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Establishment of Integrated Diagnosis and Treatment and Whole-Course Management Model of Major Depressive Disorder

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Medicinal Plant 2022年第3期13卷 65-67页

作者： Huai ZHANG Xiong CHEN chunqi ai Mental Health Center Taihe Hospital (Hubei University of Medicine) Shiyan 442000 China

Integrated diagnosis,treatment and whole-course management model of major depressive disorder(MDD)is an integrated drug-psychological-physical comprehensive treatment model based on rapid biological-psychological-social evaluation for treating patients with major depressive *** paper comprehensively evaluates the clinical efficacy and biochemical indexes of patients,and carries out symptom evaluation,problem classification,disease diagnosis and etiological analysis of visitors from the three dimensions about physiology,psychology and ***,according to the symptoms and causes of different dimensions,this paper formulates personalized drug,psychological and physical therapy programs,and constantly optimizes and adjusts the treatment plan in the treatment process,so as to cure both the symptoms and the root causes,providing a reliable strategy for the treatment of clinical MDD,and establishing a standardized characteristic model for further promotion and application of this *** present,the project has been used in the member units of Taihe Medical Group and Shiyan City and its surrounding areas,the market response is good,and will be gradually promoted to the whole country in the later stage.

关键词： Major depressive disorder Integrated therapy Whole course of disease Management model

The Characteristics of the Drug Composition in the Treatment of Insomnia by External Bath Prescription of Traditional Chinese Medicine

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Medicinal Plant 2020年第4期11卷 88-89,92页

作者： Xiong CHEN Xi WANG Lizhu LIU Dongyu XIA Gang LI chunqi ai Mental Health Center of Shiyan Taihe Hospital (Affiliated Hospital of Hubei University of Medicine) Shiyan 442000 China Sleep Disorders Center of Shiyan Taihe Hospital (Affiliated Hospital of Hubei University of Medicine) Shiyan 442000 China Mental Health Center Chinese Medicine Hospital of Zhuxi Zhuxi 442300 China

[Objectives]The research aimed to carry out a retrospective analysis on the characteristics of the drug composition in the treatment of insomnia by external bath prescription of traditional Chinese medicine,to provide ideas for the research and development of new Chinese medicine for insomnia.[Methods]The external bath prescriptions of traditional Chinese medicine related to insomnia were collected,and the appearance frequency of drug was analyzed,and statistical analysis of drug with high appearance frequency was conducted.[Results]In the external bath prescriptions of traditional Chinese medicine related to insomnia,the top ten herbs with high appearance frequency were as follows:Chaozaoren,Drgonsbones,Margaritifera,Yejiaoteng,Schisandrae Chinensis Fructus,Lilii Bulbus,Platycladi Semen,Poria,Coptidis Rhizoma,and Scutellariae *** to the classification by efficacy,these herbs mostly have the effects of calming,nourishing and heat clearing.[Conclusions]Traditional Chinese medicine is most closely related to heart,kidney,liver and other *** and sedative drugs should be chosen,which corresponds with the understanding on pathogenesis of insomnia in traditional Chinese medical science,and embodies the characteristics of external bath prescription of traditional Chinese medicine in the treatment of insomnia.

关键词： Traditional Chinese medicine External treatment of traditional Chinese medicine Prescription Insomnia

Wavelength injection locking actively Q-switched random fiber laser based on random phase-shifted fiber Bragg grating and electro-optic modulator

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Optoelectronics Letters 2024年第3期20卷 135-141页

作者： PAN Honggang ZHANG Bo SONG Dianyou CHEN Zhipan CHEN chunqi LI Rupeng School of Integrated Circuit Science and Engineering Tianjin University of TechnologyTianjin 300384China

In this paper, an actively Q-switched wavelength injection locking random fiber laser(RFL) based on random phase-shifted fiber Bragg grating(RPS-FBG) is proposed, and the performance of the laser is verified by experiments. Within the reflection bandwidth range of RPS-FBG, spanning from 1 549.2 nm to 1 549.9 nm, different laser modes with stable central wavelength and peak power can be selectively chosen by varying the injected light wavelength. The power fluctuation within 1 h is less than 0.1 d Bm, and the central wavelength drift is less than 0.02 nm. When the pump power increases from 90 mW to 300 mW, the pulse width decreases from 3.2 μs to 1.5 μs, and the pulse repetition frequency is 20 kHz. The RFL can reach a stable locking state at the lowest pump power of 100 mW and the lowest injection power of 3 d Bm. When the wavelength is locked, the output pulse is a single pulse. On the contrary, the unlocked output pulse is multi-pulse. The laser has the characteristics of high wavelength tunability in the reflection range of RPS-FBG and it can be an ideal light source in the fields of laser imaging and pulse coding.

