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Nano Research 2022年第5期15卷 3872-3879页

作者： Man Wen Beibei Ren Xiangzhi Ye Jianxiong He Hong Jiang chunrong xiong State Key Laboratory of Marine Resource Utilization in South China Sea Special Glass Key Lab of Hainan ProvinceHainan Provincial Fine Chemical Engineering Research CenterHainan UniversityHaikou 570228China Hainan haikong Special Glass Techology Co. Ltd.Chengmai 571900China

Silica aerogel was prepared by a sol-gel method with combination of freeze drying.The aerogel was filled with TiCl4 in autoclave and used to fabricate a hierarchical structure of TiO_(2) nanofiber shell and SiO_(2) aerogel core(SiO_(2)@TiO_(2)).The TiO_(2) nanofibers with a diameter of 10-15 nm were highly crystalline and mainly grew along the(101)or(001)planes,favoring charge migration along the growth axis of the fibers.The photoluminescence(PL)emission spectra show that the TiO_(2) nanofibers exhibited much lower PL intensity than P25.The free standing TiO2 nanofibers loaded with CuO had a band gap of 3.04 eV.When CuO was hierarchically loaded on the nanofiber surface and into the aerogel core(SiO_(2)/CuO@TiO_(2)/CuO),the absorption edge significantly red shifted,and the band gap was further narrowed to 2.66 eV.Meanwhile,Fe^(3+)implanted TiO_(2) nanofibers on the aerogel surface(SiO_(2)@Fe-TiO_(2))were also fabricated in the same strategy.The CuO loaded nanofibers(SiO_(2)/CuO@Fe-TiO_(2)/CuO)had a band gap of 2.62 eV.The photocatalytic reduction of CO_(2) was performed under light irradiation by a 300 W Xe-lamp for 4 h.The methanol yield over the SiO_(2)/CuO@Fe-TiO_(2)/CuO reached~2,400 μmol·gcat^(-1) in the absence of sacrificial agent.

关键词： hierarchical structure fibrous morphology high crystallinity lattice doping without sacrificial agent

Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release

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Friction 2023年第7期11卷 1194-1211页

作者： Xiaowei MAO Kexin CHEN Yanlong ZHAO chunrong xiong Jing LUO Yuguang WANG Bo WANG Hongyu ZHANG School of Chemical Engineering and Technology Hainan UniversityHaikou 570228China State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Peking University School of Nursing&National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing 100191China Beijing Research Institute of Automation for Machinery Industry Co. Ltd.Beijing 100120China Center of Digital Dentistry Peking University School and Hospital of Stomatology&NHC Research Center of Engineering and Technology for Computerized DentistryBeijing 100081China College of Chemical and Biological Engineering Shandong University of Science and TechnologyQingdao 266590China

Osteoarthritis is associated with the significantly increased friction of the joint,which results in progressive and irreversible damage to the articular cartilage.A synergistic therapy integrating lubrication enhancement and drug delivery is recently proposed for the treatment of early-stage osteoarthritis.In the present study,bioinspired by the self-adhesion performance of mussels and super-lubrication property of articular cartilages,a biomimetic self-adhesive dopamine methacrylamide-poly(2-methacryloyloxyethyl phosphorylcholine)(DMA-MPC)copolymer was designed and synthesized via free radical polymerization.The copolymer was successfully modified onto the surface of biodegradable mesoporous silica nanoparticles(bMSNs)by the dip-coating method to prepare the dual-functional nanoparticles(bMSNs@DMA-MPC),which were evaluated using a series of surface characterizations including the transmission electron microscope(TEM),Fourier transform infrared(FTIR)spectrum,thermogravimetric analysis(TGA),X-ray photoelectron spectroscopy(XPS),etc.The tribological test and in vitro drug release test demonstrated that the developed nanoparticles were endowed with improved lubrication performance and achieved the sustained release of an anti-inflammatory drug,i.e.,diclofenac sodium(DS).In addition,the in vitro biodegradation test showed that the nanoparticles were almost completely biodegraded within 10 d.Furthermore,the dual-functional nanoparticles were biocompatible and effectively reduced the expression levels of two inflammation factors such as interleukin-1β(IL-1β)and interleukin-6(IL-6).In summary,the surface functionalized nanoparticles with improved lubrication and local drug release can be applied as a potential intra-articularly injected biolubricant for synergistic treatment of early-stage osteoarthritis.

