by the in situ developed WC/WO_(3-x)heterostructure and the oxygen vacancies.

关键词： hydrogen evolution reaction(HER) porous ceramic membrane WC/WO_(3−x)heterostructure self-supported electrode oxygen vacancies

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dietary supplementation with 2-hydroxy-4-methyl(thio)butanoic acid and DL-methionine improves productive performance,egg quality and redox status of commercial laying ducks

引用

Animal Nutrition 2023年第3期14卷 101-110页

作者： Yanan Zhang Zhiwei Zhuang Tahir Mahmood Yves Mercier Yongyan Jin Xuebing huang Kaichao Li Shuang Wang Weiguang Xia Shenglin Wang Miao Yu Wei Chen chuntian Zheng Institute of Animal Science Guangdong Academy of Agricultural SciencesKey Laboratory of Animal Nutrition and Feed Science(South China)of Ministry of AgricultureState Key Laboratory of Livestock and Poultry BreedingGuangdong Public Laboratory of Animal Breeding and NutritionGuangdong Key Laboratory of Animal Breeding and Nutrition510640GuangzhouChina Institute of Life Science and Engineering Foshan University528200FoshanChina Adisseo France S.A.S.Centre of Excellence and Research in Nutrition CommentryFrance

This experiment aimed to study the effects of supplemental methionine sources,2-hydroxy-4 methyl(thio)butanoic acid(HMTBa)and DL-Methionine(DL-Met),on productive performance,egg quality,and redox status of laying ducks.A total of 792 healthy 25-wk-old Longyan laying ducks with similar body weights were randomly allotted to 11 treatment *** treatment group had 6 replicates of 12 *** trial lasted for 16 *** were fed a basal deficient diet(Met:0.24%;Met+Cys:0.51%)or supplemented with DL-Met or HMTBa at 0.05%,0.12%,0.19%,0.26%,and 0.33%of diet,*** with the basal diet,supplementation with either DL-Met or HMTBa increased the average egg weight,egg mass,and decreased feed to egg ratio during the whole trial period(P<0.05).Albumen weight and its ratio to total egg weight were increased,but yolk and shell ratio,albumen height,Haugh unit and shell breaking strength were decreased(P<0.05).Dietary DL-Met or HMTBa supplementation increased taurine,methionine,leucine,tryptophan and arginine content,and decreased serine and lysine content in plasma(P<0.05).The redox status of laying ducks was improved by enhancing the glutathione peroxidase and catalase activities,glutathione content and its ratio relative to glutathione(oxidized)content and decreasing malondialdehyde content and increasing mRNA expression of superoxide dismutase-1,glutathione peroxidase-1,hemeoxygenase-1 and nuclear factor-like 2 in liver and ileum with the supplementation of DL-Met or HMTBa(P<0.05).Liver health status measured by average area proportion lipid droplet was improved with supplementation of DL-Met or HMTBa(P<0.05).Villus height and villus height to crypt depth ratio in the ileum and the ileal gene expression of tight junction protein and occludin were increased with DL-Met or HMTBa supplementation(P<0.05).Taken together,these results suggested that the efficacy of dietary supplementation of HMTBa was similar to DL-Met,and it ranged from 98%to 100%for productive

关键词： DL-Methionine 2-Hydroxy-4 methyl(thio)butanoic acid Productive performance Efficacy Laying duck

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

饲粮添加维生素D 3对产蛋后期蛋鸭产蛋性能、蛋品质、脂质代谢和盲肠微生物的影响

引用

动物营养学报 2024年第7期36卷 4350-4364页

作者：夏焕婷金永燕陈伟王爽夏伟光金成龙黄雪冰李凯潮王胜林郑春田张亚男(广东省农业科学院动物科学研究所猪禽种业全国重点实验室农业农村部华南动物营养与饲料重点实验室广东省动物育种与营养公共实验室广东省畜禽育种与营养研究重点实验室广州510640 仲恺农业工程学院广州510225

本试验旨在研究饲粮添加维生素D_(3)(VD_(3))对产蛋后期蛋鸭产蛋性能、蛋品质、脂质代谢和盲肠微生物的影响。选用432只健康、产蛋率相近的产蛋后期(58周龄)龙岩山麻鸭,随机分为6组,每组6个重复,每个重复12只鸭。对照组饲喂基础饲粮(不... 详细信息

本试验旨在研究饲粮添加维生素D_(3)(VD_(3))对产蛋后期蛋鸭产蛋性能、蛋品质、脂质代谢和盲肠微生物的影响。选用432只健康、产蛋率相近的产蛋后期(58周龄)龙岩山麻鸭,随机分为6组,每组6个重复,每个重复12只鸭。对照组饲喂基础饲粮(不添加VD_(3)),试验组分别饲喂在基础饲粮中添加800、1600、2400、3200和4000 IU/kg VD_(3)的饲粮。预试期2周,正试期16周。结果表明:1)饲粮添加VD_(3)可显著提高产蛋后期蛋鸭产蛋率和日产蛋重(P0.05),且肝脏总胆固醇和低密度脂蛋白含量随饲粮VD_(3)添加水平的提高呈先降低后升高的二次变化(P<0.05)。4)与对照组相比,饲粮添加2400 IU/kg VD_(3)显著降低产蛋后期蛋鸭十二指肠隐窝深度(P<0.05),显著提高十二指肠绒隐比(P<0.05),且十二指肠绒隐比随饲粮VD_(3)添加水平的提高呈先升高后降低的二次变化(P<0.05)。5)饲粮添加VD_(3)对产蛋后期蛋鸭盲肠微生物丰富度和多样性无显著影响。在属水平上,饲粮添加VD_(3)能够显著提高短链脂肪酸(SCFA)合成菌如布劳特氏菌属(Blautia)、另枝菌属(Alistipes)和Lachnoclostridium相对丰度(P<0.05)。综上所述,饲粮添加VD_(3)可改善产蛋后期蛋鸭产蛋性能、脂质代谢和肠道形态,促进盲肠SCFA合成菌富集,建议产蛋后期蛋鸭饲粮VD_(3)添加水平为2400~3200 IU/kg。

关键词：维生素D 3 蛋鸭产蛋性能脂质代谢肠道微生物

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：