关键词： fiber switched modulator

Novel Optimal Dispatch Method for Multiple Energy Sources in Regional Integrated Energy Systems Considering Wind Curtailment

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CSEE Journal of Power and Energy Systems 2024年第5期10卷 2166-2173页

作者： Yang Gao Qian ai Key Laboratory of Control of Power Transmission and Conversion Ministry of EducationShanghai Jiao Tong UniversityShanghai 200240China

Power-to-gas technology uses temporary surplus electricity to create either renewable hydrogen or renewable natural gas,which can then be stored in natural-gas pipelines and used when *** a result,P2G transforms conventional one-way coupling of a power/heat/natural-gas system into twoway ***,its operating characteristics makes it possible to more effectively utilize *** paper describes a new optimal dispatch model for integrated electricity/gas/heat energy *** model considers the effective use of surplus wind-energy with electricity-to-gas ***,a multi-energy network model is built,taking into account both equipment and network ***,we apply a novel two-layer optimization method,which uses P2G,to“absorb”wind *** the top-layer model is used for the dayahead dispatch of the natural-gas network containing P2G,the bottom-layer model describes the day-ahead economic dispatch of the electricity/heat system,which includes wind *** on the Karush-Kuhn-Tucher conditions of the bottom-layer model,the two-layer model is transformed into a single-layer model,and we linearize the nonlinear equation to convert the nonlinear model into a mix-integer linear programming problem,which is solvable using the General Algebraic Modeling ***,numerical case-studies are performed to evaluate the accuracy and effectiveness of the proposed method.

关键词： Multi-enery coupling power-to-gas two-layer optimization wind-power consumption

Resonance Analysis in a High-Rise Building: Combined Translational and Rotational Measurements

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Journal of Earth Science 2024年第3期35卷 1069-1074页

作者： Linpeng Qin Yun Wang Chang Chen Yongxiang Wei chunqi Liao Yi Zhang Chao Wang Wentao Wan Quanyang Shao School of Geophysics and Information Technology China University of GeosciencesBeijing 100083China Fujian Earthquake Agency Fuzhou 350003China Institute of Geochemistry Chinese Academy of SciencesGuiyang 550081China

0 INTRODUCTION Resonance frequency is an important indicator for structure health monitoring,which can be exacerbated by various natural forces,such as rainfall,earthquakes,and hurricanes(Wu et al.,2021;Shan et al.,2020;Gentile et al.,2016;Moser and Moaveni,2011).Clinton et al.(2006)found that changes in environmental factors could significantly affect the resonance frequency of the Millikan Library;and that compared with temperature,humidity and strong wind have greater impacts on resonance ***,some studies have confirmed the effects of environmental factors through mathematical statistical analyses,including Xia et al.(2006),Yuen and Kuok(2010),and Guéguen et al.(2017).Other studies(e.g.,Astorga et al.,2018)revealed a building’s self-healing ability,where the building’s resonance frequency drifts due to earthquake events,environmental factors,or random forced vibrations could gradually return to its original level,but the recovery time of frequency drift could be considerably different with respect to different environmental factors.

关键词： humidity rainfall earthquake

Reliability ensemble averaging reduces surface wind speed projection uncertainties in the 21st century over China

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Advances in Climate Change Research 2024年第2期15卷 222-229页

作者： Zheng-Tai ZHANG Chang-ai XU Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric SciencesLanzhou UniversityLanzhou 730000China

Accurate prediction of future surface wind speed(SWS)changes is the basis of scientific planning for wind *** studies have projected SWS changes in the 21st century over China on the basis of the multi-model ensemble(MME)of the 6th Coupled Model Intercomparison Project(CMIP6).However,the simulation capability for SWS varies greatly in CMIP6 multi-models,so the MME results still have large *** this study,we used the reliability ensemble averaging(REA)method to assign each model different weights according to their performances in simulating historical SWS changes and project the SWS under different shared socioeconomic pathways(SSPs)in *** results indicate that REA considerably improves the SWS simulation capacity of CMIP6,eliminating the overestimation of SWS by the MME and increasing the simulation capacity of spatial *** spatial correlations with observations increased from 0.56 for the MME to 0.85 for ***,REA could eliminate the overestimation of the SWS by 33%in *** for southeastern China,the SWS generally decreases over China in the near term(2020-2049)and later term(2070-2099),particularly under high-emission *** SWS reduction projected by REA is twice as high as that by the MME in the near term,reaching-4%to-3%.REA predicts a larger area of increased SWS in the later term,which expands from southeastern China to eastern *** study helps to reduce the projected SWS uncertainties.