关键词： surface functionalization phosphorylcholine coating mesoporous silica nanoparticles hydration lubrication osteoarthritis

麻杏仙葶汤对湿热证肺炎幼龄大鼠的疗效机制研究

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中华中医药杂志 2024年第5期39卷 2560-2564页

作者：贺喜盈王睿睿吴忻晨江春融郗域江蔡政潮熊磊云南中医药大学昆明650500

目的:探究麻杏仙葶汤治疗湿热证肺炎幼龄大鼠的疗效机制。方法:4~6周龄SD大鼠35只,随机分为空白组、肺炎组、湿热证肺炎组、地塞米松组和麻杏仙葶汤高、中、低剂量组。采用“高脂高糖饮食+湿热环境+腹腔注射脂多糖”方式制备湿热证肺炎... 详细信息

目的:探究麻杏仙葶汤治疗湿热证肺炎幼龄大鼠的疗效机制。方法:4~6周龄SD大鼠35只,随机分为空白组、肺炎组、湿热证肺炎组、地塞米松组和麻杏仙葶汤高、中、低剂量组。采用“高脂高糖饮食+湿热环境+腹腔注射脂多糖”方式制备湿热证肺炎幼鼠模型,并予相应药物灌胃治疗。观察幼鼠一般情况变化,检测其肺脏指数、肺组织病理学和血浆促炎因子IL-1β、IL-6、TNF-α含量。结果:湿热证肺炎幼龄大鼠模型制备成功。与空白组比较,湿热证肺炎组大鼠体温、肺脏指数显著升高(P<0.01),肺组织损伤严重,血浆IL-1β、IL-6、TNF-α含量显著升高(P<0.01)。与湿热证肺炎组比较,麻杏仙葶汤中、高剂量组体温、肺脏指数显著降低(P<0.05,P<0.01);各剂量组大鼠肺组织损伤有不同程度减轻;中、高剂量组血浆IL-1β、IL-6、TNF-α含量显著降低(P<0.05,P<0.01)。结论:麻杏仙葶汤能有效改善湿热证肺炎幼鼠的症状,抑制炎症反应,减轻肺组织损伤。

关键词：儿童肺炎湿热证病证结合动物模型麻杏仙葶汤炎症反应肺组织损伤疗效机制

m(ZnO)/m(B_(2)O_(3))质量比对低熔点封接玻璃Bi_(2)O_(3)-B_(2)O_(3)-ZnO结构、性能与润湿性的影响

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硅酸盐通报 2024年第4期43卷 1341-1349页

作者：康涛熊春荣符有杰蔡邦辉魏曙光李军葛姜宏海南大学海南省特种玻璃重点实验室海口570228 海南海控特玻科技有限公司澄迈571924 四川英诺维新材料科技有限公司达州635107

针对真空玻璃封接的性能要求,本文采用高温熔融法制备了一种针对真空玻璃封接的铋系非晶无铅玻璃粉,通过高温X射线衍射、粉末X射线衍射、拉曼光谱、差式扫描量热仪、热膨胀测试和扫描电子显微镜等测试方法,研究了m(ZnO)/m(B_(2)O_(3))... 详细信息

针对真空玻璃封接的性能要求,本文采用高温熔融法制备了一种针对真空玻璃封接的铋系非晶无铅玻璃粉,通过高温X射线衍射、粉末X射线衍射、拉曼光谱、差式扫描量热仪、热膨胀测试和扫描电子显微镜等测试方法,研究了m(ZnO)/m(B_(2)O_(3))质量比对Bi_(2)O_(3)-B_(2)O_(3)-ZnO玻璃的网络结构、特征温度、热膨胀系数和封接温度的影响。结果表明,增加m(ZnO)/m(B_(2)O_(3))质量比可促进锌氧多面体由[ZnO_(4)]向[ZnO_(6)]转变,导致热膨胀系数降低,特征温度升高。当m(Bi_(2)O_(3))∶m(B_(2)O_(3))∶m(ZnO)质量比为80∶7∶13,玻璃具有较低的玻璃化转变温度T_(g)(371℃)和膨胀软化温度T_(f)(401℃),热膨胀系数为9.3×10^(-6)℃^(-1),封接温度为450℃,可满足真空玻璃封接对低熔点封接玻璃粉的要求。

