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Transition of electric activity of neurons induced by chemical and electric autapses

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Science China(Technological Sciences) 2015年第6期58卷 1007-1014页

作者： SONG XinLin wang chunni MA Jun TANG Jun Department of Physics Lanzhou University of Technology College of Science China University of Mining and Technology

Autapse connected to the neuron can change the electric activity of neuron. The effect of autapse on neuronal activity is often described by adding an additive forcing current along a close loop, which is described by a time-delayed feedback on the membrane potential. Neuron often responds to electric autapse forcing sensitively and quickly, while the chemical autapse changes the electric activity of neuron slowly. By applying external forcing, a shift transition of electric activity can be more easily induced by the electric autapse than the chemical autapse. Our results confirm that chemical autapse can enhance and/or suppress the transition of electric activity with excitable or inhibitory type driven by electric autapse, vice versa. It indicates that an appropriate switch-off-on for autapse can make the neuron give different types of response to external forcing. Particularly, cooperation and competition between chemical and electric autapse help neuron response to external forcing in the most reliable way.

关键词： autapse neuron spiking bursting

2018-2022年淄博市预防艾滋病、梅毒和乙肝母婴传播实施效果研究

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中国卫生产业 2024年第1期21卷 216-218,222页

作者：王春妮王玲王茜云朱华淄博市妇幼保健院保健部山东淄博255012 淄博市博山区计划生育服务中心区妇幼保健院山东淄博255200

目的研究2018—2022年淄博市预防艾滋病、梅毒和乙肝母婴传播工作实施效果。方法提取2018-2022年淄博市工作月报表及个案卡信息,分析艾滋病、梅毒和乙肝检测率、阳性检出率、治疗率及干预效果等。结果淄博市分娩产妇均在孕产期接受艾梅... 详细信息

目的研究2018—2022年淄博市预防艾滋病、梅毒和乙肝母婴传播工作实施效果。方法提取2018-2022年淄博市工作月报表及个案卡信息,分析艾滋病、梅毒和乙肝检测率、阳性检出率、治疗率及干预效果等。结果淄博市分娩产妇均在孕产期接受艾梅乙检测,孕期检测率呈上升趋势,差异有统计学意义(P<0.001);梅毒孕产妇阳性检出率2.03‰,呈上升趋势;乙型病毒性肝炎(Viral Hepatitis Type B,HBV)阳性检出率2.55%,呈下降趋势;艾滋病病毒(Human Immunodeficiency Virus,HIV)感染孕产妇及所生儿童抗HIV用药率均为100%;梅毒感染孕产妇治疗率及所生儿童预防性治疗率呈上升趋势,差异有统计学意义(P<0.001);HIV母婴传播率为0,先天梅毒报告发病率为1.56/10万活产;乙肝母婴传播率为0.68%。结论全市预防母婴传播工作成效明显,但仍需继续努力,为消除母婴传播工作奠定基础。

关键词：艾滋病梅毒乙肝母婴传播孕产妇

Phase coupling synchronization of FHN neurons connected by a Josephson junction

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Science China(Technological Sciences) 2020年第11期63卷 2328-2338页

作者： ZHANG Yin wang chunni TANG Jun MA Jun REN GuoDong Department of Physics Lanzhou University of TechnologyLanzhou 730050China School of Physics China University of Mining and TechnologyXuzhou 221116China School of Science Chongqing University of Posts and TelecommunicationsChongqing 430065China

Avariety of nonlinear circuits can be tamed to reproduce the main dynamical properties in neural activities for biological neurons while designing reliable artificial synapses for connecting these neural circuits becomes a *** this paper,a Josephson junction is used to build coupling channel for connecting two FitzHugh-Nagumo neural circuits driven by periodical voltage *** hybrid synapse is designed by using a linear resistor paralleled with a Josephson junction,which can estimate the effect of external magnetic field by generating additive phase error between the ***,it activates nonlinear coupling due to phase diversity in the Josephson *** coupled circuits are estimated in dimensionless dynamical systems by applying scale transformation on the variables and parameters in neural *** fact,the intrinsic parameters of coupling channel are adjusted to detect the occurrence of *** analysis is calculated to predict and confirm the occurrence of synchronization between two neural *** is found that synchronization can be stabilized between two FHN neural circuits by selecting appropriate values for parameters in the Josephson junction involved in the coupling *** gives useful guidance for implementing artificial synapse for signal processing in neural circuits.