关键词： Surface wind speed Uncertainty Multi-model ensemble Reliability ensemble averaging CMIP6

Recent progress in MOFs-based nanozymes for biosensing

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Nano Research 2024年第1期17卷 39-64页

作者： Imamdin Chandio Yongjian ai Lei Wu Qionglin Liang MOE Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryLaboratory of Flexible Electronics TechnologyCenter for Synthetic and Systems BiologyTsinghua University-Peking University Joint Centre for Life SciencesTsinghua UniversityBeijing 100084China

Nanozymes are nanomaterials with enzyme-mimicking catalytic *** to natural enzymes,nanozymes show various properties such as easy to manufacture,stable,adjustable,and *** play key roles in biosensing,biocatalysis,and disease *** an important kind of nanozymes,metal-organic framework(MOF)-based nanozymes are receiving a lot of attention due to their structural properties and *** developing MOF with enzymes-like catalytic properties has opened new perspectives in *** review summarizes the up-to-date developments in synthesizing two-dimensional and three-dimensional MOF-based nanozymes and their applications in ***,classification of nanozymes obtained by MOFs is categorized,and different properties of MOF-based nanozymes are ***,the distinctive applications of MOF-based nanozymes in identifying various analytes are thoroughly ***,the recent challenges and progressive directions in this area are highlighted.

关键词： metal-organic frameworks nanozymes metal-organic framework (MOF)-based nanozymes biosensing analytes

Wellbore Cleaning Degree and Hydraulic Extension in Shale Oil Horizontal Wells

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Fluid Dynamics & Materials Processing 2024年第3期20卷 661-670页

作者： Xin ai Mian Chen College of Petroleum Engineering China University of Petroleum(Beijing)BeijingChina Daqing Oil Field Company Limited DaqingChina

The efficient development and exploitation of shale oil depends on long-distance horizontal wells. As the degreeof cleaning of the wellbore plays a key role in these processes, in this study, this problem is investigated experimentallyby focusing on the dimensionless cuttings bed height. A method is proposed to calculate the horizontalwellhydraulic extension taking into account the influence of the wellbore cleaning degree on the wellborepressure distribution and assess the effect of a variety of factors such as the bottom hole pressure, the circulatingpressure drop, the drilling pump performance and the formation properties. The analysis shows that the hydraulicextension of horizontal wells decreases with an increase in the cuttings bed height, and the higher the displacementof drilling fluid, the faster the hydraulic extension declines. The annular pressure drop of the horizontalsection increases with the increase of the cuttings bed height, resulting in a higher bottom-hole pressure. Severalarguments are provided to guide the safe drilling of shale oil horizontal wells and overcome the limits of currenttechnological approaches.

关键词： Shale oil horizontal well hydraulic extension wellbore cleaning degree pressure distribution mechanism analysis

Classifying hepatitis B therapies with insights from covalently closed circular DNA dynamics

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Virologica Sinica 2024年第1期39卷 9-23页

作者： Jie-Li Hu ai-Long Huang Key Laboratory of Molecular Biology on Infectious Diseases Ministry of EducationChongqing Medical UniversityChongqing400016China

The achievement of a functional cure for chronic hepatitis B(CHB)remains limited to a minority of patients treated with currently approved *** primary objective in developing new anti-HBV drugs is to enhance the functional cure rates for CHB.A critical prerequisite for the functional cure of CHB is a substantial reduction,or even eradication of covalently closed circular DNA(cccDNA).Within this context,the changes in cccDNA levels during treatment become as a pivotal *** have previously analyzed the factors influencing cccDNA dynamics and introduced a preliminary classification of hepatitis B treatment strategies based on these *** this review,we employ a systems thinking perspective to elucidate the fundamental aspects of the HBV replication cycle and to rationalize the classification of treatment strategies according to their impact on the dynamic equilibrium of *** upon this foundation,we categorize current anti-HBV strategies into two distinct groups and advocate for their combined use to significantly reduce cccDNA levels within a well-defined timeframe.

关键词： Hepatitis B cccDNA Functional cure Dynamics Treatment Strategy