关键词： m(ZnO)/m(B_(2)O_(3))质量比特征温度 Bi_(2)O_(3)-B_(2)O_(3)-ZnO玻璃真空玻璃封接温度封接玻璃粉

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Li_(2)O-Al_(2)O_(3)-SiO_(2)系微晶玻璃的研究进展

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硅酸盐通报 2024年第4期43卷 1181-1196页

作者：任贝贝刘亚鑫黄欣王霆王娜姜宏熊春荣郝红勋天津大学国家工业结晶工程技术研究中心天津300072 海南大学海南省特种玻璃重点实验室海口570228

Li_(2)O-Al_(2)O_(3)-SiO_(2)(LAS)系微晶玻璃由于具有热膨胀系数低、透明度高、力学性能优良等特点,被广泛应用于国防、建筑、化工、生物医药等多个领域,近年来受到研究者的广泛关注。本文综述了LAS系微晶玻璃的研究现状,介绍了LAS晶... 详细信息

Li_(2)O-Al_(2)O_(3)-SiO_(2)(LAS)系微晶玻璃由于具有热膨胀系数低、透明度高、力学性能优良等特点,被广泛应用于国防、建筑、化工、生物医药等多个领域,近年来受到研究者的广泛关注。本文综述了LAS系微晶玻璃的研究现状,介绍了LAS晶相体系及相关玻璃产品,对比分析了LAS系微晶玻璃各制备工艺的特点,并讨论了LAS系微晶玻璃晶核剂的种类及成核机理,最后总结了LAS系微晶玻璃性能、应用以及相应表征技术和测试手段,并指出了LAS系微晶玻璃存在的问题及未来的发展方向。

关键词： LAS系微晶玻璃高铝低锂低热膨胀组分设计晶核剂

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曲靖市麒麟区芥蓝—甜玉米轮作优质高产栽培技术

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长江蔬菜 2024年第11期 8-10页

作者：韩正波熊春荣万双粉曲靖市麒麟区经济作物管理服务中心云南曲靖655000 曲靖市麒麟区农业产业化办公室

多年来,曲靖市麒麟区稳步发展农业,将蔬菜产业作为种植业的压舱石,大力发展外销蔬菜种植,已成为发展最快、外向度最高和带动农户增收最强劲的曲靖种植业第一大产业,在优化产业结构和助农增收上,取得了显著成效。但由于多年连作,种植种... 详细信息

多年来,曲靖市麒麟区稳步发展农业,将蔬菜产业作为种植业的压舱石,大力发展外销蔬菜种植,已成为发展最快、外向度最高和带动农户增收最强劲的曲靖种植业第一大产业,在优化产业结构和助农增收上,取得了显著成效。但由于多年连作,种植种类单一,部分蔬菜基地盐渍化程度加重,土传病害严重,连作障碍突出,影响了蔬菜品质、产量、效益。近年来,麒麟区聚集保障粮食安全,积极探索菜粮轮作新模式,因地制宜推广外销蔬菜+甜玉米轮作技术,有效控制了蔬菜土传性病虫害的发生,有力促进了农民增收、耕地增效、粮食增产,保证了菜粮的协调可持续发展,实现了菜粮双丰收。

关键词：芥蓝甜玉米高产栽培技术

腹泻型肠易激综合征常见证型粪便肠道菌群宏基因组学横断面研究

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中医杂志 2024年第5期65卷 503-511页

作者：熊钦李奕霖姚承佼罗利红谢凤娇杨春荣董朝强冯培民成都中医药大学附属医院四川省成都市610075

目的探讨腹泻型肠易激综合征(IBS-D)常见证候肠道菌群结构及功能特征。方法招募2020年1月1日至2021年3月31日就诊于成都中医药大学附属医院的IBS-D患者,及同期成都中医药大学附属医院体检中心招募的健康受试者。IBS-D患者分为肝郁脾虚型... 详细信息