关键词： neuron synchronization hybrid synapse neural circuit bifurcation

Autapse-induced target wave, spiral wave in regular network of neurons

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Science China(Physics,Mechanics & Astronomy) 2014年第10期57卷 1918-1926页

作者： QIN HuiXin MA Jun wang chunni CHU RunTong Department of Physics Lanzhou University of Technology

Autapse is a type of synapse that connects axon and dendrites of the same neuron, and the effect is often detected by close-loop feedback in axonal action potentials to the owned dendritic tree. An artificial autapse was introduced into the Hindmarsh-Rose neuron model, and a regular network was designed to detect the regular pattern formation induced by autapse. It was found that target wave emerged in the network even when only a single autapse was considered. By increasing the(autapse density) number of neurons with autapse, for example, a regular area(2×2, 3×3, 4×4, 5×5 neurons) under autapse induced target wave by selecting the feedback gain and time-delay in autapse. Spiral waves were also observed under optimized feedback gain and time delay in autapses because of coherence-like resonance in the network induced by some electric autapses connected to some neurons. This confirmed that the electric autapse has a critical role in exciting and regulating the collective behaviors of neurons by generating stable regular waves(target waves, spiral waves) in the network. The wave length of the induced travelling wave(target wave, spiral wave), because of local effect of autapse, was also calculated to understand the waveprofile in the network of neurons.

关键词： target wave spiral wave network autapse time-delay memory

Dynamics of electric activities in neuron and neurons of network induced by autapses

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Science China(Technological Sciences) 2014年第5期57卷 936-946页

作者： QIN HuiXin MA Jun JIN WuYin wang chunni Department of Physics Lanzhou University of Technology College of Mechano-Electronic Engineering Lanzhou University of Technology

The effect of autapse on adjusting the membrane of potentials of neuron is described by imposing a time-delayed feedback on the membrane of neuron in a close loop type,and the Hindmarsh-Rose(HR)neuron under autapse is ***,the electric activity of single HR neuron under electric autapse and chemical autapse is *** is found that quiescent neuron is activated due to appropriate time delay and feedback gain in the autapse,and the autapse plays an important role in waking up *** parameter region for periodic,chaotic activity of neuron under autapse is calculated in a numerical way,and transition from spiking to bursting is observed by increasing the feedback gain and time delay ***,the collective electric activities of neurons in a ring network is investigated and abundant electric activities are observed due to the competition between the autapse and the time-delayed coupling between adjacent neurons in the network,and time delay in coupling between neurons also plays an important role in enhancing synchronization in the network.

关键词： time delay bifurcation Lyapunov exponent neuron network

Emergence of target waves in neuronal networks due to diverse forcing currents

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Science China(Physics,Mechanics & Astronomy) 2013年第6期56卷 1126-1138页

作者： MA Jun wang chunni YING HePing WU Ying CHU RunTong Department of Physics Lanzhou University of Technology Department of Physics Zhejiang University School of Aerospace Xi'an Jiaotong University

The electric activities of neurons could be changed when ion channel block occurs in the *** forcing currents with diversity are imposed on the regular network of Hodgkin-Huxley(HH) neuron,and target waves are induced to occupy the *** forcing current I1 is imposed on neurons in a local region with m 0 ×m 0 nodes in the network,neurons in other nodes are imposed with another forcing current *** wave could be developed to occupy the network when the gradient forcing current(I1-I2) exceeds certain threshold,and the formation of target wave is independent of the selection of boundary *** is also found that the developed target wave can decrease the negative effect of ion channel block and suppress the spiral wave,and thus channel noise is also *** potential mechanism of formation of target wave could be that the gradient forcing current(I1-I2) generates quasi-periodical signal in local area,and the propagation of quasi-periodical signal induces target-like wave due to mutual coupling among neurons in the network.

关键词： target wave network of neuron channel block Hodgkin-Huxley

Immunohistochemical prognostic markers of esophageal squamous cell carcinoma:a systematic review

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Chinese Journal of Cancer 2017年第11期36卷 592-608页

作者： chunni wang Jingnan wang Zhaoli Chen Yibo Gao Jie He Department of Thoracic Surgery National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeScience Building Center for Cancer Precision Medicine Chinese Academy of Medical Sciences and Peking Union Medical College