目的探讨腹泻型肠易激综合征(IBS-D)常见证候肠道菌群结构及功能特征。方法招募2020年1月1日至2021年3月31日就诊于成都中医药大学附属医院的IBS-D患者,及同期成都中医药大学附属医院体检中心招募的健康受试者。IBS-D患者分为肝郁脾虚型IBS-D、脾虚湿盛型IBS-D,与健康受试者分别组成肝郁脾虚组、脾虚湿盛组及健康组。采集一般资料,包括年龄、性别、身体质量指数(BMI),IBS-D患者另采集肠易激综合征症状严重程度量表(IBS-SSS)、肠易激综合征生活质量评分量表(IBS-QOL)评分。同时收集新鲜粪便标本,采用宏基因组测序技术进行检测,对注释的肠道菌群结构与功能进行丰度统计展示、PCoA、Anosim、LEfSe生物信息分析。结果三组受试者一般资料差异无统计学意义(P>0.05);肝郁脾虚组、脾虚湿盛组IBS-SSS、IBS-QOL评分差异无统计学意义(P>0.05)。研究纳入肝郁脾虚组、脾虚湿盛组及健康组各28例。肝郁脾虚组患者特有基因数量为269135个,脾虚湿盛组特有基因数量为216156个,健康组特有基因数量为249759个,三组共有基因数量为1784036个。三组间在肠道菌群排名前十物种的相对丰度分布上存在差异,在门、纲、目层级差异较小,在科、属、种层级差异较大。三组间肠道菌群结构与功能相对丰度存在差异。种水平的物种PCoA、Anosim分析显示三组间菌群组成有明显差别。进一步LEfSe分析显示,肝郁脾虚组患者筛选到14种优势菌种,其中Clostridium sp.CAG 217、Lachnospira pectinoschiza、Anaerotruncus sp.CAG 528、Paeniclostridium sordellii、Eubecterium sp.CAG 76、Bacillus cereus丰度差异影响程度较大;脾虚湿盛组筛选到24种优势菌种,其中Roseburia inulinivorans、Eubacterium sp.CAG 251、Roseburia hominis、Unclassified Eubacterium rectale、Roseburia intestinalis、Megamonas funiformis丰度差异影响程度较大;未筛选到肝郁脾虚组患者的优势功能基因,脾虚湿盛组筛选到鞭毛装配(ko02040)、卟啉代谢(ko00860)、沙门氏菌感染(ko05132)、苯甲酸降解(ko00362)4种优势功能基因。肝郁脾虚组、脾虚湿盛组差异优势功能基因可能主要集中在新陈代谢(包括外源物质的生物降解和代谢、能量代谢、脂质代谢等)方面。结论肝郁脾虚型IBS-D患者肠道菌群结构特征表现为包括Clostridium sp.CAG 217在内的14种菌种富集。脾虚湿盛型IBS-D患者肠道菌群结构特征表现为包括Roseburia inulinivorans在内的24种菌种富集,功能特征表现为鞭毛装配等4种功能富集。Clostridium sp.CAG 217、Roseburia inulinivorans分别有望成为肝郁脾虚、脾虚湿盛型IBS-D患者的生物标志物。

关键词：腹泻型肠易激综合征肝郁脾虚脾虚湿盛宏基因组学肠道菌群

Heterostructure engineering in electrode materials for sodium-ion batteries:Recent progress and perspectives

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eScience 2023年第5期3卷 1-11页

作者： Eric Gabriel chunrong Ma Kincaid Graff Angel Conrado Dewen Hou Hui xiong Micron School of Materials Science and Engineering Boise State UniversityBoiseID83725USA X-ray Sciences Division Argonne National LaboratoryLemontIL60439USA College of Textiles&Clothing Qingdao UniversityQingdao266071China Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdao266071China Center for Nanoscale Materials Argonne National LaboratoryLemontIL60439USA Center for Advanced Energy Studies Idaho FallsID83401USA

Sodium-ion batteries(SIBs)have stepped into the spotlight as a promising alternative to lithium-ion batteries for large-scale energy storage systems.However,SIB electrode materials,in general,have inferior performance than their lithium counterparts because Nat is larger and heavier than Lit.Heterostructure engineering is a promising strategy to overcome this intrinsic limitation and achieve practical SIBs.We provide a brief review of recent progress in heterostructure engineering of electrode materials and research on how the phase interface influences Nat storage and transport properties.Efficient strategies for the design and fabrication of heterostructures(in situ methods)are discussed,with a focus on the heterostructure formation mechanism.The heterostructure's influence on Nat storage and transport properties arises primarily from local distortions of the structure and chemomechanical coupling at the phase interface,which may accelerate ion/electron diffusion,create additional active sites,and bolster structural stability.Finally,we offer our perspectives on the existing challenges,knowledge gaps,and opportunities for the advancement of heterostructure engineering as a means to develop practical,highperformance sodium-ion batteries.

关键词： Heterostructure Sodium-ion batteries Electrode materials Heterogeneous materials Interface engineering Intergrowth

UHPLC-MS-based metabolomics analysis reveals the process of Schistosomiasis in mice

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UHPLC-MS-based metabolomics analysis reveals the process of ...

充氮蒸馏-离子色谱法测定香菇中二氧化硫残留量

2021中国畜牧兽医学会兽医寄生虫学分会第16次学术研...

作者： Yuzheng Huang Qiong Wu Liang Zhao chunrong xiong Yongliang Xu Xin Dong Yan Wen Jun Cao

Metabolomics,as an emerging technology,has been demonstrated to be a very powerful tool in the study of the host metabolic responses to infections by parasites.Schistosomiasis is a parasitic infection caused by schistosoma worm via the direct contact with the water containing cercaria,among which Schistosoma japonicum（S.japonicum） is endemic in Asia.In order to characterize the schistosome-induced changes in the host metabolism and further to develop the strategy for early diagnosis of schistosomiasis,we performed comprehensive LC-MS-based metabolomics analysis of serum from mice infected by S.japonicum for five weeks.With the developed diagnosis strategy based on our metabolomics data,we were able to successfully detect schistosomiasis at the first week post-infection,which was three weeks earlier than "gold standard" methods and two weeks earlier than the methods based on H NMR spectroscopy.Our metabolomics study revealed that S.japonicum infection induced the metabolic changes involved in a variety of metabolic pathways including amino acid metabolism,DNA and RNA biosynthesis,phospholipid metabolism,depression of energy metabolism,glucose uptake and metabolism,and disruption of gut microbiota metabolism.In addition,we identified seventeen specific metabolites whose down-regulated profiles were closely correlated with the time-course of schistosomiasis progression and can also be used as an indicator for the worm-burdens.Interestingly,the decrease of these seventeen metabolites was particularly remarkable at the first week post-infection.Thus,our findings on mechanisms of host-parasite interaction during the disease process pave the way for the development of an early diagnosis tool and provide more insightful understandings of the potential metabolic process associated with schistosomiasis in mice.Furthermore,the diagnosis strategy developed in this work is cost-effective and is superior to other currently used diagnosis methods.

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食品科技 2022年第2期47卷 299-303页

作者：谭春蓉罗长琴熊双重庆市万州食品药品检验所重庆404100

建立了充氮蒸馏-离子色谱法测定香菇中二氧化硫残留量的分析方法。称取3.00 g样品加入蒸馏瓶后加入150 mL蒸馏水和5 mL盐酸,以20 mL过氧化氢溶液为接收液,经充氮蒸馏(功率300 W,氮气流速200 mL/min)8 min后定容并稀释,采用离子色谱法测... 详细信息

建立了充氮蒸馏-离子色谱法测定香菇中二氧化硫残留量的分析方法。称取3.00 g样品加入蒸馏瓶后加入150 mL蒸馏水和5 mL盐酸,以20 mL过氧化氢溶液为接收液,经充氮蒸馏(功率300 W,氮气流速200 mL/min)8 min后定容并稀释,采用离子色谱法测定,外标法定量。在此试验方法下,二氧化硫在0~5.00 mg/L范围内呈良好线性关系,线性相关系数r^(2)=0.99978;检出限为0.2 mg/kg,定量限为0.6 mg/kg;在高中低3个加标水平下干香菇中二氧化硫平均回收率为74.0.%~84.1%,相对标准偏差(RSD)为0.9%~3.2%;新鲜香菇的平均回收率为76.0%~110.3%,RSD为0.9%~5.1%。在实际样品测定中,55份香菇样品中二氧化硫检出率为100%,范围为5.24~110.97 mg/kg,超标率为56.7%(鲜香菇)和28.0%(干香菇)。结果表明,该方法精密度高、重现性好,可用于香菇中二氧化硫残留量的测定。

关键词：香菇二氧化硫充氮蒸馏离子色谱法残留量