Background: Esophageal squamous cell carcinoma(ESCC) is an aggressive malignancy, with a high incidence and poor prognosis. In the past several decades, hundreds of proteins have been reported to be associated with the prognosis of ESCC, but none has been widely accepted to guide clinical care. This study aimed to identify proteins with great potential for predicting prognosis of ***: We conducted a systematic review on immunohistochemical(IHC) prognostic markers of ESCC according to the 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA) Guidelines. Literature related to IHC prognostic markers of ESCC were searched from PubMed, Embase, Web of Science, and Cochrane Library until January 30 th, 2017. The risk of bias of these original studies was evaluated using the Quality in Prognosis Studies(QUIPS) ***: We identified 11 emerging IHC markers with reproducible results, including eight markers [epidermal growth factor receptor(EGFR), Cyclin D1, vascular endothelial growth factor(VEGF), Survivin, Podoplanin, Fascin,phosphorylated mammalian target of rapamycin(p-mTOR), and pyruvate kinase M2(PKM2)] indicating unfavorable prognosis and 3 markers(P27, P16, and E-cadherin) indicating favorable prognosis of ***: Strong evidence supports that these 11 emerging IHC markers or their combinations may be useful in predicting prognosis and aiding personalized therapy decision-making for ESCC patients.

关键词： Esophageal squamous cell carcinoma Prognosis Survival Immunohistochemical markers

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油气输送管道失效分析技术现状及研究进展

石油管材与仪器 2024年第1期10卷 1-8页

作者：王春妮李健白真权王聪孙冰花李奥西安石油大学材料科学与工程学院陕西西安710065 中国石油集团工程材料研究院有限公司油气钻采输送装备全国重点实验室陕西西安710077

油气输送管道在长期服役过程中易出现失效问题并带来安全和经济风险。概述了油气输送管道的失效类型及特点,对失效分析技术现状及其研究进展进行了综述。将数字技术和智能化技术融入到传统的无损检验和断口失效分析中,大幅提高了常用失... 详细信息

油气输送管道在长期服役过程中易出现失效问题并带来安全和经济风险。概述了油气输送管道的失效类型及特点,对失效分析技术现状及其研究进展进行了综述。将数字技术和智能化技术融入到传统的无损检验和断口失效分析中,大幅提高了常用失效分析技术的时效性和准确性;总结归纳了油气输送管道失效评估技术与计算机模拟分析技术的研究现状及进展,评述了其中的问题,指出了未来的发展方向。最后对油气输送管道失效预测预警新技术进行了展望。

关键词：油气输送管道失效失效分析失效评估计算机模拟分析

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老年肌肉减少症与新型炎症标志物的相关性

中国骨质疏松杂志 2024年第1期30卷 50-55页

作者：蒋思琪黄欢欢胡吉丽罗业涛王春妮罗欣黄琪陈梅赵庆华贾雯碧重庆医科大学附属第一医院护理部重庆400016 大溪沟街道社区卫生服务中心护士站重庆400015 陆军军医大学第二附属医院感染控制科重庆400037 重庆医科大学公共卫生学院重庆400016 重庆医科大学附属璧山医院(重庆市璧山区人民医院)护理部重庆402760

目的了解炎症标志物与老年肌肉减少症之间的相关性。方法2023年1~6月在社区卫生服务中心连续招募符合纳入排除标准的老年人,根据亚洲肌少症工作组(AWGS)2019将其分为非肌肉减少症组、肌肉减少症组。分析两组临床资料,采用多因素Logisti... 详细信息

目的了解炎症标志物与老年肌肉减少症之间的相关性。方法2023年1~6月在社区卫生服务中心连续招募符合纳入排除标准的老年人,根据亚洲肌少症工作组(AWGS)2019将其分为非肌肉减少症组、肌肉减少症组。分析两组临床资料,采用多因素Logistic回归筛选老年肌肉减少症的危险因素。采用受试者工作特征(ROC)曲线分析炎性指标对老年肌肉减少症的诊断价值。采用Spearman相关性分析探讨炎性指标与肌肉减少症相关指标的相关性。结果共纳入研究对象377名,肌肉减少症的检出率为17.51%。Logistic多因素回归分析显示,年龄(OR=1.147,95%CI:1.091~1.206)、全身免疫炎症指数(SII)(OR=1.043,95%CI:1.025~1.061)和中性粒细胞/淋巴细胞比率(NLR)(OR=3.236,95%CI:1.984~5.278)、体质量指数(BMI)(OR=1.147,95%CI:1.091~1.206)是老年人发生肌肉减少症的危险因素。ROC曲线显示,SII、NLR、血小板/淋巴细胞比值(PLR)三者联合诊断能力高于3个单项指标,曲线下面积(AUC)为0.818(95%CI:0.764~0.872)。Spearman相关性分析结果显示,SII、PLR与肌肉健康指标呈负相关(P<0.05)。结论老年肌肉减少症与SII、NLR、PLR等新型炎症标志物具有一定相关性,对肌肉减少症的早期筛查和干预有重要意义。

关键词：肌肉减少症炎症全身免疫炎症指数老年人